• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4409-4413
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• 2013

Background: Cigarette smoking is a well-established risk factor of pancreatic cancer (PC). Although an association between nicotine dependence phenotype, namely time to first cigarette (TTFC) after waking, and the risk of several smoking-related cancers has been reported, an association between TTFC and PC risk has not been reported. We assessed the impact of smoking behavior, particularly TTFC, on PC risk in a Japanese population. Materials and Methods: We conducted a case-control study using 341 PC and 1,705 non-cancer patients who visited Aichi Cancer Center in Nagoya, Japan. Exposure to risk factors, including smoking behavior, was assessed from the results of a self-administered questionnaire. The impact of smoking on PC risk was assessed with multivariate logistic regression analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Cigarettes per day (CPD) and/or smoking duration were significantly associated with PC risk, consistent with previous studies. For TTFC and PC risk, we found only a suggestive association: compared with a TTFC of more than 60 minutes, ORs were 1.15 (95%CI, 0.65-2.04) for a TTFC of 30-60 minutes and 1.35 (95%CI, 0.85-2.15) for that of 0-30 minutes (p trend=0.139). After adjustment for CPD or smoking duration, no association was observed between TTFC and PC. Conclusions: In this study, we found no statistically significant association between TTFC and PC risk. Further studies concerning TTFC and PC risk are warranted.

• Tuberculosis and Respiratory Diseases
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• v.62 no.3
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• pp.197-202
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• 2007

Background: Cigarette smoking is an important risk factor for chronic bronchitis and COPD. Airway epithelial cells exposed to cigarette smoke components such as nicotine, cotinine and benzopyrene can generate reactive oxygen species (ROS) and be subject to oxidative stress. This oxidative stress can induce the inflammatory response in the lung by the oxidant itself or by the release of proinflammatory cytokines. It has been reported that nicotine stimulates ROS, which are associated with NF-${\kappa}B$. Methods: Beas2B cells were treated with nicotine, cotinine and benzopyrene. RT PCR was used to measure the expression of several antioxidant factors using the total RNA from the Beas2B cells. The level of superoxide dismutase(CuZnSOD), thioredoxin, glutathione reductase expression was examined. Results: 0.5 to 4 hours after the benzopyrene, nicotine and cotinine theatments, the level of thioredoxin and glutathione reductase expression decreased. Longer exposure to these compounds for 24 to 72 hours inhibited the expression of most of these antioxidant factors. Conclusion: During exposure to smoke compounds, thioredoxin and glutathione reductase are the key antioxidant factors induced sensitively between 0.5 and 4 hours but the levels these antioxidants decrease between 24 hour and 72hours.

• Korean Journal of Health Education and Promotion
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• v.8 no.1
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• pp.45-58
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• 1991

The purpose of this study was to investigate determinants of stop smoking. The data on which the analysis was based come from a survey of 355 middle-aged men in Seoul. The data was analyzed using proportion, x²-test, Pearson's Correlation Coefficient and Stepwise Multiple Regression. The following were the results; 1. Success rate of stop smoking is 19.9% of 229 persons who attempted to quit smoking. 2. As for the number of quit attempts, 33.3% of ex-smokers tried once; 25.4% of current smokers tried twice. 3. As for methods of quit attempts ex-smokers showed higher tendency in using will power and books/guides than current smokers who in using will power alone. 4. For the attitudes on smoking of family, the majority of ex-smokers and current smokers were opposed absolutely. 5. The main opposite to smoking were wives in cases of both ex-smokers and current smokers, but More ex-smokers answered that the main opposite to smoking were others than current smokers. 6. As for the measures of smoking in the office, more ex-smokers answered inviting than current smokers and more current smokers assigned a smoking spot than ex-smokers. 7. Majority of ex-smokers approve of restriction at public spot strongly. 8. As for the attitude about caution on a cigarette case, more ex-smokers insisted than current smokers. 9. There was a relation between the degree of exposure about knowledge and the degree of knowledge. 10. Stepwise Multiple Regression portray that following factors influence stop smoking in order named. (1) attitude on the smoking restriction at public spot, (2) methods of quit attempt, (3) attitude about caution on cigarette case. Even so, it turned out that these factors alone can explain only 20% of self-examination. Therefore study for the other factors ought to be continued. I submit following suggestions ending this study. 1. Continuous study of the other factors affecting stop smoking must be carried on. 2. Since there was a relation the degree of exposure about knowledge and the degree of knowledge, efficient health education is required using campaign and mass media.

• Journal of Preventive Medicine and Public Health
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• v.29 no.1 s.52
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• pp.113-131
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• 1996

This study was carried out to evaluate the relations among workers' general characteristics, work-related behaviors and health related behaviors in a steel industry with 1,134 workers in Pohang. The results were as follows; 1. The mean age of workers was 50 years old and working duration was 15 years and over. Most of them were married(94.5%) and had studied beyond high school (53.0%). They performed three shift work and most of them(63.0%) had experienced industial accidents. The frequency of noise and dust exposure was defined by a minimum of 6 hours per day, and workers complained about noise exposure(62.9%) and dust(55.6%). There were current smokers(67.7%), current drinkers(74.3%) and current exercising workers(32.3%) in the industry. The number of cigarette consumption in current drinkers was significantly high $(13.6{\pm}8.4\;pieces/day)$ and the alcohol consumption in current smokers was significantly high$(104.5{\pm}113.5\;g/wk)$. And the number of cigarette consumption of exercisers was significantly low and the alcohol consumption of exercisers was higher than non-exercisers. 3. The ratio of current smokers on frequent noise in exposed workers versus non-exposed workers was not significantly high but the current drinkers in frequent noise and dust exposed workers was significantly higher than non-exposed. 4. The normal levels of SGOT workers in non-smokers were significantly higher than in current smokers, and the normal levels of LFT (SGOT, SGPT, $\gamma-GTP$ workers in nondrinkers were significantly high. The normal levels of SBP and DBP workers in current smokers were not significantly high but were significantly high in non-drinkers. 5. The ratio of current smokers in voters unsatisfied with their job and working condition was higher than non-smokers, but the ratio of current drinkers in workers satisfied with their job and working condition were higher. 6. The significant factors for SGOT and $\gamma-GTP$ were age, the drinking amount and BMI. But the only significant factor for r-GTP was BMI. The significant factors for DBP were age, the alcohol consumption and BMI. And the significant factors for SBP were age, BMI.

• Journal of Conservation Science
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• v.30 no.2
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• pp.137-148
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• 2014

Large scale anoxic chamber system(volume $28m^3$) was developed and installed at The National Folk Museum of Korea for the first time in Korea. In order to get optimal anoxic treatment condition, we compared the disinfection of adults, larvae and eggs of cigarette beetles using nitrogen and argon. The time for complete disinfection of cigarette beetles in pine wooden blocks exposed to nitrogen at oxygen concentration 0.01% and 50% in relative humidity were 15 days at $20^{\circ}C$, 10 days at $25^{\circ}C$, and 7 days $30^{\circ}C$. Time were 10 days at $20^{\circ}C$, 7 days at $25^{\circ}C$, and 5 days $30^{\circ}C$ in argon anoxic atmosphere. From the mortality of cigarette beetles, optimal disinfection condition was oxygen concentration 0.01%, $25^{\circ}C$ in temperature, 50% in relative humidity and exposure time 21 days at nitrogen atmosphere. And when large scale anoxic chamber system was supplied nitrogen by nitrogen generator for anoxic treatment of many collections or large collections, it could be operated stably. To verify optimal disinfection condition, museum insects(adults, larvae, pupae and eggs of cigarette beetles in pine wooden blocks, cotton fabrics and Korean paper book, adults and larvae of drugstore beetles in pine wooden blocks, cotton fabrics and Korean paper book, larvae of varied carpet beetles in pine wooden block and silk fabrics, adults and larvae of hide beetles and adults of rice weevils in breeding boxes) which exposed at optimal disinfection condition, were completely killed.

• Journal of the Korean Society of Tobacco Science
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• v.37 no.1
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• pp.18-24
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• 2015

Urinary mutagenicity is widely recognized as a useful biomarker for the assessment of mutagen exposure level in human. In this study, we optimized the several parameters affecting the activity of Urinary mutagenicity using highly sensitive mutation test(microsuspension assay) instead of the conventional Ames test. First of all, we chose YG1024 as a highly sensitive strain from three str ains of Salmonella typhimurium(TA98, TA100, YG1024) using r epr esentative mutation substances, such as Benzo[a]pyrene, 2-Aminonaphthalene, 2-amino-3-methyl-9H-pyrido[2,3-b]indole($MeA{\alpha}C$) and cigarette total particulate matter(TPM). And we established the several kinds of test conditions such as number of bacter ia, concentr ation of metabolic activation system and incubation time for the most sensitive reaction. Also, we optimized efficient pre-treatment method using commercial C18 column. As a r esults, this method was shown a aver age of 94 % recovery value and 13 % relative standard deviation. When we compared the Urinary mutagenicity between several participants, we confirmed that compar ative measurements were possible for different levels of urine mutagenicity. In conclusion, the optimized highly sensitive mutation test to measure the Urinary mutagenicity may be useful in biological monitoring of mutagen exposure level.

• Journal of environmental and Sanitary engineering
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• v.14 no.4
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• pp.85-92
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• 1999

Indoor air quality tends to be the dominant contributor to personal exposure because most people spend over 90% of their time indoors. For some contaminants, exposure to indoor air poses a potentially greater health threat than outdoor air exposures. Indoor nitrogen dioxide ($NO_2$) levels are mainly affected gas range, flue gas spillage, kerosene heaters, wood-burning appliances and cigarette smoke. In addition, indoor $NO_2$ levels are influenced by such house characterization as surface reaction and air exchange rate. In this study, the measurements of indoor and outdoor $NO_2$ concentrations were taken using identical protocols, and information was collected on housing characteristics using identical questionnaires in 14 houses out of 15 houses for daily 30 daily 30 days in Brisbane, Australia.The usage of gas range was the most contributing factor in indoor $NO_2$ concentration in relation to house characteristics. Average indoor and outdoor ratios of NO2 concentration in electronic and gas cooking houses were $0.6{\pm}0.1$ and $0.9{\pm}0.2$, respectively. The frequency distributions of $NO_2$ concentration in each house were approximately log-normal Geometric mean of indoor $NO_2$ concentrations of electronic and gas cooking houses for daily 30 days ranged from 2.5 ppm to 11.5 ppm with a mean 6.8 and from 4.7 ppm to 28.6 ppm with a mean 15.6 ppm, respectively. The $NO_2$ concentrations between electronic and gas cooking houses were significantly different (p<0.05). Since each house has different life-style and house characteristics, sampling interval to measure the $NO_2$ levels was recommended above 7 days.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4927-4935
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• 2015

Northeastern India is a major nasopharyngeal carcinoma (NPC) high risk-area although the rest of the country has very low incidence. A case-control study of 105 NPC cases and 115 controls was conducted to identify the potential risk factors for NPC development in this region. Information was collected by interviewer about socio-demographic characteristics, cigarette smoking, alcohol consumption, dietary history, occupational history, and a family history of cancer. Epstein-Barr viral load was assayed from the blood DNA by real time PCR. Associations between GSTs genotypes, cytochrome P450 family including CYP1A1, CYP2E1 and CYP2A6 polymorphisms and susceptibility to relationship between the diseases were studied using PCR-RFLP assay. Results indicate that Epstein-Barr virus load was significantly higher in patients compared to controls (p<0.0001). Furthermore, concentration of blood EBV-DNA was significantly higher in advanced stage disease (Stage III and IV) than in early stage disease (Stage I and II) (p<0.05). Presence of CYP2A6 variants that reduced the enzyme activity was significantly less frequent in cases than controls. Smoked meat consumption, exposure to smoke, living in poorly ventilated house and alcohol consumption were associated with NPC development among the population of Northeastern India. Thus, overall our study revealed that EBV viral load and genetic polymorphism of CYP2A6 along with living practices which include smoked meat consumption, exposure to smoke, living in poorly ventilated houses and alcohol consumption are the potential risk factors of NPC in north eastern region of India. Understanding of the risk factors and their role in the etiology of NPC are helpful forpreventive measures and screening.

• KIEAE Journal
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• v.1 no.2
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• pp.21-28
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• 2001

Naturally-ocurring short-lived decay products of radon gas in indoor air are the dominant source of ionizing radiation exposure to the general public. It is written in BEIR VI Report(l999l the radon progeny were identified as the second cause of lung cancer next to cigarette or 10 % to 14 %(15,400 to 21,800 persons p.a.) of all lung cancer deaths in USA. Indoor radon concentrations in houses typically result from radon gaining access to houses mainly from the underlying soil. In the States, they have "Indoor Radon Abatement Act" which was converted from "Toxic Substance Control Act" in 1988 to establish the national long-term goal that indoor air should be as free of radon as the ambient air outside of buildings. To review and study techniques for controlling radon, two test cells were constructed for a series of tests and are under measuring indoor and soil gas (underneath of floor slab)radon concentrations according to EPA's measurement protocol. In this paper, important theoretical studies are previewed and the following paper will explain the test results and confirm the theories reviewed to find out suitable coefficients. On the basis of test analysis, it will be described and evaluated various techniques that can be used to mitigate elevated indoor concentration of radon including the control of radon and its decay products.

• Tuberculosis and Respiratory Diseases
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• v.80 no.1
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• pp.11-20
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• 2017

Approximately one in four patients with chronic obstructive pulmonary disease (COPD) have asthmatic features consisting of wheezing, airway hyper-responsiveness or atopy. The Global initiative for Asthma/Globalinitiative for chronic Obstructive Lung Disease committee recently labelled these patients as having asthma-COPD overlap syndrome or ACOS. ACOS also encompasses patients with asthma, ${\geq}40$ years of age, who have been cigarette smokers (more than 5-10 pack years) or have had significant biomass exposure, and demonstrate persistent airflow limitation defined as a post-bronchodilator forced expiratory volume in 1 second ($FEV_1$)/forced vital capacity of <70%. Data over the past 30 years indicate that patients with ACOS have greater burden of symptoms including dyspnea and cough and show higher risk of COPD exacerbations and hospitalizations than those with pure COPD or pure asthma. Patients with ACOS also have increased risk of rapid $FEV_1$ decline and COPD mortality. Paradoxically, experimental evidence to support therapeutic decisions in ACOS patients is lacking because traditionally, patients with ACOS have been systematically excluded from therapeutic COPD and asthma trials to maintain homogeneity of the study population. In this study, we summarize the current understanding of ACOS, focusing on definitions, epidemiology and patient prognosis.