• YAKHAK HOEJI
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• v.42 no.1
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• pp.75-81
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• 1998

Effects of swainsonine (SW: 8${\alpha}$, ${\beta}$-indolizidine-1alpha, 2${\alpha}$, 8${\beta}$-triol from Locoweed) on the cellular and nonspecific immune responses of lipopolysaccharide (LPS) wer e studied in ICR mice. Mice were divided into 4 groups (10mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7mg/kg of SW by i.p. injection twice a week for 14 days at a dose of 2mg/kg. Immune responses of the delayed-type hypersensitivity response (DTH) to sheep red blood cells (s-RBC), phagocytic activity and natural killer (NK) cell activity were evaluated. LPS treatment didn`t affect NK cell activity, phagocytic activity, DTH to s-RBC compared with those in controls, and phagocytic activity of sareoma 180 tumor bearing mice. However, circulating leukocytes were significantly decreased. Combinaton of LPS and SW increased circulating leukocytes significantly compared vath that in LPS alone, and DTH to s-RBC, NK cell activity and phagocytic activities of normal and sarcoma tumor bearing mice were not affected. These findings indicate that SW didn`t affected the cellular immune responses suppressed by LPS but significantly increased circulating leukocytes.

• Transactions of the Korean hydrogen and new energy society
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• v.30 no.5
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• pp.436-447
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• 2019

The circulating fluidized bed boiler has an advantage that can burn a variety of fuels from low-grade fuel to coal. In this study, for the design of a circulating fluidized bed boiler using wood pellets, a circulating fluidized bed combustion test device using no external heater was manufactured and used. According to the increase of co-combustion rate with wood pellet, combustion fraction and heat flux by combustor height were measured and pollutant emission characteristics were analyzed. In terms of combustibility, the effect on primary and secondary air ratio were also studied. In addition, as a result of analysis of the effect of corrosive nanoparticles on the combustion of coal with wood pellets, it was confirmed that coal is mostly composed of Ca and S, whereas wood pellets are mostly composed of K, Cl, and Na.

• The Transactions of the Korean Institute of Power Electronics
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• v.26 no.3
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• pp.237-240
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• 2021

This research proposes a new rectifier circuit to reduce the circulating current of a phase-shifted full bridge converter. The proposed circuit is a structure in which the output inductor of the secondary rectifier circuit is changed to a coupled inductor in the phase-shifted full bridge with the existing center-tapped rectifier. The parts are rearranged after adding a diode. After applying the proposed circuit, the circulating current to the primary current of the transformer and the voltage stress of the rectifier diode on the secondary side of the transformer are reduced. Accordingly, the snubber loss of the rectifier is improved. By reducing the circulating current and snubber loss, the circuit achieves higher efficiency than conventional circuits. In this research, we present the structure of the proposed circuit, its strengths, and the analysis results from experiments. Furthermore, its effectiveness is verified through the experimental results of a prototype converter with an input of 300-400 V and an output of 50 V/1 kW.

• The Transactions of the Korean Institute of Power Electronics
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• v.27 no.5
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• pp.367-375
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• 2022

Generally, a proportional-resonant controller is used to eliminate steady-state errors during the voltage-current control of a double-conversion uninterruptible power supply (UPS) in a stationary reference frame. Additionally, the feed-forward control compensating for the load current, which can be considered a disturbance of the voltage controller, can be used to improve the disturbance rejection performance. However, during the parallel operation of UPSs, circulating current can occur between UPS modules when performing both feed-forward control and droop control because feed-forward control reduces the circulating current impedance. This study proposes a feed-forward compensation technique that considers the impedance of circulating current. An additional feed-forward compensation technique is developed to enhance the disturbance rejection performance. The validity of the proposed feed-forward compensation technique is verified by the experiment results of the parallel operation of a 500 W double-conversion UPS module.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2020.06a
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• pp.126-127
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• 2020

Recently, as interest in environmental issues increases, minimizing carbon dioxide generated during cement manufacturing is a problem to be solved. In order to solve such a problem, it is required to use an industrial by-product of recycled aggregate, blast furnace slag, and circulating fluidized bed boiler fly ash to replace it on the basis of geopolymer(=cementless). This study examines the characteristics of eco-friendly artificial stone according to the mixing ratio of geopolymer-based recycled aggregate. As a result of the experiment, when the addition rate of the alkali stimulant was 15% and the mixing ratio of the circulating aggregate was 70%, the flexural strength and compressive strength were the highest. Density and water absorption decreased as density of circulating aggregates increased and water absorption increased. However, when the mixing ratio of the circulating aggregate exceeded 70%, the flexural strength and compressive strength decreased. Therefore, in order to obtain strengths meeting the KS standards, the mixing ratio of recycled aggregate was set to 70%, and artificial stone was manufactured using industrial by-products.

• Journal of Korean Medical classics
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• v.20 no.2
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• pp.61-123
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• 2007

We translated 'poems of prograde' and 'poems of acupoints' which in the poems of acupoints and based on that, We considered the circulating direction and region of twelve meridian comparing the notion in common today with that in the 'poems of acupoints'. Finally, we got the conclusion like below 1. About circulating line of lung meridian, it'll be proper to correct that lung meridian passes through inner edge of biceps brachii muscle like heart and pericardium meridian. 2. On the part of kidney meridian in 'poems of prograde', it's right to be corrected as the circulating line that thru the inner line of vertebrae, enters heart and lung, and scattered tho breast. 3. 'Poems of prograde' can be separated two kinds go by starting-acupoints, ending- acupoints. First is 'poems of prograde' is begun from the end of members and ended in the body. Second is from Jungbu(中府) to Kimun(期門), circulating the members and the body with no ending. 4. On the above, we can find first 'poems of prograde' in "Chimkudaejeon(鍼灸大全)", "YangKyungjechimkujeonso(楊敬齋鍼灸全書)", "Chimkudaeseong(鍼灸大成)", also second can be found in "Neungmunjeonsudonginjihyul(凌門傳授銅人指穴)", "Chimkushinso(鍼灸神書)", "Kumchimbijeon(金針秘傳)", "Kyungrakhoepyun(經絡匯編), "Kyungrakko(經絡考)", "Jungsohoechamdongindosol(重西匯參銅人圖說)", "Kyungrakdoko(經脈圖考)", "ChimkuChuiyoung(針灸聚英)", "Shipsakyoungbalhwee(十四經發揮)", "Jakushimbopyokyul(刺灸心法要訣)", "Yukyoungdoik(類經圖翼)", "Yihakimmun(醫學入門)", etc. 5. Drawing an inference from above, the forms of "Jokbishibilmaek(足臂十一脈)" and "YumYangshibilmaek(陰陽十一脈)" are in "Mawangtoebaekso(馬王堆帛書)", are rather foreforms of circulation line that from the end of members and ended in the body than meridian prograde.

• Nutrition Research and Practice
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• v.14 no.4
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• pp.412-422
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• 2020

BACKGROUND/OBJECTIVES: This study investigates correlations between circulating microRNAs (miRNAs) and obesity-related parameters among young women (aged 20-30 years old) in Korea. SUBJECTS/METHODS: We analyzed TaqMan low density arrays (TLDAs) of circulating miRNAs in 9 lean (body mass index [BMI] < 25 kg/㎡) and 15 obese (BMI > 25 kg/㎡) women. We also performed gene ontology (GO) analyses of the biological functions of predicted miRNA target genes, and clustered the results using the database for annotation, visualization and integrated discovery. RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR-144-5p, miR-192, miR-320, miR-320b, miR-484, miR-324-3p, and miR-378. Among them, miR-484 and miR-378 displayed the most significant inverse correlations with BMI (miR-484, r = -0.5484, P = 0.0056; miR-378, r = -0.5538, P = 0.0050) and visceral fat content (miR-484, r = -0.6141, P = 0.0014; miR-378, r = -0.6090, P = 0.0017). GO analysis indicated that genes targeted by miR-484 and miR-378 had major roles in carbohydrate and lipid metabolism. CONCLUSION: Our result showed the differentially expressed circulating miRNAs in obese subjects compared to lean subjects. Although the mechanistic study to reveal the causal role of miRNAs remains, these miRNAs may be novel biomarkers for obesity.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2219-2224
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• 2012

Background: Circulating lymphocyte subsets reflect the immunological status and might therefore be a prognostic indicator in cancer patients. Our aim was to evaluate the clinical significance of circulating lymphocyte subset in gastric cancer (GC) cases. Methods: A retrospective study on a prevalent cohort of 846 GC patients hospitalized at Hospital from Aug 2006 to Jul 2010 was conducted. We calculated the patient's disease free survival (DFS) after first hospital admission, and hazard ratios (HR) from the Cox proportional hazards model. Results: Our findings indicated a significantly decreased percentage of CD3+, and CD8+ cells, a significantly increased proportion of $CD4^+$, $CD19^+$, $CD44^+$, $CD25^+$, NK cells, and an increased $CD4^+/CD8^+$ ratio in GC patients as compared with healthy controls (all P < 0.05). Alteration of lymphocyte subsets was positively correlated with sex, age, smoking, tumor stage and distant metastasis of GC patients (all P<0.05). Follow-up analysis indicated significantly higher DFS for patients with high circulating $CD19^+$ lymphocytes compared to those with low $CD19^+$ lymphocytes (P=0.037), with $CD19^+$ showing an important cutoff of $7.91{\pm}2.98%$ Conclusion: Circulating lymphocyte subsets in GC patients are significantly changed, and elevated CD19+ cells may predict a favorable survival.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10647-10652
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• 2015

Background: The aim of our study was to establish COLD-PCR combined with an unlabeled-probe HRM approach for detecting KRAS codon 12 and 13 mutations in plasma-circulating DNA of pancreatic adenocarcinoma (PA) cases as a novel and effective diagnostic technique. Materials and Methods: We tested the sensitivity and specificity of this approach with dilutions of known mutated cell lines. We screened 36 plasma-circulating DNA samples, 24 from the disease control group and 25 of a healthy group, to be subsequently sequenced to confirm mutations. Simultaneously, we tested the specimens using conventional PCR followed by HRM and then used target-DNA cloning and sequencing for verification. The ROC and respective AUC were calculated for KRAS mutations and/or serum CA 19-9. Results: It was found that the sensitivity of Sanger reached 0.5% with COLD-PCR, whereas that obtained after conventional PCR did 20%; that of COLD-PCR based on unlabeled-probe HRM, 0.1%. KRAS mutations were identified in 26 of 36 PA cases (72.2%), while none were detected in the disease control and/or healthy group. KRAS mutations were identified both in 26 PA tissues and plasma samples. The AUC of COLD-PCR based unlabeled probe HRM turned out to be 0.861, which when combined with CA 19-9 increased to 0.934. Conclusions: It was concluded that COLD-PCR with unlabeled-probe HRM can be a sensitive and accurate screening technique to detect KRAS codon 12 and 13 mutations in plasma-circulating DNA for diagnosing and treating PA.

• Journal of Korean Medical classics
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• v.19 no.2 s.33
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• pp.30-45
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• 2006

Analyzed the subject of ‘To heart' meridian system(向心服系), and 'Circulating' meridian system(備環服系), and considered relativity between the circulating pattern of the channels, the collaterals and the circulating distinction YoungGi (營氣), WiGi(衛氣). The subject of 'To heart' meridian system is WiGi, and this system is similiar to the moving pattern of the fifteen major collaterals(十五絡服). The subject of 'Circulating' meridian system is YoungGi, and this system is same with the moving pattern of the twelve regular channels(十二經脈). YoungGi and WiGi have the same origin, and they are intrinsic one thing with functional ambivalency. It is WiGi, the subject of the movement of Collateral, because it is identical the moving pattern of Collaterals(絡服) and that of WiGi as the subject of the movement of Collateral. It is YoungGi, the subject of movement of Channel because it is identical the moving pattern of Channels(經服) and that of YoungGi. It can be defined that Wigi as the subject of the movement of Collateral, also YoungGi as the subject of movement of Channel, but that is from i 염 function and action, there's no need to be separated within the framework of going through Meridian. YoungSuBosa(迎隨補鴻) in acupuncture, defines its basis not only on the moving direction of YoungGi, but on combinated difference between the directions, moments, and sex. Until now it is under discussion the rights and wrongs, It's not contradictory concept between two basis of YoungSuBoSa, from the thought the distinct movement of WiGi and the circulation pattern of Collaterals have no specified directions.