• Tuberculosis and Respiratory Diseases
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• 제46권3호
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• pp.372-385
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• 1999

Background: The purpose of this study was to examine the causes and pathologic process of chronic non-productive cough as an isolated symptom with a normal spirometry and chest radiograph by investigating clinicopathologic findings. Method: We studied 25 adults with chronic non-productive cough over a 3-week period with a normal chest radiograph and pulmonary function tests without any other symptoms. Clinical assessment, cough score, chest and sinus radiograph, pulmonary function tests, methacholine challenge, allergic skin prick test, and bronchoscopy for bronchial biopsies were performed. Subjects were then treated with prednesolone 20 to 30 mg/day for 1 to 2 weeks. Results: The experimental group was divided into two subgroups-those infiltrated with eosinophils, and those infiltrated with lymphocytes depending on eosinophil and lymphocyte counts, both of which were respectively higher than those of the control group. Eosinophils infiltrated group had mean numbers of eosinophil of 89.8 $cells/mm^3$ while control group's mean was 0.4 $cells/mm^2$(p=0.005). Lymphocyte infiltrated group was 4 patients whose mean was 84.3 $cells/mm^2$ with 28.4 $cells/mm^2$ of control group(P=0.026). In addition, the mean thickness of the basement membrane of experimental group was $14.20{\pm}5.20{\mu}m$ in contrast of control group whose mean was $3.50{\pm}1.37{\mu}m$(P=0.001). With the methacholine challenge test, 7 of the 21 eosinophil infiltrated subjects were diagnosed with cough variant asthma ; the other 14 with eosinophilic bronchitis. Three subjects with eosinophilic bronchitis were atopic positive (21.4%) with the skin prick test In the lymphocyte dominant group, all four subjects were diagnosed with lymphocytic bronchitis. Cough score was improved after steroid treatment in 22 of 25 subjects in the experimental group (88.0%). Conclusion: These results suggest chronic non-productive cough as an isolated symptom with a normal spirometry and chest radiograph was associated with airway inflammation by eosinophil and lymphocyte infiltration. The causes for chronic non-productive cough were eosinophilic bronchitis, cough variant asthma, and lymphocytic bronchitis(written in frequency). They further suggest that therapeutic treatment with steroids can provide effective symptomatic relief.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• 제10권2호
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• pp.27-35
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• 2015

Objectives: The purpose of this study is to discriminate the cough-induced rib fracture with chest pain occurred after chuna therapy. Methods: A 68-year-old female patient who is suffering from left chest wall pain with chronic cough was treated by Korean medical treatment and chuna therapy from November 11th 2014 to November 15th 2014. The improvement of the patient's pain was measured by 100 mm Visual Analog Scale (VAS). For diagnosis the rib fracture, we conducted the radiography, computed tomography (CT), and bone scan. Results: After treatment, pain intensity was decreased and the rib fracture was negative in radiography and CT. But, in bone scan, the 5th-8th rib fractures in left side were detected. Conclusions: When the patient with chest pain visit the hospital after chuna therapy, a doctor keep in mind the possibility of coughinduced rib fracture.

• Korean Journal of Psychosomatic Medicine
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• 제6권1호
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• pp.85-89
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• 1998

Psychogenic cough is barky, croupy, and explosive and disappears during sleep, and is not affected by antitussive drugs. Physical and radiological examinations of the respiratory tract and other routine laboratory test are normal. It is helpful to recognize this condition early in its course so that appropriate treatment can be instituted before iatrogenic problems resulting in multiple hospitalizations and chronic steroid use occur. We experienced two child and adolescent cases that showing typical psychogenic cough so reported it with the literatures review.

• The Journal of Pediatrics of Korean Medicine
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• 제14권1호
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• pp.153-168
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• 2000

The cough is one of the most common respiratory symptom in children. Boeumjunggi-tang(BEJG) is herbal medicine mainly treat cough due to yin deficiency(陰虛咳嗽) in Oriental Medicine. During 3 momths from February, 1, 2000 to April, 30, 2000, BEGJ is administered to the pediatric out-patients with the cough due to yin deficiency have visited Pundang Dongguk Oriental medicine Hospital and among these patients, this study is performed for 50 patients of which the result of treatment could be gained. The conclusion is following. 1. In the distribution of patients, male(60%) is more than female(40%) and group of age in between 1 and 6 years(76%) are the first. 2. In the type of cough, group of chronic(more than 3 weeks), and group that the symptom make worse in night are the most. 3. In the distribution of remedial effect, group of symptom-relieved is the first(58%), symptom-disappearing is second(22%), symptom-unchanging is third(14%), symptom-aggravated is fifth(6%). 4. The chracteristic of cough have little influence on the remedial effect of BEGJ.

• The Journal of Internal Korean Medicine
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• 제38권2호
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• pp.252-258
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• 2017

Objectives: The purpose of this case report is to describe the clinical effectiveness of Korean medicine, especially Jungcheonwhadam-tang and Bopyeoyangyeong-jun, in a patient with chronic thoracic empyema while receiving treatment for this condition. Methods: The patient who had been diagnosed with empyema complained of a cough, with sputum. The patient was diagnosed with pe-ong (肺癰) based on his symptoms and x-ray findings. He was treated with a range of Korean medicines, including a herbal decoction, acupuncture, moxibustion, and cupping. A visual analogue scale and percentage pain reduction scale were administered after treatment. Results: After 20 days of the treatment, the patient's cough decreased by 80%, and sputum decreased by 50%. Conclusion: According to this study, Korean medicine, including Jungcheonwhadam-tang and Bopyeoyangyeong-jun, is effective in the treatment of chronic thoracic empyema.

• The Journal of Korean Medical History
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• 제26권1호
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• pp.19-26
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• 2013

There are many children suffering from chronic upper respiratory infections with high fever(CURIHF) for years. High fever mainly caused by tonsillitis comes from cold and flu season-related. Observing CURIHF children, they also have a night sweat(盜汗) and a thick voice, a chronic cough, a loss of appetite in common. I found that after administering the Daqinglong-tang(大靑龍湯) to the 6 CURIHF children, high fever was dropping quickly and did not recur for 233~733 days. Also, the symptoms of a night sweat(盜汗) and a thick voice, a chronic cough, a loss of appetite are improved significantly. These case report suggests that in case of CURIHF, Daqinglong-tang could effectively control recur of high fever in children.

• The Journal of Korean Physical Therapy
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• 제24권5호
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• pp.340-347
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• 2012

Purpose: This study was conducted in order to investigate the effect on respiratory function, trunk control, and functional activities of daily living (ADL) through respiratory muscle strength training in patients with chronic stroke. Methods: Eighteen subjects who were six months post stroke participated in this study. The subjects were randomly allocated to two groups: experimental (n=10) and control (n=8). Both groups received physical therapy for five sessions, 30 minutes per week, during a period of six weeks. Subjects in the experimental group participated in an additional respiratory muscle strength training program, in which the threshold PEP device was used for 30 minutes per day, three days per week, during a period of six weeks. Results from pretest-posttest control were evaluated by pulmonary function forced vital capacity (FVC), forced expiratory volume at one second (FEV1), FEV1/FVC, peak expiratory flow (PEF), capacity of cough, trunk control, and functional ADL. Results: Significant improvement in the FEV1, PEF of pulmonary function (p<0.05), cough function (p<0.05), and trunk control (p<0.05) was observed among the groups. Conclusion: Respiratory muscle strength training improves pulmonary function, capacity of cough, and trunk control. These results suggest that respiratory muscle strength training is feasible and suitable for individuals with chronic stroke.

• Tuberculosis and Respiratory Diseases
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• 제72권2호
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• pp.236-241
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• 2012

Cough syncope is characterized by the loss of consciousness occurring after vigorous coughings. There are approximately 90 reported cases of cough syncope within the medical literature. Most cases involving middle aged, overweight and chronic bronchitic male smokers. Although many studies have been published in the medical literature, the mechanism and pathophysiology for cough syncope has not been well established. Cough syncope is treated by correcting the underlying cause when identified, or by avoiding conditions that may cause the cough syncope. In addition, cough suppression modalities can also be used. We herein report 3 cases of cough syncope presenting in lung cancer patients.

• The Korean Journal of Physiology and Pharmacology
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• 제28권3호
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• pp.229-237
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• 2024

Cough is a common symptom of several respiratory diseases. However, frequent coughing from acute to chronic often causes great pain to patients. It may turn into cough variant asthma, which seriously affects people's quality of life. For cough treatment, it is dominated by over-the-counter antitussive drugs, such as asmeton, but most currently available antitussive drugs have serious side effects. Thus, there is a great need for the development of new drugs with potent cough suppressant. BALB/c mice were used to construct mice model with cough to investigate the pharmacological effects of pectolinarigenin (PEC). Hematoxylin-eosin and Masson staining were used to assess lung injury and airway remodeling, and ELISA was used to assess the level of inflammatory factor release. In addition, inflammatory cell counts were measured to assess airway inflammation. Airway hyperresponsiveness assay was used to assess respiratory resistance in mice. Finally, we used Western blotting to explore the potential mechanisms of PEC. We found that PEC could alleviate lung tissue injury and reduce the release of inflammatory factors, inhibit of cough frequency and airway wall collagen deposition in mice model with cough. Meanwhile, PEC inhibited the Ras/ERK/c-Fos pathway to exhibit antitussive effect. Therefore, PEC may be a potential drug for cough suppression.

• The Journal of Pediatrics of Korean Medicine
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• 제36권4호
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• pp.1-17
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• 2022

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