• Journal of Microbiology and Biotechnology
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• v.34 no.6
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• pp.1189-1196
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• 2024

Bacterial resistance to commonly used antibiotics is one of the major challenges to be solved today. Bacteriophage endolysins (Lysins) have become a hot research topic as a new class of antibacterial agents. They have promising applications in bacterial infection prevention and control in multiple fields, such as livestock and poultry farming, food safety, clinical medicine and pathogen detection. However, many phage endolysins display low bactericidal activities, short half-life and narrow lytic spectrums. Therefore, some methods have been used to improve the enzyme properties (bactericidal activity, lysis spectrum, stability and targeting the substrate, etc) of bacteriophage endolysins, including deletion or addition of domains, DNA mutagenesis, chimerization of domains, fusion to the membrane-penetrating peptides, fusion with domains targeting outer membrane transport systems, encapsulation, the usage of outer membrane permeabilizers. In this review, research progress on the strategies for improving their enzyme properties are systematically presented, with a view to provide references for the development of lysins with excellent performances.

• Journal of Korean Medical classics
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• v.21 no.3
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• pp.1-25
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• 2008

Myeong(明) Dynasty Period put together clinically various medical theory in Song(宋) Dynasty and Geum-Won(金元) age, organized medical system. They have been developed in theory, which thought of Byeonjeungronchi(辨證論治) more important, and clinical part which included diagnosis, therapy, prevention. In that age reactional medical thought was in fashion because of affect of Ihak(理學), therefore pediatrics have been affected from them. Especially, looking at the symptom of Byeonjeungronchi doctors, Manjeon(萬全), Nobaeksa(魯伯嗣), Wangdaeryun(王大綸), Wanggeungdang(王肯堂), Nuyeong(樓英) had succeed to Jeoneul(錢乙)' the five viscera Byeonjeung(辨證) system. Manjeon advocated Samyuyeosabujokron(三有餘四不足論) about Jangbu(臟腑) and organized the curative principle about Ojangheosil(五臟虛實). Gupyeong(寇平), commented on diagnosis of five viscera and classification of disease of five viscera. Wangdaeryun in the close of Myeong Dynasty Age explained main pulse, pulse of illness in detail according to weakness or strength of five viscera, pathological or physiological features of five viscera and Saenggeuk(生克) relation of Ohaeng(五行) in the book of "Yeongdongryuchwe(嬰童類萃)". Wanggeungdang and Nuyeong had organized system of argument which classified disease as a result of symptom of five viscera. "Yugwajeungchijunseung(幼科證治準繩)" and "Uihakgangmok(醫學綱目) Soabu(小兒部)" had been written by this principle. Nobaeksa had arranged the principle of cure about five viscera and explained method of common use about each organ's disease. Besides, Seolgi(薛己), Janggyeong-ak(張景岳), insisted about Myeongmun(命門) because he thought of Bisin(脾腎) of children and vigor by nature importance. Seolgi had applied and used very well Bojung-ikgitang(補中益氣湯) based on Idongwon(李東垣)'s Biwiseol(脾胃說) and controled and helped spleen and stomach. At the same time, he took a serious view about supplementing children's Sin-gi(腎氣) according to so many spleen and stomach disease was fallen because they couldn't make warm the spirit of Jungju(中州), result of weakening Hwa(火) of Myeongmun. Also Janggyeong-ak took a serious view strengthen of Bisin, so he assorted and used Insam(人蔘) and Buja(附子) to supplement children's weaken energy in kidney Jeonggi(精氣).

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.3
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• pp.325-336
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• 2009

The purpose of this study was to investigate the eruption pattern of the mandibular first molar in sagittal, frontal and horizontal views using the cone beam CT scanning. CT images were obtained from healthy 83 children (42 boys, 41 girls) between 3 to 10 years of age with a normal dentition according to Nolla stage. 1. In the frontal and horizontal view, the intermolar width decreased continuously with stage and slightly increased at the last stage. 2. In the sagittal and frontal view, eruption distances from occlusal plane were observed the largest change between stage 5 and 7. 3. In the horizontal and sagittal view, mandibular first molar from distal surface of primary second molar moved distally between stage 4 and 6. 4. In the sagittal view, angle from occlusal plane to mesio-distal axis increased between stage 4 and 8. 5. In the frontal view, angle from occlusal plane to bucco-lingual axis increased continuously during all stage. 6. In the horizontal view, angle from midsagittal plane to long axis increased between stage 5 and 8.

• Korean Journal of Childcare and Education
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• v.11 no.4
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• pp.239-269
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• 2015

The purpose of this study is to understand the different views of grandparent's that are rearing children from the grandmother and working mom as co-caregivers by studying conflicts and the experience made by grandmothers by rearing children through a phenomenological approach, and to help to build healthy relationships and furthermore to promote a healthy educational environment. Data were collected from six working mothers from a child care center in Gyeonggi, and their six grandmothers who were rearing grandchildren through in-depth interviews, emails and observation based on the instruction of semi-structured interviews. For analysis, a phenomenological analysis method is used. As a result, 78 meaning units, 15 sub-elements and 6 theme categories were drawn. Theme categories were (1) grandmothers' rearing experience; perform a double-role through grandchildren-rearing (2) working moms' rearing experience; conflicts over ideologue of motherhood (3) grandmothers' rearing positive effect: increasing grandmothers' efficacy and intimate relationships with grandchildren (4) working moms' rearing positive effect: reducing working moms' children-rearing stress (5) negative effect: increasing grandmothers' children-rearing stress and working moms' low children-rearing efficacy (6) rearing conflicts: the two mothers' conflicts over children-rearing values. Through the study, it implies that social intervention is needed to solve the conflicts between two mothers over the rearing attitudes and methods as understanding and intervention is needed.

• Childhood Kidney Diseases
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• v.2 no.2
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• pp.169-177
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• 1998

Purpose : Renal duplication is a common occurrence, and the range of ureteral and renal anomalies draining the two poles of the duplex kidney leads to a variety of clinical presentations. Method : A series of 61 children with duplicated systems was studied retrospectively who were admitted during last 12years. Results : Of the children $60.6\%$ were accompanied with urologic anomalies that required surgical treatment, and most children initially were presented with urinary tract infection. $42.6\%$ of children were either diagnosed incidentally during evaluation of other non-urologic disease or during follow-up evaluation of abnormal antenatal renal sonogram. Conclusion : From our point view, children with history of abnormal antenatal renal sonogram, or with symptoms such as urinary tract infection, hematuria, abdominal pain should be evaluated radiologially fully to confirm further abnormality and accompanied complications. And routine follow-up using abdominal ultrasonogram, VCUG, and urine culture should be used to prevent and detect early treatable complications.

• Journal of The Korean Association of Information Education
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• v.6 no.3
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• pp.328-337
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• 2002

Looking at multimedia education contents from a design point of view, the instructor's design model may differ from the child's understanding model due to gap of the instructor's and child's knowledge. This fact implies it impacts the effectiveness of the education contents. The learning efficiency of Korean typography in WBI for children depends on the font-family, line space, font-size, the age of user, the output device such as the monitor, and other various factors. In this paper, we measured and analyzed on readability of Korean typography in WBI for children by reading speed method. The results of experiments show that readability depends on the font-family of typography, age(grade), and sex of children. In detail, "Goolymche" has the shortest time to be read, and girl and the highest grade students of elementary school have shorter time than boy and the lower grade students. Moreover, we consider the elegance of typography in WBI for holding children's interests because they prefer "Yopseoche". We provide some CSSs in WBI for children based on the experimental results, to used in school fields.

• The Journal of the Korea Contents Association
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• v.20 no.2
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• pp.182-196
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• 2020

This study presents the effects and phenomenological meanings of child poverty on child development by implementing in-depth interviews with 19 adults and 20 children in Korean Welfare Qualitative Panel Study and analyzing multi-dimensional categories of child poverty experiences. By focusing on relative deprivation, this study lists the insider's view on poverty experiences such as pauperization, housing, health, education, child-raising, culture, family and child's dream, and then it describes poverty experiences in a heuristic and hermeneutic way from the child's view. Findings shows that poverty experiences of childhood are associated with negative child development experiences such as trauma, deprivation of growth and opportunity, childhood adultification, intergenerational transmission of poverty and limiting dreams. This qualitative study based on the insider's view, can contribute not only to profound understandings of multi-dimensional child poverty but to identification of client based policy demand, which enables poverty policy studies expand their boundaries.

• Hwankyungkyoyuk
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• v.13 no.2
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• pp.63-73
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• 2000

The purpose of this study are two-fold; 1) to identify the differences in the view of environmental value between 6-years-olds and 12-years-old, 2) to identify the differences in the attitude towards animals and plants between male-and female students. To accomplish the purposes of this study, two researchers deeply interviewed ten 6-years-old and 12-years-old boys and girls, respectively. First, the interviewees are asked to rank six constituents in nature, human-being, tiger, ant, gingko tree, weed, and stone, from their views of environmental value. Then, the interviewees were asked to talk about their various interaction with animals and plants. The results of this study are as follows; 1) In evaluating the value of nature constituents, 12-years-olds tended to be affected by scientific knowledge. On the other hand, 6-years-olds tended to evaluate the value of nature constituents by their emotional feeling; 2) From the perspectives of environmental ethics, 12-years-olds showed attitudes in anthropocentric or holistic ethics. On the other hand, 6-years-olds showed attitudes in nonanthropocentric ethics; 3) In evaluating the value of nature constituents, 12-year-olds tended to consider the constituent′s instrumental values and 6-years-olds tended to consider their intrinsic values; 4) From the perspectives of "ethics of care", females, especially 12-years females tended to take care of plants. The results propose more emphasis of environmental "sensuous" in school environmental education. And male- and female students should be expected fairly in their environmental attitudes, especially in taking care of natural creatures.

• Korean journal of communication and information
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• v.36
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• pp.348-373
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• 2006

In the era of digital media, one of the most distinctive characteristics is the activity what audience play. This characteristic can be particularly demonstrated in the case of PPV(Pay-Per-View) use. Since this service is related with payment by audience according to each behaviour of their own media use. In doing so, this paper explores the characteristics and behavioral pattern in PPV use. In particular, the study tries to predict from the result that which trait of characteristic can explain the adoption of PPV. The analytical result shows that PPV users are much more active in gathering information as well as achieving the diversity in terms of program choice compared to non PPV users. At the same time, PPV users are prone to be unsatisfied against the other media and naturally willing to adopt the new media. PPV users are much more keen to use toward age related programme classification system in order to protect their children from inappropriate programmes. The variable of participational behaviour is the most relevant variable to predict the degree of PPV use, however, it fails to predict to distinguish the PPV users group from non PPV users group. It maybe given as a conclusion that PPV users are much more active in not only choosing their own program they like to watch but also planning ahead for maximising their pleasure from viewing.

• The Journal of the Korea Contents Association
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• v.7 no.8
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• pp.207-214
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• 2007

The special educational technology is the combination term of special education and educational technology. These days, the applications of educational technology in special education field is very increasing through the development of IT and the progress of teaching methods. The development of IT bring out the applications of assistive technology. The various development and operation strategies of the individualized educational program have promoted the advancement of teaching methods for the children with disabilities. The purpose of this paper is to inquiry and to present the applicable contents of special educational technology for the children with disabilities. The important study problems of this study are to examine the differences between educational technology and special educational technology, to categorize special educational technology in the view of application and to develop the contents of instructional design and assistive technology device. Finally it is to suggest the progress tasks for the development of the special educational technology.