• 대한한방소아과학회지
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• 제35권3호
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• pp.43-52
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• 2021

Objectives This study aimed to analyze the clinical characteristics of 63 patients with autism spectrum disorder (ASD) who received Korean medicine treatment. Methods This study identified and retrospectively reviewed the first visit records and clinical characteristics of all of the patients who visited the Kyung Hee University Korean Medicine Hospital and Kyung Hee University Korean Medicine Hospital at Gangdong in South Korea with ASD as their chief complaints. The herbal medicines that were prescribed according to the patient's symptoms were analyzed by separating them into categories. Results The data of 83 children with ASD were collected. Among them, the primary medical record charts of 63 patients were reviewed. Additional analysis was performed for 56 patients who were treated with herbal medicine. Through a retrospective chart review, the patients' clinical characteristics and the tendency of the prescribed herbal medicine was identified. Conclusions This study was conducted to provide preliminary data that proposes Korean medicine as a new alternative medical treatment. Our study is meaningful as it used the demographic and clinical records of 63 patients with ASD in Korea who visited an Korean medicine hospital in the last 11 years to identify tendencies and analyzed the prescriptions of two or more Korean medicine pediatricians.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제35권1호
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• pp.29-38
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• 2024

We conducted a comprehensive review of behavioral and educational interventions for individuals with autism spectrum disorder (ASD). The most prominent type of intervention, Comprehensive Early Intervention, often referred to as Early Intensive Behavioral Intervention (EIBI), has been found to be particularly effective in improving intelligence and adaptive behaviors. The naturalistic developmental behavioral intervention, designed to enhance social and communication abilities, showed effectiveness in improving language, cognitive function, and social initiation. However, more studies are needed to examine its effectiveness. Intensive individualized intervention, which provides a tailored intervention for a specific target behavior, was effective in improving social skills and communication, as well as reducing sleep, eating, and toileting problems. Cognitive behavioral therapy (CBT) is the most effective method for dealing with emotional difficulties, but it has not been widely used because of the shortage of trained experts. Parent-mediated intervention (PMI) involves parents acquiring knowledge and specific skills to improve their child's functioning or reduce challenging behaviors. Speech and language therapy, sensory integration, Treatment and Education of Autistic and related Communications Handicapped Children, developmental approaches, and social stories are frequently used interventions. However, evidence of their effectiveness has yet to be well established. Based on these findings, intervention recommendations for autism include EIBI, Early Start Denver Model, intensive individualized intervention, CBT, and PMI. The choice of intervention should be tailored to the individual's needs and delivered by qualified professionals with expertise in the specific intervention.

• 재활치료과학
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• 제8권3호
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• pp.83-95
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• 2019

목적: 본 연구는 자폐범주성장애아동을 대상으로 한 파워카드 전략이 이들의 수용어휘 및 표현어휘 향상에 미치는 효과에 대하여 알아보고자 실시하였다. 연구방법: 연구 참여 대상자는 3명의 학령기 자폐범주성장애아동을 선별하였으며, 대상자 간 중다기초선설계를 적용하여 파워카드 전략 언어 중재를 시행하였다. 대상자 개별 선호캐릭터를 조사하여 목표어휘를 선정하고 파워카드를 제작하여 기초선 단계, 중재 단계, 유지 단계를 거쳐 어휘력 향상을 위한 중재를 적용하였다. 결과: 파워카드 전략의 적용으로 자폐범주성장애아동의 수용어휘 습득률이 증가하였고, 표현어휘 습득률 역시 향상되는 결과가 나타났다. 결론: 자폐범주성장애아동이 선호하는 캐릭터를 조사하여 각 대상 아동에게 적합한 파워카드 전략을 계획하고 적용함으로써 대상 아동들에게는 강한 동기가 형성되고, 반복적이고 체계적 반복 연습을 통하여 중재 기간 대상 아동의 수용어휘 습득률 및 표현어휘 습득률이 향상되었으며 중재 이후 유지 단계에서도 습득률이 유지되었음을 알 수 있었다. 이는 파워카드 전략이 학령기로 접어든 자폐범주장애아동의 어휘 향상에 효과적인 것으로 나타났다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.287-293
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• 2011

Objectives : The region of chromosome 5p14 is known to be associated with autism spectrum disorder (ASD). The cadherin9 (CDH9) and cadherin10 (CDH10) genes are located in the region of chromosome 5p14 and reported to be associated with ASD in the Caucasian population. We performed an association study to identify if single nucleotide polymorphisms (SNPs) located on the CDH9 and CDH10 genes are associated in the Korean population. Methods : Genomic DNA was extracted from the blood of 214 patients with ASD and 258 controls. SNPs selected from two genes were genotyped using an Illumina Golden-Gate Genotyping assay with VeraCode technology. Statistical analysis was performed using SAS and Plink software. Results : All controls and ASD patients were in Hardy-Weinberg equilibrium. In the results of logistic regression analyses for the genotype model and the chi-square test for the allele model, we found that SNPs on the CDH9 and CDH10 genes were not associated with ASD. Conclusion : Our data suggests that the CDH9 and CDH10 genes are not associated with ASD in the Korean population.

• 재활치료과학
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• 제10권2호
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• pp.129-140
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• 2021

목적 : 본 연구에서는 자폐스펙트럼장애(ASD) 영유아와 영유아의 어머니를 대상으로 수면문제 경계선 및 임상 수준과 정상 수준 간 사회성숙도와 문제행동의 차이를 검증하였다. 연구방법 : 서울시에 소재한 종합병원의 소아정신과, 발달장애 클리닉, 재활의학센터 등에서 2010년부터 2015년까지 ASD로 진단된 만 1-5세 영유아와 영유아 어머니 102명을 대상으로 축적된 자료를 활용하였으며 유아행동평가척도(CBCL 1.5-5)와 사회성숙도 검사(SMS) 자료를 최종분석에 사용하였다. 결과 : ASD 영유아의 수면문제 수준은 T점수에서 56.58로 나타났다. 수면문제는 CBCL 1.5-5의 하위척도들과 유의한 상관관계를 나타냈으나, 사회지수와 유의한 상관관계를 나타내지 않았다. 본 연구에서는 수면문제 경계선 및 임상 수준 집단과 정상 수준의 2개 집단으로 나누었다. 집단 간 사회성숙도의 차이를 검증한 결과, 경계선 및 임상 수준 집단이 정상 수준 집단보다 SMS의 사회지수가 낮았다. 또한, 정서적 반응성, 불안/우울, 신체증상, 위축 등 내재화 문제와 주의집중문제, 공격행동 등 외현화 문제가 심각했다. 이외 DSM 전반적 발달문제, DSM 주의력결핍/과잉행동장애, DSM 반항행동문제 등 외현화 DSM 장애 증상이 유의하게 심각했다. 결론 : 수면문제 경계선 및 임상 수준 집단은 정상 수준 집단과 비교하여 유의하게 낮은 사회성숙도와 심각한 문제행동을 나타낸다는 것을 확인하였다.

• 대한감각통합치료학회지
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• 제21권3호
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• pp.27-38
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• 2023

목적 : 본 연구는 Sensory Processing and Self-Regulation Checklist(이하 SPSRC)의 국내사용을 위해 일반아동과 자폐스펙트럼장애(Autism Spectrum Disorder; ASD) 아동을 대상으로 타당도와 신뢰도 검증을 실시하였다. 연구방법 : 동시타당도를 검증하기 위해 Short Sensory Profile(SSP)을 사용하여 피어슨 적률 상관계수 (Product-moment correlation coefficient)를 산출하였다. 구성타당도는 두 집단의 감각처리능력과 자기조절능력을 비교하여 검증을 실시하였다. 신뢰도 검증을 위한 내적 일치도의 경우 Cronbach's α를 산출하였으며, 검사-재검사 신뢰도는 피어슨 상관계수(Pearson correlation coefficient)를 통해 검증하였다. 결과 : 동시타당도의 검증 결과 한글판 SPSRC와 SSP는 통계적으로 유의한 상관관계를 나타냈으며(p<.01), 구성타당도는 한글판 SPSRC의 영역 및 하위항목에 대해 두 집단이 통계적으로 유의한 차이가 있는 것으로 확인되었다(p<.001). 내적 일치도는 Cronbach's α값의 범위가 .700 ~ .975로 나타났으며, 검사재검사 신뢰도는 상관계수의 범위가 .937 ~ .997로 나타났다. 결론 : 한글판 SPSRC는 높은 타당도와 신뢰도를 가지는 평가도구로 확인되었다. 따라서 임상에서 치료목표를 계획하기 위한 평가도구로 사용되는 것 뿐만 아니라 향후 관련된 연구에 의미 있는 근거자료로 사용되기를 기대한다.

• Mass Spectrometry Letters
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• 제5권2호
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• pp.42-48
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• 2014

A specific and sensitive liquid chromatography-electrospray ionization tandem mass spectrometry method (LC-ESI-MS/MS) was developed and validated for the simultaneous quantification of porphyrins (coproporphyrin, pentacarboxylporphyrin, hexacarboxylporphyrin, heptacarboxylporphyrin, and uroporphyrin) in human plasma and urine. Acidified plasma samples and urine samples were prepared by using liquid-liquid extraction using ethyl acetate and protein precipitation with acetonitrile, respectively. The separation was achieved onto a Synergi Fusion RP column ($150mm{\times}2.0mm$, $4{\mu}m$) with a gradient elution of mobile phase A (0.1% formic acid in 2 mmol/L ammonium acetate, v/v) and mobile phase B (20% methanol in acetonitrile, v/v) at a flow rate of $450{\mu}L$/min. Porphyrins and the internal standard (IS), coproporphyrin I-$^{15}N_4$, were detected by a tandem mass spectrometer equipped with an electrospray ion source operating in positive ion mode. Multiple reaction monitoring (MRM) transitions of the protonated precursor ions and the related product ions were optimized to increase selectivity and sensitivity. The proposed method was validated by assessing selectivity, linearity, limit of quantification (LOQ), precision, accuracy, recovery, and stability. The calibration curves were obtained in the range of 0.1-100 nmol/L and the LOQs were estimated as 0.1 nmol/L for all porphyrins. Results obtained from the validation study of porphyrins showed good accuracy, precision, recovery, and stability. Finally, the proposed method was successfully applied to clinical studies on the autism spectrum disorder (ASD) diagnosis of 203 Korean children.