• Title/Summary/Keyword: Chung-Sang

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청상사화탕(淸上瀉火湯)이 토끼의 수축혈관에 미치는 영향 (Effects of ChungSangSaWhaTang on The Arteral Contraction in Rabbit)

  • 전성배;김이화;남창규
    • 대한약침학회지
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    • 제6권3호
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    • pp.49-55
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    • 2003

  • This study was undertaken to define the effect of ChungSangSaWhaTang on the norepinephrine-induced arterial contraction and the mechanism of ChungSangSaWhaTang-induced relaxation. In order to investigate the effect of ChungSangSaWhaTang on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of ChungSangSaWhaTang-induced relaxation, ChungSangSaWhaTang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, $N_{\omega}$-nitro-L-arginine, or tetraethylammonium chloride. ChungSangSaWhaTang relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, ChungSangSaWhaTang-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by ChungSangSaWhaTang was decreased by the pretreatment of $N_{\omega}$-nitro-L-arginine, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. We suggest that ChungSangSaWhaTang may inhibit agonist-induced contraction through the formation of nitric oxide in the vascular endothelial cells.

  • https://doi.org/10.3831/KPI.2003.6.3.049 인용 PDF

Esophagitis and IL-1$\beta$-induced alteration of MAP kinase activity in esophageal smooth muscle

  • Lee, Tai-Sang;Min, Young-Sil;Choi, Tae-Sik;Sim, Sang-Soo;Shin, Yong-Kyoo;Lee, Moo-Yeol;Sohn, Uy-Dong
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.117.1-117.1
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    • 2003

  • We investigated whether experimental esophagitis and IL-1$\beta$ could induce the activation of MAP kinases in esophageal smooth muscle. With two models of experimental esophagitis, we assessed the activity of p38 MAP kinase, p44/42 MAP kinase and JNK. In feline acute experimental esophagitis, immunoblotting of normal and esophagitis-induced smooth muscle with each types of MAP kinase antibodies revealed the slight increase of phosphorylated form of p38 MAP kinase, especially in membrane fraction. (omitted)

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