• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.18
• /
• pp.7995-8001
• /
• 2014

Interferon-gamma (IFN-${\gamma}$) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-${\gamma}$ are poorly understood. In the present study, we examined the in vitro antitumor activity of IFN-${\gamma}$ on two human non-small-cell lung carcinoma (NSCLC) cell lines, H322M and H226. Our findings indicated that IFN-${\gamma}$ treatment caused a time-dependent reduction in cell viability and induced apoptosis through a FADD-mediated caspase-8/tBid/mitochondria-dependent pathway in both cell lines. Notably, we also postulated that IFN-${\gamma}$ increased indoleamine 2,3-dioxygenase (IDO) expression and enzymatic activity in H322M and H226 cells. In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-${\gamma}$-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-${\gamma}$. These results provide new mechanistic insights into interferon-${\gamma}$ antitumor activity and further support IFN-${\gamma}$ as a potential therapeutic adjuvant for the treatment of NCSLC.

• The Journal of Korea Assosiation for Disability and Oral Health
• /
• v.7 no.1
• /
• pp.38-43
• /
• 2011

Treatment of the mandibular fracture consists of reduction and fixation. Primary wire & Arch bar are perhaps the ideal method for intermaxillary fixation. But, daily feeding, swallowing, speech, and in some instances, respiration is difficult to maintain during the period of intermaxillary fixation, owing to muscle weakness, emotional disorder and poor oral hygiene in a position of the long-term bed disabled patient with multiple injuries. Therefore, Intermaxillary fixation is not applied in the disabled bed patient, the alternative methods must be obtained. In the case of the mandibular fracture, because of the absence of weight bearing, osseous union may eventually occur even without immobilization if the patient is maintained without wound infection on a controlled soft diet. For the purpose of the prevention of the wound infection, the establishment of an drainage on the oral lacerated wound is necessary for the removal of the hematoma & seroma in the fracture site. This is the report of a case that was managed conservatively without the intermaxillary fixation in the long-term disabled bed patient with a mandibular compound fracture.

• The Journal of Korea Assosiation for Disability and Oral Health
• /
• v.7 no.2
• /
• pp.107-114
• /
• 2011

Dental extraction is potentially stress-inducing in many disabled patient. The body's response to dental stress involves the cardiovascular system(an increase in cardiovascular workload), the respiratory organ and the endocrine system(change in metabolism). To minimize the stress, the stress reduction method was established. The obtained contents were as follows: (1) Recognize the patient's degree of medical risk, (2) Complete medical consultation before dental therapy, (3) Schedule the patient's appointment in the morning, (4) Monitor and record preoperative and postoperative vital signs, (5) Use psychosedation during therapy, (6) Use adequate pain control during therapy, (7) Short length of appointment : do not exceed the patient's limits of tolerance, (8) Follow up with postoperative pain/anxiety control, (9) Telephone the risk patient later on the same day that treatment was given. Though the stress reduction method above was applied to the dental extraction in disabled patients with the advanced infected teeth, the complications(syncope, shock, bleeding & infection, etc.) may be occurred. For prevention of complications associated with the extraction, the authors treated the advanced infected teeth with endodontic drainage and incision & drainage before extraction. The final extraction and wound closure were then done after about 3 weeks.

• Proceedings of the Korea Society of Costume Conference
• /
• 2004.08a
• /
• pp.252-260
• /
• 2004

• Journal of Contemporary Eastern Asia
• /
• v.6 no.1
• /
• pp.17-32
• /
• 2007

• Women's Health Nursing
• /
• v.26 no.3
• /
• pp.250-250
• /
• 2020

• Korean Journal of Psychosomatic Medicine
• /
• v.11 no.2
• /
• pp.170-181
• /
• 2003

Objectives: The purpose of this study was to evaluate the quality of life in hemodialysis patients and compare it with those of depression or anxiety patients. Methods: Quality of life in hemodialysis patients(n=33) and depression or anxiety patients(n=34) was evaluated. we performed Korean Version of WHO Quality of Life Scale Abbreviated Version(WHOQOL-BREF), Beck Depression Inventory(BDI), State-Trait Anxiety inventory(STAI) to both hemodialysis patients and depression or anxiety patients. Results: The WHOQOL mean scores showed no differences between hemodialysis patients and depression or anxiety patients. Among WHOQOL domains, psychological domain score of WHOQOL was significantly higher in hemodialysis patients than in depression or anxiety patients. Anxiety score of hemodialysis patients was significantly lower than that of depression or anxiety patients, while depression score showed no difference. Conclusion: These results show that psychological domain score of WHOQOL was higher and anxiety score was lower in hemodialysis patients than in depression or anxiety patients. However, there were no significant differences in total QOL and depression between hemodialysis patients and depression or anxiety patients, and the prevalences of depression and anxiety were higher in hemodialysis patients than those of general population. This suggest that hemodialysis patients need more specialized help for psychiatric problems.

• Journal of Christian Education in Korea
• /
• v.62
• /
• pp.285-311
• /
• 2020

Many people are suffering from the economic crisis and poverty that are deepening due to the recent spread of the COVID-19 epidemic. In this situation, this study focuses on the biblical Jubilee in order to seek how "Jubilee justice" can be realized in the modern context. The Law of Jubilee consists of four contents: the liberation of slaves, debt remission, land return and fallow. Ultimately it aims to prevent human slavery and preserve equality. Nevertheless, the thought of Jubilee has been distorted theologically and situationally, and as a result, it has been overlooked in the field of Christian education, and there is a limit in Christian practice for social justice. The thought of Jubilee, however, can be an alternative to overcome various problems of modern society such as the issue of the privatization of Christianity or the deepening of polarization caused by neoliberal globalization and can contribute positively to the practice of social justice. In other words, the thought of Jubilee can act as a biblical initiative in reforming wrong laws and establishing institutions for the poor on the institutional level; on the personal level, it can be a great motive in terms of the change of perception and the practice of the sharing economy. Jubilee education, which aims for Jubilee justice, helps to break the misconceptions and change the existing meaning perspectives on the basis of various interdisciplinary knowledge and supports social behavior for transforming social structure through activation of public opinion and fund raising at the practical level. Therefore, the learners of Christian education can play a public role in transforming the unjust society.

• The korean journal of orthodontics
• /
• v.37 no.3 s.122
• /
• pp.220-230
• /
• 2007

Objective: The purpose of this study was to determine the changes of mandibular anterior alveolar bone thickness with age. Methods: Cephalometric radiographs of 160 skeletal class I patients (male 80, female 80) with normal vertical growth pattern was investigated by measuring the buccolingual thickness of mandibular alveolar bone on the basis of root axis. Results: As the age increases, both male and female showed a significant decrease in buccolingual width of the mandibular anterior alveolar bone and in the width of mandibular anterior lingual alveolar bone except the CEJ area of females. However, there was no significant difference in the thickness of mandibular anterior buccal alveolar bone and in the width of maximum prominence of mandibular symphysis with age. Conclusion: From the above results, it is concluded that Korean children whose growth pattern is sagittally skeletal class l with a vertical normal growth pattern have a greater mandibular anterior lingual alveolar bone width than Korean adults; therefore, lingual movement of mandibular incisors, which is usually accompanied in extraction treatment, is considered to be more preferable in younger patients.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.3
• /
• pp.480-491
• /
• 2017

Fluorescent pseudomonads have been isolated from halophytes, mesophytes, and xerophytes of Pakistan. Among these, eight isolates, GS-1, GS-3, GS-4, GS-6, GS-7, FS-2 (cactus), ARS-38 (cotton), and RP-4 (para grass), showed antifungal activity and were selected for detailed study. Based on biochemical tests and 16S rRNA gene sequences, these were identified as strains of P. chlororaphis subsp. chlororaphis and aurantiaca. Secondary metabolites of these strains were analyzed by LC-MS. Phenazine-1-carboxylic acid (PCA), 2-hydroxy-phenazine, Cyclic Lipopeptide (white line-inducing principle (WLIP)), and lahorenoic acid A were detected in variable amounts in these strains. P. aurantiaca PB-St2 was used as a reference as it is known for the production of these compounds. The phzO and PCA genes were amplified to assure that production of these compounds is not an artifact. Indole acetic acid production was confirmed and quantified by HPLC. HCN and siderophore production by all strains was observed by plate assays. These strains did not solubilize phosphate, but five strains were positive for zinc solubilization. Wheat seedlings were inoculated with these strains to observe their effect on plant growth. P. aurantiaca strains PB-St2 and GS-6 and P. chlororaphis RP-4 significantly increased both root and shoot dry weights, as compared with uninoculated plants. However, P. aurantiaca strains FS-2 and ARS-38 significantly increased root and shoot dry weights, respectively. All strains except PB-St2 and ARS-38 significantly increased the root length. This is the first report of the isolation of P. aurantiaca from cotton and cactus, P. chlororaphis from para grass, WLIP and lahorenoic acid A production by P. chlororaphis, and zinc solubilization by P. chlororaphis and P. aurantiaca.