• Journal of Nutrition and Health
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• 제25권6호
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• pp.429-449
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• 1992

The consumption of foods rich in TDF should not be associated with impaired mineral absorp-tion and long-term mineral status. In surveys of populations consuming high amounts of TDF e.g Third World populations and vegetarinas gross deficiencies in mineral nutrition have not been noted. If mineral status is low among these groups it is most likely caused by the inadequacy or imbalance of the diet and not by the TDF. The key word is interaction which should be inte-rpreted in dietary imbalances that produce nut-rient deficiencies. There are no strong data to support the concept that TDF inhibits mineral absorption through a binding chelation mechanism. Limited data sug-gest that positively charged groups on polymers such as chitosan and cholestyramine will decrease iron absorption in humans and animals. Because TDF does not contain positively charged groups future research should be directed at the possible role of protein consumed along with TDF and the combination of effects on mineral nutrition Phytic acid is acknowledged as a potent chela-tor of zinc. However its association with zinc and its propensity to lower Zn bioavaiability may enhance the absorption of other elements notably copper and iron. The importance of interactions among nutrients including TDF will gain addi-tional attention in the scientific community. Soluble and insoluble dietary fiber function di-fferently in the intestine. Insoluble fibers accele-rate movement through the intestine. Soluble die-tary fibers appear to regulated blood concentra-tions of glucose and cholesterol albeit by some unknown mechanism. In creased viscosity produ-ced by the SDF in the intestine may provide an explanation of how this class of polymers affects plasma glucose cholesterol and other nutrients. Employing a double-perfusion technique in the rat we demonstrated that viscosity produced by SDF will delay transfer of zinc into the circulatory system. This delayed absorption should not be interpreted as decreased utilization. A great deal of additional research is required to prove the importance of luminaly viscosity produced by SDF on slowing nutrient absorption or regulating bllod nutrient homeostasis. Increased intake of TDF in the total human diet appears desirable. A dietary intake of 35g/day should not be considered to have a negative effect on mineral absorption. It is important to educate people that an intake of more than 35g TDF/day may cause an imbalance in the diet that can adve-rsely affect mineral utilization. Acknowledgments. Appreciation is given to Dr. George V. Vahouny(deceased) who was intense a great competitor in and out of science and who gave the author inspiration Portions of this work were supported by the University of Missouri Ag-ricultural Station and by a grant from the Univer-rch Support Grant RR 07053 from the National Institutes of Health. Contribution of the Missouri Agriculatural Experiments Station Journal Series No. 10747.

• 한국식품과학회지
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• 제38권2호
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• pp.279-283
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• 2006

홍화씨의 폴리페놀 성분들이 HMGR 활성, LDL-oxidation과 Hep3B 세포로부터의 Apo A1 분비능에 미치는 영향을 조사하였다. 홍화씨 성분은 matairesinol(lignan), acacetin(flavone) 및 N-feruloylserotonin과 matairesinol의 대사산물인 enterolactone을 사용하였다. 그 결과, HMCR 저해활성은 mevastatin이 53%로 가장 높은 활성을 나타내었고 다음은 홍화씨 serotronin 유도체인 N-feruloylserotonin이 45%의 저해활성을 보여 홍화씨 폴리페놀 중에서는 가장 높은 활성을 보였으며 genistein은 35%의 활성을 보인 반면 나머지는 활성이 거의 미미하였다. N-feruloylserotonin의 활성은 용량 의존적 반응을 나타내었다. LDL 산화 억제효과는 사용한 모든 홍화씨 폴리페놀성분에서 나타났는데, 특히 N-feruloylserotonin에서 가장 강한 활성을 보였고 역시 용량 의존적 반응을 보였다. Hep3B에서의 Apo A1 분비능은 mevastatin에서 가장 높았고 enterolactone, genistein 및 ${\beta}-estradiol$에서 분비 증강활성을 나타내었다. 이상의 결과들로 미루어 볼 때, 홍화씨 폴리페놀 성분들은 콜레스테를 생합성과 LDL의 산화를 억제시킴으로서 지질대사 및 동맥경화 개선에 기여할 수 있을 것으로 사료된다.