• Journal of the Korean Chemical Society
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• v.5 no.1
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• pp.38-41
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• 1961

By varying groups on biologically active molecules, it is possible to produce analogues which sometimes inhibit the action of the parent compound. Such is true of taurine(${\beta}$-amino-ethane sulfonic acid)as an analogue of ${\beta}$-alanine and of pantoyl taurine for pantothenic acid. It seemed possible that the sulfonic acid analogues of amino acids built into peptides might possibly produce inhibition of the parent peptide. Tauryl-L-histidine was selected to prepare as an analogue of carnosine(${\beta}$-alanyl-L-histidine). There were several reasons for this choice. Camosine causes a slight contraction of isolated uterine muscle and inhibition of this action can be easily tested. Also, taurine, being a ${\beta}$-amino sulfonic acid, is much more stable than the ${\beta}$-amino sulfonic acids. Phthalyl tauryl-L-histidine methyl ester was prepared by condensing phthalyl tauryl chloride with histidine methyl ester in chloroform. The yields were quite low possibly due to reaction between the acid chloride and the imidazole of histidine. Approximately 50 per cent yield of crude amorphous product was obtained, but upon purification by crystallization they yielded only 25 percent of a pure product. The methyl ester was removed by acid hydrolysis to prevent partial cleavage of the phthalyl group. Crystalline tauryl histidine was then obtained from this acid by removal of the phthalyl group by hydrazinolysis. Tests for inhibition were carried out by comparing the action of camosine on isolated uterine muscle before and after tauryl histidine had been added to the bath surrounding the muscle strip. Only in very high relative concentrations of tauryl histidine was there any demonstrable inhibition.

• Korean Journal of Biological Psychiatry
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• v.1 no.1
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• pp.17-30
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• 1994

Several different classes of antidepressants(ADs) with newer drugs becoming available have been used for the phamacological management of a broad spectrum of mental disorders, among which depressive disorder is most commonly indicated. Successful clinical use of ADs requires a complete understanding of the psychopharmacological properties of ADs and on accurate knowledge of patients, characteristics based on clinical experience and theoretical framework. This paper aims at providing some practical information on the clinical use of ADs to assist clinicians in treating patients with major depression. The author describes (1) different classes of ADs and their presumed mechanisms of action, (2) clinical characteristics of ADs focusing on side-effect profiles, (3) some issues arising during the treatment course such as : a) pretreatment tasks, b) choice of ADs, c) therapeutic drug dose and monitoring of drug concentration, d) three stages of treatment and e) strategies in refractory depression and (4) ADs in special patient groups.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.25
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• pp.165-187
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• 2005

Arbitration is a creature of contract. The parties agree that selective dispute resolution clause provides them with a choice to litigate or arbitrate certain disputes. Under the agreements, the parties had the option in the action. In the event any dispute arises between the parties concerning our representation or payment of our fees and disbursements which cannot be promptly resolved to our mutual satisfaction, you agree that dispute will be submitted to arbitration. Arbitration is a matter of contract and a party cannot be required to submit to arbitration any dispute which he has not agreed so to submit. The selective arbitration agreement has become an accepted method of dispute resolution. However, the trend of dispute settlement has changed. The selective arbitrations clauses are to be construed as broadly as possible, and arbitration will be compelled unless it may be said with positive assurance that arbitration clause is not susceptible of an interpretation that covers the asserted dispute.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.05a
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• pp.239-244
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• 2001

Hot hydrostatic extruder was developed. The main objective of the development is forming fine wire and tube. On account of effectiveness and high performance, the extruder was designed to have double action. Therefore the main cylinder and mandrel can be driven independently. To cope with severe condition of high temperature and pressure, wire-wound container equipped with heater was used. Sealing technique also is important in this process, so seal ring was made of super-elastic metal. Another key for successful forming is choice of proper pressure medium. Fine wire and tube produced by the extruder can be used in semiconductor industry and medicine.

• Smart Structures and Systems
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• v.4 no.4
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• pp.407-428
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• 2008

The nonlinear mechanics of cable vibration is caught either by analytical or numerical models. Nevertheless, the choice of the most appropriate method, in consideration of the problem under study, is not straightforward. A feedback control policy might even enhance the complexity of the system. Thus, in order to design a suitable controller, different approaches are here adopted. Devices mounted transversely to the cable in the two directions, close to one of its ends, supply the feedback control action based on the observation of the response in a few points. The low order terms of the control law are, at first, analyzed in the framework of linear models. Explicit analytic solutions are derived for this purpose. The effectiveness of high order terms in the control law is then explored by means of a finite element model(FEM), which accounts for high order harmonics. A suitably dimensional analytical Galerkin model is finally derived, to investigate the effectiveness of the proposed control strategy, when applied to a physical model.

• 한국무역상무학회:학술대회논문집
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• 2004.12a
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• pp.149-170
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• 2004

Arbitration is a creature of contract. The parties agree that selective dispute resolution clause provides them with a choice to litigate or arbitrate certain disputes. Under the agreements, the parties had the option in the action. In the event any dispute arises between the parties concerning our representation or payment of our fees and disbursements which cannot be promptly resolved to our mutual satisfaction, you agree that dispute will be submitted to arbitration. Arbitration is a matter of contract and a party cannot be required to submit to arbitration any dispute which he has not agreed so to submit. The selective arbitrations clauses are to be construed as broadly as possible, and arbitration will be compelled unless it may be said with positive assurance that arbitration clause is not susceptible of an interpretation that covers the asserted dispute.

• Asia pacific journal of information systems
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• v.5 no.1
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• pp.52-85
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• 1995

This paper develops a new approach to dealing with qualitative reasoning processes involved in managerial decisions, drawing upon choice strategies that have been developed within the general framework of multi-criteria decision making. Issues such as choices under uncertainty and preference formulation are addressed. An MCDM DSS intended to assist in high-level management decisions must focus on helping the decision maker to properly define the problem by providing a structure to it and to dynamically evaluate the alternative courses of action. A conceptual architecture is developed and presented to propose a general model for designing decision support systems specifically designed to assist in MCDM in a managerial context. A commercial loan approval judgment case is described to illustrate the real-world situation where decisions are made under fuzziness and usually require a high degree of intuition and subjective judgment. Development of a prototype system intended to partially represent application of the architecture is described.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1996.06c
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• pp.679-684
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• 1996

The work was aimed at realize the problem of seed processing . Solving this problem it was ascertained that the existing mathematical methods are reliable enough, but they are used practically very seldom. The work offers to use the expert system technology which allows to solve problems connected with practical knowledge of experts in the region of investigation effectively. The method of knowledge structuring and analizing as well as technique of knowledge acquisition which is necessary for realization of this technology are worked-out in the work. As the result applying the worked-out method the prototypes of the expert system (ES) are created : -ES " Sieves " ; research prototype for the sieve choice for the seed sorting machines -ES " Diagnostics " ; displaying prototype for the technological determination of action disrepair of seed sorting machines.

• Annals of Clinical Neurophysiology
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• v.8 no.1
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• pp.6-15
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• 2006

Intravenous immunoglobulin (IVIg) is the treatment of choice for many autoimmune neuropathic disorders such as Guillain-Barre syndrome (GBS), chronic inflammatory Demyelinating neuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is preferred because the adverse reactions are milder and fewer than the other immune-modulating methods such as steroid, other immunosuppressant such as azathioprine, and plasmapheresis. IVIg also has been used in other autoimmune neuromuscular disorders (inflammatory myopathy, myasthenia gravis, and Lambert-Eaton myasthenic syndrome) and has been known as safe and efficient agent in these disorders. Since IVIg would get more indications and be used more commonly, clinicians need to know the detailed mechanism of action, side effects, and practical points of IVIg.

• Proceedings of the KIEE Conference
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• 2001.07a
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• pp.97-100
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• 2001

This paper describes preventive control for transient stability. Preventive control encompasses in general a twofold problem : Severity assessment of a instability originating from the occurrence of a dangerous contingency, and Choice of an action able to stabilize it. In this paper we assess contingencies in a power systems using PASF(Power Angle Shape Filtering) and control power systems by a generation rescheduling. The proposed method is applied to prevent loss of synchronism of all the generators at a site, KEPCO Systems.