• 무역상무연구
• /
• 제70권
• /
• pp.159-179
• /
• 2016

Companies do not be resolved by the FTA services of external aid should be operational by assigning dedicated personnel inside the company. FTA is a choice, not an essential trade agreement requirements. If the exporter contracts to provide a certificate of origin in trade agreements, it shall issue a certificate of origin of goods originating management is performed. When considering the future trend of spreading wide FTA, it should be extended to one year to take advantage of the FTA Certificate of Origin environments utilizing a comprehensive environment for regional countries that require proof of origin between certain countries, such as current. FTA utilization of the future is to utilize the GVC(Global Value Chain) efficiently. In other words, the expansion of the consumer market and take advantage of an efficient production base across borders. These environmental changes are needed development of the FTA utilization promotion and FTA experts. The experts studying how to procure raw materials or intermediate goods exports in a variety of regional foreign countries, to meet the rules of origin is required for a successful FTA utilization. One of the objectives of Origin managers are qualified experts in the country of origin can take advantage of the FTA plan. Therefore, managers of origin shall collect their ability to expand the understanding and information about the industry as an international business perspective beyond the Certificate of Origin. In addition, it should be in their best learning expertise for the introduction and development of country of origin control system in an effort to effectively perform its international FTA utilization. Once the FTA is more widespread in the future and build a common origin information it must not be disconnected until the export enterprises from terminal manufacturers systematically. Therefore origin management is preferred by expanding the knowledge base of teaching and learning in the common sense to the universal subject of specialization from professional schools to promote the relevant departments so that they can be opened in a college or university. An FTA hub linking East and West, also need the confidence that in order to become a center of Glabal Supply Chain Using an FTA Certificate of Origin and stable environment for importers to import products from the country offers. Certificate of Origin and all of them thoroughly exporters and companies related to the administration of origin and should create an atmosphere that can effectively respond to the origin verification. Korea shall endeavor to elicit a geopolitical value (FTA Hub), as well as securing a competitive advantage in the global industry leverage, trading at a reasonable price competitive products thereby enhancing production and economic growth through the FTA.

• 대한치과보철학회지
• /
• 제39권1호
• /
• pp.58-70
• /
• 2001

For the successful treatment of complete denture, obtaining a good retention is essential. There are lots of factors affecting denture retention. Denture material, one of those factors affecting denture retention, was the subject of this study, and internal surface treatment also considered for the method of enhancing denture retention. Two resin(Lucitone $199^{(R)}$(heat cured resin) Vertex $CP^{(R)}$(self cured resin)) and two metal($Biosil^{(R)}$(Co-Cr alloy), $Vitallium^{(R)}$(Co-Cr alloy)) denture base materials were used for making test denture base. Newly developed device was used for measuring denture retention. After the retention was measured. We treated internal surface of test denture base with $50{\mu}m\;Al_2O_3$ powder, under 90psi, for 1 minute. Then the retention was measured again. The result was analyzed with K-S test, one-way ANOVA test and independent t-test to deter mine the significant differences as the 95% level of confidence. The results are as follows : In cases of without internal surface treatment, the retention was increased in order of $Vitallium^{(R)},\;Biosil^{(R)},\;Vertex CP^{(R)}$ and Lucitone $199^{(R)}$. Except between Vertex $CP^{(R)}$ and $Biosil^{(R)}$, retention of the other materials was significantly different (p<0.05). After the treatment of internal surface, the retention was increased in order of $Vitallium^{(R)},\;Biosil^{(R)},\;Lucno\;199^{(R)},\;Vertex\;CP^{(R)}$. Except between Lucitone $199^{(R)}$ and Vertex $CP^{(R)}$, $Vitallium^{(R)}$ and $Biosil^{(R)}$ the retention of remaining groups was significantly different each other (p<0.05). In the matter of each material, after the internal surface treatment the retention was increased with Vertex $CP^{(R)},\;Biosil^{(R)}\;and\;Vitallium^{(R)}$ and the value of differences were statistically significant. When we compare the retention of resin and metal denture base, the retention of both denture bases increased significantly with internal surface treatment, and resin denture base showed better retention. As the results show, selecting denture base material could be an important choice of complete denture treatment. To increase denture retention, internal surface treatment can be considered as a possible method.

• 한국과학교육학회지
• /
• 제32권10호
• /
• pp.1580-1598
• /
• 2012

본 연구에서는 중학교 과학 영재들을 대상으로 하여 어린 시절 가정에서의 과학 경험, 학교에서의 과학 경험, 학교 밖 교육 기관의 과학 경험 등이 중학교 영재들의 과학 분야로의 성장에 있어서 어떠한 의미를 주는가를 심층적으로 탐색하였다. 연구 참여자는 교육청 영재 교육원 경험을 2년 이상 하였거나, 영재교육원을 거쳐 과학고를 진학한 학생 총 12명을 대상으로 진행하였고, 회고적인 심층 면담을 통해서 자료를 수집하였다. 연구 결과, 어린 시절 가정에서의 과학경험으로는 비형식 교육의 장인 과학관, 식물원, 동물원 등의 경험과 DVD와 다큐멘터리, 도서 활동의 경험을 주로 하였다. 이러한 경험은 자연 현상에 대한 호기심을 통한 과학에 대한 흥미, 과학을 깊게 알고자하는 탐구심의 증가, 과학 분야로의 진로를 결정하는데 영향을 주었다. 교육 기관의 경험으로는 학교 과학 수업이나 실험 수업이 주를 이루었으며, 이를 통해서 영재 스스로 자신의 과학적 재능을 인식하게 되었을 뿐만 아니라 과학 교사로부터 과학에 대한 다양한 정보를 제공받고 탐구하는 방법 등을 배움으로써 과학에 대한 태도를 긍정적인 방향으로 변화시킬 수 있었다. 학교 밖 교육 기관의 경험으로는 영재 교육원, 캠프, 동아리 활동, 과학 전문 사교육 기관 등이 대부분을 이루었다. 이러한 경험을 통해서 단순한 호기심에 의한 과학에 대한 흥미가 아닌 기존의 알고 있는 개념이나 원리를 구체적으로 확인하고 스스로 탐구하는 활동을 통해 새로운 결과를 얻게 되는 활동을 통해서 과학에 대한 흥미를 느끼고 있었다. 뿐만 아니라, 리더의 역할을 주도하는 것에만 그치는 것이 아니라 그동안 영재들에게 부족하다고 언급되었던 자신감, 성취감, 도전의식, 협동심 등의 리더쉽 부분에서 긍정적인 변화가 일어났음을 알 수 있었다.

• Journal of Gastric Cancer
• /
• 제19권4호
• /
• pp.408-416
• /
• 2019

Purpose: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. Materials and Methods: Eighty-six patients with stage IIIC to IV gastric cancer were assessed for TP and DPD expression by immunohistochemistry. The association between CAPOX or SOX efficacy and TP/DPD expression was retrospectively analyzed. Results: There were no significant differences in the objective remission rate (ORR, 52.27% vs. 47.62%; P>0.05), disease control rate (72.73% vs. 73.81%, P>0.05), progression-free survival (hazard ratio [HR], 1.119; 95% confidence interval [CI], 0.739-1.741; P=0.586), and overall survival (OS; HR, 0.855; 95% CI, 0.481-1.511; P=0.588) between CAPOX and SOX. A higher number of stage IV patients showed TP positivity, while DPD-positive patients predominantly showed intestinal type of gastric cancer. In TP-positive patients, the ORRs associated with CAPOX and SOX treatments were 57.14% and 38.10%, respectively; OS was better with CAPOX than with SOX (HR, 0.447; 95% CI, 0.179-0.978; P=0.046). Among DPD-positive patients, the SOX treatment-associated ORR (60.87%) was significantly higher than the CAPOX treatment-associated ORR (43.48%). Furthermore, SOX treatment resulted in better OS than did CAPOX treatment (HR, 2.020; 95% CI, 1.019-4.837; P=0.049). Conclusions: No significant difference in clinical efficacy was found between CAPOX and SOX. TP-positive patients might respond better to CAPOX while DPD-positive patients may respond better to SOX. Our findings might serve as a guide for personalized chemotherapy for gastric cancer.

• 대한불안의학회지
• /
• 제14권2호
• /
• pp.53-62
• /
• 2018

Objective : The Korean Association of Anxiety Disorders developed Korean guidelines for treatment of panic disorder (PD) 2018. In this paper, we discussed the consensus among psychiatrists, regarding initial and maintenance treatment strategies for pharmacological treatment of PD in Korea. Methods : Based on current treatment guidelines published by the American Psychiatric Association, the National Institute for Clinical Excellence, and the Canadian Psychiatric Association, we developed questionnaires pertinent to initial and maintenance treatment strategies for pharmacological treatment of PD. Seventy-two experts in PD answered questionnaires. We classified expert opinions into three categories, first, second, and third-line treatment strategies, by analyzing the 95% confidence interval. Results : Antidepressants, benzodiazepine anxiolytics, and cognitive-behavioral therapy (CBT) were recommended as treatments of choice (ToC), and first-line strategies for initial treatment of PD. Escitalopram, paroxetine, sertraline, and venlafaxine were preferred from among many anti-panic drugs. Mean starting dose of anti-panic drugs for initial treatment of PD was relatively lower, than that for other psychiatric illnesses such as major depressive disorder. In the case of maintenance treatment of PD, antidepressants and CBT were selected as ToC and first-line strategies. Patients were typically examined every four weeks during treatment, to review effectiveness and side effects of the drug. Pharmacotherapy was generally continued for one year or more. Conclusion : This study provides information about consensus among Korean experts regarding pharmacological treatment strategies for patients with panic disorder.

• 대한교통학회지
• /
• 제23권2호
• /
• pp.107-116
• /
• 2005

교통정보 제공 측면에서 여행시간에 대한 정보는 교통관리 영역 내에서 교통혼잡을 효과적으로 분산시킬 수 있는 핵심정보 중 하나이다. 특히 여행시간에 대한 정보는 운전자가 운전 중 경로선택을 의사결정하는데 있어서 주요한 요소로서 현실적인 신뢰도 확보를 전제로 한다. 본 연구는 남산권 교통정보시스템의 일환으로 총 연장도로 6.1km를 대상으로 구성된 6개의 교통축(corridor)을 대상으로 혼잡시 VMS, ARS, WEB을 이용한 정보 제공을 목적으로 도착예정시간 알고리즘을 개발하였다. 시스템의 공간적 범위는 각 축별 2~3.5km 범위내의 구간을 대상으로 하며, 각 교통축의 출발 및 도착지점에 신호교차로가 존재하여 단순한 연속교통류 특성이외 단속류 교통특성이 교통류내에 포함되어 있다. 목표 알고리즘은 ILD기초자료를 활용하여 수요교통량과 대기길이정보를 이용한다. 수요교통량은 각 지점간 밀도추정을 대상으로 하였으며 이를 위하여 Greenburg Model이 채택되었다. 대기길이 정보는 각 지점별 속도와 밀도에 의하여 산출된다. 연구모형은 단위시간당 변동성을 안정화하기 위하여 전략적으로 번호판 매칭기법에 의한 AVI를 도입하였으며, 이를 통한 관측 된 여행시간 정보를 이용하였다. AVI여행시간 정보는 1일 1회 대기길이에 따른 교통류 특성을 구분하여 ILD에 의한 여행시간을 생성하는데 기반모수로 적용될 수 있도록 Hybrid Model로 구성하여 적용시켰다. 본 연구에 의한 알고리즘 적용결과, 혼잡상황하에서 84% 그리고 전체평균 88%이상의 정확성을 도출하는 것으로 나타났으며, 이러한 정보들은 남산권 교통정보시스템을 이용하는 운전자들에게 유용한 것으로 조사되었다.

• Gut and Liver
• /
• 제12권6호
• /
• pp.728-735
• /
• 2018

Background/Aims: The combination of nab-paclitaxel and gemcitabine (nab-P/Gem) is widely used for treating metastatic pancreatic cancer (MPC). We aimed to evaluate the therapeutic outcomes and prognostic role of treatment-related peripheral neuropathy in patients with MPC treated with nab-P/Gem in clinical practice. Methods: MPC patients treated with nab-P/Gem as the first-line chemotherapy were included. All 88 Korean patients underwent at least two cycles of nab-P/Gem combination chemotherapy (125 and $1,000mg/m^2$, respectively). Treatment-related adverse events were monitored through periodic follow-ups. Overall survival and progression-free survival were estimated by the Kaplan-Meier method, and the Cox proportional hazards regression linear model was applied to assess prognostic factors. To evaluate the prognostic value of treatment-related peripheral neuropathy, the landmark point analysis was used. Results: Patients underwent a mean of $6.7{\pm}4.2$ cycles during $6.3{\pm}4.4$ months. The median overall survival and progression-free survival rates were 14.2 months (95% confidence interval [CI], 11.8 to 20.3 months) and 8.4 months (95% CI, 7.1 to 13.2 months), respectively. The disease control rate was 84.1%; a partial response and stable disease were achieved in 30 (34.1%) and 44 (50.0%) patients, respectively. Treatment-related peripheral neuropathy developed in 52 patients (59.1%), and 13 (14.8%) and 16 (18.2%) patients experienced grades 2 and 3 neuropathy, respectively. In the landmark model, at 6 months, treatment-related peripheral neuropathy did not have a significant correlation with survival (p=0.089). Conclusions: Nab-P/Gem is a reasonable choice for treating MPC, as it shows a considerable disease control rate while the treatment-related peripheral neuropathy was tolerable. The prognostic role of treatment-related neuropathy was limited.

• Journal of Korean Neurosurgical Society
• /
• 제64권2호
• /
• pp.297-308
• /
• 2021

Objective : Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce shunt infection rate. A meta-analysis was conducted to study the effectiveness of AISCs in reduction of shunt infection in terms of age, follow-up time and high-risk patient population. Methods : This study reviewed literature from three databases including PubMed, EMBASE, and Cochrane Library (from 2000 to March 2019). Clinical studies from controlled trials for shunt operation were included in this analysis. A subgroup analysis was performed based on the patient's age, follow-up time and high-risk population. The fixed effect in RevMan 5.3 software (Cochrane Collaboration) was used for this meta-analysis. Results : This study included 19 controlled clinical trials including 10105 operations. The analysis demonstrated that AISC could reduce the infection rate in shunt surgery compared to standard shunt catheter (non-AISC) from 8.13% to 4.09% (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.40-0.58; p=0.01; I2=46%). Subgroup analysis of different age groups showed that AISC had significant antimicrobial effects in all three groups (adult, infant, and adolescent). Follow-up time analysis showed that AISC was effective in preventing early shunt infections (within 6 months after implant). AISC is more effective in high-risk population (OR, 0.24;95% CI, 0.14-0.40; p=0.60; I2=0%) than in general patient population. Conclusion : The results of meta-analysis indicated that AISC is an effective method for reducing shunt infection. We recommend that AISC should be considered for use in infants and high-risk groups. For adult patients, the choice for AISC could be determined based on the treatment cost.

• Journal of Korean Neurosurgical Society
• /
• 제65권2호
• /
• pp.287-296
• /
• 2022

Objective : Although radiotherapy (RT) is recommended for multiple myeloma (MM) involving spine, the treatment of choice between reconstructive surgery with RT and RT alone for pathologic vertebral fractures (PVFs) associated with structural instability or neurologic compromises remains controversial. The purpose of this study was to evaluate the clinical efficacies of reconstructive surgery with adjuvant RT for treatment of MM with PVFs by comparing with matched cohorts treated with RT alone. Methods : Twenty-eight patients underwent reconstructive surgery followed by RT between 2008 and 2015 in a single institution, for management of PVFs associated with structural instability of the spine and/or neurologic compromises (group I). Twenty-eight patients were treated with RT alone (group II) after propensity score matching in a 1-to-1 format based on instability of the spine, as well as age and performance. Clinical outcomes including the overall survival rates, duration of independent ambulation, neurological status, and numeric rating scale (NRS) for back pain were compared. Results : Clinical and radiological features before treatment were similar in both groups. The median survival period was similar between the two groups. However, the mean duration of independent ambulation was significantly longer in group I (88.8 months; 95% confidence interval [CI], 66.0-111.5) than in group II (39.4 months; 95% CI, 25.2-53.6) (log rank test; p=0.022). Deterioration of Frankel grade (21.4% vs. 60.7%, p=0.024) and NRS for back pain (2.7±2.2 vs. 5.0±2.7, p=0.000) at the last follow-up were higher in the group II. Treatment-related complications were similar in both groups. Conclusion : In patients with unstable PVFs due to MM, reconstructive surgery may yield superior clinical outcomes compared with RT alone in maintaining independent ambulation and neurological status, as well as pain control despite similar median survival and complications.

• 한국프랜차이즈경영연구
• /
• 제8권2호
• /
• pp.37-47
• /
• 2017

Purpose - Recently, the food service franchise market is experiencing rapid growth and competition is intensifying. Therefore, consumer choice has expanded, and reputation management has become important as a strategy for survival of corporations. Based on previous studies, this research proposed the theoretical framework about the structural relationships among reputation, trust(cognitive trust, affective trust), and loyalty. Research design, data, and methodology - This study examined the structural relationship between reputation, trust, and loyalty from the customer's perspective. Based on comprehensive validation procedures across nine food service Franchise firm types, This study found support for a five-dimensional scale with the following dimensions: Customer Orientation, Employer Brand, Reliable and Financially Strong Company, Product and Service Quality, and Social and Environmental Responsibility. In order to verify the research purposes, research model and hypotheses were developed. The data were collected from 227 food service franchise consumers through online survey. The data was analyzed with SPSS 24.0 and Amos 23.0 statistical program. Result - The results of the study are as follows. First, customer orientation, reliable·financially strong company and product·service quality have significant impact on corporate cognitive trust. And employer brand, product/service quality and social·environmental responsibility have significant impact on corporate affective trust. Second, cognitive trust and affective trust have significant impacts on consumer loyalty. Conclusions - The implications of this study are following as: From the theoretical perspective, this study considers trust as two dimensions such as cognitive and affective, not a single dimension, and identify what dimensions of franchise firms affect consumers' reputation perception and in turn lead cognitive and affective trust, and loyalty. This study also provides several managerial implications. In the franchise market where competition is intensifying, it is very important to analyze the attitudes of consumers in order to gain an advantage in competition with other competitors. In this study, it is meaningful that the study was conducted on consumers who have experience using a restaurant franchise company. Also, reputation is necessary to pay attention to the company because it is an important variable that strengthens with customer through confidence in food service franchise business, and leads loyalty and consumer consumption. Therefore, marketers should develop marketing strategies considering various reputation factors.