• 한방비만학회지
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• 제16권1호
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• pp.19-26
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• 2016

Objectives: The prevalence of obesity continues rise and obesity and metabolic syndrome is a major problem in global health care. Animal models are used in the drug discovery of novel treatment for obesity. One of common models of obesity is a high fat diet induced obesity in a C5BL/6 mouse, and the development of obesity and glucose tolerance in mouse model is different according to period of diet. Therefore, this study was performed to observe the development of obesity and glucose tolerance during a high fat diet (HFD). Methods: Male C57BL/6 mice, 5 weeks of age, were fed on a standard chow diet as a normal diet (18 kcal% fat) or a HFD (60 kcal% fat) for up to 16 weeks. The various factors related with obesity and insulin resistance were measured at 8, 12, and 16 weeks. Results: The weights of body and epididymal fat were gradually increased for 8~16 weeks, however the change of hyperglycaemia and glucose tolerance have shown different with that of body weight. Blood glucose, oral glucose tolerance and insulin tolerance were increased more clearly at week 12 and 16 than week 8. Lipid accumulation of liver and body temperature were also significantly increased at week 16, compared with normal group. Conclusions: The developments of obesity and related factors were different by a HFD period in a C57BL/6 obese mice. This result suggests that the development of obesity with glucose tolerance and liver lipid may induce clearly by a HFD for 16 weeks.

• Nutrition Research and Practice
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• 제4권3호
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• pp.177-182
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• 2010

The Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat cancers. However, limited information exists on the underlying anticancer effects of the major component of I. obliquus in vivo. We hypothesize that the pure compounds ($3{\beta}$-hydroxy-lanosta-8,24-dien-21-al, inotodiol and lanosterol, respectively) separated from I. obliquus would inhibit tumor growth in Balbc/c mice bearing Sarcoma-180 cells (S-180) in vivo and growth of human carcinoma cells in vitro. To test this hypothesis, the growth inhibition of each subfraction isolated from I. obliquus on human carcinoma cell lines (lung carcinoma A-549 cells, stomach adenocarcinoma AGS cells, breast adenocarcinoma MCF-7 cells, and cervical adenocarcinoma HeLa cells) was tested in vitro. Then, after S-180 implantation, the mice were fed a normal chow supplemented with 0, 0.1 or 0.2 mg of subfraction 1, 2 or 3 per mouse per day. All of the subfractions isolated from I. obliquus showed significant cytotoxic activity against the selected cancer cell lines in vitro. Subfraction 1 was more active than subfraction 2 and subfraction 3 against the A549, AGS and MCF-7 cancer cell lines in vitro. In in vivo results, subfraction 1 isolated from I. obliquus at concentrations of 0.1 and 0.2 mg/mouse per day significantly decreased tumor volume by 23.96% and 33.71%, respectively, as compared with the control. Subfractions 2 and 3 also significantly inhibited tumor growth in mice bearing S-180 as compared with the control mouse tumor. Subfraction 1 isolated from I. obliquus showed greater inhibition of tumor growth than subfractions 2 and 3, which agrees well with the in vitro results. The results suggest that I. obliquus and its compounds in these subfractions isolated from I. obliquus could be used as natural anticancer ingredients in the food and/or pharmaceutical industry.

• 한국약용작물학회지
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• 제15권5호
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• pp.352-356
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• 2007

The present study was investigated the anti-oxidative effects of aloe vera ingestion on brain and kidney in aged rats by monitoring several oxidative-related parameters. Male specific pathogen-free Fischer 344 rats were randomly divided into four groups of five rat each: Group A was fed test chow without aloe supplementation; Group B was fed a diet containing a 1% freeze-dried aloe filet; Group C was fed a diet containing a 1% charcoal-processed, freeze-dried aloe filet; and Group D was fed a diet containing a charcoal-processed, freeze-dried, whole leaf aloe in drinking water. Analyses of tissues were done at 4 months and 16 months of age. Results showed that a long-term intake of aloe, regardless of the preparation used, enhanced antioxidant defenses against lipid peroxidation, as indicated by reduced phosphatidylcholine hydroperoxide levels in both brain and kidney. The additional benefit of aloe intake on the anti-oxidative action was evidenced by enhanced superoxide dismutase and catalase activity in all aloe-ingested groups. Another beneficial effect of aloe shown in this study, although not an anti-oxidative parameter, was its cholesterol-lowering effect as detected in brain and kidney with significant decreases at age16 months of aloe-fed rats. Based on these findings, we conclude that a long-term dietary aloe supplementation modulated the anti-oxidative defense systems and cholesterol level.

• 간호행정학회지
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• 제3권2호
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• pp.137-150
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• 1997

This study was done to evaluate patient satisfaction with nursing care. The study subjucts were 164 patients admitted in a general hospital in Incheon province. The instrument used in this study was developed by Risser (1975) and Lim Hae Kyoung (1980) based on classification of nursing care area and modified by Chow Kwang Nam (1995). The relaiability alpha of this tool was 0.93695. The survey method was applied to collect data and the period of data collection was total 30 days from April Ist to April 30th in 1997. The data was analyzed by statistical method of %, mean, t-test and ANOVA through SAS program. 1. The highest scores of satisfaction were shown in the area of reliance, area of treatment, area of environment and area of education in order. 2. The crossed analysis of patient general characteristics and satisfaction of nursing care showed a signficance in the department of patient's admission and the highest satisfaction score was found in the general surgery ward (p<0.05). 3. General characteristics of patients which influence on the satisfaction showed a significant response according to the department of patient's admission in the treatment area, education area and environment area of nursing.(p < 0.05). Recommendation The followings are deriven from the above study results. 1. Area of nursing education which showed the lowest satisfaction should be empathized by making improvement of nursing care approach because the area in the basis to achieve nursing goal. 2. The development of systematic and objective instrument is necessary for evaluation of nursing quality and the evaluation should be performed in the area of patient satisfaction, hospital facility and hospital environment as well.

• 한국식품영양학회지
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• 제30권4호
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• pp.696-702
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• 2017

Metabolic syndrome, including obesity, glucose intolerance and elevated blood pressure, is related to type 2 diabetes and cardiovascular disease. Previous studies have reported the anti-oxidative, anti-inflammatory and anti-diabetic effects of purple corn extract. We investigated the efficacy of purple corn extract (PC) against high-fat diet (HFD)-induced obesity and glucose intolerance, and examined the underlying mechanisms by analyzing expression of proteins and genes involved in glucose regulation and macrophage infiltration. C57BL/6 mice were fed with normal chow diet (ND), or HFD treated with distilled water (DW, control) or PC, for 10 weeks. Although body weights were similar in the HFD-fed groups, we observed a decrease in the liver and epididymal adipose tissue (EAT) weights, and enhanced glucose tolerance test (GTT) results in the PC group, as compared with DW group. Liver showed increased Akt phosphorylation in the PC-treated mice; however, no changes were observed in the EAT, for all groups. In PC-treated mice, decreased macrophage infiltration was seen in the EAT, with a reduced expression of macrophage marker genes. Finally, proinflammatory cytokine gene expressions were decreased by PC in the EAT, and a modest trend for downregulation was observed in the liver. Hence, we conclude that PC may decrease glucose intolerance by increasing the phosphorylation of Akt and reducing the macrophage infiltration into the EAT.

• Nuclear Engineering and Technology
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• 제53권12호
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• pp.4098-4105
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• 2021

The aim of this study is to calculate the JO-IMRT dose distributions based on the AAPM TG-119 using Monte Carlo (MC) simulation and Prowess Panther treatment planning system (TPS) (Panther, Prowess Inc., Chico, CA). JO-IMRT dose distributions of AAPM TG-119 were calculated by the TPS and were recalculated by MC simulation. The DVHs and 3D gamma index using global methods implemented in the PTW-VeriSoft with 3%/3 mm were used for evaluation. JO-IMRT dose distributions calculated by TPS and MC were matched the TG-119 goals. The gamma index passing rates with 3%/3 mm were 98.7% for multi-target, 96.0% for mock prostate, 95.4% for mock head-and-neck, and 96.6% for C-shape. The dose in the planning target volumes (PTV) for TPS was larger than that for the MC. The relative dose differences in D99 between TPS and MC for multi-target are 1.52%, 0.17% and 1.40%, for the center, superior and inferior, respectively. The differences in D95 are 0.16% for C-shape; and 0.06% for mock prostate. Mock head-and-neck difference is 0.40% in D99. In contrast, the organ curve for TPS tended to be smaller than MC values. JO-IMRT dose distributions for the AAPM TG-119 calculated by the TPS agreed well with the MC.

• Nutrition Research and Practice
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• 제15권2호
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• pp.160-172
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• 2021

BACKGROUND/OBJECTIVES: Nutritional status and food intake during pregnancy and lactation can affect fetal programming. In the current metabolic syndrome epidemic, high-fructose diets have been strongly implicated. This study investigated the effect of maternal high-fructose intake during pregnancy and lactation on the development of metabolic syndrome in adult offspring. SUBJECTS/METHODS: Drinking water with or without 20% fructose was administered to female C57BL/6J mice over the course of their pregnancy and lactation periods. After weaning, pups ate regular chow. Accu-Chek Performa was used to measure glucose levels, and a tail-cuff method was used to examine systolic blood pressure. Animals were sacrificed at 7 months, their livers were excised, and sections were stained with Oil Red O and hematoxylin and eosin (H&E) staining. Kidneys were collected for gene expression analysis using quantitative real-time Polymerase chain reaction. RESULTS: Adult offspring exposed to maternal high-fructose intake during pregnancy and lactation presented with heavier body weights, fattier livers, and broader areas under the curve in glucose tolerance test values than control offspring. Serum levels of alanine aminotransferase, aspartate aminotransferase, glucose, triglycerides, and total cholesterol and systolic blood pressure in the maternal high-fructose group were higher than that in controls. However, there were no significant differences in mRNA expressions of renin-angiotensin-aldosterone system genes and sodium transporter genes. CONCLUSIONS: These results suggest that maternal high-fructose intake during pregnancy and lactation induces metabolic syndrome with hyperglycemia, hypertension, and dyslipidemia in adult offspring.

• 한국유통학회지:유통연구
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• 제12권3호
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• pp.23-48
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• 2007

전통적으로 제조업체는 자사 브랜드를 중심으로한 매장관리를 원하고, 유통업체 입장에서는 특정 브랜드가 많이 팔리는 것 보다는 여러 메이커 브랜드가 뒤섞여 카테고리 또는 전체매장의 매출이 높아지는데 관심이 있다. 최근 이러한 유통업체와 공급업체의 인식차이가 카테고리 관리 개념에 의해 좁혀지고 있다. 본 논문의 큰 연구목적은 점포유형과 시장포지션에 따라 어떤 카테고리 전술 즉 제품구색(브랜드의 수, 카테고리 내 브랜드 간의 분산구조), 가격정책(정규가격수준, 가격변화율), 매장진열(매장진열재고량), 상품보충(취급율, 품절율, 재고소진일) 등이 매출성과에 영향을 미치는 가를 분석하고자 하는 것이다. 다양성 추구 카테고리 역할을 하는 네 종류의 샴푸, 치약, 세탁세제, 주방세제 카테고리에 대한 성과 및 전술들에 대한 데이터를 전국의 2,859개의 대형슈퍼와 15,565개의 소형슈퍼로부터 수집한 닐슨자료를 가설검정에 이용하였다. 회귀분석과 Chow Test를 이용하여 분석한 결과 대형수퍼-시장선도자의 경우 품절율, 진열재고량, 브랜드분산, 재고소진일 등의 카테고리 전술들이 카테고리 매출액에 유의하게 작용하였고, 대형슈퍼-추종자의 경우는 진열재고량, 브랜드분산, 재고소진일 등의 전술들이 매출액 변화에 중요한 역할을 하였다. 소형슈퍼-시장선도자와 소형슈퍼-추종자의 경우는 동일하게 취급율, 진열재고량, 브랜드분산, 재고소진일 등의 카테고리 전술들이 카테고리 매출액에 유의한 영향을 주는 것으로 나타났다. 기대와는 달리 브랜드의 수와 가격정책은 점포유형과 시장포지션에 상관없이 모두 중요하게 작용하지 못하였다. 본 논문은 공급업체들이 왜 경쟁업체보다 시장에서 더 나은 또는 더 못한 성과를 얻는지를 파악할 수 있고 더 나아가 공급업체의 제한된 자원을 점포유형과 시장포지션에 따라 어떤 카테고리전술을 이용하여 재분배할 수 있는가에 대한 지침을 제공한다.

• 경영과정보연구
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• 제32권2호
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• pp.237-257
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• 2013

본 연구는 쇼핑체험이 충동구매에 미치는 영향에 있어 소비자의 조절초점이 어떤 역할을 하는지 검토하는데 초점을 맞춘다. 즉 의류매장에서 느끼는 쇼핑체험이 소비자의 조절초점성향에 따라 충동구매에 미치는 영향에 차이가 있는지를 실증한다. 실증연구 결과를 요약하면 다음과 같다. 첫째, 의류매장의 체험요소인 감각적 체험과 감성적 체험은 통계적으로 유의한 수준에서 충동구매에 긍정적인 영향을 미치고 있는 것으로 나타난 반면, 합리적 체험은 충동구매에 부정적 영향을 미치고 있는 것으로 조사되었다. 둘째, 쇼핑체험 요소가 충동구매에 미치는 영향은 소비자의 조절초점성향에 따라 차이가 있음을 확인하였다. 감성적 체험이 충동구매에 미치는 영향은 예방초점 소비자보다는 향상초점 소비자에게서 더 크게 작용하는 것으로 나타났다. 이에 반해 합리적 체험이 충동구매에 미치는 부(-)적 영향은 향상초점 소비자보다는 예방초점 소비자집단에서 더 낮은 것으로 나타났다. 연구결과를 종합하면, 소비자의 쇼핑체험은 충동구매행동에 유의한 영향을 미치며, 이러한 영향은 소비자의 조절초점에 따라 차이가 있음이 확인되었다.

• 한국콘텐츠학회논문지
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• 제15권11호
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• pp.486-500
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• 2015

본 연구는 인터넷 쇼핑과 모바일 쇼핑에서 현재의 소비자들을 장기적으로 유지하는 문제 즉, 어떻게 이들로부터 고객충성도를 이끌어 낼 것인가를 연구하고자 한다. 구체적으로, 본 연구는 각각의 쇼핑 환경에서 고객충성도에 가장 영향력 있는 변수가 무엇인지를 비교, 규명하고자 한다. 수많은 선행연구들에서 고객충성도의 출발점은 우수한 서비스품질임을 강조하였다. 이에, 본 연구는 서비스품질을 고객충성도의 핵심 선행변수로 고려한다. 또 다른 선행변수로써 실용적 가치인 유용성과 쾌락적 가치인 즐거움을 제시한다. 마지막으로, 본 연구는 인터넷 쇼핑과 모바일 쇼핑의 각 집단에서 서비스품질 및 쇼핑가치가 고객충성도에 미치는 효과에 차이가 존재하는지를 분석한다. 실증분석 결과는 첫째, 인터넷 쇼핑 집단에서는 쾌락적 가치인 즐거움을 제외한 나머지 선행변수들 즉, 서비스품질 차원인 대응성과 공감성 그리고 실용적 가치인 유용성이 모두 고객충성도를 증가시키는 것으로 나타난 반면에, 모바일 쇼핑 집단에서는 즐거움만이 고객충성도에 유의하였다. 둘째, 서비스품질 및 쇼핑가치가 고객충성도에 미치는 효과는 인터넷 쇼핑 및 모바일 쇼핑에 따라 명백한 차이가 존재하는 것으로 나타났다. 이 결과는 각각의 쇼핑에 효과적인 고객충성도 관리방법이나 전략이 다를 수 있음을 시사한다.