• Journal of Pharmacopuncture
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• v.9 no.2
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• pp.155-166
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• 2006

Objectives : This research examined about dietary therapy on the diarrhea based on the literary findings, for clinical treatment and prevention of the diarrhea. Methods : This Research examined on histories, compositions, applications, and effects of the diarrhea on about 100 cases of dietary therapy of the diarrhea from recent Chinese literatures Results : 1. Various vegetables, animals and mineral materials including herbs, grains, vegetables, fruits, food and drink were used for the dietary therapy. 2. Methods of the preparation for use as therapeutics were decoction, pulvis, gruel, medicinal wine, cake, tea, paste and gelatin and etc. 3. Frequently used materials were sesame oil, honey, ear mushroom, shiitake mushroom, kelp, walnut seed, hemp seed, groundnut, glutinous rice, apricot stone, yellow bean peel, radish, potato, spinage, and spring onion. Conclusion : Though dietary therapy for the diarrhea is not based on clinical or experimental data, but through experience. It is mostly based on Yin-Yang and five elements, visceral manifestation, channels and their collateral channels and chinese herbal medicine theories. If we use them properly according to oriental medicine method, it will be effective on treating and preventing the diarrhea.

• Journal of Pharmacopuncture
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• v.21 no.3
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• pp.203-206
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• 2018

Objectives: There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional "single compound, single target" approach as demonstrated in our current modern drug development. TCM might be the new cornerstone of treatment alternative when the current treatment option is no longer as effective or that we have exhausted it as an option. Orthogonal stimulus-response compatibility group study is one of the most frequently employed formulas to produce optimal herbal combination for treatment of multi-syndromic diseases. This approach could solve the relatively low efficacy single drug therapy usage and chronic adverse effects caused by long terms administration of drugs that has been reported in the field of pharmacology and medicine Methods: The present review was based on the Science Direct database search for those related to the TCM and the development of antihypertensive TCM herbal combination using orthogonal stimulus-response compatibility group studies approach. Results: Recent studies have demonstrated that the orthogonal stimulus-response compatibility group study approach was most frequently used to formulate TCM herbal combination based on the TCM principles upon the selection of herbs, and the resulting formulated TCM formula exhibited desired outcomes in treating one of global concerned complex multi-syndromic diseases, the hypertension. These promising therapeutic effects were claimed to have been attributed by the holistic signaling mechanism pathways employed by the crude combination of herbs. Conclusion: The present review could serve as a guide and prove the feasibility of TCM principles to be used for future pharmacological drug research development.

• The Journal of Korean Medical History
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• v.22 no.2
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• pp.99-109
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• 2009

Jejung Sinpyeon (New Edition of Medical Prescriptions) is a medical book that was compiled in order to overcome the shortcomings of Donguibogam (Exemplar of Korean Medicine), to improve and offer prescriptions suitable for new diseases according to the changing times, and simply to publish new medical books. As a result of an analysis of Yakseongga of Jejung Sinpyeon (a book of medicine written by Kang Myeong-gil in 1799, the 23rd year of the reign of King Jeongjo of the Joseon Dynasty), it was found that a total of 303 lines had been quoted from Wan-bing-hui-chun of the Ming Dynasty of China] and Dongeui Susebowon and that 83 lines had been newly inserted by the author. Of the 303 lines, 296 were quoted from Dongeui Susebowon, and only seven from Wan-bing-hui-chun. This means that the author of Jejung Sinpyeon chiefly used Dongeui Susebowon as the source of Yakseongga quoted therein. 275 lines, or 76%, of a total of 386 lines of Yakseongga of Jejung Sinpyeon, have their Korean names marked. Medicinal herbs marked as Chinese herbs number 83 out of 386. Among the 83 herbs named, one belongs to the part newly inserted by the author, while the remaining 82 are quoted from Yakseongga. The foregoing suggests that the author expected that the knowledge could be used by people easily based on an effort to make it localized knowledge, although Yakseongga was compiled based on quotations from Chinese literature. Yakseongga of Jejung Sinpyeon has significant value as the country's first State-compiled book of medicine to contain Yakseongga.

• The Korea Journal of Herbology
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• v.24 no.3
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• pp.147-152
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• 2009

Objectives : This paper intends to shed light on the value of Jejungsinpyeon, which is known to have had a considerable impact on the country's medicine in the later period Joseon Period, and its position in the Joseon history of medicine. To such an end, this paper focuses on how Yakseongga was developed and transformed in the later period Joseon Period through a bibliographical study of it. Methods : (1) To make comparison and analysis of the 303 lines, which the author said he quoted from Wan.bing.hui.chun and Susebowon, with Yakseongga of Jejungsinpyeon to see association between them based on Yakseongga contained in Jejungsinpyeon (2) To make a table concerning the names of the books, their authors, when they were published, how many kinds there are, their formats based on a survey of literature containing Yakseongga published after Jejungsinpyeon. (3) To see influences made by Jejungsinpyeon on books of medicine in the later Joseon Period. Results : It was found that a total of 303 lines had been quoted from Wan bing hui chun and Susebowon and that 83 lines had been newly inserted by the author. As a result of an analysis of Yakseongga of Jejungsinpyeon, Of the 303 lines, 297 were quoted from Susebowon, and only six from Wan bing hui chun. This means that the author of Jejungsinpyeon chiefly used Susebowon as the source of Yakseongga quoted therein. 275 lines, or 76%, of a total of 386 lines of Yakseongga of Jejungsinpyeon, have their Korean names marked. Medicinal herbs marked as Chinese herbs number 83 out of 386. Among the 83 herbs named, one belongs to the part newly inserted by the author, while the remaining 82 are quoted from Yakseongga. Conclusions : It shows the author's intention to make what is contained in Yakseongga localized knowledge and used by the people easily, although Yakseongga was compiled based on quotations from Chinese literature.

• Korean Journal of Medicinal Crop Science
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• v.16 no.4
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• pp.225-230
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• 2008

Diabetes mellitus is the fifth leading cause of death among Koreans. Control of hyperglycemia and dyslipidemia is strongly correlated with decrease in risks for cardiovascular diseases, the most common and fatal diabetic complication. The effects of chronic feeding of a mixture of Chinese herbs on blood lipid profile were measured in an animal model of type 2 diabetes mellitus, db/db mice (C57BL/Ks). The Chinese herb mixture was composed of Panax ginseng C. A. Meyer,Astragalus membranaceus, Glycyrrhiza uralensis, Lycium chinense, Morus, Pueraria thunbergiana, Prunella vulgaris var. lilacina, Acanthopanax sessiliflorus, Schizandra chinensis, Scutellaria baicalensis, Dioscorea batatas, Polygonatum doratumvar. pluriflorum, Paeonia lactiflora, and Rehmannia glutinosa in a ratio of 1 : 0.7 : 0.4 : 0.7 :0.4 : 0.7 : 1.1 : 0.9 : 0.4 : 0.4 : 0.7 :0.7 : 0.9 : 0.9. Methanol extract of the Chinese herb mixture was tested for the inhibitory activity against yeast ${\alpha}$-glucosidase in vitro. The Chinese herb mixture extract inhibited ${\alpha}$-glucosidase by 25.2% at the concentration of 0.5mg/mL. Four weekold male db/db mice (n = 14) were fed AIN-93G semipurified diet or diet containing 10% powder of the Chinese herb mixture for 6 weeks after 1 week of adaptation period. Body weight (39.5 ${\pm}$ 1.6 g) and food intake (4.3 ${\pm}$ 0.6 g/day) of the Chinese herb group were not significantly different from those of the control group (40.4 ${\pm}$ 2.6 g and 4.5 ${\pm}$ 0.6 g/day). Consumption of Chinese herb mixture significantly decreased plasma glucose level (442.5 ${\pm}$ 36.0mg/dL) compared with the control group (489.8 ${\pm}$ 34.6 mg/dL, p < 0.05). Plasma cholesterol level (159.2 ${\pm}$ 18.4 mg/dL) of the Chinese herb group was significantly lower than that of the control group (185.4 ${\pm}$ 13.7 mg/dL, p < 0.05). Blood glycated hemoglobin (6.3 ${\pm}$ 0.8%) and plasma triglyceride levels (99.4 ${\pm}$ 15.0mg/dL) of the Chinese herb group were not significantly different from those of the control group (6.7 ${\pm}$ 0.7% and 108.8 ${\pm}$ 11.0mg/dL). Thus, the Chinese herb mixture could be useful in the treatment of diabetes and cardiovascular complications of diabetes.

• Korean Journal of Medicinal Crop Science
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• v.10 no.5
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• pp.366-374
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• 2002

Pen-tsao-kang-mu(Bon-cho-kang-mok), chinese medicinal plant book, was written by Lee sijin(1578), China. The subject of this study were 158 articles of vegetable part in Pen-tsao-kang-mu. Among them only 139 articles were able to be identified by authority of several references. By Engler's system they were classified into 8 divisions, 10 classes, 6 subclasses, 31 orders, 22 suborders, 52 families, 85 genera, 99 species, 12 varieties and 2 forma, and were confirmed 113 kinds of original plants. Among the divisions, Angiospermae was the most numerous division with 92 kinds(80.70%) and the second division was Fungi with 12 kinds(10.53%). The next was Rhodophyta with 4(3.51%) kinds. Other 19 articles were unable to be classified because of their ambiguous name.

• Korean Journal of Medicinal Crop Science
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• v.10 no.1
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• pp.58-67
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• 2002

Pen-tsao-kang-mu(Bon-cho-kang-mok), chinese medicinal plant book, was written by Si-jin Lee, 1578, China. The subject of this study were 210 articles of grain part in Pen-tsao-kang-mu. Among them only 193 articles were able to be identified by authority of several references. By Engler's system they were classified into 4 divisions, 5 classes, 3 subclasses, 28 orders, 17 suborders, 46 families, 95 genera, 100 species, 11 varieties and 1 form, and were confirmed 112 kinds of original plants. Among the divisions, angiospermae was the most numerous division with 107 kinds(91.98%) and the second division was gymnospermae with 3 kinds(2.70%). The next were phaeophyta and fungi with 1 kind(0.90%) on each. Other 17 articles were unable to be classified because of their ambiguous name.

• Journal of the Korean Society of Food Culture
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• v.28 no.5
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• pp.438-449
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• 2013

During the Joseon Dynasty, medicinal foods derived from herbs were often more effective than traditional medicines. In addition, the royal family of the Joseon Dynasty believed that foods could be used as various disease treatments. Grain-based foods, especially medicinal porridges (藥粥), were most frequently used for diet therapy. We investigated various types of diet-related diseases suffered by King Injo (仁祖) as well as how the diseases were treated using medicinal porridges based on information in the SeungjeongwonIlgi (承政院日記), which is the daily record of the Royal Secretariat of the Joseon Dynasty. This study examined the SeungjeongwonIlgi of King Injo from his1st year (1623) to 27th year (1649) on a website database maintained by the National Institute of Korean History. According to the records, King Injo suffered from severe diarrhea several times due mainly to febrile disease (煩熱症) as well as abdominal dropsy (脹滿) throughout his entire life. Major diseases affecting King Injo were due to his unhealthy eating habits and psychological factors. For treatment, royal doctors prescribed around 15 medicinal porridges, including nelumbo (seed) porridge (Yeonja-juk), milk porridge (Tarak-juk), Chinese dioscorea porridge (Sanyak-juk), mungbean porridge (Nokdu-juk), perilla seed porridge (Imja-juk), adzuki-bean porridge (Pat-juk), soybean porridge (Kong-juk), Korean-leek porridge (Buchu-juk), and so on, in addition to other medical treatments. Diet therapy using medicinal porridges has been used throughout history since the Joseon Dynasty period. However, knowledge of traditional diet therapy and medicinal porridges used by monarchs in the Joseon Dynasty is insufficient. Therefore, in-depth study is needed to understand the theory of traditional medicinal foods as well as explore their application to patients in the context of modern medicine.

• Korean Journal of Medicinal Crop Science
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• v.9 no.2
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• pp.116-123
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• 2001

This study was carried out to investigate antioxidative, antimicrobial activity and the effect on hepatotoxicity in various extracts of Artemisia iwayomogi. The herb has been used widely for jaundice, hepatitis and liver cirrhosis in chinese medicine. Solid yield by various extraction solvents, 18.1%, was the highest in water extract. To find antioxidative activity in Artemisia iwayomogi was estimated radical scavenging effect by DPPH method in various extracts and change of the POV(peroxide value) of various extracts added in soybean oil during 20 days at $60^{\circ}C$. Radical scavenging effect by DPPH method was the most effective in methanol extract. Added 1,000ppm water extract and methanol extract in soybean oil, the POV of them, 46.8(meq/kg) and 50.8(meq/kg) were lower than that of control, 79.1(meq/kg), during 20 days storage. After antimicrobial activity of various extracts of Artemisia iwayomogi on bacteria was carried out by paper disc method, it found that the ethanol extract was the strongest activity on Vibrio parahaemolyticus. In vivo experiment was to investigate the effect of Artemisia iwayomogi water extract(AIWE) on hepatotoxicity by carbon tetrachloride$(CCl_4)$ in rats. The experiment groups were divided into five groups for recovery(for 3 days) and three groups for protection(for 10 days) in rat liver. The weights and morphological changes of liver and the body weight were examined in each groups. Compared with $CCl_4$ treatment groups$(CCl_4\;only)$, liver and liver/body(%) weights of AIWE pretreatment groups for 3 days and AIWE posttreatment groups for 10 days were declined. In macrography, fibrious exudates and swelling of liver were decreased in AIWE treatment groups. Accumulation of lipid droplets and necrosis of hepatocytes were also decreased in AIWE treatment groups in microscopically. In these results, AIWE seems to enhance hepato-protective and recoverable effect on $CCl_4$ induced hepatotoxicity in rats.

• International Journal of Contents
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• v.7 no.4
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• pp.108-115
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• 2011

The current study aims to analyze the acceptance of International Standard Terminology (IST) related to herbs and formulas used in Korea. It also intends to examine limitations of each term source by linking texts for herbal medicine research and formula research used in schools of oriental medicine with medicinal substance-formula classification names within the IST framework. This study examined 64 medicinal classification names of IST, including synonyms, 41 formula classification names, 65 classification names of "Herbal Medicine Study," 89 medicinal classification names of "Shin's Clinical Herbal Medicine Study," and lastly 83 formula classification names of "Formula Study." Data on their chief virtue, efficacy and characteristics as medicinal substances were extracted from their definitions, and such data were used to perform Chinese character-English mapping using the IST. The outcomes of the mapping were then analyzed in terms of both lexical matching and semantic matching. In terms of classification names for medicinal substances, "Herbal Medicine Study" had 60.0% lexical matching, whereas "Shin's Clinical Herbal Medicine Study" had 48.3% lexical matching. When semantic matching was also applied, "Herbal Medicine Study" showed a value of 87.7% and "Shin's Clinical Herbal Medicine Study" 74.2%. In terms of formula classification names, lexical matching was 28.9% of 83 subjects, and when semantic matching was also considered, the value was 30.1%. When the conceptual elements of this study were applied, some IST terms that are classified with other codes were found to be conceptually consistent, and some terms were not accepted due to different depths in the classification systems of each source.