Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)
- 2002.06a
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- Pages.15-15
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- 2002
Telomere Erosion-Induced Mitotic Catastrophe in Chinese Hamster Don Cells
- Sohn, Sea H. (Department of Animal Science and Biotechnology, Jinju National University) ;
- Multani, Asha S. (Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Cente) ;
- Gugnani, Pankaj K. (Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Cente) ;
- Pathak, Sen (Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center)
- Published : 2002.06.01
Abstract
Telomere erosion is the earliest chromatin modification in cells entering the apoptotic regime. The purpose of this investigation was to demonstrate that loss of telomeric DNA was involved in the induction of mitotic catastrophe and cell death of Chinese hamster Don cells that were grown continuously without subculturing for several days. Don, which is a diploid male Chinese hamster-derived cell line, was grown without sub-culturing for one to four days at 37℃ and then harvested for cytological preparations. (omitted)
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