• Investigative Magnetic Resonance Imaging
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• 제4권2호
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• pp.94-99
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• 2000

목적 : 국한적 수분억제 생체내 양성자 자기공명분광학을 사용하여 만성 알코을 중독자와 정상 건강인의 뇌대사물질의 비율을 비교평가하였다. 대상 및 방법 : 만성 알코을 중독자 10명,정상 건강인 10명의 좌측 소뇌와 basal ganglia의 관심부위 $2{\times}2{\times}2{\;}\textrm{cm}^3$를 각각 선택하여 STEAM펄스시퀀스를 이용하였다 Creatine (Cr)을 기준으로 Marquart알고리즘을 이용하여 각 대사물질의 비율을 산출하였다. 결과 만성 알코을 중독자의 특징적인 소견은 정상인과 비교하여 볼 때 N-acetyl aspartate (NAA)/Cr비율이 감소하였다. 그러나 Choline (Cho)/Cr등 다른 대사비율은 정상인과 유이한 차이를 발견할수 없었다. NAA/Cr비율은 임상평가와 상당한 상호관계가 있는 것으로 나타났다. 결론 : 본 예비실험 결과는 만성 알코을 중독자의 NAA/Cr의 비율 감소를 토대로 환자 소뇌의 신경세포 소실을 추정할 수 있었다. NAA/Cr비율은 향후 만성 알코을 중독자의 임상평가를 추정할수 있는 대사표준으로 사용될 수 있음을 시사해주고 있다. 따라서 생체내 양성자 자기공명분광법은 양성자 비율을 토대로 만성 알코을 중독자의 임상평가에 유용한 방법으로 사용될 수 있으리라 사료된다.

• 대한간호
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• 제10권3호통권53호
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• pp.87-90
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• 1971

• 대한한방내과학회지
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• 제22권2호
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• pp.239-243
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• 2001

Alcoholism is a chronic behavior disorder that disturbs the health, social, and economical functions by intaking alcohol repeatedly. Alcoholism includes some habituation, dependency, and addiction. It may be clinically silent or severe enough to lead to the rapid development of hepatic, renal and gastrointestinal failure. Alcoholism can also cause death. In this case, we administrated saenggangunbitang and sungjoocheonggantang to a patient suffering from alcohoism and its withdrawal symptoms. After administration of saenggangunbitang-sungjoocheonggantang medication, clinical symptoms, including liver function with diabetes mellitus and splenomegaly improved. saenggangunbitang-sungjoocheonggantang showed desirable effect on alcoholism symptoms.

• Journal of Community Nutrition
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• 제1권1호
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• pp.60-65
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• 1999

Chronic alcoholism often leads to folate deficiency. In recent years it has been reported that mild elevation of plasma homocysteine (Hcy) is associated with an increased risk of coronary artery disease. In the present study we investigated the effects of chronic ethanol consumption on folate status and the relation between plasma folate and Hcy. A human study was conducted to determine plasma folate, total Hcy, cysteine(Cys), total cholesterol and hemoglobin(Hb) concentrations in 44 Korean alcoholics(men aged 30 to 50yr) and 45 Korean non-alcoholic subjects(men aged 30 to 50 yr). In alcoholic subjects, 52.6% were folate deficient and 34.2% were marginally deficient, which suggested that most alcoholics were subnormal in folate status. Plasma total Hcy concentration of alcoholics was twice as high as in control subjects (p<0.001). We found a negative correlation between plasma folate and plasma total Hcy(r=-0.271, p<0.05) and a positive correlation between plasma folate and plasma Cys(r=0.249, p<0.05) in total subjects. Hb concentrations in alcoholics was significantly lower than in control subjects, but there was no difference in total cholesterol concentration between alcoholics and controls. These results suggest that chronic alcohol consumption may impair the disposal of Hcy by interfering with folate metabolism.

• 한국보건교육건강증진학회:학술대회논문집
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• 한국보건교육건강증진학회 2001년도 제4회 국제학술 심포지움
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• pp.1-9
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• 2001

Health Insurance System in Korea was introduced in 1977 and expanded health insurance benefits for all people in 1989. The development of medical service and technology takes a growing concerning for public health and medicine. And also, it helps to extend the average life span of Koreans. Therefore, the old people are steadily increased over seven percent of total population and will take more than 14% in 2023. Generally, the old people have the chronic disease such as diabetes and hypertension. Also, smoking, stress, environmental pollution and lack of exercise, leading cause of cancer, cardiovascular disease and respiratory infections have affected to state economy negatively. Therefore, health promotion law was established for a variety of health promotion process, including education, program implementation and community development. The goals and strategies for health promotion are as following: . Practice of healthy life: - Strengthen publicity activities on smoking and exercise. - Program development for nonsmoking and exercise. - Program extent for community health. Strengthen of mental health: - Planning of national survey for mental patient. - Prevention of alcoholism - Setting up special hospital for alcoholism . Constant cancer management under government - Developing medical treatment and prevention program. - Early diagnosis for the whole nation . Management of chronic disease - Strengthen of Prevention Program . Reinforcing of oral health - A national survey of oral health - Oral health education

• Journal of Korean Neurosurgical Society
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• 제50권6호
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• pp.512-516
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• 2011

Objective : Patients with asymptomatic chronic subdural hematoma (SDH) are prone to fall or slip. Acute trauma on these patients may develop acute subdural bleeding over the chronic SDH. We recently experienced 9 patients with acute-on-chronic SDH. We report the clinical and radiological features of this lesion. Methods : We retrospectively examined the computed tomographic (CT) scans of 107 consecutive patients who diagnosed as chronic SDH from January 2008 to December 2010. All cases of CSDH were diagnosed on CT with or without MRI scan. Results : Acute-on-chronic SDH is not rare, being 8% of chronic SDH. The most common cause of trauma was a slip in drunken state. Alcoholism with multiple episodes of trauma was one of the prominent histories. Acute-on-chronic SDH appeared as a hyperdense layer of clot with irregular blurred margin or lumps in liquefied hematoma. Single or two burr holes was usually effective to remove the hematoma. Conclusion : Repeated trauma may cause acute bleeding over the chronic SDH. It will be helpful to understand the role of repeated trauma as a mechanism of hematoma enlargement.

• 생물정신의학
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• 제16권2호
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• pp.127-132
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• 2009

Marchiafava-Bignami disease(MBD) is a rare complication of chronic alcoholism characterized by symmetrical demyelination of the corpus callosum. We report a case of MBD in a Korean patient having chronic alcohol dependence. The patient exhibited mental depression, weakness of all four limbs and dysarthria. Laboratory data showed mild hyponatremia. Magnetic resonance imaging(MRI) revealed unusual symmetrical resolving lesions of the putamen in addition to the typically observed lesion of the corpus callosum. The neurologic disturbances were gradually improved with the normalization of low plasma sodium levels. Marked improvement of abnormal MRI findings was noted after thiamine supplement, though the patient still exhibited severe cognitive impairment.

• 대한임상독성학회지
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• 제3권2호
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• pp.130-134
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• 2005

Lithium is mainly prescribed for manic and depressive disorder, also frequently prescribed for the other diseases such as migraine, cluster headache, alcoholism, and obsessive-compulsive disorder. An acute lithium intoxication occurs in cases of patients ingesting large amount lithium at a time, a chronic lithium intoxication occurs in patients on chronic lithium therapy. Acute or chronic lithium poisoning occurs frequently in case of patients on chronic lithium therapy ingesting larger dose than prescribed. Manifestations of lithium poisoning are various. It is possible nervous, cardiovascular, renal, gastrointestinal and endocrine systems to be involved. Due to intracellular high concentration, mortality rate is high in acute lithium intoxication patients on chronic lithium therapy. We report a case of acutely intoxicated 40-year-old male on chronic lithium therapy. His chief complaints were deterioration and high fever. On his arrival to an emergency department, he was in cardiac arrest. He restored return of spontaneous circultion (ROSC) 5 minutes later after cardiopulmonary cerebral resuscitation (CPCR) and referred to department of internal medicine for hemodialysis. Vigorous treatment was given to the patient, but he was expired at 4th hospital day.

• 한국자기공명학회:학술대회논문집
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• 한국자기공명학회 2000년도 동계총회 및 제16회 자기공명 학술발표회
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• pp.9-11
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• 2000

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2857-2860
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• 2016

Background: Chronic hepatitis B (CHB) infection is one of the important causes of hepatocellular carcinoma (HCC) in Thailand, involved in the pathogenesis and leading to a development of HCC with or without cirrhotic changes of the liver. This study was aimed to investigate the predictive factors for HCC among CHB patients in a tertiary care center in Thailand. Materials and Methods: We conducted a retrospective study of CHB patients with or without HCC during the period of January 2009 and December 2014 at Thammasat University Hospital, Pathumthani, Thailand. Data on clinical characteristics, biochemical tests and radiologic findings were collected from review of medical records. Results: A total of 266 patients were diagnosed with CHB in Thammasat university hospital during the study period. However, clinical information of only 164/266 CHB patients (98 males, 66 females with mean age of 49.4 years) could be completely retrieved in this study. The prevalence of HCC in CHB infection in this study was 38/164 (23.2%). CHB patients with HCC had a mean age older than those without HCC (59.5 vs 47 years, P-value = 0.01). Furthermore, history of upper GI bleeding, tattooing, blood transfusion, and chronic alcoholism were significantly more common in CHB patients with HCC than patients without HCC (13.2% vs 3.2% P-value 0.03, OR = 4.6, 95%CI = 1.2-18.1, 20% vs 3.9%, P-value = 0.01, OR= 6.1, 95% CI= 1.6-23.6, 20% vs 6.3%, P-value = 0.03, OR = 3.8, 95%CI =1.1-12.7, 62.2% vs 30.3%, P-value <0.0001, OR = 3.7, 95%CI= 1.7-8.1 respectively). Interestingly, more CHB patients with HCC had evidence of cirrhosis than those without HCC (78.9% vs 20.4%, P-value <0.0001, OR = 14.6, 95%CI = 5.8-36.7). In CHB patients with HCC, surgical therapy provided longer survival than radiofrequency ablation (RFA) (72 vs 46.5 months, P-value= 0.04). The mean survival time after HCC diagnosis was 17.2 months. Conclusions: HCC remains a major problem among patients with CHB infection in Thailand. Possible risk factors are male gender, history of upper GI bleeding, chronic alcoholism, tattooing, blood transfusion and evidence of cirrhosis. For early stage HCC patients, surgical treatment provided longer survival time than RFA. Most HCC patients presented with advanced disease and had a grave prognosis. Appropriate screening of CHB patients at risk for HCC might be an appropriate approach for early detection and improvement of long-term outcomes.