• Journal of Environmental Health Sciences
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• v.22 no.1
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• pp.91-98
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• 1996

산업장이나 생활환경에서 접하기 쉬운 수용성 염화물을 중심으로 19개 원소 24종의 금속화합물이 Chinese Hamster Don 세포에 있어서의 sister chromatid exchange(SCE) 출현빈도에 미치는 영향을 조사하였다. Chinese Hamster Don 세포에 대한 자매염색분체 교환출현빈도의 증가가 $CrO_3, K_2CrO_4, K_2Cr_2O_7, MnCl_2, K_2SeO_3, CH_3HgCl$ (p<0.01), $CoCl_2, Na_2HAsO_4, HgCl_2$ (p<0.05) 9종의 금속화합물에서 나타났으며, dose-response relationships이 현저한 금속화합물은 6가 크로화합물과 $K_2SeO_3$이었다.

• Proceedings of the KSAR Conference
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• 2002.06a
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• pp.15-15
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• 2002

Telomere erosion is the earliest chromatin modification in cells entering the apoptotic regime. The purpose of this investigation was to demonstrate that loss of telomeric DNA was involved in the induction of mitotic catastrophe and cell death of Chinese hamster Don cells that were grown continuously without subculturing for several days. Don, which is a diploid male Chinese hamster-derived cell line, was grown without sub-culturing for one to four days at 37℃ and then harvested for cytological preparations. (omitted)