• 한국안전학회지
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• 제37권6호
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• pp.25-31
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• 2022

In this study, the spill and leak system is developed to provide real-time remote monitoring of industrial complexes where chemical accidents have been occurring every year. The spill and leak monitoring system uses IR-RCD equipment mounted on a 70m-high steel tower to detect chemical substances, thereby detecting chemical accidents such as leaks, fires, and explosions in real time. If IR-RCD equipment can actually detect chemical substances at a long distance, accurate and rapid initial response can be expected. Therefore, in order to confirm that IR-RCD equipment can detect chemical leakage accidents occurring at a long distance, acetone was selected as the experimental substance and a detection experiment was designed. The experiment was conducted using the acetone pool evaporation method at the wharf which was located 1.5 km away from IR-RCD equipment, and it was confirmed whether IR-RCD equipment could detect acetone in real time through the control monitor.

• Toxicological Research
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• 제9권1호
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• pp.83-98
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• 1993

LBD-007, a newly developed recombinant human interferon alpha A, was at dose levels of 0, 3 $\times$ $10^6$, 6 $\times$ $10^6$ and 12 $\times$ $10^6$ IU/kg/day administered subctaneously to pregnant Sprague-Dawley rats during the organogenetic period. Ethylenethiourea was used as a positive control. 2/3 of dams per group were subjected to caesarean section on day 20 of pregnancy and the remaining 10 dams per group were allowed to deliver. Effects of test substance on dams, embryonal development development of F1 fetuses, as well as growth, behaviour and mating performance of F1 offspring were examined. 1. No treatment-related changes in clinical signs, food consumption, body weight and necropsy findings of dams were observed.

• Journal of Microbiology and Biotechnology
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• 제8권5호
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• pp.455-460
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• 1998

In the course of screening for new antitumor substances, a novel cytotoxic agent inducing apoptotic cell death was isolated from the culture broth of marine bacterial strain SCRC A-20. Strain SCRC A-20 was separated from a mollusk and was chemotaxonomically identified as a Streptomyces sp. The cytotoxic substance was purified by organic solvent extraction followed by silica gel column chromatography and preparative TLC. HRFAB-MS determined its molecular formula to be $C_{30}H_{40}N_2O_5$ (MW 508). The 1D and 2D NMR spectral data demonstrated that the substance has a novel lactam structure of a 20-membered macrocycle coupled with a unique acyl tetramine and bicyclo［3.3.0］ octane, which includes three methyl groups, six olefinic protons, five carbonyl groups, a conjugated diene and a dienone. The substance, named aburatubolactam C, appeared to be cytotoxic for various continuously proliferating tumor cells of human and murine origins. The $IC_{50}$ values determined by MIT assay were in the range of 0.3 to $5.8\mug/ml$. When Jurkat T cells were treated with $3\mug/ml$. of aburatubolactam C, the apoptotic DNA fragmentation was detectable within 3 h, indicating that the cytotoxic effect of aburatubolactam C on tumor cells is attributable to the induced apoptosis.

• 한국미생물·생명공학회지
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• 제5권1호
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• pp.36-45
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• 1977

공시균의 배양여액으로부터 독성물상을 chloroform 에 전용하여 농축한 후 avicel column chromatography 및 avicel TLC로 정제하였다. 독성물질 생성에 요구되는 영양원은 생육에 필요한 영양첨과 일치하지 않았으며 Valine, asparagine, arginine, 요소, D-glucose, D-mannose, L-rhamnose, D-ribose, D-xylose, D-arabitol, starch 등이 독성물질생성에 요구됨이 인정되었다. 또한 오탄당의 대사과정중 ribose, xylose, fructose, glucose가 대사되는 과정이 본 물질생성의 주된 경로로 추정된다. Vitamin류는 무관함에 비해 Mg가 필수적으로 요구되었다. 물질의 생성은 균의 증식에 비례되었으며 6일간 3$0^{\circ}C$에서 배양했을때 가장 많이 생성되었다. 독성물질 처리후의 잉어 조직은 아가미 신장 췌장등에서 핵진의 굴곡과 더불어 접의 심한 수축과 세포질의 괴사가 현저하였다. 본 물질의 화학식은 $C_{38}$ $H_{66}$ $NO_4$로 추정되며 UV조사시 회청색형광을 나타내었다.

• 한국재난정보학회 논문집
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• 제11권4호
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• pp.515-519
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• 2015

'13년 87건, '14년 104건의 화학사고는 인명과 환경에 막대한 피해를 가져왔다. 또한 산업계는 피해처리와 복구에 많은 비용지출을 하였고 기업이미지에 큰 영향을 받았다. 대기 중으로의 빠른 확산과 독성을 갖는 화학사고는 근로자 뿐만 아니라 주변 거주 주민 등에도 위협적인 존재이다. 이러한, 화학사고의 원인을 철저히 분석하기 위해서는 체계적인 조사절차와 신뢰성 있는 결과가 도출되어야 한다. 본 연구를 통해 사고조사를 담당하는 각 기관의 제도를 비교 분석하여 화학사고 현장조사 체계마련 시 기본 자료로 활용이 가능할 것으로 판단된다.

• 한국산업보건학회지
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• 제25권4호
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• pp.446-464
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• 2015

Objectives: This study was conducted to evaluate the task-specific hazards of chemicals used by nail technicians in Daegu Metropolitan City. Materials: A total of 30 nail shops located in Daegu City were surveyed to investigate the major tasks and practices performed by nail technicians and the ingredients listed in nail care products used in shops. We also collected instructions for use and material safety data sheets(MSDSs) of nail care products and compared CAS Nos. of ingredients with the lists of chemicals regulated by the Industrial Safety and Health Act(ISHA) and Chemical Substances Control Act(CSCA). Results: A total of 125 chemical ingredients were found in 468 nail care products used at the 30 nail shops. The most frequently found ingredients were ethyl acetate(72%), followed by n-butyl acetate(71.8%), isopropanol(56%), benzophenone(51.1%), nitrocellulose(46.4%) and ethanol(45.3%). Comparing six tasks, the task of manicuring used the most products at 222 products containing 91 ingredients. Among the 125 ingredients, there are 31 chemicals with occupational exposure limits(OEL) designated by the Ministry of Employment and Labor(MoEL), eight categorized as carcinogens, one mutagen and two reproductive toxic chemicals. In terms of carcinogens, formaldehyde was identified as the only confirmed human carcinogen(1A). We found that there was one chemical with a permissible limit, one special management substance, 18 workplace monitoring substances and ten special health diagnosis substances regulated by ISHA. For CSCA, nine poisonous substances, six substances requiring preparation for accidents and one restricted substance were identified. Conclusions: Based on these findings, formaldehyde was identified as one of the chemicals that should most strictly be controlled for the protection of the health of nail technicians and customers. At the same time, it is necessary to distribute materials with detailed hazardous information of nail care products for nail shop technicians.

• 한국산업보건학회지
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• 제23권4호
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• pp.367-373
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• 2013

Objectives: Employee exposure record refers to a record containing information about environmental (workplace) monitoring or measuring of a toxic substance or harmful physical agent. The aims of this study were to examine problems related to exposure records and provide some amendments to the Korean Industrial Safety & Health Act for the effective management of chemical substances under the law. Methods: This study performed a literature search and review on legal provisions related to exposure records of a number of different countries, including Korea, the USA, Japan, EU, Germany, and the UK. They were compared and investigated and the amendment of articles was suggested. Results: The results of this study were provided as suggested amendments to the related act. There were a variety of ways of improvement, including a 30-year retention period and the introduction of new access methods, contents, transfer, and maintenance methods. All exposure data elements have to be standardized, including reference to a similar exposure group (SEG), sampling strategy, and circumstances of exposure (e.g., date, shift length, use of personal protective equipment, etc.). The SEGs are described by process, job, task, and environmental agent. Conclusions: This study is expected to provide for the amendment of the related act in order to ensure effective management of exposure records and is helpful for solving the cause and result of occupational disease by keeping exposure records according to the Industrial Safety & Health Act.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.2
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• pp.818-821
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• 2003

Ozonic use of sterilization and heat treatment of raw material to extend the conservation period of food recently is increased by hard vegetable or microorganism sterilization purpose of fruit. If ozone can create as is easy comparatively because do air or oxygen by raw material and schedule period passes, there is advantage that do not leave the second contaminant because being gotten restored by oxygen. Also, because the effect is big to decolorization beside sterilization effect about microorganism, deodorization, disjointing of venomousness hazardous substance, food save, indoor air purge, good hand processing, hydrospace agricultural chemicals processing etc. the use extent is wide. This research ran parallel a sterilization experiment of E.coli colitis germs by ozone that manufacture ozonizer that use doped diamond maund electrode (BDD) by boron and searched special quality electrochemistry enemy of the ozonizer and is created. E.coli. After cultivate E.coli colitis germs during 37C 1 day is LB ship, after do ozonation, was sterilized more than 90% by ozone as result that examine sterilizing power by substance microscope and could confirm excellency of diamond electrode.

• Korean Chemical Engineering Research
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• 제54권4호
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• pp.465-469
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• 2016

공정의 안전을 위해서 취급물질의 정확한 연소특성치의 사용은 매우 중요하다. 화학산업에서 다양하게 사용되고 있는 큐멘의 안전한 취급을 위해서 인화점과 최소자연발화온도를 측정하였다. 폭발하한계는 실험에서 얻어진 하부인화점을 이용하여 계산하였다. 큐멘의 Setaflash 밀폐식은 $31^{\circ}C$, Pensky-Martens 밀폐식에서는 $33^{\circ}C$ 그리고 Tag 개방식에서는 $43^{\circ}C$, Cleveland 개방식에서는 $45^{\circ}C$로 측정되었다. ASTM E659 장치에 의한 큐멘의 최소자연발화온도는 $419^{\circ}C$로 측정되었다. 측정된 하부인화점 $31^{\circ}C$에 의한 폭발하한계는 0.87 vol%로 계산되었다. 폭발한계는 측정된 인화점이나 문헌에 제시된 인화점을 이용하여 예측가능함을 알 수 있었다.

• 한국식품영양과학회지
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• 제35권2호
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• pp.177-181
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• 2006

야생 및 재배지치의 methanol 추출물로 조제한 n-herane 용매 분획물에 대하여 shikonin 및 그 유도체 화합물을 표품으로 해서 HPLC/MS로 물질을 분리하였다. 분리된 물질의 구조 확인을 위해 $^1H-NMR$, $^{13}C-NMR$을 통해 분석한 결과, compound I은 화학식이 $C_{16}H_{16}O_5$이며 분자량이 288.3인 shikonin이었고, compound II는 화학식이 $C_{16}H_{16}O_4$이며 분자량이 272.3인 deoxyshikonin것으로 밝혀내었다. 야생지치에 함유된 shikonin과 deoxyshikonin은 $2.23\%,\;0.87\%$이었고, 재배지치에는 각각 $2.24\%,\;0.41\%$이었다. 지치의 동정된 색소물질 총량은 야생지치 $3.12\%$, 재배지치 $2.64\%$로 야생지치가 재배지치보다 유의적으로 많았다(p<0.05).