• Title/Summary/Keyword: Chosun

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Alpha-lipoic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced cell injury by inhibiting autophagy and apoptosis

  • Kang, Kyeong-Rok;Kim, Jae-Sung;Kim, Tae-Hyeon;Seo, Jeong-Yeon;Lim, HyangI;Park, Jong-Hyun;Yang, Kwang Yeol;Yu, Sun-Kyoung;Kim, Heung-Joong;Kim, Chun Sung;Chun, Hong Sung;Lee, Dong-Seol;Park, Joo-Cheol;Kim, Do Kyung
    • International Journal of Oral Biology
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    • 제46권1호
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    • pp.15-22
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    • 2021
  • Alpha-lipoic acid (ALA) is a naturally occurring antioxidant and has been previously used to treat diabetes and cardiovascular disease. However, the autophagy effects of ALA against oxidative stress-induced dopaminergic neuronal cell injury remain unclear. The aim of this study was to investigate the role of ALA in autophagy and apoptosis against oxidative stress in the SH-SY5Y human dopaminergic neuronal cell line. We examined SH-SY5Y phenotypes using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay (cell viability/proliferation), 4′,6-diamidino-2-phenylindole dihydrochloride nuclear staining, Live/Dead cell assay, cellular reactive oxygen species (ROS) assay, immunoblotting, and immunocytochemistry. Our data showed ALA attenuated hydrogen peroxide (H2O2)-induced ROS generation and cell death. ALA effectively suppressed Bax up-regulation and Bcl-2 and Bcl-xL down-regulation. Furthermore, ALA increased the expression of the antioxidant enzyme, heme oxygenase-1. Moreover, the expression of Beclin-1 and LC-3 autophagy biomarkers was decreased by ALA in our cell model. Combined, these data suggest ALA protects human dopaminergic neuronal cells against H2O2-induced cell injury by inhibiting autophagy and apoptosis.

조선총독부 도서관 분류표에 관한 연구 (A Study on the Chosun Government-General Library Classification)

  • 여지숙;오동근
    • 한국도서관정보학회지
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    • 제35권3호
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    • pp.293-319
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    • 2004
  • 이 연구는 우리나라 최초의 관립도서관이며 국립중앙도서관의 전신인 조선총독부도서관에서 사용한 분류표에 관한 것이다. 조선총독부 도서관 분류표는 신서부, 고서부, 양서부의 세 개 분류표를 편찬하여 사용하였다. 이에 이 연구는 일제강점기 당시 관립도서관이었던 조선총독부도서관분류표의 특징에 대해 분석하였다. 또한 조선총독부 도서관 분류표와 관련 있는 분류표를 비교 분석하여 그 영향관계를 파악하였다.

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다공성 실리콘을 근거한 실리콘 양자점을 이용한 휘발성 알콜 증기의 감지 (Detection of Volatile Alcohol Vapors Using Silicon Quantum Dots Based on Porous Silicon)

  • 조보민;엄성용;진성훈;최태은;양진석;조성동;손홍래
    • 통합자연과학논문집
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    • 제3권2호
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    • pp.117-121
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    • 2010
  • Silicon quantum dots base on photoluminescent porous silicon were prepared from an electrochemical etching of n-type silicon wafer (boron-dopped<100> orientation, resistivity of 1~10 ${\Omega}-cm$) and used as a alcohol sensor. Silicon quantum dots displayed an emission band at the wavelength of 675 nm with an excitation wavelength of 480 nm. Photoluminescence of silicon quantum dots was quenched in the presence of alcohol vapors such as methanol, ethanol, and isopropanol. Quenching efficiencies of 21.5, 32.5, and 45.8% were obtained for isopropanol, ethanol, and methanol, respectively. A linear relationship was obtained between quenching efficiencies and vapor pressure of analytes used. Quenching photoluminescence was recovered upon introducing of fresh air after the detection of alcohol. This provides easy fabrication of alcohol sensor based on porous silicon.

DBR 다공성 실리콘과 Host 다공성 실리콘으로 이루어진 이중 다공성 실리콘의 제조와 광학적 특성 (Preparation and Optical Characterization of DBR/Host Dual Porous Silicon Containing DBR and Host Structures)

  • 최태은;양진석;엄성용;진성훈;조보민;조성동;손홍래
    • 통합자연과학논문집
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    • 제3권2호
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    • pp.78-83
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    • 2010
  • DBR/Host dual porous silicons containing DBR and host structure were prepared and their optical properties were characterized using Ocean Optics spectrometer. In this dual porous silicon, single porous silicon layer was used as host layer for possible biomolecule and drug materials and DBR porous silicon layer was used for signal transduction due to the recognition of molecules. Optical reflection spectrum of dual porous silicon displayed only DBR reflection but Fabry-Perot fringe pattern. DBR reflection band of dual porous silicon shifted to the shorter wavelength as the etching time of host layer increased. Cross-sectional FE-SEM image of dual porous silicon displayed a thickness of about 20 micrometer for DBR porous silicon layer. Developed etching technology could be useful to prepare DBR porous silicon which exhibited specific reflection resonance at the required wavelength and to provide an label-free biosensors and drug delivery materials.

Maxillary Sinus Grafts for Endosseous Implant Placement: A Literature Review

  • Park, Seung-Byung;Kim, Su-Gwan;Baek, Sung-Moon;Ahn, Yu-Seok;Moon, Kyung-Nam;Jeon, Woo-Jin;Oh, Ji-Su;Lee, Jeong-Hoon;Im, Jae-Hyung;Yoo, Kyung-Hwan;Kim, Jin-Ha
    • Journal of Korean Dental Science
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    • 제3권1호
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    • pp.25-31
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    • 2010
  • This study sought to evaluate the effect of the type of grafts used in sinus lifting. A review of literature through MEDLINE search covering the period 1980 ~ 2006 was performed. After screening, this study was narrowed down to 2,452 patients receiving sinus lift grafts wherein 7,151 implants were placed. In this study, the types of grafts used in sinus augmentation were autogenous bone, allogenic bone, corticocancellous block bone, and various alloplastic materials. The success rate varied from 69% to 100% depending on the graft material type. The highest success rate was reported for the autogenous bone, with high success rates recorded for the most part in most studies.

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일제시대(日帝時代)의 조선총독부(朝鮮總督府)편찬 이과교과서(理科敎科書) (Science Textbooks under the Rule of CHOSUN Government General)

  • 영전영치;송민영
    • 한국과학교육학회지
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    • 제13권3호
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    • pp.389-395
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    • 1993
  • Science textbooks which were compiled by CHOSUN Government General are known as books which appeared after 'Science Textbook for Common School' (1923-) compiled by CHOSUN Government General which are almost similar to state authorized textbooks and are also known as leaving the effect on 'Science Textbook for Elementary School' (1931-) which were focused on the subjects being issued since then and 'Science Text for Elementary Course' (1942-) being compiled by the Education Ministry, However in this research it was found out that there were publications in 1911, 1913 and 1921 and they were harbingers for 'Science Textbook for Elementary School' 0931-). For this reason it was decided to report overall picture on the science textbooks being compiled by CHOSUN Government General. And it was possible to illustrate that such textbooks can be classified into following 5 periods ; The 1st period:The time for search--'Science Textbook for Students of Common school' 1911 compiled by CHOSUN Government General. The 2nd period:Commencing separate compilation--'Science Textbook for Common School' 1913 compiled by CHOSUN Government General. (The 2'nd period:Final Separate Compilation-- Reissue after corrections of 'Science Textbook for Common School' compiled by CHOSUN Government General, 1921.) The 3rd period:Same as the state authorized science textbook of Japan--' Science Textbook for Common School' compiled by CHOSUN Government General, totally 3 books 1923-. The 4th period:Separate compilation, centered on subjects--'Science Textbook for Elementary School' compiled by CHOSUN Government General, 1931-. (The 4'th period:Changers of subjects--'Science Text for Elementary School' compiled by CHOSUN Government General, 1937-. The 5th period:Matched to compiled by the Education Ministry--'Observation of Nature' compiled by CHOSUN Government General, 1942-'Science Text for Elementary School'(Writing laterally) 1943-.

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Successful Treatment of Invasive Gastric Mucormycosis in a Kidney Transplant Recipient

  • Kim, Hyung Nam;Han, Sun Ae;Park, Ha Yeol;Kim, Hyun Woo;Hong, Ran;Choi, Nam Gyu;Shin, Min Ho;Yoon, Na Ra;Kim, Hyun Lee;Chung, Jong Hoon;Shin, Byung Chul
    • 대한이식학회지
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    • 제32권4호
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    • pp.104-107
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    • 2018
  • Mucormycosis is an extremely rare but potentially life-threatening fungal infection. Gastrointestinal (GI) mucormycosis is very rare and occurs primarily in highly malnourished patients, especially in infants and children. A 55-year-old man with end-stage renal disease due to diabetic nephropathy, who had undergone deceased donor kidney transplantation 2 years prior, complained of abdominal pain and distension with a 3-day duration. Computed tomography revealed diffuse gastric wall thickening, and a huge amount of grey colored necrotic debris surrounded by erythematous erosive mucosa was observed at the antrum to upper body by GI endoscopy. The microscopic examination obtained from a GI endoscopic specimen demonstrated peptic detritus with numerous non-septate mucor hyphae in the mucosa and submucosa. Mucormycosis was diagnosed based on the clinical findings and morphological features. A total gastrectomy was performed and an antifungal agent was administered. A microscopic examination of the surgical specimen demonstrated invasive mucormycosis with numerous fungal hyphae with invasion into the mucosa to subserosa. The patient and graft were treated successfully by total gastrectomy and antifungal therapy.

대체에너지 이용 시범주택 전원용 50KW 태양광발전시스템 (50KW Photovoltaic Generation System for Model House Power Supply Using Alternative Energy)

  • 박정민;박진형;김기범;이강연;신사현;조금배;백형래
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2002년도 하계학술대회 논문집 B
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    • pp.1335-1337
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    • 2002
  • This paper presents experimental operation with utility interactive 50kw photovoltaic generation system. And that describe configuration of utility interactive photovoltaic system which power supply for dormitory. The status of photovoltaic generation system components and interconnection and safety equipment will be summarized. This paper discusses property operation state which system endure division of power for dormitory.

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쿠퍼씨 방법을 이용한 상악 전방부 골절단술 (ANTERIOR SEGMENTAL MAXILLARY OSTEOTOMY USING CUPAR'S METHOD : PRELIMINARY STUDY)

  • 김소영;김수관;이상호;김수흥;정태영;안태훈
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제23권5호
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    • pp.422-427
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    • 2001
  • Anterior segmental osteotomy were performed in 8 patients with Angle's II malocclusion or anterior maxillary protrusion. Cupar's method was used for operation. The period of follow up for patients were 15 months by average. This study discussed the postoperative complications and soft tissue change after anterior segmental maxillary osteotomy. There are not specific major complications.

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MPPT를 적용한 독립형 PV용 배터리 제어기 설계 (Battery Controller Design of Stand-alone PV System using MPPT)

  • 임지혜;백승학;장인혁;문은아;최연옥;조금배;백형래
    • 전력전자학회:학술대회논문집
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    • 전력전자학회 2011년도 추계학술대회
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    • pp.267-268
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    • 2011
  • In order to increase the efficiency of the PV solar can get maximum power output from a control is up. But MPPT request Converter since Solar module always work MPP about out condition. This paper study of 170W stand-alone PV MPPT system for charge and discharge control system of the battery. The proposed system is a way of Flyback converters, and controls the algorithm used P&O control method and ATmega128.

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