• BMB Reports
• /
• v.41 no.10
• /
• pp.716-721
• /
• 2008

To explore the effects of deregulated expression of the EBNA1 binding protein 2 (EBP2) on cell growth, we generated human HEK293 stable clones constitutively expressing an EBP2-EGFP fusion protein. We found both RNA and protein levels of cyclin E1, a dominant oncoprotein, were elevated in the EBP2- EGFP stable clones. These findings were confirmed by flow cytometry bivariate analysis of cyclin expression versus DNA content. Moreover, the increase in p21 expression and the specific phosphorylation at Ser1981 of ATM and Ser15 of p53 were also observed in these stable clones, and these observations may explain the failure to observe an increase in Cdk2 kinase activity. In addition, after one year of passage culture, the EBP2-EGFP stable clones tended to lose 4 to 5 chromosomes per cell when compared to that of control cells. All of these findings provide a possible link between deregulated expression of EBP2 and tumor development.

• Bulletin of the Korean Chemical Society
• /
• v.34 no.6
• /
• pp.1891-1894
• /
• 2013

• Bulletin of the Korean Mathematical Society
• /
• v.54 no.2
• /
• pp.359-373
• /
• 2017

In this paper, we propose the Stancu type generalization of a kind of modified q-Gamma operators. We estimate the moments of these operators and give the basic convergence theorem. We also obtain the Voronovskaja type theorem. Furthermore, we obtain the local approximation, rate of convergence and weighted approximation for these operators.

• Bulletin of the Korean Chemical Society
• /
• v.26 no.10
• /
• pp.1631-1634
• /
• 2005

• 대한생식의학회:학술대회논문집
• /
• 2006.06a
• /
• pp.158.1-158.1
• /
• 2006

• 대한생식의학회:학술대회논문집
• /
• 2006.06a
• /
• pp.158.2-158.2
• /
• 2006

• Bulletin of the Korean Chemical Society
• /
• v.27 no.8
• /
• pp.1206-1210
• /
• 2006

Four isostructural amino-acid-based polyoxomolybdates, {$M(H_2O)_3(pro)Mo_4O_{13}$}$_2{\cdot}2H_2O$ (pro = proline, M = Co (1), Ni (2), Cu (3), Zn (4)), have been synthesized and structurally characterized by single crystal X-ray diffraction, elemental analysis, IR spectrum, TG analysis. The structures of 1-4 are layered networks built up from {$Mo_8O_{26}(pro)_2$}$^{4-}$ units and {$M(H_2O)_3O_3$} octahedra, the uncoordinated water molecules occupying the interlayer regions.

• Nuclear Engineering and Technology
• /
• v.54 no.2
• /
• pp.617-626
• /
• 2022

To effectively monitor the variety of distributions of neutron flux, fuel power or temperatures in the reactor core, usually the ex-core and in-core neutron detectors are employed. The thermocouples for temperature measurement are installed in the coolant inlet or outlet of the respective fuel assemblies. It is necessary to reconstruct the measurement information of the whole reactor position. However, the reading of different types of detector in the core reflects different aspects of the 3D power distribution. The feasibility of reconstruction the core three-dimension power distribution by using different combinations of in-core, ex-core and thermocouples detectors is analyzed in this paper to synthesize the useful information of various detectors. A comparison of multilayer perceptron (MLP) network and radial basis function (RBF) network is performed. RBF results are more extreme precision but also more sensitivity to detector failure and uncertainty, compare to MLP networks. This is because that localized neural network could offer conservative regression in RBF. Adding random disturbance in training dataset is helpful to reduce the influence of detector failure and uncertainty. Some convolution neural networks seem to be helpful to get more accurate results by use more spatial layout information, though relative researches are still under way.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.9 no.1
• /
• pp.73-78
• /
• 2004

The impact of low concentration fluoride on toxification was studied by treating $3^rd$ instar silkworm larvae of Qiufeng${\times}$Baiyu (Fluoride resistant strain) and Jinshong${\times}$Haoyue (Fluoride sensitive strain). The $5^th$ instar silkworm larvae of Zhenong-l, Shu-12, Qiufeng ${\times}$ Baiyu, Chunhua ${\times}$ Qhiushi, Jinshong and Haoyue were fed mulberry leaves treated with sodium fluoride at different concentrations to determine its effect on fecundity. Harmful effects of low concentration fluoride at early instars on growth, development and economic characters of Bombyx mori are related to its resistance. Harmful effect on resistant strain Qiufeng${\times}$Baiyu manifested on prolongation of instar duration of 15 and 6% in 70 ppm, where as the sensitive breed Jinshong${\times}$Haoyue manifested with 100% mortality in 50 ppm. The impact of low concentration fluoride on fecundity resulted in considerable increase in formed eggs (9%) and laid eggs (9%) in Zhenong-l and Shu-12 among treated population over control. The present observations emphasis that fluoride apart from exhibiting harmful effects on silkworm growth and development, however, its low concentration do playa vital role in inducing some positive effect on fecundity and cocoon traits.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.9 no.1
• /
• pp.114-125
• /
• 2017

This paper addresses a study of inner-tank sloshing effect on motion responses of a Floating Liquefied Natural Gas (FLNG) system, through experimental analysis and numerical modeling. To investigate hydrodynamic characteristics of FLNG under the conditions of with and without LNG-tank sloshing, a series of numerical simulations were carried out using potential flow solver SESAM. To validate the numerical simulations, model tests on the FLNG system was conducted in both liquid and solid ballast conditions with 75% tank filling level in height. Good correlations were observed between the measured and predicted results, proving the feasibility of the numerical modeling technique. On the verified numerical model, Response Amplitude Operators (RAOs) of the FLNG with 25% and 50% tank filling levels were calculated in six degrees of freedom. The influence of tank sloshing with varying tank filling levels on the RAOs has been presented and analyzed. The results showed that LNG-tank sloshing has a noticeable impact on the roll motion response of the FLNG and a moderate tank filling level is less helpful in reducing the roll motion response.