• Journal of Oriental Neuropsychiatry
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• v.23 no.1
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• pp.93-114
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• 2012

Objective : This study aimed to review the performance of traditional herbal prescriptions for treating dementia and present a strategy for research on dementia therapy utilizing herbal medicine. Methods : A definition was made to clarify the technology regarding the development of herbal prescriptions for treating dementia. The queries were compounded based on the initial keywords provided by experts in the field, then applied to the Web of Science database search engines from January 1986 to September 2011 to search related scientific articles. Before performing the analysis, papers were extracted from the initial search reviewed by experts and 80 articles were selected. Then, the selected papers were analyzed in terms of publish year, country, and type of herbal prescriptions. Furthermore, the research performance evaluation for treating dementia by herbal prescriptions was also created in terms of country and organization based on forward citation analysis. In addition to, for the evaluation regarding research quality, we classified and reviewed papers into two types: clinical studies and experimental studies. Results : According to the quantitative information analysis of 80 articles, the number of papers has increased by 21.9% per the yearly mean from 1995, and Japan had the largest portion within this research field. There were 34 kinds of traditional herbal prescriptions, among them Ukgansan had the highest number of studies followed by Jodeungsan, Dangkisoosan and so on. In addition, quality index as calculated by cites per paper is higher than average in Switzerland, Turkey and Japan. In the view of the evaluation on quality there were 12 clinical studies, 8 RCT reported that herbal prescriptions had efficacy at cognition, behavioral & psychological symptoms (BPSD) and activity of daily life (ADL) in various type of dementia. In experimental studies most of the studies were performed using animal models. The studies using Ukgansan were aimed at improving BPSD. The papers studied with Jodeungsan and Dangkisoosan targeted vascular dementia. Conclusions : In this study, research to develop traditional herbal prescriptions for treating dementia has the potential to improve symptoms since herbal medicines work as both multi-function and multi-target in dementia with multiple pathological or neurotoxic pathways. Therefore, the results of the research should be used in order to establish strategies to develop technology for treating dementia with traditional herbal prescriptions in the future.

• Journal of the Korean Society for Library and Information Science
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• v.41 no.1
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• pp.411-429
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• 2007

This study Performed five weeks' education on library use as a regular cultural subject at the target on university students and analyzed the difference in their library anxiety between Pre-education and Post-education as well as the difference in educational effectiveness based on the frequency of library use. The result intends to Present the result for basic materials which aye necessary for promoting the education on library use. The object of study selected the university freshmen. located in Gyeonggi-do, taking a lessen of cultural essential subjects. The education contents on library use were the understanding of library organization and function, the structure of library materials, the kind and use of academic information, the citation of materials, the description of bibliography, and the copyright in a library. The study methods applied in the study, were literature researches and two-times' questionnaire surveys in the first week of the education and the last week of that. Total 92 materials were applied for this study. This study performed faired t-test and independent t-test. As a result, four factors of six ones on library anxiety were selected in the verification of hypotheses after performing an education on university students' library use. In addition, the difference in education effectiveness based on university students' library use frequency was excluded in the course of hypothesis verification on six factors or library anxiety.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3139-3145
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• 2016

Cancer is the leading cause of morbidity and mortality worldwide, characterized by irregular cell growth. Cytotoxicity or killing tumor cells that divide rapidly is the basic function of chemotherapeutic drugs. However, these agents can damage normal dividing cells, leading to adverse effects in the body. In view of great advances in cancer therapy, which are increasingly reported each year, we quantitatively and qualitatively evaluated the papers published between 1981 and December 2015, with a closer look at the highly cited papers (HCPs), for a better understanding of literature related to cytotoxicity in cancer therapy. Online documents in the Web of Science (WOS) database were analyzed based on the publication year, the number of times they were cited, research area, source, language, document type, countries, organization-enhanced and funding agencies. A total of 3,473 publications relevant to the target key words were found in the WOS database over 35 years and 86% of them (n=2,993) were published between 2000-2015. These papers had been cited 54,330 times without self-citation from 1981 to 2015. Of the 3,473 publications, 17 (3,557citations) were the most frequently cited ones between 2005 and 2015. The topmost HCP was about generating a comprehensive preclinical database (CCLE) with 825 (23.2%) citations. One third of the remaining HCPs had focused on drug discovery through improving conventional therapeutic agents such as metformin and ginseng. Another 33% of the HCPs concerned engineered nanoparticles (NPs) such as polyamidoamine (PAMAM) dendritic polymers, PTX/SPIO-loaded PLGAs and cell-derived NPs to increase drug effectiveness and decrease drug toxicity in cancer therapy. The remaining HCPs reported novel factors such as miR-205, Nrf2 and p27 suggesting their interference with development of cancer in targeted cancer therapy. In conclusion, analysis of 35-year publications and HCPs on cytotoxicity in cancer in the present report provides opportunities for a better understanding the extent of topics published and may help future research in this area.

• Journal of The Korean Association For Science Education
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• v.42 no.5
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• pp.543-555
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• 2022

This study aims to identify the trends in 'Aesthetic Science-Education' research through bibliographic analysis and provide future implications for research in this field. To this research, 100 studies were extracted using the search function of the Web of Science provided by Clarivate Analytics. Detailed bibliometrics was analyzed using the Bibliometrix package of the R program. As a result of the analysis, the average number of papers increased from 1993 to 2022, and academic journals in which related papers were published were evenly distributed locally. As a result of keyword analysis, papers with top citations, author collaboration networks, and literature co-citation networks, Aesthetic Science-Education could be classified as inducing aesthetic experience by integrating art in science education, and categories using 'formalist aesthetic' and 'emotional response'. The implications derived from this study are as follows: first, the aesthetic aspects of science should be actively studied to emphasize 'Agency' and 'Active Learning' in future science education. Second, it is necessary to develop a new approach to science education by further utilizing the 'formalist aesthetic' of science in science education. Third, the aesthetic aspect of science can change the perception of the Nature of Science of teachers, pre-service science teachers, and students. Fourth, it is necessary to discover implications for utilizing aesthetic aspects in science education through extensive research on the aesthetic aspects of science for teachers, students, and pre-service teachers. This study is meaningful because it provides an overview of the 'Aesthetic Science-Education' research to realize the above implications.