• Journal of Nutrition and Health
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• 제35권2호
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• pp.213-222
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• 2002

The alkaline comet assay has been used with increasing popularity to investigate the level of DNA damage in biomonitoring studies within the last decade in Western countries. The purpose of this study was to evaluate the usefulness of the alkaline comet assay as a biomarker of oxidative DNA damage for monitoring in the Korean population, and also to evaluate the effect of nutritional status and lifestyle factors on H2O2 induced oxidative DNA damage measured by the alkaline comet assay in human lymphocytes. The study population consisted of 61 healthy Korean male volunteers, aged 20-28. Epidemiological background data including dietary habits, smoking habits and anthropometrical measurements were collected through personal interviews. After blood collection, the comet assay in peripheral lymphocytes and plasma lipids analysis was carried out and the results analyzed. Tail moment (TM) and tail length (TL) of the comet assay were use\ulcorner to measure DNA damage in the lymphocytes of the subjects. Statistically significant (p < 0.05) positive correlations were observed between DNA damage (TM or TL) and smoking habits expressed as cigarettes smoked per day and pack years (r = 0.311 and 0.382 for TM, r = 0.294 and 0.350 for TL, respectively). There were also significant positive correlations between DNA damage parameter and waist-hip ratio. Higher plasma triglyceride levels were associated with increased damage to DNA. There were no correlations between the consumption frequencies of vegetables and DNA damage to the subjects. However, consumption frequencies of fruit and fruit juice intake were inversely associated with the TM and TL. The results indicate that die comet assay is a simple, rapid and sensitive method for detecting lymphocyte DNA damage induced by cigarette smoking. Consumption of fruit or fruit juices could potentiall modify the damaged DNA in the human peripheral lymphocytes of young Korean men.

• Journal of Nutrition and Health
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• 제36권6호
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• pp.635-645
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• 2003

This study was conducted to investigate the effects of smoking on nutrient intake and blood mineral status. The subjects were composed of two groups.55 smokers and 52 non-smokers. A 24-hour recall method was used along with questionnaires and serum mineral levels were analyzed by ICP spectrometer. The average ages of the smokers and non-smokers were 55.5 and 59.3 years old, respectively. The height, obesity degree, BMI, and WHR of the smokers were significantly higher than those of the non-smokers (p < 0.05, p < 0.05, p < 0.05, p < 0.01) Approximately 45.5% of the smokers smoked 16-20 cigarettes per day. The average age that the smokers started smoking was 22.0 years old and their smoking history was 33.5 years. About 74.5% of the smokers drank alcoholic beverages, while 44.2% of the non-smokers did. The smokers tended to eat less meals and breakfast meal, but drink coffee more often compared to the non-smokers. The mean daily energy intake and CPF energy intake ratio were 1231.8 ㎉ and 69.8 : 14.8 : 14.7 in the smokers and 1210.2 ㎉ and 72.1 : 14.7 12.7 in the non-smokers, respectively. The results show that the smokers tended to consume more energy, lipid, and cholesterol compared to the non-smokers. The results also show that in both groups, nutrient intake was lower than the RDA. The two groups were not significantly different in terms of the intake frequency of green-yellow vegetables and fresh fruits. There were no significant differences in serum levels of Ca, P, Mg, Cu, Fe, Mn, and Zn. However, serum Se level of the smokers was significantly higher than that of the non-smokers. In conclusion, the subjects of this study showed a serious imbalance in the nutrient intake, and the smokers showed a more undesirable dietary intake in the light of their high intake of energy, lipid, cholesterol, alcoholic beverages, and coffee. The serum Se level of the smokers was higher than that of the non-smokers, showing that Se is involved in smoking, Therefore, it could be suggested that more systematic research be conducted with respect to Se and smoking and that increased nutrition education and guidelines for smokers are required.

• 대한가정학회지
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• 제42권6호
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• pp.55-72
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• 2004

Alcohol has as much effect on our lives as the different taste for foods that people have all of the world. Recently, the interest about drinking habits has increased with the rise in health problems for college students with poor health related behavior. The purpose of this study was to evaluate alcohol consumption, smoking and eating behavior of college students in the Kyungsan area. This survey was administered through questionnaires, and the subjects were 177 male and 189 female college students. The self-administered questionnaire was composed of questions concerning social-demographic factors, general characteristics, cigarette smoking, alcohol consumption and eating behavior. The data were analyzed by $\chi$$^2$-test and t-test. According to the survey results, almost of all of the survey subjects drank alcohol. The mean alcohol consumption level per day for male students (33.9${\pm}$29.7g) were significantly higher than for the female students (18.5${\pm}$16.5g), and more than 39.6% of the subjects drank alcohol 1-3 days a week. Alcohol consumption changed the students eating habits. Most students had dietary problems such as fast eating, skipping meal and spending too much money on fast food. The survey about eating behavior of the students showed the male students had more problems when compared with female students. Alcohol consumption levels and alcohol dependence showed a significant positive correlation with smoking cigarettes (r=0.386, p＜0.001). The correlation coefficient between alcohol consumption and eating behavior was negatively correlated with skipping meals (r=-0.121, p＜0.001). However, there were significant and positive correlations with overeating when students were depressed (r=0.130, p＜0.05), with eating meals when watching TV or videos (r=0.085) and with spending money on fast food(r=0.235, p＜0.235). The results indicate that health related behaviors of college students in the present study were fairly good. More attention should be given to college students and their habits of skipping meal, alcohol drinking and smoking, and the fairly good students can act as a model for correct dietary behavior so as to improve overall student health.

• 한국융합학회논문지
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• 제9권4호
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• pp.65-74
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• 2018

본 연구는 만 40세 생애전환기 군 근무자의 건강검진 결과를 분석하고 비대사증후군과 대사증후군 그룹의 관련 요인을 탐색하기 위해 실시되었다. 이를 위해 국민건강보험공단에서 제공받은 건강검진 결과자료를 활용하여 이차분석을 실시하였고, 연구대상자는 2015년 건강검진을 실시한 군 근무자 중 생애전환기(만 40세)에 해당하는 4898명이였다. 연구 결과, 대사증후군 그룹은 비대사증후군 그룹에 비해 현재 흡연률, 1일 흡연량, 흡연기간, 하루 음주량이 더 많았고, 비만도, 혈중 총 콜레스테롤, AST, ALT 및 GGT의 수치가 높게 나타났다. 본 연구를 바탕으로, 만 40세 생애전환기 군 근무자들은 군 조직 내 중요 직책을 수행하는 집단이기에, 이들을 위한 효과적인 금연 및 절주프로그램 개발이 필요하며 연령 및 군 신분을 고려한 건강관리 프로그램 요구도에 대한 사전 조사가 이루어져야 할 것이다.

• Journal of Preventive Medicine and Public Health
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• 제31권2호
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• pp.265-274
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• 1998

To investigate the change of nitric oxide(NO), copper, and zinc in serum on smoking and alcohol ingestion in young adults, this study was performed in a cross-sectional study in 127 healthy men in Korea who had HBsAg(-), HCVAb(-), and no symptomatic liver, heart, gastrointestinal, chronic diseases, and inflammatory sign(lower than 10,000 white blood cell count in CBC). At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of NO, copper, and zinc. Each man completed a questionnaire that provided information on smoking, alcohol intake and present and past medical history NO was analyzed by HPLC(Green et al., 1982), copper and zinc by atomic absorption spectrophotometer with air-acetylene flame and total cholesterol(TC) by Spectrum EPX. Smoking(number of cigarettes per day and pack-year) and alcohol intake was grouped fertile. Copper was adjusted for age and zinc and for age and TC. NO, copper, and zinc on smoking and alcohol ingestion were analyzed in general linear models, respectively. NO, copper and zinc in serum did not show statistical differences between non-smoking and high-smoking group and no-alcohol intake and high-alcohol intake group. This study suggested that copper, zinc, and NO was not. good biological marker for early effect by smoking and alcohol intake in young adults. However, selection bias should be considered in evaluation of this result. A large prospective study will be needed in advance on usefulness of copper, zinc, and NO as a marker for risk factors and early change of atherosclerosis.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6875-6881
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• 2013

Background: Studies evaluating smoking cessation treatment outcomes in cancer patients are scarce, despite smoking cessation importance in cancer care. We sought to add to the literature by evaluating smoking cessation in a challenging group of cancer patients (medium-to-heavy smokers) visiting an out-patient smoking cessation clinic (SCC) in a cancer center in Amman, Jordan. Materials and Methods: Patients smoking >9 cigarettes per day (CPD) and referred to the SCC between June 2009 and May 2012 were studied. Clinic records were reviewed to measure demographic and baseline clinical characteristics, and longitudinal (3-, 6- and 12- month) follow-up by phone/clinic visit was conducted. At each follow-up, patients were asked if they experienced medication side-effects, if they had returned to smoking, and reasons for failing to abstain. Descriptive and multivariable logistic regression analyses were performed. Results: A total of 201 smokers were included in the analysis. The 3-month abstinence was 23.4% and significantly associated with older age, being married, and presenting with lower (${\leq}10ppm$) baseline carbon monoxide (CO) levels. On a multivariable level, lower CO levels, a higher income (relative to the lowest income group), being older, and reporting severe dependence (relative to dependence reported as 'somewhat' or 'not') were significant predictors of higher odds of abstinence at three months. Reasons for failing to quit included not being able to handle withdrawal and seeing no value in quitting. Long-term ARs did not reach 7%. Conclusions: In a sample of Jordanian smokers (>9CPD) with cancer and receiving smoking cessation treatment, ARs were low and further declined with time. Results underscore the need for more aggressive patient management and rigorous follow-up during and after smoking cessation treatment, particularly when this takes place in challenging settings. Observed reasons for failure to abstain should be used to tailor counseling practices.

• Tuberculosis and Respiratory Diseases
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• 제76권6호
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• pp.276-283
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• 2014

Background: We aimed to investigate the role of the physician in practice and the factors that influence the success rate of smoking cessation. Methods: This study retrospectively analyzed 126 adult smokers who had visited the outpatient department of pulmonology, and received motivational interviewing with or without supplement drugs. The findings include continuous smoking abstinence rate, which was evaluated at 6, 12 and 24 weeks, and the factors associated with continuous abstinence for 6 months or longer. Results: The patients with only motivational interviewing accounted for 57.9%, while the nicotine patch therapy was applied to 30.2%; and varenicline was prescribed to 11.9%. The smoking cessation success rates of at 6, 12, and 24 weeks were 55.6%, 47.6%, and 33.3%, respectively. However, even in the failure group at six months, tobacco consumption was decreased under 10 cigarettes per day in 42.1% (53/126). In multivariate logistic regression analysis, degree of Fagerst$\ddot{o}$m Test for Nicotine Dependence (p=0.034; odds ratio, 3.607; 95% confidence interval [CI], 1.102-1.807), the absence of smoking-related lung disease (p=0.008; odds ratio, 4.693; 95% CI, 1.497-14.707), and education level (p=0.001; odds ratio, 181.420; 95% CI, 8.414-3,911.502) were the predictors of successful smoking cessation. Conclusion: An improved continuous smoking abstinence rate can be obtained by motivational interviewing, regardless of the association with pharmacotherapy.

• 대한간호학회지
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• 제37권7호
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• pp.1159-1165
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• 2007

Purpose: The purpose of this study was to investigate the stages of change in smoking cessation after a Coronary Artery Bypass Graft(CABG) and to identify the related factors. Methods: The subjects (n=157) were patients who underwent a CABG in a university hospital from March 1998 to October 2005 and were smokers before the CABG. Data was collected viachart review and a telephone interview, and analyzed with descriptive statistics, $X^2$ test, one-way ANOVA, and Kruskal-Wallis procedure by the SPSS/PC win 12.0 program. Results: The subjects smoked for an average of 34 years (21 cigarettes per day) before surgery. Eleven percent of the subjects were in pre-contemplation, 6.4% in contemplation, 13.5% in preparation, 4.5% in action, and 64.5% in the maintenance stage. Nicotine dependence and self-efficacy were different among the groups with different stages of change in smoking cessation. Nicotine dependence was the lowest (p=0.00) and self-efficacy was the highest (p=0.00) in the maintenance stage. The number of subjects in pre-contemplation and contemplation significantly increased 6 years after surgery(p=0.05). Conclusions: To implement effective smoking cessation interventions for CABG patients, the intervention should be developed to accommodate individual readiness for smoking cessation, especially so for those who had a CABG more than 6 years previously.

• 대한지역사회영양학회지
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• 제2권1호
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• pp.44-51
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• 1997

Secrum lipid and vitamin E levels were determined and smoking, alcohol drinking and exercise habits were asked in 357 healthy male subjects aged 49.4$\pm$6.7 years in Taegu. Average serum levels of total cholesterol, HDL-cholesterol and triglyceride(TG) were 189$\pm$43mg/이, 42$\pm$13mg/dl and 136$\pm$73mg/이, respectively. Serum level of lipid peroxide measured as thiobarbituric acid reactive substances(TBARS) of the subjects was 2.01$\pm$0.73MDA nmoles/ml and that of $\alpha$-tocopherol was 9.53$\pm$3.14ug/ml. The correlation coefficients between $\alpha$-tocopherol and serum lipids were 0.3631 for triglyceride, 0.2993 for cholesterol, and 0.3025 for total lipid. Heavy smokers who smoked more than 20 cigarettes a day had higher levels of TG and TBARS than those who smoke less. Alcohol drinkers had higher levels of TG and TBARS than nondrinkers. Vitamin E level(per ml serum)was significantly higher in the heavy smokers and drinkers, which was reflected by the higher level of serum lipid. When the level of $\alpha$-tocopherol was expressed as $\alpha$-tocopherol/triglyceride, it was negatively correlated with serum TBARS level and was lower in the heavy smokers than in the moderate smokers. It is concluded that vitamin E level as $\alpha$-tocopherol/triglyceride would be better compared to $\alpha$-tocopherol/total cholesterol or $\alpha$-tocopherol/total lipid for the evaluation of vitamin E status in Korean men.

• 보건교육건강증진학회지
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• 제25권2호
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• pp.19-30
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• 2008

This study has comparatively analyzed the primary success factors in smoking cessation among new enrollees and re-enrollees of a smoking cessation clinic in order to find out how to efficiently operate smoking cessation clinics at public health centers. The study was conducted with 262,837 smokers aged 19 or over who were provided with smoking cessation services for more than 6 months after being registered with the smoking cessation clinic at public health centers(250 clinics nationwide) from July 16, 2006 to July 15, 2007. After dividing smokers into re-enrollees and new enrollees of the smoking cessation clinic, the success rate of and success factors for smoking cessation over 6 months have been investigated. The success factors in smoking cessation have been compared between new enrollees and re-enrollees of smoking cessation clinics. The results can be summarized as follows: First, the success rate of smoking cessation for 6 months at smoking cessation clinics of public health centers was higher in new enrollees (46.3%) than in re-enrollees (41.1%). Second, the common factors that had an influence on the success of smoking cessation of both new enrollees and re-enrollees of the smoking cessation clinic included age, social security, service, frequency of counseling, number of cigarettes per day, and alcoholic problems. Third, compared to new enrollees, re-enrollees had a higher success rate of smoking cessation as they got older. In terms of the success rate of health insurance, on the contrary, new enrollees were better than re-enrollees. Fourth, the study showed a higher success rate in smoking cessation in both new and re-enrollees if they had no alcoholic problems. In particular, a higher success rate was observed in re-enrollees when there were no alcoholic problems. To efficiently operate smoking cessation clinics at public health centers, this study confirmed that counseling should be tailored depending on the types of enrollees in the program.