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http://dx.doi.org/10.5352/JLS.2006.16.5.746

Cytotoxic Flavonoids from the Whole Plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura  

Kwon, Hyun-Sook (Division of Applied Life Science(BK21 program), Institute of Agriculture & Life Sciences, Gyeongsang National University)
Ha, Tae-Joung (Yeongnam Agricultural Research Institute, National Institute of Crop Science, RDA)
Hwang, Seon-Woo (Division of Applied Life Science(BK21 program), Institute of Agriculture & Life Sciences, Gyeongsang National University)
Jin, Young-Min (Division of Applied Life Science(BK21 program), Institute of Agriculture & Life Sciences, Gyeongsang National University)
Nam, Sang-Hae (Department of Food Science, Jinju National University)
Park, Ki-Hun (Division of Applied Life Science(BK21 program), Institute of Agriculture & Life Sciences, Gyeongsang National University)
Yang, Min-Suk (Division of Applied Life Science(BK21 program), Institute of Agriculture & Life Sciences, Gyeongsang National University)
Publication Information
Journal of Life Science / v.16, no.5, 2006 , pp. 746-749 More about this Journal
Abstract
Two known flavonoids, luteolin (1) and acacetin (2) were isolated from a $CHCI_3$ soluble fraction of the whole plants of Chrysanthemum zawadskii Herbich var. latilobum Kitamura, and their structures were determined by NMR analysis. The luteolin (1) was isolated from this plant for the first time. These compounds were examined for their in vitro cytotoxic activities against four human cancer cell lines including HCT116 (colon), UO-31 (renal), PC-3 (prostate) and A549 (lung) by sulforhodamine B(SRB) assay. Acacetin (2) showed significant cytotoxic activity against HCT116 and UO-31 cells with an $IC_{50}$ of 2.44 and $2.89\;{\mu}g/ml$, respectively.
Keywords
Chrysanthemum zawadskii Herbich var. latilobum Kitamra; luteolin; acacetin; sulforhodamine B; cytotoxic activity;
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1 Kim, Y. Y., S. Y. Lee and D. S. Yim. 2001. Biological activities of linarin from Chrysanthemum zawadskii var latilobum. J. Pharm. Soc. Korea 45, 604-610   과학기술학회마을
2 Shin, K. H., S. S. Kang, E. A. Seo and S. W. Shin. 1995. Isolation of aldose reductase inhibitors from the flowers of Chrysanthemum boreale. Arch. Pharm. Res. 18, 65-68   DOI
3 Skehan, P., R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J. T. Warren and M. R. Boyd. 1990. New colorimetric cytotoxicity assay for anticancer drug screening. J. Nat. Cancer Insti. 82, 1107-1112   DOI
4 Hu, C. Q., K. Chen, Q. Shi, E. K. Robert, Y. C. Cheng and K. H. Lee. 1994. Anti-AIDS agents, $acacetin-7-O-{\beta}-D-galactopyranoside$, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids. J. Nat. Prod. 57, 42-51   DOI   ScienceOn
5 Jang, D. S., K. H. Park, J. R. Lee, T. J. Ha, Y. B. Park, S. H. Nam and M. S. Yang. 1999. Antibacterial activities of sesquiterpene lactones isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale. J. Korean Soc. Agric. Chem. Biotechnol. 42, 176-179
6 Ha, T. J., S. W. Hwang, H. J. Jung, K. H. Park and M. S. Yang. 2002. Apigenin, tyrosinase inhibitor from the flowers of Hemisteptia lyrata Bunge. Agric. Chem. Biotechnol. 45, 170-172
7 Lee, Y. C. 1967. Constituents of Chrysanthemum sibiricum. J. Pharm. Soc. Korea 11, 7-16
8 Harborne, J. B., C. A. Williams and K. L. Wilson. 1985. Flavonoids in leaves and inflorescences of Australian cyperaceae. Phytochemistry 24, 751-766   DOI   ScienceOn
9 Jang, D. S., K. H. Park, S. U. Choi, S. H. Nam and M. S. Yang. 1997. Antibacterial substances of the flower of Chrysanthemum zawadskii Herbich var latilobum Kitamura. J. Korean Soc. Agric. Chem. Biotechnol. 40, 85-88   과학기술학회마을
10 Jang, D. S., K. H. Park, H. M. Kim, D. H. Hong, H. K. Chun, Y. H. Kho and M. S. Yang. 1998. Biological activity of sesquiterpene lactones isolated from several compositae plants. Part 1 Cytotoxicity against cancer cell lines. Kor. J. Pharmacogn. 29, 243-247   과학기술학회마을
11 Jang, D. S., B. M. Kwon and M. S. Yang. 1999. Biological activity of sesquiterpene lactones isolated from several compositae plants. Part 2 FPTase inhibitory. Kor. J. Pharmacogn. 30, 70-73   과학기술학회마을
12 Robert, M. H. and G. Bruno. 1960. Flavonoids of citrus. IV. Isolation of some aglycones from the lemon (Citrus limon). J. Org. Chem. 25, 2183-2187   DOI
13 Jang, D. S., K. H. Park, H. L. Ko, H. S. Lee, B. M. Kwon and M. S. Yang. 1999. Biological activity of sesquiterpene lactones isolated from several compositae plants. Part 3 Inhibitory activity on nitric oxide release and ACAT. Kor. J. Pharmacogn. 30, 74-78   과학기술학회마을