• Journal of Preventive Medicine and Public Health
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• 제52권4호
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• pp.205-213
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• 2019

Objectives: Maternal folic acid supplementation is considered mandatory in almost every country in the world to prevent congenital malformations. However, little is known about the association of maternal folic acid intake with the occurrence of childhood cancer. Hence, this study aimed to determine the effects of maternal folic acid consumption on the risk of childhood cancer. Methods: A total of 158 related articles were obtained from PubMed, Google Scholar, Scopus, and ProQuest using standardized keywords, of which 17 were included in the final review. Results: Eleven of the 17 articles showed a significant protective association between maternal folic acid supplementation and childhood cancer. Using a random-effects model, pooled odds ratios (ORs) showed a protective association between maternal folic acid supplementation and childhood acute lymphoblastic leukaemia (OR, 0.75; 95% confidence interval [CI], 0.66 to 0.86). However, there was no significant association between maternal folic acid supplementation and acute myeloid leukaemia (OR, 0.70; 95% CI, 0.46 to 1.06) or childhood brain tumours (OR, 1.02; 95% CI, 0.88 to 1.19). Conclusions: Maternal folic acid supplementation was found to have a protective effect against childhood acute lymphoblastic leukaemia. Thus, healthcare professionals are recommended to provide regular health education and health promotion to the community on the benefits of folic acid supplementation during pregnancy.

• 한국전자파학회논문지
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• 제14권10호
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• pp.1017-1023
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• 2003

최근 전기전자기기 등의 사용에 의한 전자파 발생으로 인체 위해성에 대한 논쟁이 시작되었으며, 지난 20여년 동안 고압선로에서 발생되는 극저주파 전자기장에 만성적인 노출로 인한 인체 위해성에 관한 역학적 연구가 많은 나라에서 진행되어 왔다. 2 mG 이상의 자기장에 지속적으로 노출될 경우에 소아백혈병 등과 같은 암 질병이 발생한다는 연구논문이 발표되고 있다. 고압선로로부터 발생되는 전자파에 의한 장기적인 노출과 암 발생에 관한 상관관계가 과학적으로 명확하게 규명되지 않았고, 또한 잠재적인 건강 위험성에 대한 평가가 입증되지 않았음에도 불구하고, 2000년에 스위스는 민감한 정온시설 지역에 대하여 엄격한 예방적 원칙을 적용하고 있으며, 여러 국가들도 이러한 건강 위험성에 대한 저감정책의 일환으로 자기장 노출 가이드라인을 설정하려는 움직임을 보이고 있다. 다시 말하면, 과학적인 불확실성이 높은 상황에서도 과학적인 연구결과만을 기다리지 않고, 잠재적인 위험성을 예견하여 차후 심각한 위험성에 대한 조치를 미리 적용하는 관리정책이다. 우리나라에서는 아직 이러한 건강 위험성에 대한 관리정책이 아직 마련되어 있지 않은 상태이다. 따라서 고압선로에서 발생되는 전자기장에 만성적인 노출과 소아백혈병 발생과의 상관관계를 밝히기 위한 연구를 지속적으로 해야 하며, 유아원, 초등학교 등의 환경민감시설에 대한 단계별 전자파 방출 권고치를 설정하는 등의 예방적 관리정책을 부분적이나마 도입할 필요가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5205-5210
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• 2015

Background: Acute leukaemia is characterized by fast growth of abnormal clones of haemopoietic precursor cells inside bone marrow leading to undue accumulation in the bone marrow. Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. Materials and Methods: The study concerned 50 children diagnosed with ALL (mean age, $8.55{\pm}2.54$) compared to 40 healthy controls (mean age, $8.00{\pm}1.85$). The Hb, serum copper, ceruloplasmin oxidase, advanced oxidation protein products (AOPPs), total antioxidant activity (TAA) and protein were measured in all groups.One proteinous component was isolated by gel filtration chromatography from the precipitate produced by polyethylene glycol. Results: Significantly higher levels of AOPP, copper and decrease in total antioxidant activity were noted in the cases. Statistical analysis also showed a significant increase (p<0.01) in the activity of serum ceruloplasmin oxidase in patients with ALL compared to normal subjects .The maximum velocity (Vmax) and Michaelis constant had values of 104.2 U/L and 11.7 mM, respectively. The ${\Delta}H^*$ values for ceruloplasmin oxidase in ALL patients were positive, confirming the reaction to be endothermic. Conclusions: The results from this study showed a significant increase in AOPP, ceruloplasmine oxidase and decrease in total antioxidant activity .These parameters may play a role in development of DNA damage in childhood patients with acute lymphoblastic leukemia (ALL).The ${\Delta}S^*$ and ${\Delta}G^*$ values were negative, these refer that the reaction of ES formation is spontaneous, but needs energy in a so-called endergonic reaction. Also the negative ${\Delta}S^*$ value of ceruloplasmin oxidase indicates that the complex [$ES^*$] is further modulated through increasing structure arrangement.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1709-1710
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• 2012

Cancer is a major public health problem in Indonesia, becoming the 7th largest cause of death based on a national survey in 2007, accounting for 5.7 of all mortality. A cancer registry was started in 1970, but it was partial and was stopped mainly because no government body was responsible. Realizing the above situation, the Indonesian government established the Sub Directorate of Cancer Control within the Ministry of Health, with responsibility for developing a national cancer control program, including a cancer registry. A sustainable cancer registry was then started in 2007 within Jakarta Province, first hospital-based but then expanded to be population-based. Steps of cancer registration in Jakarta are data collection, data verification, data validation, data management and analysis, and data publication. Data collection is conducted by health facilities (hospitals, laboratories, primary health centers) at the district/municipal level, with reports to the provincial level. Data are collected passively by holding meetings every three months in the district/municipality. Verification of data is the responsibility of the medical doctor or pathologist in each data source. Data validation is conducted by a team in the cancer registry, consisting of district/municipal/province health officers, pathologists, and registrars. Data management and analyses are conducted by a cancer registry team at the provincial level, assisted by the national team. We use software named Indonesian Cancer Registry System (SRIKANDI) which is adopted from CanReg4 IARC. Data from the population-based cancer registry in Jakarta Province showed the leading cancers among females in 2005-2007 to be breast cancer, cervical cancer, ovarian cancer, colorectal cancer and among males are bronchus and lung cancer, colorectal cancer, liver cancer, pharyngeal cancer, and prostate cancer. The leading childhood cancers are leukaemia and retinoblastoma.