• Title/Summary/Keyword: Chinese science

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Alkaloids of Linderae Radix suppressed the lipopolysaccharide-induced expression of cytokines in cultured macrophage RAW 264.7 cells

  • Chou, David Jiyao;Lam, Kelly Yinching;Chen, Jianping;Yao, Ping;Dong, Tina Tingxia;Xiong, Aizhen;Chou, Guixin;Wang, Zhengtao;Tsim, Karl Wah-Keung
    • CELLMED
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    • v.4 no.4
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    • pp.28.1-28.27
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    • 2014
  • Linderae Radix, the dry roots of Lindera aggregata (Sims) Kosterm, has long been used as traditional Chinese medicine for treatment of inflammatory diseases. The total alkaloids are believed to be the active components responsible for anti-inflammation of Linderae Radix. Here, the total alkaloids of Linderae Radix were extracted and isolated, including 12 isoquinoline alkaloids and 1 furan sesquiterpene. Within the alkaloids, norisoboldine, boldine, linderaline, isoboldine, reticuline, N-methyllaurotetanine, norjuziphine were found to be the major ingredients. In lipopolysaccharide-treated macrophage RAW 264.7 cells, application of Linderae Radix extract, or total alkaloids, suppressed the transcription of proinflammatory cytokines, interleukin-$1{\beta}$ and interleukin-6. Out of the 12 alkaloids, norisoboldine, boldine, and isoboldine were tested in lipopolysaccharide-treated macrophages, and norisoboldine was the strongest alkaloid in suppressing the cytokine expressions. The current studies suggested that the identification of alkaloids from Linderae Radix could provide a plausible explanation for herbal therapeutic functions.

Effect of Chinese Cinnamon Powder on the Quality and Storage Properties of Ground Lamb Meat during Refrigerated Storage

  • Hussain, Zubair;Li, Xin;Ijaz, Muawuz;Xiao, Xiong;Hou, Chengli;Zheng, Xiaochun;Ren, Chi;Zhang, Dequan
    • Food Science of Animal Resources
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    • v.40 no.3
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    • pp.311-322
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    • 2020
  • This study was undertaken to evaluate the impact of Chinese cinnamon powder (w/w), at the levels of 0.5%, 1.5%, and 2.5% and control (without additive) on ground lamb meat quality. The samples were stored at 4℃ and examined for pH, color, lipid oxidation (thiobarbituric acid reactive substances) and total viable counts (TVC). The results demonstrated that pH values were declined with the increase of Chinese cinnamon levels compared to control group. The L* values throughout the storage were significantly higher (p<0.05) in the control group than in other treatment groups, while a* values were decreased with the increase of Chinese cinnamon levels. The addition of Chinese cinnamon powder strongly inhibited (p<0.05) thiobarbituric acid reactive substances (TBARS) and TVC in all treated samples. It can be concluded that Chinese cinnamon powder in lower concentration 0.5% has the ability to maintain the quality of ground lamb in comparison with other treated samples.

A review of Chinese named entity recognition

  • Cheng, Jieren;Liu, Jingxin;Xu, Xinbin;Xia, Dongwan;Liu, Le;Sheng, Victor S.
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.15 no.6
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    • pp.2012-2030
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    • 2021
  • Named Entity Recognition (NER) is used to identify entity nouns in the corpus such as Location, Person and Organization, etc. NER is also an important basic of research in various natural language fields. The processing of Chinese NER has some unique difficulties, for example, there is no obvious segmentation boundary between each Chinese character in a Chinese sentence. The Chinese NER task is often combined with Chinese word segmentation, and so on. In response to these problems, we summarize the recognition methods of Chinese NER. In this review, we first introduce the sequence labeling system and evaluation metrics of NER. Then, we divide Chinese NER methods into rule-based methods, statistics-based machine learning methods and deep learning-based methods. Subsequently, we analyze in detail the model framework based on deep learning and the typical Chinese NER methods. Finally, we put forward the current challenges and future research directions of Chinese NER technology.

Linkage Disequilibrium Estimation of Chinese Beef Simmental Cattle Using High-density SNP Panels

  • Zhu, M.;Zhu, B.;Wang, Y.H.;Wu, Y.;Xu, L.;Guo, L.P.;Yuan, Z.R.;Zhang, L.P.;Gao, X.;Gao, H.J.;Xu, S.Z.;Li, J.Y.
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.6
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    • pp.772-779
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    • 2013
  • Linkage disequilibrium (LD) plays an important role in genomic selection and mapping quantitative trait loci (QTL). In this study, the pattern of LD and effective population size ($N_e$) were investigated in Chinese beef Simmental cattle. A total of 640 bulls were genotyped with IlluminaBovinSNP50BeadChip and IlluminaBovinHDBeadChip. We estimated LD for each autosomal chromosome at the distance between two random SNPs of <0 to 25 kb, 25 to 50 kb, 50 to 100 kb, 100 to 500 kb, 0.5 to 1 Mb, 1 to 5 Mb and 5 to 10 Mb. The mean values of $r^2$ were 0.30, 0.16 and 0.08, when the separation between SNPs ranged from 0 to 25 kb to 50 to 100 kb and then to 0.5 to 1 Mb, respectively. The LD estimates decreased as the distance increased in SNP pairs, and increased with the increase of minor allelic frequency (MAF) and with the decrease of sample sizes. Estimates of effective population size for Chinese beef Simmental cattle decreased in the past generations and $N_e$ was 73 at five generations ago.

Relationship between the Polymorphisms of 5' Regulation Region of Prolactin Gene and Milk Traits in Chinese Holstein Dairy Cows

  • Li, J.T.;Wang, A.H.;Chen, P.;Li, H.B.;Zhang, C.S.;Du, L.X.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.4
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    • pp.459-462
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    • 2006
  • Prolactin (PRL) plays an important role in promoting mammalian mammary gland development, and milk production during lactation. Therefore the PRL gene was chosen as a candidate gene for milk traits in Holstein dairy cows. PCR-SSCP and PCR-RFLP were used to analyze genetic variations in the 5' regulation region of the PRL gene. In this part of the gene, two new polymorphic sites were detected in the Chinese Holstein dairy cows. One was a XbaI-RFLP locus, and the other was an SSCP locus. Statistical analysis showed that the XbaI-RFLP locus and the SSCP locus had a significant positive effect on milk traits.

Using Semantic Knowledge in the Uyghur-Chinese Person Name Transliteration

  • Murat, Alim;Osman, Turghun;Yang, Yating;Zhou, Xi;Wang, Lei;Li, Xiao
    • Journal of Information Processing Systems
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    • v.13 no.4
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    • pp.716-730
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    • 2017
  • In this paper, we propose a transliteration approach based on semantic information (i.e., language origin and gender) which are automatically learnt from the person name, aiming to transliterate the person name of Uyghur into Chinese. The proposed approach integrates semantic scores (i.e., performance on language origin and gender detection) with general transliteration model and generates the semantic knowledge-based model which can produce the best candidate transliteration results. In the experiment, we use the datasets which contain the person names of different language origins: Uyghur and Chinese. The results show that the proposed semantic transliteration model substantially outperforms the general transliteration model and greatly improves the mean reciprocal rank (MRR) performance on two datasets, as well as aids in developing more efficient transliteration for named entities.

Experimental and simulation study on the backstreaming positive ions on the quarter-size negative ion source for CRAFT NNBI test facility

  • Yongjian Xu;Yuwen Yang;Jianglong Wei;Ling Yu;Wen Deng;Rixin Wang;Yuming Gu;Chundong Hu;Yahong Xie
    • Nuclear Engineering and Technology
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    • v.56 no.2
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    • pp.546-551
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    • 2024
  • As an effective methods of plasma heating, neutral beam injection (NBI) systems based on negative hydrogen ion sources will be utilized in future magnetic-confinement nuclear fusion experiments. Because of the collisions between the fast negative ions and the neutral background gas, the positive ions are inevitable created in the acceleration region in the negative NBI system. These positive ions are accelerated back into the ion source and become high energy backstreaming ions. In order to explore the characters of backstreaming ions, the track and power deposition of backstreaming H+ beam is estimated using the experimental and simulation methods at NNBI test facility. Results show that the flux of backstreaming positive ions is 1.93 % of that of negative ion extraction from ion source, and the magnet filed in the beam source has an effect on the backstreaming positive ions propagation.

African Maternal Origin and Genetic Diversity of Chinese Domestic Donkeys

  • Lei, Chu-Zhao;Ge, Qing-Lan;Zhang, Hu-Cai;Liu, Ruo-Yu;Zhang, Wei;Jiang, Yong-Qing;Dang, Rui-Hua;Zheng, Hui-Ling;Hou, Wen-Tong;Chen, Hong
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.5
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    • pp.645-652
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    • 2007
  • The origin of domestic donkeys in China has been controversial. To clarify the origin of Chinese domestic donkeys, we investigated the partial mitochondrial D-loop sequences of 126 samples from 12 native breeds. The results revealed two mitochondrial origins, lineage Somali and lineage Nubian of African wild ass detected in Chinese domestic donkeys. Lineage Somali was predominant in Chinese domestic donkey breeds. The pattern of genetic variation in ass mtDNA D-loop sequences indicated that the two lineages Somali and Nubian from China had undergone population expansion events. In a combined analysis of lineages Somali and Nubian between previously published sequences from other countries/regions and sequences of Chinese domestic donkeys, the results indicated that the two lineages of Chinese domestic donkeys were from Africa and supported the African maternal origins of Chinese domestic donkeys. There was no obvious geographical structure in Chinese domestic donkey breeds, but the population showed abundant mtDNA diversity. The spread routes of Chinese domestic donkeys were also discussed.

Genetic architecture and candidate genes detected for chicken internal organ weight with a 600 K single nucleotide polymorphism array

  • Dou, Taocun;Shen, Manman;Ma, Meng;Qu, Liang;Li, Yongfeng;Hu, Yuping;Lu, Jian;Guo, Jun;Wang, Xingguo;Wang, Kehua
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.3
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    • pp.341-349
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    • 2019
  • Objective: Internal organs indirectly affect economic performance and well-being of animals. Study of internal organs during later layer period will allow full utilization of layer hens. Hence, we conducted a genome-wide association study (GWAS) to identify potential quantitative trait loci or genes that potentially contribute to internal organ weight. Methods: A total of 1,512 chickens originating from White Leghorn and Dongxiang Blue-Shelled chickens were genotyped using high-density Affymetrix 600 K single nucleotide polymorphism (SNP) array. We conducted a GWAS, linkage disequilibrium analysis, and heritability estimated based on SNP information by using GEMMA, Haploview and GCTA software. Results: Our results displayed that internal organ weights show moderate to high (0.283 to 0.640) heritability. Variance partitioned across chromosomes and chromosome lengths had a linear relationship for liver weight and gizzard weight ($R^2=0.493$, 0.753). A total of 23 highly significant SNPs that associated with all internal organ weights were mainly located on Gallus gallus autosome (GGA) 1 and GGA4. Six SNPs on GGA2 affected heart weight. After the final analysis, five top SNPs were in or near genes 5-Hydroxytryptamine receptor 2A, general transcription factor IIF polypeptide 2, WD repeat and FYVE domain containing 2, non-SMC condensin I complex subunit G, and sonic hedgehog, which were considered as candidate genes having a pervasive role in internal organ weights. Conclusion: Our findings provide an understanding of the underlying genetic architecture of internal organs and are beneficial in the selection of chickens.