• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.369-372
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• 2016

Background: Acute myeloid leukemia is an acquired clonal heterogeneous stem cell disorder. Hence, various parameters are sought out to categorize this disease into subtypes, so that as a consequence specific treatment modalities can be offered. Conventionally, the practically used method for classification utilizes French American British (FAB) criteria based on morphology and cytochemistry. The aim of present study was to determine the current spectrum of AML sub types in patients in Karachi. Materials and Methods: This single centre cross sectional study was conducted at Liaquat National Hospital, Karachi, extending from January 2010 to December 2014. Data were retrieved from archives were analyzed with SPSS version 22. Results: A total of 125 patients were diagnosed at our institution with de novo AML during five years period, 76 males and 49 females. Median age was 34.5 years. AML-M1 was the predominant FAB subtype (23.2%) followed by M2 (18.4%), M3 and M4 (16% each), M0 (14.4%), M5 (7.2%), M6 (3.2%) and M7 (1.6%). Conclusions: AML in Pakistani patients is seen in a relatively young population. The most common FAB subtype observed in our study was acute myeloblastic leukemia, without maturation (M1).

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5621-5624
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• 2013

Mucosal head and neck cancers are squamous cell carcinomas that develop in the upper-aero digestive epithelium. Together they constitute the sixth most common cancer with an estimated 900,000 new cases and 350,000 deaths each year reported worldwide. The risk factors are tobacco, alcohol and human papillomavirus (HPV). Our research team initially reported a high incidence rate of HNC in the indigenous population of the Northern Territory. Mortality rates also vary in the Australian States and Territories, with particularly high mortality observed in the Northern Territory. There is a paucity of incidence studies of HNC for the Australian States and Territories. Therefore this review primarily focuses on variation in incidence and mortality iacross the country and highlights specifically the high incidence and mortality in the Northern Territory. Attention is also given to sex-specific incidence and mortality rates.

• Journal of Chest Surgery
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• v.21 no.4
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• pp.630-640
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• 1988

We clinically evaluated 222 cases of ventricular septal defect which we experienced at Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital between July 1981 and March 1988. These patients were occupied 46.2% of all congenital heart disease operated on its same period. Of 222 cases, 132 patients were male and 90 patients were female. Their age distribution ranged from 8 months to 34 years of age and their mean age was 10.3 years. Among these patients, 86 patients had associated cardiac anomalies, which were patent foramen ovale 43 cases[19.5%], Atrial septal defect 18 cases[8.1%], patent ductus arteriosus 8 cases[3.6%], aortic insufficiency 7 cases[3.2%], infundibular pulmonary stenosis 5 cases[2.3%] and etc. There was statistically significant correlationship between VSD size and Qp/Qs, Rp/Rs, Pp/Ps respectively. All cases were operated under cardiopulmonary bypass and 157 patients[70.7%] would be corrected through right atrial approach. 158 patients[71.2%] underwent closure of ventricular septal defect with primary closure and the remained patients[28.8%] with patch closure. In anatomical classification by Kirklin, type I constituted 23.4%, type II 73.4%, type III 0.5%, type I and type II 1.4%, and type II and type III 1.4%. Important postoperative EGG changes were noted in 57 cases[25.7%] and incomplete right bundle branch block was most common[12.6%]. 54 patients[24.3%] developed minor and major postoperative complications and 9 patients died of several complications and overall operative mortality was 4.1%.

• Interdisciplinary Bio Central
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• v.2 no.3
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• pp.7.1-7.3
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• 2010

Stroke, also called an attack on the brain, is a complex disease that results from the interaction of many genetic and environmental factors. StrokePortal is a comprehensive resource for information on stroke that integrates and provides essential findings regarding stroke pathology, diagnostics, and treatments, based on Oriental and Western medicine. The stroke information was collected from various sources, such as journal articles, books, websites, and news stories, and it was refined, classified, and stored into a relational database system by automatic classification and manual curation. To provide the stored information effectively to users, a specialized retrieval system, based on web interfaces, was implemented. StrokePortal provides cutting-edge information to experts; interested people, including patients and their families; and investigators to broaden their knowledge of effective treatments for patients and offer many preventive measures. It provides a specialized feature with which users can upload their information and opinions to StrokePortal, which will enrich and mature the content even further. StrokePortal is freely accessible at http://genomics.kribb.re.kr/StrokePortal/.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.12
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• pp.52-57
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• 1994

간 기능 진단에 초음파 영상이 가장 많이 이용되고 있다. 간이 나빠지면 간 표면의 입자가 굵어지고 이것이 영상에서는 밝기(intensity)와 입자의 거칠기(Coarseness)가 높아지는 등의 특성이 나타난다. 진단에 사용되는 인자는 표면의 거칠기와 밝기 외에도 소엽의 크기와 모양 그리고 문맥 혈관의 크기 등도 고려가 된다. 초음파상으로 이러한 크기와 모양의 구분은 그렇게 어렵지 않다. 그러나, 영상의 밝기와 거칠기의 미세한 변화는 구분하기가 어렵다. 본 연구는 밝기와 거칠기를 나타내는 변수를 제시하고 이를 기준으로 간 질환을 분류하였다. 간 조직의 거칠기에 따라 크게 정상(Normal), 만성 간염(Chronic), 간경변증(Cirrhosis) 세단계로 질환의 상태를 진단하고 영상의 밝기에 따라 다른 간질환과 지방간(fat liver)을 구별해 낸다. 본 분석에 이용된 임상 영상은 주로 만성 간염과 간경변증을 갖고 있는 환자들의 것과 약간의 지방간 영상들이다.

• Progress in Medical Physics
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• v.9 no.2
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• pp.115-121
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• 1998

In this paper, basic study of diagnostic device development for early detection of cancer, we present the optical property measurements of 12 histologically classified biological tissue and blood specimens in order to determine whether significant optical contrast exists for detection of disease(cancer). In vitro, optical properties of each 630nm, 660nm, 780n, 880nm and 940nm shows consistent changes in effective absorbtion coefficients, ${\mu}$$\_$${\alpha}$/ with tissue classification of pig an chicken and human blood according to the 27.3%, 35.4%, 45.6% and 59.1% of HCT. We found differences in optical properties at each of specific wavelengths and histologically classified biological tissue.

• Health Policy and Management
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• v.28 no.4
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• pp.360-368
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• 2018

Background: The proportion of pharmaceutical expenditure out of total health-care expenditure in South Korea is high. In 2016, 25.7% of national health insurance (NHI) spending was for pharmaceuticals. Given the increasing demands for the access to newly introduced medicines and following increase in pharmaceutical spending, the management of NHI pharmaceutical expenditure is becoming more difficult. Methods: This study analyzed the data claimed to NHI for pharmaceutical reimbursement from 2010 to 2016. Results: The policy implications with respect to the trends and problems in spending by drug groups were elicited. First, the proportion of off-patent drugs spending which were treated to chronic disease was much higher than anti-cancer drug spending. Second, the spending to the newly introduced high-costed medicine increased, however, current price-reduction mechanism was not sufficient to manage their expenditure efficiently. Conclusion: Our system seems to need several revisions to improve the efficiency of pharmaceutical expenditure and to cope with high-costed medicines. This study suggested that the prices of off-patent drugs need to be regularly readjusted and the Price-Volume Agreement System should be operated more flexibly as well.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.3
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• pp.1-12
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• 2022

With the rapid development of artificial intelligence technology that gives existing sensors functions similar to human intelligence is drawing attention. Previously, researches were mainly focused on an improvement of fundamental performance indicators as sensors. However, recently, attempts to combine artificial intelligence such as classification and prediction with sensors have been explored. Based on this, intelligent sensor research has been actively reported in almost all kinds of sensing fields such as disease detection, motion detection, and gas sensor. In this paper, we introduce the basic concepts, types, and driving mechanisms of artificial intelligence and review some examples of its use.

• Journal of Microbiology and Biotechnology
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• v.34 no.7
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• pp.1385-1394
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• 2024

Collagenolytic proteases are widely used in the food, medical, pharmaceutical, cosmetic, and textile industries. Mesophilic collagenases exhibit collagenolytic activity under physiological conditions, but have limitations in efficiently degrading collagen-rich wastes, such as collagen from fish scales, at high temperatures due to their poor thermostability. Bacterial collagenolytic proteases are members of various proteinase families, including the bacterial collagenolytic metalloproteinase M9 and the bacterial collagenolytic serine proteinase families S1, S8, and S53. Notably, the C-terminal domains of collagenolytic proteases, such as the pre-peptidase C-terminal domain, the polycystic kidney disease-like domain, the collagen-binding domain, the proprotein convertase domain, and the β-jelly roll domain, exhibit collagen-binding or -swelling activity. These activities can induce conformational changes in collagen or the enzyme active sites, thereby enhancing the collagen-degrading efficiency. In addition, thermostable bacterial collagenolytic proteases can function at high temperatures, which increases their degradation efficiency since heat-denatured collagen is more susceptible to proteolysis and minimizes the risk of microbial contamination. To date, only a few thermophile-derived collagenolytic proteases have been characterized. TSS, a thermostable and halotolerant subtilisin-like serine collagenolytic protease, exhibits high collagenolytic activity at 60℃. In this review, we present and summarize the current research on A) the classification and nomenclature of thermostable and mesophilic collagenolytic proteases derived from diverse microorganisms, and B) the functional roles of their C-terminal domains. Furthermore, we analyze the cleavage specificity of the thermostable collagenolytic proteases within each family and comprehensively discuss the thermostable collagenolytic protease TSS.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.2
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• pp.988-1001
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• 2018

Arrhythmia has recently emerged as one of the major causes of death in Koreans. Premature Ventricular Contraction (PVC) is the most common arrhythmia that can be found in clinical practice, and it may be a precursor to dangerous arrhythmias, such as paroxysmal insomnia, ventricular fibrillation, and coronary artery disease. Therefore, we need for a method that can detect an abnormal heart beat and diagnose arrhythmia early. We extracted the features corresponding to the QRS pattern from the subject's ECG signal and classify the premature ventricular contraction waveform using the features. We modified the weighting and bias values based on the error back-propagation algorithm through learning data. We classify the normal signal and the premature ventricular contraction signal through the modified weights and deflection values. MIT-BIH arrhythmia data sets were used for performance tests. We used RR interval, QS interval, QR amplitude and RS amplitude features. And the hidden layer with two nodes is composed of two layers to form a total three layers (input layer 0, output layer 3).