• Title/Summary/Keyword: Clear

Search Result 11,420, Processing Time 0.042 seconds

Profiling of Gene Expression According to Cancer Stage in Clear Cell Type of Renal Cell Carcinoma

  • Won, Nam-Hee;Ryu, Yeon-Mi;Kim, Ki-Nam;Kim, Meyoung-Kon
    • Molecular & Cellular Toxicology
    • /
    • v.1 no.1
    • /
    • pp.62-71
    • /
    • 2005
  • For toxicity model in the kidney, renal cell carcinoma (RCC) is one of the most important model to assess the structural and functional alterations. Most RCCs are sporadic, and environmental agents are suspected to play a role in the etiology of the disease. In this study, we discovered novel evidence for previously unknown gene expression patterns related to progression according to cancer stage in RCC. Four clear cell RCC tissue samples along with five corresponding patient-matched normal kidney tissue samples were obtained from patients undergoing partial or radical nephrectomy. To examine the difference of gene expression profile in clear cell RCC, radioactive cDNA microarrays were used to evaluate changes in the expression of 1,152 genes in a total. Using $^{33}P-labeled$ probes, this method provided highly sensitive gene expression profiles including drug metabolism, and cellular signaling. 29 genes were identified with expression levels that differed by more than 2.0 value of z-ratio, compared with that in control. Whereas expression of 38 genes were decreased by less than-2.0 value of z-ratio. In conclusion, this study has identified 67 gene expression alterations in clear-cell type of RCC. Most notably, genes involved in cell growth were up-regulated in stage I more than stage III whereas genes involved in signal transduction were down-regulated in which both stage I and stage III. The identified alteraions of gene expression will likely give in sight in to clear cell RCC and tumor progression.

Clear Cell Chondrosarcoma of the Scapula in a Child -A Case Report- (소아의 견갑골에 생긴 투명세포연골육종 - 1예 보고 -)

  • Lee, Kyung-Ji;Lee, An-Hi;Kim, Jean-A;Kim, Hyoung-Min;Lee, Kyo-Young
    • The Journal of the Korean bone and joint tumor society
    • /
    • v.15 no.2
    • /
    • pp.155-159
    • /
    • 2009
  • Clear cell chondrosarcoma is a rare, low-grade variant of chondrosarcoma that comprises approximately 2% of all chondrosarcomas. This tumor usually involves the epiphysis and epimetaphysis of long bones, especially the proximal part of the femur or humerus, whereas involvement of the scapula is rare. It occurs at any age, but the peak is third to fifth decade, and is rarely seen in the first and second decades of life. Histologically, tumor cells with abundant clear cytoplasm and benign giant cells are usually found. We report on a case of clear cell chondrosarcoma of the scapula in an 8-year-old girl.

  • PDF

College Students' Images of Nurses (대학생의 간호사에 대한 이미지)

  • Kim, Bok-Lang;Kim, Seon-Hee;Kim, Ok-Sook;Nam, Young-Hwa;Lee, Kil-Ja;Chung, Bok-Yae
    • The Korean Nurse
    • /
    • v.35 no.4
    • /
    • pp.75-91
    • /
    • 1996
  • The purpose of this study was to identify the college students' images of Nurses. Data were collected by open-ended questionnaire. 326 subjects were composed of nursing students and non nursing students who attended in universities and junior colleges at Pusan, Kyung-buk, and Chung-buk from April 30 to May 31, 1995. Collected data were analyzed by all researchers. Statements were categorized and endowed with Key meaning. The results were 1. Positive images of nurses were classified into 21 categories. They were , , , , , , , , , , , , , , , , , , , . 2. Among the positive images categories, statements about the were the most. Statements about , , , were a lot. 3. For nusing students, statements about the were the most. Statements about , , , were a lot 4. For non-nursing students statements about the were the most. Statements about , , , were a lot. 5. For nursing students who have no experience of the clinical practice statements about , , were a lot. 6. For nursing students who have not experience of the clinical practice, statements about , , were a lot. 7. Negative images of nurses were classified into 21 categories. They were , , , , , , , , , , , , , , , , , , , . 8. Among the negative image categories, statements about the were the most. satements about , , , , were a lot.

  • PDF

Prevalence and Clinical Significance of Mammalian Target of Rapamycin Phosphorylation (p-mTOR) and Vascular Endothelial Growth Factor (VEGF) in Clear Cell Carcinoma of the Ovary

  • Khemapech, Nipon;Pitchaiprasert, Sunaree;Triratanachat, Surang
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.13 no.12
    • /
    • pp.6357-6362
    • /
    • 2012
  • Background: To determine the prevalence of mammalian target of rapamycin phosphorylation (p-mTOR) and vascular endothelial growth factor (VEGF) and any correlation with clinical characteristics and prognosis in ovarian clear cell carcinoma patients. Materials and Method: Seventy four paraffin-embedded specimens of such carcinomas frompatients who underwent surgery, received adjuvant chemotherapy and were followed up at King Chulalongkorn Memorial Hospital during January 2002 to December 2008 were stained with rabbit monoclonal IgG p-mTOR and rabbit polyclonal IgG VEGF using immunohistochemical methods. Medical records were reviewed and clinical variables were analysed. Results: The prevalence of positive p-mTOR in ovarian clear cell carcinoma was 87.9% and significantly higher in advance-stage than early-stage patients (100% versus 83.6%, P<0.05). Two-year disease free survival and 2-year overall survival in patients with positive p-mTOR expression were 60% and 69.2% with no differences from patients with negative p-mTOR expression (p>0.05). The prevalence of VEGF expression was 63.5% and significantly higher in chemo-sensitive than chemo-resistant patients (70.7% versus 37.5%, P<0.05). Two-year disease free survival and 2-year overall survival in patients with VEGF expression were 72.3% and 83% respectively which were significantly different from patients with negative VEGF expression (p<0.05). Conclusions: p-mTOR expression in ovarian clear cell carcinoma was significantly correlated with the stage of disease. VEGF expression was significantly correlated with chemosensitivity, and survival. Further studies of related targeted therapy might be promising.

Functional Properties of Korean Atractylodes japonica Koidz (한국산 삽주의 기능성)

  • 강은미;정창호;심기환
    • Food Science and Preservation
    • /
    • v.8 no.1
    • /
    • pp.86-91
    • /
    • 2001
  • To study the availability of the Korean Atractylodes japonica Koidz. as ingredients for functional flood, functional properties of solvent extracts were investigated and the results were followed. Yield was 14.8% by ethanol extraction of fresh Korean A. Japonica and 17.7% by water fraction. Acetone extract and butanol fraction showed stronger activity of the hydrogen donating activities, each of 72.9% and 74.2%, respectively, in fresh Korean A. japonica and methanol extract and butanol fraction showed stronger activity of the nitrite scavenging effects, each of 95.0% and 79.2%. in fresh Korean A. japonica. Among the solvent extacts from fresh Korean a. japonica, extract by methanol showed strong antimicrobial activity in which clear zone showed 20 mm for Bacillus subtilis and 19 mm for Pseudomonas aeruginosa. Butanol fraction derived from methanol extract showed moderate antimicrobial activity : 18 mm clear zone for Bacillus subtilis and Vibrio parahaemolyticus. Minimum inhibitory concentrations of methanol extract and butanol fraction were about 2 mg/disc and 4 mg/disc against gram(+) bacteria and 6 mg/disc against gram(-) bacteria, respectively.

  • PDF

A Study on the standardizing of Recipe for Soup Making - Focused on Clear Soup - (국조리의 과학화에 관한 연구 - 맑은장국을 중심으로 -)

  • Hong, Jin Sook
    • Korean journal of food and cookery science
    • /
    • v.15 no.6
    • /
    • pp.595-602
    • /
    • 1999
  • This study was intended to develop traditional Korean soup recipe which can be used for food service and meet consumers' taste with a focus on clear soup such as clear radish soup, sea mustard soup, dried pollack soup, croaker soup, and backbone soup. The developed sample(S1) showed the highest level of overall preference among consumers. There were significant differences in sensory characteristics of the samples especially between S1 and others. The sensory characteristics of each soup showed a slight difference depending on the kind of soup, however, all items had an effect on overall preference. One of the standardized recipe to make broth was presented as follows: The ingredients for broth consists of the shank or brisket of beef(100 g), water(10 cup), spring onion(20 g), onion(30 g), garlic(10 g), salt(1 teaspoonful), and black pepper power(1/10 teaspoonful). 1) The meat part of shank or brisket is prepared. 2) The unfrozen meat is immersed in cold water for 20 min, whereby blood is extracted from the meat. 3) 10 cups of water are poured into the pan and boiled enough. 4) After water has boiled enough, the lump of meat with blood extracted is cut into 2 or 3 pieces and is boiled in the boiling water by high-intensity heat with the pan lid uncovered, and dirty foam is scooped out while boiling. 5) If the broth begins to be extracted, the intensity of heat is lowered for boiling for one hour or so, and then again boiled for 30 min with spring onion, garlic, onion and the like. If the broth is extracted enough, spring onion, garlic, onion, and others are removed from the pan. the broth is seasoned with salt and black pepper powder, and foam is removed by using fine mesh sieve or gauze. Then, 6 cups of clear broth is obtained finally.

  • PDF

Enhanced Segmentized Clear Channel Assessment Method for IEEE 802.15.4 Network (IEEE 802.15.4 Network의 전송효율 향상을 위한 Enhanced Semgentized Clear Channel Assessment 기법)

  • Son, Kyou Jung;Chang, Tae Gyu
    • Journal of IKEEE
    • /
    • v.20 no.3
    • /
    • pp.322-325
    • /
    • 2016
  • This paper proposed Enhanced Segmentized Clear Channel Assesment(ESCCA) for the IEEE 802.15.4 networks. This method divides original CCA into two groups to check precise channel status and perform additional CCA to increase throughput performance. Through the proposed method, the device can access the channel more often, so the transmission efficiency of the IEEE 802.15.4 network improves. To confirm the feasibility and usability of the proposed method, computer simulation has been performed. In the simulation, a star topology with one coordinator and a lot of devices is considered and the traffic flows are all one way, with the communication directed to the coordinator. Simulation results_ show the proposed method is improving maximum 10 kbps of throughput and decreasing maximum 15 of the average number of total CCA than IEEE 802.15.4 CCA method.

A Morphological and Histochemical Study on the Posterior Tentacle Antenna of the Korean Slug , Incilaria fruhstorferi (한국산 산민달팽이 ( Incilaria fruhstorferi ) 후촉각의 형테 및 조직화학적인 연구)

  • 김영언;장남섭
    • The Korean Journal of Malacology
    • /
    • v.12 no.1
    • /
    • pp.1-17
    • /
    • 1996
  • Morphological and histochemical characteristics of the cells in posterior tentacle antenna of Korean slug, Incilaria fruhstorferi were observed with light microscope. The epithelium of the posterior tentacle antenna was composed of supporting cells, sensory neurons and type-a clear cell. The columnar supporting epithelium was widely distributed in the posterior tentacle antenna, and the upper end of the cell was covered with acidic mucopolysaccharide. Nerve endings of the sensory neuron were distributed between type-a clear cells. It was usually located in tentacular knob, and the number of them gradually decrdased as close as tentacular stalk. Several cilia were observed on the nerve ending. Type-a clear cells were very brightly stained with all staining used, and the neutral mucous guanules distributed in the cytoplasm. Collar cells, type-b clear cell and various types of secrdtory cells distributed in the connective tissue. The collar cells were clustering in connective tissue, and the cytoplasm were filled with neutral mucous guanules. The cells and granules were stained with dark brown by silver nitrate stain. Type-b clear cells were irregular in shape and their cytoplasms were brightly stained wth many stains used. Ten types of secretory cells evenly distributed in the connective tissue and muscle layers of the posterior tentacle antenna. The five types of the secretory cells(A, B, E, J and L)seemed to secrete acidic mucopolysaccharide, and the other five type of the cell(C, D, F, H, and L)seemed to secrete neutral mucopolysaccharide. Muscular tissue composed of well-developed thick longitudinal muscle layers and thin circular muscle layers. Type-L secretory cells clustered only in muscular layers and they contained acidic mucopolysaccharides.

  • PDF

A Study on Analysis for Energy Demand of the Heating, Cooling and Lighting in Office Building with Transparent Thin-film a-Si BIPV Window (투광형 박막 BIPV 창호 적용에 따른 냉난방 및 조명 부하 저감에 관한 연구)

  • Yoon, Jong-Ho;An, Young-Sub;Park, Jang-Woo;Kim, Bit-Na
    • KIEAE Journal
    • /
    • v.13 no.3
    • /
    • pp.91-96
    • /
    • 2013
  • The purpose of this study was to analyze the annual energy demand including heating, cooling and lighting according to kind of windows with transparent thin-film a-Si Building Integrated Photovoltaic(a-Si BIPV) for office building. The analysis results of the annual energy demand indicated that the a-si BIPV window was reduced by 8.4% than the clear gazing window. The base model A was combinate with a-Si BIPV window area of 67% and clear window area of 33% among the total exterior area. The model B is to be applied with low-e clear glass instead of clear glass of the base model A. The model B was reduced to annual energy demand of 1% more than the model A. Therefore, By using a-si BIPV solar module, the cooling energy demand can be reduced by 53%(3.4MWh) and the heating energy demand can be increase by 58%(2.4MWh) than clear glazing window in office building. Also, Model C applied to the high efficient lighting device to the model B was reduced to annual energy demand of 14.4% more than the Model D applied to the high efficient lighting device to the model A. The Model E applied with daylight dimming control system to the Model C was reduced to annual energy demand of 5.9% more than Model C.

Analysis of Mechanical Properties of Polymer Material for Clear Aligner using Uniaxial Tensile Test (일축인장시험을 통한 투명교정장치용 고분자 소재의 역학적 특성 분석)

  • Jeong, Ji-Young;Je, Tae-Jin;Jeon, Eun-chae
    • Journal of the Korean Society of Manufacturing Process Engineers
    • /
    • v.17 no.5
    • /
    • pp.64-69
    • /
    • 2018
  • Clear aligners are popular in the field of dental orthodontic treatment because they offer a discreet alternative to braces due to their use of transparent materials. They are formed from flat transparent polymer materials by hot pressed molding. It is necessary to know the mechanical properties of the polymer materials to be able to form the exact shapes of the clear aligners. However, this information is not publicly available. In this study, we present a method to reliably measure the mechanical properties of clear aligner polymer materials and analyze the factors effecting these mechanical properties. First, we surveyed standards related to the mechanical properties of polymer materials to obtain reliable data. Consequently, ISO 527 was selected for use in this study because of the size and thickness of the flat transparent polymer material. The uniaxial tensile tester was constructed and it was verified whether displacement of a crosshead could be regarded as a displacement of gauge-length by optical analysis. Uniaxial tensile tests of three thicknesses from three different companies were performed and each engineering stress-strain curve was measured. Tensile strengths and elastic moduli were obtained by analysis of the stress-strain curves. The tensile strength and elastic modulus of ISO 527 was found to be approximately 50MPa and 2.3GPa, respectively. Both values showed material and thickness dependency.