• Toxicological Research
• /
• 제21권1호
• /
• pp.77-85
• /
• 2005

Cadmium is an environmental pollutant exposed from contaminated foods or cigarette smoking and known to cause oxidative damage in organs. We investigated the cadmium-induced apoptosis and cell arrest in human breast cancer cells, MCF-7 cells and MDA-MB-231 cells. Obvious apoptotic cell death was shown in CdCl₂ 100 μM treatment for 12 hr, which were determined by DAPI staining and flow cytometric analysis. In cell cycle analysis, MCF-7 cells and MDA-MB-231 cells were arrested in S phase and G2/M phase respectively. These could be explained by the induction of cell cycle inhibitory protein, p21/sup Waf1/Cip1/ and p27/sup Kip1/, expression and reduction of cyclin/Cdk complexes in both cell lines. The decreased expression of cyclin A and Cdk2 in MCF-7 cells and cyclin B1 and Cdc2 in MDA-MB-231 cells were consistent with the flow cytometric observation. p-ERK expression was increased dose-dependent manner in both cell lines. It suggests that ERK MAPK pathway are involved in cadmium-induced cell cycle arrest and apoptosis. Moreover, cotreatment of zinc (100 μM, 12 hr) recovered the cadmium-induced cell arrest in both cells, which shows cadmium-induced oxidative stress mediates apoptosis and cell cycle arrest in human breast cancer cells.

• 한국학교ㆍ지역보건교육학회지
• /
• 제11권1호
• /
• pp.79-91
• /
• 2010

Objectives: This study was conducted to analyze health behavior and utilization of university health clinics by college and university students. Methods: There are 376 colleges and universities in Korea as of May 2007. Of them 243 (69.6%) run health clinics in their campuses. Twenty of them were selected and 1,754 students were surveyed by using self reporting questionnaires. The data collected were analyzed by SPSS ver. 12.0. Results: Out of 1,754 students 56.5% were in good health. Of the subjects 15.6% were cigarette smokers, 30% were non drinkers, 20.8% exercise regularly, 53.7% sleep for seven to eight hours a day, 48% had proper body weight (BMI) 20-25) and 20% had physical examination in the past two years. The scores of health practices were higher in male students than female students (P 0.05). Perception rates of university clinics were higher in female students than male students. (P 0.01). Many students have intention to use the clinics (P 0.01). On health promotion program 35.2% of the subjects used clinics for emergency service, 32.8% participated in drinking control program, 32.8% in smoking cessation program, 20.4% in immunization program and 19.2% in regular health screening program. Conclusions: Comprehensive data for health behavior and need of health promotion services by the students should be collected regularly in order to meet the needs of students and faculty members in higher education institutes. The university authorities should pay more attention on the activities of health clinics in order to promote health of the students.

• 한국대기환경학회지
• /
• 제3권2호
• /
• pp.27-32
• /
• 1987

大氣汚染의 疫學的 硏究의 일부로서 미국내 휴스턴시의 家庭을 對象으로 5가지 主要硏究物質($SO_2$, $NO_2$, CO, $O_3$)에 대한 室內外 濃度를 調査하였다. 室內濃度는 침실, 부엌, 거실에서 調査하였고 室外濃度와 比較하였다. 그 結果 오존을 除外한 각 汚染物質에서 부엌과 거실의 濃度는 室外濃度 보다 높았다. 또한 $NO_2$와 $O_3$를 除外한 각 汚染物質의 室內外 濃度比는 1.8 ~ 2.7을 나타냈다. 특히 家庭 內에서 汚染物質의 室內濃度는 家庭의 住宅構造, 居住者의 吸煙狀況 등에 影響을 받는 것으로 시사되었다.

• Nutrition Research and Practice
• /
• 제1권2호
• /
• pp.79-83
• /
• 2007

The present study was conducted to document the association between plasma homocysteine levels and the presence of macrovascular angiopathy with food and nutrient intake patterns among patients with Type II diabetes mellitus in Korea. Plasma total homocysteine concentration was analyzed by HPLC-fluorescence detector method in 127 patients with non-insulin dependent diabetes mellitus. Logistic regression analyses were performed respectively to study the association of plasma homocysteine levels with clinical and dietary characteristics and macroangiopathy (MA). The average plasma homocysteine level of patients with MA was $14.2{\mu}mol/l$, which was significantly higher than that of patients without MA ($11.4{\mu}mol/l$). The proportions of patients with MA showed a significant difference, being 32.3% in hyperhomocysteinemic ($>14.0{\mu}mol/l$) patients and 13.5% in others with homocysteine levels lower than $14.0{\mu}mol/l$. Odds ratios for macroangiopathy by tertile increase of plasma homocysteine concentration were 1.633 ($Q_2$) and 4.831 ($Q_3$), when adjusted for age, sex, and cigarette smoking. Patients with MA consumed reduced amounts of vitamin $B_1,\;B_2$, and folate. The results indicate that the plasma homocysteine levels are significantly increased in NIDDM patients who have macroangiopathy. Dietary management such as increased fruits and vegetables and decreased potatoes and starches might be beneficial for the prevention of macroangiopathy in diabetic patients.

• 보건교육건강증진학회지
• /
• 제11권2호
• /
• pp.125-145
• /
• 1994

The objectives of this study were to characterize the health status, the requirement of home nursing care, and dependency of daily life of the elderly so that the result could be used to provide basic data necessary for establishing home nursing care practices. The study subjects were 249 elders over 65 years old who resided at home in low income areas of three districts in Pusan. The field survey was conducted from December 27, 1993 through January 27, 1994, with a structured questionnaire. Statistical analysis was done by X²-test and Student's T-test using SPSS/PC/sup +/ program. The result were as follows; 1. Alcohol drinking rate was 50.0% for men and 27.7% for women, and cigarette smoking rate was 77.8% for men and 27.1% for women. 92.9% of elders aged 65-75 exercised regularly as compared to 81.9% of elders aged 75 and over(p<0.05). 2. 63.9% of male and 85.9% of female elders had chronic diseases showing singnificant differences(p<0.01), and both sexes had 1.7 kinds of chronic diseases in average; musculoskeletal diseases were the most common in 25.7%, while 6.8% of the elderly had cardiovascular diseases. 3. Partially movable elderly was 6.9% for men and 6.8% for woman, showing 47.1% of causes being cerebrovascular accidents. 4. The home nursing requirement was the highest for medication(66.3%), intramuscular injection(53.8%), and measurement of blood pressure·body·temperature·pulse rate(47.0%). 5. Among Physical Activities of Daily Life, bathing(10.4%) and movement(4.0%) showed high dependency rates, and among Instrumental Activities of Daily Life, phone calling(25.3%), shopping(24.5%), going out by bus(22.5%) showed high dependency rates. 6. For five categories of home nursing showing high requirements such as physical health examination, blood pressure·temperature·pulas rate measurements, medication, and intravascular injection, the requirements were different by age groups, education, and marital status(p<0.05).

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권11호
• /
• pp.6327-6330
• /
• 2013

Haematuria is a common presentation of bladder cancer and requires a full urologic evaluation. This study aimed to develop a scoring system capable of stratifying patients with haematuria into high or low risk groups for having bladder cancer to help clinicians decide which patients need more urgent assessment. This cross-sectional study included all adult patients referred for haematuria and subsequently undergoing full urological evaluation in the years 2001 to 2011. Risk factors with strong association with bladder cancer in the study population were used to design the scoring system. Accuracy was determined by the area under the receiver operating characteristic (ROC) curve. A total of 325 patients with haematuria were included, out of which 70 (21.5%) were diagnosed to have bladder cancer. Significant risk factors associated with bladder cancer were male gender, a history of cigarette smoking and the presence of gross haematuria. A scoring system using 4 clinical parameters as variables was created. The scores ranged between 6 to 14, and a score of 10 and above indicated high risk for having bladder cancer. It was found to have good accuracy with an area under the ROC curve of 80.4%, while the sensitivity and specificity were 90.0% and 55.7%, respectively. The scoring system designed in this study has the potential to help clinicians stratify patients who present with haematuria into high or low r isk for having bladder cancer. This will enable high-risk patients to undergo urologic assessment earlier.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권13호
• /
• pp.5427-5432
• /
• 2015

Background: Oral cancer stands among the 10 top causes of cancer death in the world. Considering the role of epidemiologic information on planning and effective interventions, the present study aimed to investigate the epidemiology of oral cancer in Iran. Materials and Methods: The required information for this systematic review study was obtained from PubMed, Google Scholar, CINAHL,SID, Medlib, Magiran and Iranmedex databases, using key words "cancer", "oral cancer", "squamous cell carcinoma", "oral cavity carcinoma" and their Persian equivalents in combination with keywords of epidemiology, prevalence, etiology, frequency, and Iran from 1990 to 2014. From 1,065 related studies found, finally 25 were included to the study. Results: The mean age of 8,248 patients in 25 studies was $54.0{\pm}15.1years$. The male/female ratio for oral cancer was 1.91. Tongue with average percentage of 29.9 was the most involved site. Regarding microscopic grade, 65.7% of cases were grade 1. SCCs, accounting for an average of 70.0%, was the most common among all types of oral cancer. In the majority of studies, smoking including cigarette, hookah, and tobacco consumption was found to be a risk factor. Conclusions: The epidemiological pattern of oral cancer in Iran is somewhat similar to that of other countries. Yet the information on hand in this field is limited and considering the role of epidemiological data we suggest conducting more accurate studies to catch data that is required for effective programs and interventions.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권12호
• /
• pp.4927-4935
• /
• 2015

Northeastern India is a major nasopharyngeal carcinoma (NPC) high risk-area although the rest of the country has very low incidence. A case-control study of 105 NPC cases and 115 controls was conducted to identify the potential risk factors for NPC development in this region. Information was collected by interviewer about socio-demographic characteristics, cigarette smoking, alcohol consumption, dietary history, occupational history, and a family history of cancer. Epstein-Barr viral load was assayed from the blood DNA by real time PCR. Associations between GSTs genotypes, cytochrome P450 family including CYP1A1, CYP2E1 and CYP2A6 polymorphisms and susceptibility to relationship between the diseases were studied using PCR-RFLP assay. Results indicate that Epstein-Barr virus load was significantly higher in patients compared to controls (p<0.0001). Furthermore, concentration of blood EBV-DNA was significantly higher in advanced stage disease (Stage III and IV) than in early stage disease (Stage I and II) (p<0.05). Presence of CYP2A6 variants that reduced the enzyme activity was significantly less frequent in cases than controls. Smoked meat consumption, exposure to smoke, living in poorly ventilated house and alcohol consumption were associated with NPC development among the population of Northeastern India. Thus, overall our study revealed that EBV viral load and genetic polymorphism of CYP2A6 along with living practices which include smoked meat consumption, exposure to smoke, living in poorly ventilated houses and alcohol consumption are the potential risk factors of NPC in north eastern region of India. Understanding of the risk factors and their role in the etiology of NPC are helpful forpreventive measures and screening.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권sup3호
• /
• pp.197-200
• /
• 2016

On an international scale, the burden of cancer in absolute numbers continues to increase, mainly due to aging of population in many countries, the overall growth of the world population, changing lifestyle with increasing cancer-causing behavior, like cigarette smoking, changing dietary habits and sedentary life. Cancer is the second-leading cause of death and disability in the world, after only heart disease. Recently, increasing incidence and mortality of cancer have also become evident in the developing world. In Iraq and particularly in Basrah in the southern part of the country, the burden has definitely increased and deserves extensive research. The present paper is part of an extensive household survey carried out in Basrah in 2013. Among the objectives was to validate official cancer registration in the governorate. The cross-sectional survey had a retrospective component to inquire about the incidence of cancer and cancer-related deaths during the three years preceding the date of inquiry (2010-2012). A convenient sample of 6,999 households with 40,688 inhabitants using multistage cluster sampling was surveyed involving all urban and rural areas of Basrah. The official cancer registration activities in Basrah seemed to have attained a high level of registration coverage (70-80%) but the gap, represented by missed cases, is still high enough to criticize the system. Most of the missing cases were either not notified by treating facilities or they were diagnosed and treated outside Basrah. Using a set of parameters, the pattern of cancer was consistent based on data of the household survey and data of the cancer registry but a gap still existed in the coverage of incident cancer and mortality by cancer registration. Integrated serious steps are required to contain the risk of cancer and its burden on the patient through improving the registration process, improving early detection, diagnostic and management capabilities and encouraging scientific research to explore the hidden risk factors and possible causes of low registration coverage. Periodic household surveys seemed feasible and essential to support routine registration.

• Journal of Nutrition and Health
• /
• 제12권3호
• /
• pp.9-23
• /
• 1979

The known risk factors for atherosclerosis include plasma low density lipoproteins (LDL)or Cholesterol, low PUFA in the diet, hypertension, and high Na intake, obesity, diabetes, lack of exercise, cigarette smoking, sugar, low fiber and nicotinic acid in the diet, sources of Protein foods, and Psychological factors. Among various dietary factors, fat is known as the most serious causative agent for atherosclerosis. The genetic factor is a18o known as an important one but is out of scope in this paper. Since atherosclerosis is a progressive disease which may develop for many years before showing any definitive symptoms, it is very important to develop preventive programs especially in the country like Korea that is not quite overdevelopted as some western countries. In this paper all the factors mentioned above were reviewed and the dietary suggestion were made on the basis of the content of polyunsaturated and saturated fat in the diet to prevent or/and to cure this disease. Most of the available data on diet therapy with emphasis. on P/S ratio were tabulated together. after tile patient's habitual dietary intake is analized the guidelines of personalized fat-controlled diet can be recommended. It is of utmost importance to develop Korean diets for beth prevention and cure of atherosclerosis emphasizing individual eating habit in the near future which can be more Practicaly used both at home and in the hospital.