• Clinical and Experimental Pediatrics
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• 제62권7호
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• pp.274-280
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• 2019

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children's Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were positive for mutations of the PTPN11, RAF1, and SOS1 genes. The five genes undetected (FGU) group was negative for PTPN11, RAF1, SOS1, KRAS, and BRAF gene mutations. The influence of genotype was retrospectively analyzed by comparing the growth parameters after GH therapy. Results: The mean chronological age at the start of GH treatment was $5.85{\pm}2.67years$. At the beginning of the GH treatment, the height standard deviation score (SDS), growth velocity (GV), and lower levels of insulin-like growth factor-1 (IGF)-1 levels were not statistically different among the groups. All the 23 NS patients had significantly increased height SDS and serum IGF-1 level during the 3 years of treatment. GV was highest during the first year of treatment. During the 3 years of GH therapy, the PTPN11, RAF1, and SOS1 groups showed less improvement in height SDS, IGF-1 SDS, and GV, and less increase in bone age-to-chronological age ratio than the FGU group. Conclusion: The 3-year GH therapy in the 23 prepubertal patients with NS was effective in improving height SDS, GV, and serum IGF-1 levels. The FGU group showed a better response to recombinant human GH therapy than the PTPN11, RAF1, and SOS1 groups.

• 대한소아치과학회지
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• 제37권1호
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• pp.57-64
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• 2010

본 연구는 수직적 안모형태와 치아성숙도의 관계를 평가하고 이러한 연관성에 대한 사춘기 성장의 영향을 평가하기 위한 것이다. 이번 연구를 위해 7세에서 9세, 13세에서 15세 환자 1306명을 Ricketts의 VERT index를 이용하여 수직적 안모 형태를 분류하였고 환자들의 치령을 Demirjian법으로 평가하여 다음과 같은 결과를 얻었다. 1. 모든 군에서 치령이 역령과 비교 시 통계적으로 유의한 수준에서 크게 측정되었다. 2. 사춘기 연령군에서 brachyfacial type의 경우가 dolichofacial type 보다 치아성숙도가 크게 나타나는 경향을 보였다. 여성의 경우는 통계적으로 유의성있게 차이가 나타났으며, 남성의 경우는 통계적 유의성은 보이지 않았다. 3. Brachyfacial type의 경우 사춘기전 군들과 비교 시 사춘기 군들에서 치아성숙도가 유의성있게 높게 나타났으며, dolichofacial type의 경우는 연령층간 치아성숙도의 차이를 보이지 않았다.

• 대한한방소아과학회지
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• 제12권1호
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• pp.95-110
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• 1998

I intended to be helpful to understand significant cause for treated patients comed to Dept of Pediatrics growth clinic in short stature of delayed growth and effect of oriental medical therapy. I studied at first 54 patients(36 men and 18 women) comed to Dept. of Pediatrics growth clinic of Dongguk Pundang Oriental Hospital and investigated characteristics, remidial value and side effect which 20 patients(1l men and 9 women) treated oriental medical therapy in short stature of delayed growth between June 1997 and October 1998. First study resulted the average was 8.37 year(chronological age), 6.96 year(bone age), 15.43 (height percentile by age), 164.2 cm(mid parental height) and the ratio of using the prescription was Bojunggunatang-derivative at first. second study resulted the distribusions of remedial values were improved(55.0%) and no improved(45.0%) patients. remedial values was affected by appetite.

• 음성과학
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• 제12권1호
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• pp.15-25
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• 2005

The purpose of the present study was to investigate the characteristics of metalinguistic awareness of children with specific language impairment. Forty-five children participated in this study; 15 children with specific language impairment (SLI group) whose range of the language age was 4;6-6;6, 15 normal children chronological age matched (CA controls) and 15 normal children language age matched with the SLI group (CA controls). A metalinguistic task involving the identification and revision of syntactic, semantic, and phonologic errors was used. The SLI group performed significantly poorer than CA controls as well as LA controls in identifying and correcting error sentences, especially sentences with syntactic error. These results revealed the relation between language problems of children with SLI and metalinguistic abilities.

• 말소리와 음성과학
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• 제10권4호
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• pp.67-76
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• 2018

This study was performed to investigate acoustic characteristics of sustained vowels produced by Seoul Korean speakers. For this study, three hundred nine healthy adults were chosen as participants from Korean Standard Speech Database. These subjects were divided into five chronological age groups (20s, 30s, 40s, 50s, 60-70s) and two gender groups (male and female). Fundamental frequency (f0), jitter, shimmer, and NHR (noise-to-harmonics ratio) was measured with 8 Korean vowels (/ɑ/, /æ/, /ʌ/, /e/, /o/, /u/, /ɯ/, /i/) by using Praat. The results showed that the vowel type significantly affected all acoustic parameters. Gender affected f0, jitter, and NHR significantly. The mean female speakers' f0 was greater than the males', and the mean jitter and NHR of male speakers was greater than the females'. Moreover, age affected shimmer and NHR significantly; in particular, the shimmer and NHR of elderly speakers was greater than the young speakers.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2022년도 제65차 동계학술대회논문집 30권1호
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• pp.153-154
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• 2022

본 논문에서는 역연령으로 구분되었던 기존 생물학적 성숙도에 기반한 체력 지표가 아닌 골성숙도를 활용한 생물학적 성숙도에 기반하여 유소년의 신체에 맞는 체계적인 운동을 추천하는 기법을 제안한다. 이를 통해 유소년의 성장기에 개인화된 운동능력 발달을 성취하게 함으로써 국민 체력 증진에 기여하고 체육 공교육 활성화 및 유소년 피트니스 관리 산업 발전에 도움이 될 것으로 기대한다.

• 한국의류산업학회지
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• 제13권1호
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• pp.55-65
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• 2011

The purposes of this study were to measure Shangri-La Syndrome through the difference age(i.e. chronological age-cognitive age) of Korean in their 40s and 50s, and to examine the variables which have an effect on the syndrome, requirements of Shangri-La Syndrome and means to look young. The research was conducted on 365 men and women in their 40s and 50s from Ulsan, Busan, and Seoul. The statistical analysis methods used for the study were reliability analysis, factor analysis, frequencies analysis, t-test, correlation analysis, ANOVA, Duncan test, and regression analysis. The results of this study are as follows : First, difference age showed to be 9.5 on the average and appeared to be largest in terms of feel and interests ages and smallest in terms of look and health ages. Second, it was found that Shangri-La Syndrome was influenced by health and self-love factors from among physical and social-psychological characteristics, and age, educational status, job, and hobby out of demographic characteristics. Third, it was shown that health body was the most important condition for a living with Shangri-La Syndrome and clothing was the most effective tool available for young appearances.

• 대한한의진단학회지
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• 제15권2호
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• pp.175-190
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• 2011

Objectives: Even though there has been no consensus on the concept of viscera organ between the oriental and western medicine, we tried to investigate the correlation between clinical biomarkers of five Jang and chronological age and develop the models for predicting five Jang biological ages by statistical analysis. Methods: We obtained data from about 120,000 subjects who visited health promotion centers for health promotion and disease prevention from January 2004 to June 2009. Participants were included if they were over 20 years old, and excluded if reported to have cardiovascular disease or other serious medical illness such as cancer, malignant hypertension, uncontrolled diabetes, cardiopulmonary insufficiency, liver disease, pancreatic disease or renal disease. Among the clinical biomarkers obtained, we selected the biomarkers which were associated with the function of 5 Jang in previous studies, or showed statistically significant correlation with age. Multiple regression models were used for building prediction models of biological age after adjusting for potential confounders for men and women, respectively. Pearson correlation coefficient was calculated to examine the linear relationship between age and various biomarkers, and multiple regression analysis was used for building the prediction models of five Jang biological ages for men and women, respectively. All statistical data analysis was performed by using SPSS Version 12.0 software and statistical significance was obtained if p<0.05. Results: For males, the best models were developed using 12, 2, 8, 3, and 4 biomarkers for predicting biological ages of heart, lung, liver, pancreas, and kidney, respectively (R2 = 0.57, 0.43, 0.11, 0.24, and 0.93, respectively). Similar to males, for the females, 10, 2, 8, 3, and 4 biomarkers were selected as the models respectively (R2 = 0.76, 0.44, 0.14, 0.38, and 0.89, respectively). Conclusions: As we have developed for the first time the models for predicting five Jang biological ages with common clinical biomarkers, it is expected that these models may be used as clinical supplementary tools in the evaluation of aging status and functional decline of five Jang according to age in health promotion centers and private clinics. At the same time, it is considered that the use as objective tools to evaluate aging status and functional decline of each Jang.

• 대한소아치과학회지
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• 제49권1호
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• pp.35-44
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• 2022

이 연구의 목적은 하악 좌측 제3대구치의 치아 성숙도에 대한 한국인의 참고 자료를 제공하고, 하악 좌측 제3대구치의 석회화 단계와 연대기적 연령 사이의 상관관계를 분석 및 치아 발육 단계를 이용하여 연령을 예측할 수 있을지 알아보는 것이다. 연세대학교 치과대학병원에 내원한 만 7 - 23세 사이의 건강한 환자 1653명의 파노라마 방사선 사진을 이용하여 보완된 Demirjian의 방법으로 하악 좌측 제3대구치의 발육 단계를 평가했다. 제3대구치의 석회화는 평균 9세에 시작하였으며 치관과 치근의 형성은 각각 평균 14세, 21세에 완성되었다. 치관의 형성과 치근 길이가 완성되는 발육 단계에서 남성이 여성보다 다소 빨랐으며, 그 차이는 통계적인 유의성을 보였다. 그 외의 발육 단계에서는 남성과 여성 사이의 유의미한 차이는 없었다. 하악 좌측 제3대구치과 연령은 양의 상관관계를 나타냈으며, 제3대구치의 발육 단계를 이용하여 연령을 예측할 수 있었다. 파노라마 방사선 사진을 이용한 하악 좌측 제3대구치의 치아 성숙도 평가 방법을 통하여 제3대구치의 발육 시기를 분석할 수 있었고, 하악 좌측 제3대구치가 연령을 예측하는 수단으로 활용될 수 있음을 알 수 있었다.

• 혜화의학회지
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• 제7권2호
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• pp.609-620
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• 1999

Over the period between January 1997 and December 1998, herbal medicine was more than three times administered to the patients coming to Na dong gyu's Oriental Medical Clinic on account of the symptom of growth deficiency. According to radiological opinions about the patients providing cooperation for measuring their height and weight as well as their bone age every three months, it was found that the growth plates were not closed. A research was conducted for 200 children randomly selected of patients in prepuberty (they grew by less than 5cm a year before treatment at a age of 12years for female children and 14years for male children). As a result, the following conclusion was drawn: 1. The randomly selected subjects were made up of 116 male and 84 female children in terms of gender. The age direstribution was most 10 to 12 years in 86 children(34.00%), followed by 8-10 years(27.50%) and 12 to 14 years(19.50%). 2. Considering the distribution of sick children's parental height, the fathers of 141 children(70.50%) measured less than 170cm high, the subaverage height, while the mothers of 172 children(86%) measured less than 160cm high, the subaverage height. It was shown that sick childen's height was genetically influenced by their parents. 3. Children patients's weight at a time of birth was most 3.1-3.5kg for 85 children(44%) and less than 2.5kg which came under the range of growth dificiency for 19 children(9.5%). 4. The highest proportian of the children patients with growth dificiency(56.33%) had the symptom of digestive disorders, of which 77 children patients(18.78%) had anorexia, 16.59% of children patients had the high level of respiratory disorders. Both the digestive disorder and the respiratory disorder put together, they had the high rate of 72.92%. Therefore, this indicates that both the digestive disorder and the respiratory disorder have a great effect on children's growth dificiency. 10.74% of chilren patients were shown to have allergic disorders, which indicates that they also exert an effect on growth deficiency. Specifically, 7.07% of the children patients had the high level of obesity, which shows that an excessive uptake of nutrition may rather induce children to have growth dificiency though an appropriate amount of nutritional uptake is necessary. 5. Comparing their bone age and their chronological age, 58 children patients(29.00%) showed that they were the same at the highest percent. 79 children patients(39.50%) showed that thier bone age was lower than their chronological age. And 63 children patients(31.50%) showed that their bone age was higher than their chronological age. 6. As regards the prescription administered to children patients for treating their growth dificiency, Growth tang A related to the kidney, the congenital factor, of the causes for growth dificiency in traditional Oriental Medicine was administered to 108 children patients(54%), whereas the Growth tang B related to the spleen, the acquired factor, was administered to 92 children patients(46%). 7. 116 male children patients with growth dificiency had the average value of growth for one year before treatment, 4.39cm, while 84 female children patients had the average value of growth for one year before treatment, 4.24cm. A total of 200 children had the average value of growth for one year before treatment, 4.33cm. The annual average value of growth in growth curve surveyed by the Korea Pediatrics Society was 5.79cm. Compared to this value, the one year average value of growth for 108 male and female children patients taking Growth tang A was shown be 8.44cm, which indicates a greater growth by 4.12cm(95.37%) in comparison with the average value of growth before treatment, 4.32cm, and a greater growth by 2.65cm(45.77%) compared to 5.79cm, the average value of growth in growth curve surveyed by the Korea Pediatrics Society. Also, the average value of growth before treatment for 92 male and female children patients taking Growth tang B was shown to be 8.47cm, which indicates a greater increase by 4.15cm(96.06%) compared to 4.32cm, the average value of growth before treatment and a greater increase by 2.67cm(46.29%) in comparison with 5.79cm, the average value of growth in growth curve surveyed by the Korea Pediatrics Society. Considering the average value of growth for male and female children patients taking Growth tang A and B, it was shown to be 8.46cm, which indicates a greater increase by 4.14cm(95.81%) compared to 4.32cm, the average value of growth before treatment, and a greater increase by 2.67cm(46.11%) compared to 5.79cm, the average value of growth in growth curve surveyed by the Korea Pediatrics Society.