• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6519-6522
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• 2013

Background: Genetic polymorphisms of TP63 have been suggested to influence susceptibility to lung adenocarcinoma development in East Asian populations. This study aimed to investigate the relationship between common polymorphisms in the TP63 gene and the risk of lung adenocarcinoma, as well as interactions of the polymorphisms with environmental risk factors in Chinese non-smoking females. Methods: A case-control study of 260 cases and 318 controls was conducted. Data concerning demographic and risk factors were obtained for each subject. The genetic polymorphisms were determined by Taqman real-time PCR and statistical analyses were performed using SPSS software. Results: For 10937405, carriers of the CT genotype or at least one T allele (CT/TT) had lower risks of lung adenocarcinoma compared with the homozygous wild CC genotype in Chinese nonsmoking females (adjusted ORs were 0.68 and 0.69, 95%CIs were 0.48-0.97 and 0.50-0.97, P values were 0.033 and 0.030, respectively). Allele comparison showed that the T allele of rs10937405 was associated with a decreased risk of lung adenocarcinoma with an OR of 0.78 (95%CI=0.60-1.01, P=0.059). Our results showed that exposure to cooking oil fumes was associated with increased risk of lung adenocarcinoma in Chinese nonsmoking females (adjusted OR=1.58, 95%CI=1.11-2.25, P=0.011). However, we did not observe a significant interaction of cooking oil fumes and TP63 polymorphisms. Conclusion: TP63 polymorphism might be a genetic susceptibility factor for lung adenocarcinoma in Chinese non-smoking females, but no significant interaction was found with cooking oil fume exposure.

• Asian-Australasian Journal of Animal Sciences
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• 제33권9호
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• pp.1378-1386
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• 2020

Objective: Chinese indigenous sheep breeds can be classified into the following three categories by their tail morphology: fat-tailed, fat-rumped and thin-tailed sheep. The typical sheep breeds corresponding to fat-tailed, fat-rumped, and thin-tailed sheep are large-tailed Han, Altay, and Tibetan sheep, respectively. Detection of copy number variation (CNV) and selection signatures provides information on the genetic mechanisms underlying the phenotypic differences of the different sheep types. Methods: In this study, PennCNV software and F-statistics (F_ST) were implemented to detect CNV and selection signatures, respectively, on the X chromosome in three Chinese indigenous sheep breeds using ovine high-density 600K single nucleotide polymorphism arrays. Results: In large-tailed Han, Altay, and Tibetan sheep, respectively, a total of six, four and 22 CNV regions (CNVRs) with lengths of 1.23, 0.93, and 7.02 Mb were identified on the X chromosome. In addition, 49, 34, and 55 candidate selection regions with respective lengths of 27.49, 16.47, and 25.42 Mb were identified in large-tailed Han, Altay, and Tibetan sheep, respectively. The bioinformatics analysis results indicated several genes in these regions were associated with fat, including dehydrogenase/reductase X-linked, calcium voltage-gated channel subunit alpha1 F, and patatin like phospholipase domain containing 4. In addition, three other genes were identified from this analysis: the family with sequence similarity 58 member A gene was associated with energy metabolism, the serine/arginine-rich protein specific kinase 3 gene was associated with skeletal muscle development, and the interleukin 2 receptor subunit gamma gene was associated with the immune system. Conclusion: The results of this study indicated CNVRs and selection regions on the X chromosome of Chinese indigenous sheep contained several genes associated with various heritable traits.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5483-5487
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• 2013

Background: Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory. Methods: We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively. Results: No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians. Conclusions: Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.

• Journal of Biosystems Engineering
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• 제30권2호
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• pp.81-88
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• 2005

Manual transplanting Chinese cabbage needs 184 hours per ha in Korea. Mechanization of Chinese cabbage transplanting operation has been highly required because it needs highly intensive labor during peak season. This study was conducted to developed walking-type Chinese cabbage transplanter. In order to find out design factor of the transplanter, a kinematic analysis software, RecurDyn, was used. The prototype was tested in the circular soil bin and its operating motion was captured and analyzed using high speed camera system. Prototype was one row type which utilized original parts of engine, transmission and etc. from walking-type rice transplanter in order to save the manufacturing cost. Success ratio of pick-up device of hole-pin type and latch type were $96.0\%$ and $99.2\%$, respectively. which was highly affected by feeding accuracy of feeding device of seedling. Transplanting device of the prototype produced a elliptic loci which were coincident with those produced by the computer simulation. Prototype proved good performance in transplanting with mulching and without mulching operation, either. Working performance of prototype was 22 hours per ha and operation cost of the prototype was 961,757 won per ha. So, it would reduce $88\%$ of the labor and $29\%$ of operation cost.

• Journal of Information Processing Systems
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• 제13권5호
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• pp.1243-1258
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• 2017

A new medical materials scheduling system and its modeling method for the complex rescue are presented. Different from other similar system, first both the BeiDou Satellite Communication System (BSCS) and the Special Fiber-optic Communication Network (SFCN) are used to collect the rescue requirements and the location information of disaster areas. Then all these messages will be displayed in a special medical software terminal. After that the bipartite graph models are utilized to compute the optimal scheduling of medical materials. Finally, all these results will be transmitted back by the BSCS and the SFCN again to implement a fast guidance of medical rescue. The sole drug scheduling issue, the multiple drugs scheduling issue, and the backup-scheme selection issue are all utilized: the Kuhn-Munkres algorithm is used to realize the optimal matching of sole drug scheduling issue, the spectral clustering-based method is employed to calculate the optimal distribution of multiple drugs scheduling issue, and the similarity metric of neighboring matrix is utilized to realize the estimation of backup-scheme selection issue of medical materials. Many simulation analysis experiments and applications have proved the correctness of proposed technique and system.

• Journal of Power Electronics
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• 제2권4호
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• pp.250-257
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• 2002

This paper introduces the Interactive Power Electronics Seminar - iPES - a new software package for teaching of fundamentals of power electronic circuits and systems. iPES is constituted by HTML text with Java applets for interactive animation, circuit design and simulation and visualization of electromagnetic fields and thermal issues in power electronics. It does comprise an easy-to-use self-explaining graphical user interface. The software does need just a standard web-browser, i.e. no installations are required. iPES can be accessed via the World Wide Web or from a CD-ROM in a stand-alone PC by students and professionals. Due to the underlying software technology iPES is very flexible and could be used for on-line learning and could easily be integrated into an e-learning platform. The aim of this paper Is to give an introduction to the iPES-project and to show the different areas covered. The e- learning software is available at no costs at $\underline{www.ipes.ethz.ch}$ in English, German, Japanese, Korean, Chinese and Spanish. The project is still under development and the web page is updated in about 4 weeks intervals.

• 한국정보과학회논문지:소프트웨어및응용
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• 제36권9호
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• pp.683-690
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• 2009

은닉 마코프 모델(Hidden Markov Model: HMM)에 기반을 둔 온라인 한자 인식에서 클래스의 수가 대용량일 경우에는 인식에 걸리는 시간 증가가 좋은 인식 시스템을 구현하는데 있어서의 걸림돌이 된다. 본 논문에서는 이러한 인식 속도 문제를 해결하고자 HMM을 클러스터링하여 인식 속도를 개선하는 방법과 이에 적합한 효율적인 HMM 간의 거리계산법을 제안한다. 유니코드 한 중 일 통합한자로 정의된 총 20,902개의 한자에 대한 온라인 한자 인식 시스템을 구축하는 실험에서 약 2배 정도로 인식속도가 향상됨을 확인할 수 있었고 클러스터링을 하지 않았을 때보다 0.9%의 인식률만 하락한 95.37%의 10순위 인식률을 달성했다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제31권8호
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• pp.1083-1091
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• 2004

본 논문은 기계번역 시스템에서 파싱의 전처리 단계로 도입되는 구 묶음 시스템을 제안한다. 구 묶음 모듈은 구 묶음의 결과로 얻어지는 의존관계 제약을 통하여 분석 시스템의 성능향상에 기여할 수 있다. 중국어를 위한 구 묶음 시스템을 변형 기반 학습 기법에 근거하여 구현하며, 의존관계를 효과적으로 파서에 넘겨줄 수 있는 인터페이스를 고안한다. 구현된 모듈을 중한 기계번역 시스템에 통합하고, 중국 관련 웹사이트로부터 수집한 말뭉치를 이용한 실험을 통해 구 묶음의 도입이 기계번역에서 분석시스템의 성능 향상에 기여할 수 있음을 보인다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2283-2287
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• 2015

In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups, similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.4209-4214
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• 2012

The current situation of cancer registration in China was systematically reviewed. So far, cancer registration in China has been making a great progress in the following aspects: the number of cancer registries and covered population have increased dramatically; a registration network has been established and completed gradually; regulations and rules improved remarkably; more attention is being paid by every level of government; a lot of registration software has been created and financial support ensured. However, we are still facing some problems and challenges, such as no stable groups of registrars, shortage of training opportunities, poor data quality, insufficient utilization and lack of multidisciplinary mechanisms, so that the cancer registration system still needs to be enhanced and improved. Along with the development of economy, science and information technology, methods and patterns of cancer registration is changing. It is to be expected that cancer registration will be automatic, nationwide and integrated with community healthcare in the near future.