Esophagitis and IL-1$\beta$-induced alteration of MAP kinase activity in esophageal smooth muscle

  • Lee, Tai-Sang (College of Pharmacy and School of Medicine. Chung Ang University) ;
  • Min, Young-Sil (College of Pharmacy and School of Medicine. Chung Ang University) ;
  • Choi, Tae-Sik (College of Pharmacy and School of Medicine. Chung Ang University) ;
  • Sim, Sang-Soo (College of Pharmacy and School of Medicine. Chung Ang University) ;
  • Shin, Yong-Kyoo (College of Pharmacy and School of Medicine. Chung Ang University) ;
  • Lee, Moo-Yeol (College of Pharmacy and School of Medicine. Chung Ang University) ;
  • Sohn, Uy-Dong (College of Pharmacy and School of Medicine. Chung Ang University)
  • Published : 2003.04.01

Abstract

We investigated whether experimental esophagitis and IL-1$\beta$ could induce the activation of MAP kinases in esophageal smooth muscle. With two models of experimental esophagitis, we assessed the activity of p38 MAP kinase, p44/42 MAP kinase and JNK. In feline acute experimental esophagitis, immunoblotting of normal and esophagitis-induced smooth muscle with each types of MAP kinase antibodies revealed the slight increase of phosphorylated form of p38 MAP kinase, especially in membrane fraction. (omitted)

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