• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.433-441
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• 2010

Chenopodium album Linne (CAL) is a fast-growing weedy annual plant. The leaves and young shoots may be eaten as a leafy vegetable. In oriental medicine, CAL has been used for treatment of skin disease, fever, stomach ache, toothache, and paralysis. After a preliminary screening of CAL ethanol extract and its fractions obtained from CAL leaves for anti-gastritic and anti-Helicobacter pylori (H. pylori) activity, the butanol (BuOH) fraction was found to have the most significant effect. We also examined antioxidative properties of the total CAL extract and its fractions, and also betaine as an ingredient of the BuOH fraction. To investigate the antioxidant effects of CAL on gastritis, the reducing power, free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH), and lipid peroxidation effects were determined. Additionally, the BuOH fraction reduced cell viability in a concentration dependent manner in human gastric cancer cell lines. The results of this study revealed that CAL has excellent antioxidant activity, and may be useful in treating gastritis and gastric cancer.

• Biomolecules & Therapeutics
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• v.19 no.4
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• pp.487-492
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• 2011

In our previous study, we investigated Chenopodium album Linne (CAL) ethanol extract and its fractions on anti-gastritic actions using the HCl/ethanol and indomethacin induced gastric lesion model and Helicobacter pylori (H. pylori). Based on the results, butanol fraction was most effective among fractions obtained from CAL. This study aims to elucidate the mechanisms of butanol fraction, and betaine as a constituent of the butanol fraction, on gastritis and anti-gastric cancer cell growth. First, we examined antioxidant properties using hydrogen peroxide and superoxide radical, and we found that butanol fraction and betaine may be good antioxidants. Second, cytotoxicity was assessed by measuring cell viability and 4,6-diamidino-2-phenylinodole dihydrochloride (DAPI) staining of human gastric cancer cells (AGS cells). We also examined the relationship between the cytotoxicity and intracellular $Ca^{2+}$ signaling mechanism. The butanol fraction demonstrated cell viability 71.49% at the concentration of 100 ${\mu}g/ml$ and increased intracellular $Ca^{2+}$ concentration in a dose dependent manner. Finally, we observed the mucus content as a defensive factor and gastric secretion as an aggressive factor, and found that the mucus content noticeably increased when treated with butanol fraction and betaine and gastric secretion decreased when treated with betaine in vivo study. From these results, we suggest that CAL butanol fraction and betaine may have protective effects on gastritis.

• Journal of environmental and Sanitary engineering
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• v.5 no.2
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• pp.105-116
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• 1990

Seungbong Island is situated about 100km away Inchon Port in the western sea of the Korean Peninsula. Field investigations were conducted for two days each from June 30 through July 1, 1981 and from August 20 through 21, 1981. The results obtained are summarized as follows: Plants growing in this island consist of a total of 193 species (70 families, 151 genera, 170 species, 22 varieties and 1 forma). Pinus thunbergii was confirmed to be the dominant species. The natural degree observed in this island was high, as a whole. The coefficient of ferny plants (Pte-Q) is 0.95, lower than grass. Atractylodes japonica Koidz., Miscanthus sinensis Anders. var. purpurascense Rendle, and Rhododendron mucronulatum Turz. are distributed mainly on the forest bed of Pinus thunbergii. The poor distribution of Chenopodium album var. centrorubrum Makino, Setaria viridis (L.) Beauv., Amaranthus mangostanus Linne is considered attributable to the phenomenon of allellopathy caused by a chemical substance secreted from the leaves of Pinus thunbergii. The component ratio of species in this island is lower than that of other islands due probably to the small area of arable land and grassland. The poor growth of plants in the forest of Pinus thunbergii, the dominant species in this island, seems to be attributed to the low relative light intensity of the forest. Seaside plants consisting of a total of 7 species were distributed mainly in the vicinity of sandy beaches. Naturalized plants comprising a total of 11 species were relatively diversified in the number of species.