• Title/Summary/Keyword: Chrysanthemum zawadskii Herbich var. latilobum Kitamra

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Cytotoxic Flavonoids from the Whole Plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura (구절초에서 분리한 Flavonoids의 인체암 세포주에 대한 세포독성 효과)

  • Kwon, Hyun-Sook;Ha, Tae-Joung;Hwang, Seon-Woo;Jin, Young-Min;Nam, Sang-Hae;Park, Ki-Hun;Yang, Min-Suk
    • Journal of Life Science
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    • v.16 no.5
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    • pp.746-749
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    • 2006
  • Two known flavonoids, luteolin (1) and acacetin (2) were isolated from a $CHCI_3$ soluble fraction of the whole plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura, and their structures were determined by NMR analysis. The luteolin (1) was isolated from this plant for the first time. These compounds were examined for their in vitro cytotoxic activities against four human cancer cell lines including HCT116 (colon), UO-31 (renal), PC-3 (prostate) and A549 (lung) by sulforhodamine B(SRB) assay. Acacetin (2) showed significant cytotoxic activity against HCT116 and UO-31 cells with an $IC_{50}$ of 2.44 and $2.89\;{\mu}g/ml$, respectively.