• Journal of Digital Convergence
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• v.14 no.11
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• pp.589-596
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• 2016

The purpose of current study was to investigate the correlations of walking exercise program-induced abdominal visceral fat loss with metabolic syndrome risk factors in middle-aged women. The walking exercise program was provided at a frequency of 3 sessions, respectively, per week for a duration of 12 weeks. Then, the subjects were classified into either those whose abdominal visceral fat loss belonged to low 25 percentile (low 25% group, n=8) or those whose abdominal visceral fat loss belonged to high 25 percentile(high 25% group, n=8) based on the amount of abdominal visceral fat loss induced by the walking exercise. Metabolic syndrome risk factors(waist circumference, triglycerides, HDL-cholesterol, fasting blood glucose, blood pressure) between groups according to the 12 weekly walking exercise program had no difference. In conclusion, the findings of the present study show that the walking exercise-induced total abdominal fat and visceral fat loss were positively relate to waist and blood pressure(SBP, DBP) and that the walking exercise-induced subcutaneous fat loss were positively relate to waist and blood pressure(SBP).

• Journal of the East Asian Society of Dietary Life
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• v.15 no.4
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• pp.386-396
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• 2005

The effects of spirulina-added salad dressing on lipid profiles and antioxidant biomarkers such as total glutathionine, TBARS value, carbonyl value, GPx, GR, SOD and paraoxonase activity in plasma or liver of mice were evaluated Sixteen male ICR mice weighing 20$\pm$2 g were divided into two groups and fed low fat ($5\%$ fat) diet (low fat control: LFC) and low fat control plus dressing diet (LFD) for eight weeks. Body weight, tissue weights of liver, heart and kidney, and the distribution of body fat deposition were not significantly different between two groups. Also, the profile of TG, TC, LDL and HDL cholesterol were similar between two groups. The DNA damage was determined using the comet assay (single cell gel assay) with alkaline electrophoresis and quantified by measuring tail length (TL). Spirulina salad dressing consumption resulted in significant decrease in lymphocyte DNA damage expressed by TL (LFC: $28.8{\mu}m$, LFD: $20.3{\mu}m$). Additionally, salad dressing consumption for 8 wks decreased the lipid peroxidation assayed by TBARS to $12.6\%$ compared with the control. The levels of antioxidant vitamins such as $\beta$-carotene were significantly higher in plasma of LFD group than those in LFC group based on HPLC method This study shows that spirulina-added salad dressing exerts degenerative disease-protective effects on oxidative DNA damage and lipid peroxidation possibly via a free radical levels.

• Korean Journal of Poultry Science
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• v.47 no.3
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• pp.121-126
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• 2020

This study was conducted to investigate the effect of drinking ion water on the performance, egg quality, and serum biochemical properties of laying hens in a high-temperature environment. A total of 180 laying hens with equal egg production rates were randomly divided into three treatments with five replicates. Treatments were applied from 24 to 27 weeks of age and included the supply of ion water (IW), tap water (TW), and cold water (CW). The results showed that the egg production rate, egg weight, and feed intake of hens were significantly (P<0.01) improved in the IW group compared with those in the TW group but did not differ from those in the CW group. Egg quality parameters such as albumen height, Haugh unit, and eggshell thickness were found to be higher in the IW than in the TW group (P<0.05); however, no significant differences were observed in comparison with the CW group. Serum Ca and P concentrations tended to increase (P<0.10) in the IW group, and serum high-density lipoprotein cholesterol and albumin levels were greater (P<0.05) in response to IW than those to TW. This study provides evidence that the supply of IW can relieve the high-temperature stress during the summer. In particular, because the improved effects of the IW were confirmed to be similar to those of CW, it shows potential as a method to manage the drinking water of hens in the summer season along with the supply of CW.

• Journal of the East Asian Society of Dietary Life
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• v.27 no.4
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• pp.408-419
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• 2017

This study was carried out to compare the relationship between biochemical indices and bone mineral density (BMD) in 50 pre-menopausal and 50 post-menopausal women. The subjects were divided into normal and risk groups according to their bone status, as determined by T-scores of the lumbar spine and femur. The average T-score of the lumbar spine was higher (p<0.05) in pre-menopausal women ($0.42{\pm}0.18$) than post-menopausal women ($-0.08{\pm}0.21$). Serum levels of HDL-cholesterol, P, and Fe were significantly higher in the risk group than the normal group in pre-menopausal women (p<0.05). Serum levels of total protein, globulin, alkaline phosphatase (ALP), and osteocalcin were lower in the risk group than the normal group, whereas the level of estrogen was higher in the normal group than the risk group in post-menopausal women (p<0.05). In pre-menopausal women, P was positively correlated with Ca (p<0.01), and ALP was positively correlated with osteocalcin (p<0.01) and parathyroid hormone (PTH) (p<0.05). Further, insulin-like growth factor-I (IGF-I) was negatively correlated with the vitamin $25(OH)D_3$ and vitamin K (p<0.05). In post- menopausal women, the Ca was positively correlated with vitamin $25(OH)D_3$ (p<0.05) and vitamin K (p<0.01), and P was positively correlated with vitamin K (p<0.01), Ca (p<0.01), and IGF-I (p<0.05) and negatively correlated with PTH (p<0.05). IGF-I was negatively correlated with PTH (p<0.01) and estrogen (p<0.05), and ALP was positively correlated with osteocalcin (p<0.01) and negatively correlated with vitamin K and estrogen (p<0.05). In pre-menopausal women, the lumbar spine BMD was positively correlated with vitamin K level (p<0.01) and negatively correlated with P level (p<0.05). In post-menopausal women, the femur BMD was positively correlated with estrogen level and negatively correlated with PTH leves (p<0.05). These results suggest that vitamin K and P levels are associated with bone health in pre-menopausal women, and estrogen and PTH levels are associated with bone health in post-menopausal women.

• Korean Journal of Clinical Pharmacy
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• v.8 no.2
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• pp.107-112
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• 1998

Lovastatin is a lipid lowering agent for the treatment of hypercholesterolemia and belongs to a new class of pharmacologic compounds called the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors. By competitively inhibiting HMG CoA reductase, lovastatin disrupts the biosynthesis of cholesterol in hepatic and peripheral cells and increases the synthesis of high-density-lipoprotein HDL) receptors. Following oral administration, the lactone ring of lovastatin is hydrolysed to the active inhibitor of HMG CoA reductase, lovastatin acid. Lovastatin is known to have poor oral absorption and wide individual variation. In this study, bioequivalence test of two lovastatin formulations, the test drug ($Lovaload^{TM}$, Chong Kun Dang Pharmaceutical Co.) and the reference drug ($Mevacor^{TM}$, Chung Wae Pharmaceutical Co.) were conducted according to the guidelines of Korea Food and Drug Administration (KFDA). A total of 18 healthy male volunteers, $31.90\pm3.60$ years old and $72.17\;7.88$ kg of body weight in average, were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of lovastatin acid in plasma were measured upto 12 hours following a single oral administration of eight tablets (20 mg of lovastatin per tablet) by high-performance liquid chromatography with UV detection at 238 nm. The area under the concentration-vs-time curve from 0 to 12 hours $(AUC_{0-12h})$ was calculated by the trapezoidal summation method. The statistical analysis showed that there are no significant differences in $AUC_{0-12h),\;C_{max}\;and\;T_{max}$ between the two formulations ($6.72\%,\;1.52\%,\;and\;0.88\$, respectively). The least significant differences between the formulations at $\alpha$=0.05 were less than $20\%\;(11.65\%,\;19.73\%,\;and\;14.81\%\;for\;AUC_{0-12h},\;C_{max}\;and\;T_{max}$, respectively). The $90\%$ confidence intervals for these parameters were also within $\pm20\%\;(-1.50{\leq}{\delta}{\leq}15.00$, $-12.50{\leq}{\delta}{\leq}15.50,\;and\;-9.64{\leq}{\delta]{\leq}11.40{\leq}\;for\;\;AUC_{0-12h}$ ,$C_{max}\;and\;T_{max}$, respectively). In conclusion, the new generic product $Lovaload^{TM}$ was proven to be bioequivalent with the reference drug.

• Korean Journal of Clinical Pharmacy
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• v.21 no.4
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• pp.297-304
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• 2011

배경: 골다공증은 골대사의 불균형으로 인해 골 흡수가 골 형성보다 많아져 골밀도가 감소함으로서 발생한다. 골다공증의 이상적인 치료목표는 골형성을 증가시키거나 골소실을 방지하여 골량을 현 상태로 유지하는 것이다. 따라서 향후 발생되는 골소실을 에방하는 것이 골다공증의 원칙적이고 효과적인 치료방법이 될 것이다. 본 연구에서는 흑효모 중 $Aureobasidium$ $pullulans$으로부터 유래한 폴리칸(베타-글루칸)이 중년여성의 골대사에 미치는 영향을 규명하고자 하였다. 연구방법: 골대사에 대한 폴리칸의 효과를 규명하기 위해 12주간의 무작위배정, 이중눈가림, 플라세보 대조 임상연구를 수행하였다. 총 60명(폴리칸 투여군30명, 플라세보 투여군 30명)의 중년 여성 피험자가 등록되어 이 중 총 58명의 피험자가 최종적으로 12주간의 임상연구를 종료하였다. 결 과: 폴리칸(150 mg/d) 투여 12주 후, 폴리칸 투여군은 요 중 Deoxypyridinoline (DPD) 농도가 유의적인 감소를 보였다($P$=0.014). 혈청 중 Osteocalcin(OSC) 농도는 두 군 모두에서 유의적으로 증가하였으며, bone-specific alkaline posphatase (bALP) 와 collagen type 1 cross-linked C-telopeptide (CTx)는 유의적 변화가 보이지 않았다. 폴리칸은 골밀도(BMD)와 혈청 부갑상선 호르몬(iPTH)에 대해 유의적인 변화를 보이지 않았으나, 24시간 요 중 Ca 배설량은 폴리칸 투여군에서 유의하게 감소되었다($P$=0.028). 또한 폴리칸 투여군에서 고밀도지단백 콜레스테롤(HDL-cholesterol) 농도의 증가 경향 및 중성지방(triglyceride)의 유의적인 감소가 보였다. 임상연구 기간 중에 발생한 이상반응은 두 군간에 유의적인 차이를 보이지 않았다. 결 론: 본 연구에서는 폴리칸이 골대사 및 지질에 대해 일부 개선효과가 있음을 보여주었다. 그러나, 골다공증 예방 측면에서 보다 장기적인 임상연구와 피험자 수를 확대하여 골대사 및 지질대사에 대한 폴리칸의 예방적 효과를 규명할 필요가 있을것으로 사료된다.

• Journal of Korean Academy of Rural Health Nursing
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• v.7 no.1
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• pp.5-17
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• 2012

Purpose: The objectives of this study were to investigate the prevalence of the metabolic syndrome (MetS) and to identify associated factors with MetS among rural residents. Methods: Data were collected from 1,196 subjects over aged 30 years by a self-administered questionnaire, physical measurement, and blood test in a rural area. The prevalence of MetS was determined by the criteria of the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and 2005 the Korean society for the study of obesity. Results: The prevalence of MetS was 40.5% for men, 49.2% for women. The prevalence of risk factors of MetS was 57.4% for elevated blood pressure, 49.0% for low HDL-cholesterol, and 48.6% for abdominal obesity. Unemployment and higher Body mass index (BMI) were associated factors for MetS regardless of gender. And higher age and physical inactivity in women only increased the odds of the MetS. Especially, BMI was a strong risk factor of MetS in both men and women. Conclusion: The prevalence of metabolic syndrome was higher in a rural area. Therefore, health care providers should develop lifestyle modification program to increase physical activity level and to prevent the obesity among rural residents in order to decrease the prevalence of MetS.

• Korean Journal of Health Education and Promotion
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• v.15 no.1
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• pp.115-131
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• 1998

Understanding average abnormal obese high school students' health awareness and attitude, We analyzed problems affect on this to provide basic data for the school health education in the near future. From March, 1997, covering a month period, We investigated 300 average obese students from each 3 school, both boys and girls, around Taegu area. Followings are the summary. 1) Grouping obesity, 86.6% of boys were abdominal type and 54.0% of girls were lump types. 2) IN physical check-up and serum lipid lab., there were a lot of abnormal students for blood pressure, serum glucose, total cholesterol, high density lipoprotein(HDL), low density lipoprotein(LDL), neutral lipid, the rate of lipid in the body, atherosclerosis index and electrocardiogram (ECG).; Especially, for the rate of Lipid in the body, 100.0% were in the abnormal range. 3) The main reasons of stress were on the physique and grade. Over 50.0% of students get rid of their stress by singing and dancing. 4) 46.7% of boys and 56.0% of girls were satisfied with their desks and 51.3% of boys and 48.0% of girls were satisfied with their chairs.; 70.0% of boys and 78.7% of girls usually felt uncomfortable for their desks and chairs. 5) 100.0% of boys and 98.0% of girls have been educated for obesity.; 53.3% of boys and 50.7% of girls were not interested in whether joining in or not, if ‘Obese school’ is open. 60.7% of boys get information about weight loss from television, while 41.3% of girls get it from all sorts of publications.; Both sexes said eating convenience food is the main reason to be obese. Most frequent disease is high blood pressure.; 30.0% of boys and 31.3% of girls were hypertensives. 6) 84.7% of boys and 78.0% of girls are awake to the seriousness of obesity from their families. 58.7% of boys and 66.0% of girls sometimes have meals with their families. For the boys, 30.0% of them eat fruit and 29.3% eat cookies while 37.3% of girls eat cookies for their snacks. Both 57.3% of boys and 40.0% of girls have a snack once a day and they drink soft drinks frequently. Both 32.0% of boys and 46.7% of girls have midnight meals 1-2times a week. 7) Both 45.3% of boys and 50.0% of girls suddenly gained their weight in the elementary school times. 30.0% of boys exercise 1 hour for a week, while 48.0% of girls don't exercise. For the exercise hour, both 53.3% of boys and 42.0% of girls exercise for 10-30 minutes a time. 59.7% of boys and 82.0% of girls strongly don't trust in the informations on weight loss. Both 74.0% of boys and 75.3% of girls think physical therapy is the most suitable way for obesity care.

• Genomics & Informatics
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• v.6 no.3
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• pp.99-109
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• 2008

Protein phosphorylation at tyrosine residues is a key regulatory event that modulates insulin signal transduction. We studied the PTPN1 gene with regard to susceptibility to Korean type 2 diabetes mellitus (T2DM) and its related quantitative traits. A total of seven SNPs [g.36171G>A (rs941798), g.58166G>A (rs3787343), g.58208A>G (rs2909270), g.64840C>T (rs754118), g.69560C>G (rs6020612), g.69866G>A (rs718050), and g.69934T>G (rs3787343)] were selected based on frequency (>0.05), linkage disequilibrium (LD) status, and haplotype tagging status. We studied the seven SNPs in 483 unrelated patients with type 2 diabetes (age: $64{\pm}2.8$ years, onset age: $56{\pm}8.1$ years; 206 men, 277 women) and 1138 nondiabetic control subjects (age: $64{\pm}2.9$; 516 men, 622 women). The SNP rs941798 had protective effects against T2DM with an odds ratio of 0.726 (C.I. $0.541{\sim}0.975$) and p-value=0.034, but none of the remaining six SNPs was associated with T2DM. Also, rs941798 was associated with blood pressure, HDL cholesterol, insulin sensitivity. rs941798 also has been associated with T2DM in previous reports of Caucasian-American and Hispanic-American populations. This is the first report that shows an association between PTPN1 and T2DM in the Korean as well as Asian population.

• Korean Journal of Agricultural Science
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• v.44 no.1
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• pp.60-66
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• 2017

This study was conducted to investigate the influence of bone boiling duration on bovine bone extract supplement quality in terms of growth performance, leg bone length, and blood profile in broilers. A total of twenty ROSS 308 broilers (initial BW of $970{\pm}50g$) were randomly divided into the following 4 treatment groups: CON (basal water), T1 (1 : 1 ratio water to bone extract boiled for six hours), T2 (1 : 1 ratio water to bone extract boiled for 12 hours), and T3 (1 : 1 ratio water to bone extract boiled for 24 hours). The broilers were allowed free access to the source of fluid or diets. Average daily feed intake (ADFI), average daily gain (ADG), and feed efficiency showed no significant differences among treatments during this experiment. However, broilers fed bone extract boiled for six hours showed a tendency for increased ADG to other treatments (p < 0.17). No significant differences were observed in organ weights (liver, spleen, bursa of fabricius) or blood profiles among the treatments during the experiment, but broilers fed bone extract boiled for six hours showed a tendency for decreased cholesterol, triglycerides, and HDL compared to the control diet. In the case of leg bone length, there were significant difference (p < 0.05) on tibia and femur among treatments. It was concluded that the six hour-boiled bone extract supplementation had beneficial effects on growth performance and blood profile of broilers.