• Archives of Pharmacal Research
• /
• v.26 no.8
• /
• pp.585-590
• /
• 2003

Activity-guided fractionation of the EtOAc-soluble extract of the whole plants of Sida acuta using a bioassay based on the induction of quinone reductase (OR) in cultured Hepa 1c1c7 mouse hepatoma cells, led to the isolation of ten active compounds of previously known structure, quindolinone (1), cryptolepinone (2), 11-methoxyquindoline (3), N-trans-feruloyltyramine (4), vomifoliol (5), loliolide (6), 4-ketopinoresinol (7), scopoletin (8), evofolin-A (9), and evofolin-B (10), along with five inactive compounds of known structure, ferulic acid, sinapic acid, syringic acid, ($\pm$)-syringaresinol, and vanillic acid. These isolates were identified by physical and spectral data measurement. A new derivative of quindolinone, 5,10-dimethylquindolin-11-one (1a) was synthesized and characterized spectroscopically. Of the active substances, compounds 1-3 and 1a exhibited the most potent QR activity, with observed CD (concentration required to double induction) values ranging from 0.01 to 0.12 $\mu$ g/mL. Six compounds were then evaluated in a mouse mammary organ culture assay, with cryptolepinone (2), N-trans-feruloyltyramine (4), and 5,10-dimethylquindolin-11-one (1a) found to exhibit 83.3, 75.0, and 66.7% inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions, respectively, at a dose of 10 $\mu\textrm{g}$/mL.

• 한국항공우주법학회:학술대회논문집
• /
• 2008.05a
• /
• pp.75-89
• /
• 2008

• Journal of English Language & Literature
• /
• v.60 no.2
• /
• pp.391-393
• /
• 2014

• Advances in Traditional Medicine
• /
• v.4 no.1
• /
• pp.1-8
• /
• 2004

Ginseng root has been used as a tonic remedy in Traditional Chinese Medicine for centuries. Modern studies have demonstrated that ginseng root has complex components and multiple pharmacological properties. The effects of ginseng leaf, however, are not well known. Recent studies show that compared to ginseng root, ginseng leaf and stem exhibit a higher content of active compositions such as ginsenosides, polysaccharides, triterpene flavonoids, volatile oil, polyacetylenic alcohols, peptides, amino acids and fatty acids. Ginseng leaf possesses multiple pharmacological effects in the central nervous, cardiovascular, growth and metabolism systems. Additionally, the leaf has anti-fatigue, anti-hyperglycemic, anti-oxidant, and anti-aged effects. In general, ginseng leaf is quite safe, but adverse effects may occur if it is abused or is of poor quality. Thus, attention must be paid to dosages, quality, and standardization of ginseng leaf products.

• 식품문화 한맛한얼
• /
• v.3 no.2
• /
• pp.200-205
• /
• 2010

축제가 가지는 많은 속성 중 하나는 일탈성과 장소성이다. 축제는 일상을 벗어나지 못한 사람들에게 일상에서 느낄 수 없는 새로운 기회를 제공할 수 있는 기능이 있어야 한다. 하지만 축제의 정체성을 유지하기 위해서는 일상생활에서 유리되면 안 된다. 축제는 일상에 기반을 두어 일상에서의 벗어남을 제공해주어야 한다. 이 글에서는 Taste of Chicago를 소개해 본다. Taste of Chicago는 미국에서 꼭 가봐야 할 만큼 유명한 축제는 아니지만 도시의 삶 속에서 도시의 축제를 만들어가는 미국 축제의 일면을 보여주는 축제여서 소개하고자 한다.

• 대한생식의학회:학술대회논문집
• /
• 2007.11a
• /
• pp.98.1-98.1
• /
• 2007

• Advances in Traditional Medicine
• /
• v.2 no.2
• /
• pp.80-86
• /
• 2002

Ginseng is a perennial herb widely used in China, Japan, and Korea. It is also one of the most commonly used herbal medicines in the U.S. Although it is generally considered safe to use, adverse effects associated with ginseng use have been reported. Inappropriate ginseng use, such as high dose administration, may cause insomnia, headaches, diarrhea, as well as cardiovascular and endocrine disorders. Other factors that may contribute to adverse effects of ginseng include the variety of ginseng species, variability in commercial ginseng preparations, and potential ginseng-drug interactions. To minimize adverse effects of ginseng, consumers should be advised to use it appropriately, and the herbal industry should try to provide standardized ginseng preparations.

• Advances in Traditional Medicine
• /
• v.3 no.2
• /
• pp.51-55
• /
• 2003

Resibufogenin is a single compound isolated from the skin venom gland of the toad (Bufo bufo gargarizans cantor). Formulations containing toad venom have been widely used as complementary and alternative medicines. However, like digitalis, resibufogenin possesses both pharmacological and toxicological activities. Our previous data indicated that resibufogenin induces electro-toxicity, including delayed afterdepolarization and triggered arrhythmias at high concentration, both in cardiac fiber in vitro and in beating heart in vivo.

• Proceedings of the Ginseng society Conference
• /
• 1998.06a
• /
• pp.138-145
• /
• 1998

A validated and reproducible HPLC method was developed for the profiling and quantitative analysis of ginsenosides in commercial products available in North America. Analysis of 280 Panax ginseng and Panax quinquefolius products showed profiles indicative of the presence of ginsenosides in the majority of these products. However, the quantitative contents of the products vary greatly, not only in products of different formulations, but also of products within each of the fromulations examined.

• Archives of Pharmacal Research
• /
• v.23 no.3
• /
• pp.243-245
• /
• 2000

The diethyl ether extract of isodon excisus var. coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin(ent-1${\alpha}$-hydroxy-3${\beta}$,6a-diacetoxykau r-16-en-11,15-dione) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).