• Title/Summary/Keyword: Circulating

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Current Methods of Circulating Tumor Cell Detection (순환종양세포 검출 기술)

  • Lim, Minji;Cho, Yoon-Kyoung
    • The Korean journal of helicobacter and upper gastrointestinal research
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    • v.18 no.3
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    • pp.157-161
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    • 2018
  • Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA, and exosomes, offers a less invasive, new source of cancer-derived materials that may reflect the status of the disease better and thereby contribute to personalized treatment. Recent advances in microfluidics and molecular analysis technologies have resulted in greatly improved CTC enumeration and detection. In this article, we review commercially available technologies used to isolate CTCs from peripheral blood, including immunoaffinity and label-free, physical property-based isolation methods. Although enormous technological progress has been made, especially within the last decade, only a few CTC detection methods have been approved for routine clinical use. Here, we provide an overview of the current CTC isolation methods and examples of their potential application for early diagnosis, prognosis, treatment monitoring, and prediction of resistance to cancer therapy. Furthermore, the challenges that remain to be addressed before such tools are implemented for routine use in clinical settings are discussed.

Development of Circulating Fluidized Bed Boiler for Refused Derived Fuel (RDF연소를 위한 순환유동층보일러개발)

  • Bae, Dal-Hee;Shun, Do-Won
    • 한국연소학회:학술대회논문집
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    • 2005.10a
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    • pp.71-77
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    • 2005
  • Combustion of RDF and wastewater sludge was performed in a 0.1MWth bench scale circulating fluidized bed combustor(CFBC), Combustion characteristics of the RDF and sludge mixture demonstrated stable combustion conditions. Component analysis, Combustion characteristics was measured before and after the test, and applications for commercial 1MWe CFBC boiler were prepared. The release of hazardous components such as $SO_2$ and HCl was relatively low values of 50 and 150ppm, respectively.

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Performance Prediction Model of 340MWe Circulating Fluidized Bed Boiler (340MWe급 순환 유동상 보일러의 단순 성능 예측 모형)

  • Yang, Jongin;Choi, Sangmin
    • 한국연소학회:학술대회논문집
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    • 2012.11a
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    • pp.119-122
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    • 2012
  • Circulating fluided bed(CFB) furnace which can use a variety of low-grade fuels because of high heat capacity and good mixing characteristic in its furnace have turned out to be effective system. There is no many research to predict performance considering total boiler system with water-steam side. Most of performance prediction model have focused on hydrodynamics or chemical mechanism in furnace. so, This study is aimed to develop performance prediction model which consider water-steam side.

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An Improved ZVZCS PWM FB DC/DC Converter Using the Modified Clamp Circuit (개선된 Clamp Circuit 적용 ZVZCS FB DC/DC 컨버터)

  • 김은수;조기연;김윤호;이진수
    • Proceedings of the KIPE Conference
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    • 1999.07a
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    • pp.643-645
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    • 1999
  • The conventional high frequency phase-shifted full bridge dc/dc converter has a disadvantage that a circulating current flows through transformer and switching devices during the freewheeling interval. Due to this circulating current, RMS current stress, conduction losses of transformer and switching devices are increased. To alleviate this problem, this paper provides a circulating current free type high frequency soft switching phase-shifted full bridge (FB) dc/dc converter with the modified energy recovery snubber (ERS) attached at the secondary side of transforemr.

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Performance Simulation of Part Load Operation for 2MWe Circulating Fluidized Bed Boiler (2MWe 순환유동상 보일러의 부분 부하 운전 성능 모사)

  • Kim, Taehyun;Choi, Sangmin;Hyun, Ju-soo
    • 한국연소학회:학술대회논문집
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    • 2012.04a
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    • pp.35-36
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    • 2012
  • Part load operation usually covers large periods of the total operation time on the economic ground and electricity demand in small-scale boilers. Performance analysis of part load behavior is very important for the purpose of boiler operation optimization. A simple thermal calculation approach is applied to predict performance of a pilot-scale circulating fluidized bed (CFB) boiler at part load operation. Verification has been carried out by comparing between calculation results an operation data of the boiler.

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Failure Analysis of Circulating Water Pump Shaft in Power Plant (발전 계획에서 순환 물 펌프 고장 분석)

  • Lee, Jaehong;Jung, Nam-gun
    • KEPCO Journal on Electric Power and Energy
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    • v.7 no.1
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    • pp.125-128
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    • 2021
  • This paper presents the root cause failure analysis of the circulating water pump in the 560 MW thermal power plant. A fractured austenitic stainless-steel shaft operated for 24 years was examined. Fracture morphology was investigated by micro and macro-fractographic analysis. The metallurgical analyses including chemical analysis, metallography and hardness testing were performed. The analysis reveals that the pump shaft was fractured due to the reverse bending load with combination of rotating bending load. Corrective actions for plant operator was recommended based on the analysis.

Research on the Replacement of Bed Material and Multifunctional Additives in Circulating Fluidized Bed Combustion Using Solid Fuels (고형연료사용 순환유동층 연소로에서의 유동사 대체 및 다기능성 첨가제에 관한 연구)

  • Park, In su;Nam, Jeong soo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2023.11a
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    • pp.115-116
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    • 2023
  • In this study, it was confirmed whether kaolin can play a role as a bed materials and a role in reducing clinkers by using kaolin with a bed materials for the purpose of removing clinkers such as slagging and fouling generated in circulating fluidized bed combustion furnaces using solid fuel.

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PREPARATION AND PHARMACOKINETICS OF METHOTREXATE DELIVERY SYSTEM USING LONG-CIRCULATING LIPOSOMES

  • Hong, Myo-Sook;Kim, Chong-Kook
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.287-287
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    • 1996
  • Long-circulating liposomes have prompted interests in using them as a drug delivery system. This improvements in delivery has been thought to be the results from sustained action of liposomes in plasma without RES uptake. Although methotrexate(MTX) has been one of the most widely used antineoplastc drug, its use was limited by prompt RES uptake. The purpose of this study was to prepare long-circulating liposomes for MTX using highly water-soluble polymer (PEG-PE). In vitro, release of MTX from liposomes in phosphate buffer (pH 7.4), rat liver homogenate, and rat plasma was investigated. The pharmacokinetics and organ distribution of fee drug, conventional and long-circulating liposomes were also compared with one another after intravenous administration to rats.

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A Study of the Partial Circulating Current Type Cycloconverter with a Resonant Circuit for Induction Heating (공진회로(共振回路)를 이용한 유도가열용(誘導加熱用) 부분순환전류형(部分循環電流形) 사이크로콘버터에 관한 연구(硏究))

  • Kim, Hyun-Jung;Cho, Kyu-Min;Kim, Young-Seok
    • Proceedings of the KIEE Conference
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    • 1992.07b
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    • pp.1002-1004
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    • 1992
  • This paper presents a study of the partial circulating current type cycloconverter with a resonant circuit for induction heating. A method of input power factor improvement is proposed. Since the circulating currents flow through the circulating current reactors, the out-put currents are continuous and sinusoid. The proposed cycloconverter can keep the displacement factor at 1.0 by PWM control method regardless of load. The control functions are derived, the operational principles are described and the simulation and experimental results are presented.

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A Study on Design Characteristics of Yeosu Circulating Fluidized Bed Boiler (여수화력 순환유동상 보일러의 설계특성 고찰)

  • Kim, Jae-Sung;Lee, Jong-Min;Kim, Dong-Won;Kim, Tae-Hyun;Choi, Sang-Min
    • Journal of the Korean Society of Combustion
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    • v.16 no.1
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    • pp.1-7
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    • 2011
  • 340 MWe circulating fluidized bed (CFB) boiler in Yeosu power station is under construction. The circulating fluidized bed boiler in the Yeosu power plant has a number of differences from other domestic boilers in terms of scale and design. Evaluation of design parameters of the Yeosu CFB boiler should be required because the direct application of existing technology is limited. In this study, design characteristics of the Yeosu CFB boiler was summarized. And thermogravimetric analysis was conducted with comparing other rank coals. Watersteam side heat absorption, flue gas temperature and heat transfer coefficient were calculated by heat and mass balance. Design parameters for the Yeosu CFB boiler were discussed along with typical value in the CFB design range.