• Clinical and Experimental Pediatrics
• /
• 제64권6호
• /
• pp.310-312
• /
• 2021

• Childhood Kidney Diseases
• /
• 제26권1호
• /
• pp.1-10
• /
• 2022

Congenital isolated hydronephrosis encompasses a spectrum of physiologic states that spontaneously resolve and pathologic obstruction that necessitates surgical intervention. Distinguishing patients whose condition will resolve, those who will require stringent follow-up, and those who will eventually need surgical intervention present a challenge to clinicians, particularly because no unified guidelines for assessment and follow-up have been established. The recognition of the natural course and prognosis of hydronephrosis and a comprehensive understanding of the currently proposed consensus guidelines may aid in multidisciplinary treatment and in providing proper counseling to caregivers. In this review, we aimed to summarize the literature on the grading systems and management strategies for congenital isolated hydronephrosis.

• 대한가정학회지
• /
• 제44권11호
• /
• pp.51-65
• /
• 2006

This study examined the influence of mothers' and children's emotional expressiveness on children's social competence. Sixty-five kindergarten children and their mothers were observed in a lab setting which included 5 free play and 5 task episodes. The children's and mothers' behaviors during these episodes were videotaped and rated by two coders in terms of emotional expressiveness, sociability to others, ability to regulate frustration, compliance, and autonomy. Intercoder reliability between the two coders for each behavioral category ranged from .84 to .99. The results showed that children's social competence was significantly influenced by their positive expressiveness, indicating that children with higher expressiveness were more sociable to others and less frustrated in a stressful situation. Significant relationships were also found between mothers' and children's negative expressiveness, and children's compliance and autonomy. In particular, the consistency between mothers' and children's levels of negative expressiveness significantly predicted the children's compliance and autonomy. The socialization of emotion between mothers and children was discussed, as was the relationship between emotional and social competence. Suggestions for future study were also presented.

• 한국문헌정보학회지
• /
• 제58권1호
• /
• pp.151-179
• /
• 2024

This study aimed to discuss the utilization of a makerspace regarding 3D printers in a children's library by conducting co-design sessions targeting the end-users, children. To achieve this, a program utilizing a 3D printer was conducted for seven children at the Seoul Children's Library, followed by interviews with both the children and their parents. The results revealed several key findings: First, during the design sessions, participating children showed interest in the physical realization of ideas through the use of a 3D printer. Researchers adjusted their level of intervention based on each child's tendency, playing a supportive role. Second, children became aware of various limitations associated with 3D printers and public library makerspace. Third, the rapport between children and researchers positively influenced the design sessions, driven by the active communication of children. This study suggests a reevaluation of the value and necessity of library makerspace from the perspective of user autonomy and creativity and emphasizes the need to closely understand the end user's requirements in establishing operational strategies for library makerspace.

• 한국환경보건학회지
• /
• 제43권3호
• /
• pp.176-184
• /
• 2017

Objectives: Excluding in their homes, children spend most of their time at an elementary school, daycare center, and/or kindergarten. For educational or recreational purposes, they make use of many children's goods at these places. Some children's goods contain phthalates and heavy metals with polyvinyl chloride (PVC), so due to their physiological and behavioral characteristics children are exposed to high concentrations of phthalates and heavy metals. This study aims to measure PVC and heavy metals, which are harmful substances in children's goods which can have an effect on children's health. Methods: Six samples of children's goods were selected through cases of detected harmful substances and the results of previous research, including assembly blocks, model toys, household toys, bags, indoor play equipment, and floor mats. The selected items were measured using X-Ray Fluorescence (XRF), and the presence and content of environmentally harmful substances such as PVC or heavy metals in the materials of children's goods were examined. Results: The highest detection rate for PVC was observed in floor mats, and bags and indoor play equipment were higher than other goods in this regard. The highest detection rate for heavy metals was found in bags, followed by indoor play equipment, assembly blocks, household toys, model toys and floor mats. Except for bags containing heavy metals, five goods showed the highest level of Pb compared to other heavy metals. Floor mats contained the highest level of Pb, Cr, and Cu among all goods. Conclusion: Many children's goods contain PVC and heavy metals, and high levels of heavy metals have been detected in some goods. It is necessary to manage children's goods to support their health.

• Clinical and Experimental Pediatrics
• /
• 제55권7호
• /
• pp.254-258
• /
• 2012

Takayasu arteritis is a chronic inflammatory disease of unknown etiology primarily affecting the aorta and its major branches and usually occurring in the second or third decade of life. Here, we report a case of Takayasu arteritis in a 10-month-old patient. The infant presented with signs of congestive heart failure and severe aortic regurgitation. Echocardiography and computed tomography angiography showed an abnormally dilated thoracic and abdominal aorta. The infant was initially treated with prednisolone, followed by commissuroplasty of the aortic valve but neither approach ameliorated the heart failure. The patient was eventually treated with a mechanical aortic valve replacement surgery at the age of 12 months, and her condition stabilized. Although unusual, this case indicates that the diagnosis of Takayasu arteritis should be considered in children with unexplained systemic symptoms, aortic valve regurgitation, and heart failure. Because severe aortic regurgitation may be a fatal complication of Takayasu arteritis, early aortic valve replacement surgery should be considered, even in very young children.

• Experimental and Molecular Medicine
• /
• 제50권11호
• /
• pp.13.1-13.15
• /
• 2018

Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains unclear. Here, EPCs were isolated from the bone marrow of mice. Treatment of EPCs with melatonin alleviated advanced glycation end product (AGE)-induced apoptosis and cellular dysfunction. We further examined autophagy flux after melatonin treatment and found increased light chain 3 (LC3) and p62 protein levels in AGE-treated EPCs. However, lysosome-associated membrane protein 2 expression was decreased, indicating that autophagy flux was impaired in EPCs treated with AGEs. We then evaluated autophagy flux after melatonin treatment and found that melatonin increased the LC3 levels, but attenuated the accumulation of p62, suggesting a stimulatory effect of melatonin on autophagy flux. Blockage of autophagy flux by chloroquine partially abolished the protective effects of melatonin, indicating that autophagy flux is involved in the protective effects of melatonin. Furthermore, we found that the AMPK/mTOR signaling pathway is involved in autophagy flux stimulation by melatonin. An in vivo study also illustrated that melatonin treatment ameliorated impaired wound healing in a streptozotocin-induced diabetic wound healing model. Thus, our study shows that melatonin protects EPCs against apoptosis and dysfunction via autophagy flux stimulation and ameliorates impaired wound healing in vivo, providing insight into its mechanism of action in diabetic wound healing.

• 아동학회지
• /
• 제34권3호
• /
• pp.129-150
• /
• 2013

The effects of parental attachment and empathy on social competence were examined with a sample of 403 fifth and sixth graders (192 males, 211 females) attending elementary schools in Gyoung-gi province. All research variables were measured using self-reported questionnaires conducted by the children concerned. Data were analyzed by means of structural equation modeling. The results indicated that parental attachment had no direct effect, but there was an indirect effect on children's social competence mediated by children's empathy. Maternal attachment influenced children's social competence relatively more than paternal attachment. As compared to parental attachment, however, children's empathy was the more influential variable when it came to social competence. These results were consistent in both genders. The results of this study emphasize that children's own characteristics such as empathy tend to be important factors in developing social competence compared to the parental role in middle childhood. Accordingly, interventions aimed at improving children's empathy need to be emphasized in order to develop children's social competence regardless of gender.

• Journal of Genetic Medicine
• /
• 제10권1호
• /
• pp.47-51
• /
• 2013

Loeys-Dietz syndrome (LDS) is an autosomal dominant disorder caused by heterozygous mutations in the genes encoding transforming growth factor-${\beta}$ receptor type 1 or 2. It is typically characterized by a triad of hypertelorism, cleft palate or bifid uvula, and arterial tortuosity with aneurysm or dissection. Characteristic vascular abnormalities such as tortuosity, aneurysms, dissections, and stenosis are the most severe complications of LDS and can occur in the neurovascular system. We report a 5-year-old boy who presented with headaches and neurovascular abnormalities and was diagnosed with LDS with a novel mutation of the TGFBR1 gene. It is the first Korean report of neurovascular abnormalities in LDS.

• Advances in pediatric surgery
• /
• 제3권1호
• /
• pp.54-60
• /
• 1997

Eight pediatric patients with Peutz-Jeghers syndrome were treated from 1984 to 1994 at the Department of Surgery, Seoul National University Children's Hospital. We reviewed the clinical features of our own 8 cases as well as 56 cases reported in Korean literatures. The results were compared to those of western reports. Gastrointestinal complications in our series were more frequent than in the Korean series, but the distribution of polyps was similar. The Korean series showed the following characteristics compared to the western reports; demographic backgrounds were similar; gastrointestinal symptoms were more common; location of the polyp was more frequent in colon (2 times); and the most prevalent site of malignant change was the colon in Korean cases.