• The Journal of Internal Korean Medicine
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• v.21 no.1
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• pp.65-73
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• 2000

Objectives : The effects of cotreatment of adriamycin and ethanol extract of herb (Palgin-tang hab Hwajuck-hwan a traditional medicine for cancer treatment in oriental medicine) on the induction of apoptotic cell death were investigated in human liver origin cell lines, Chang. Methods : Chang(ATCC) liver cells were cultured in RPMI-1640(Gibco SRL Co, Gaithersburg, MD) badge including 10% fetal bovine serum. Chang liver cells were treated with various concentrations(from 10 to $0.16{\mu}l$) of adriamycin and herb extract(from 500 to $31.25{\mu}l$) After 48h later, the cells were tested for viability by Crystal violet staining assay. Adriamycin and Herb extract induced ladder pattern of DNA fragmentation in Chang cells. Genomic DNA was isolated and separated on 1.5% agarose gels. The DNA was stained with ethidium bromide and visualized under UV light. Results : The death of Chang cells was synergistically induced by the cotreatment of adriamycin and ethanol extract of herb. In addition, the cotreatment-induced cell death of Chang cells was mediated by apoptotic death signal processes. The phosphotransferase activity of JNK1 remained in a basal level in Chang cells which was treated individually with the adriamycin and ethanol extract of herb. However, it was markedly increased in Chang cells which was cotreated with adriamycin and ethanol extract of herb. In addition, the expression of Fas and FasL was markedly induced by the cotreatment of adriamycin and herb extract. For a while, the expression of Sax was a eminently increased by the ethanol extract of herb. However, Scl2 expression was not affected by the individual or cotreatment of adriamycin and herb extract. Conclusions : our results suggest that the cotreatment of adriamycin aM ethanol extract of herb induces synergistic apoptotis of human liver origin Chang cells via the upregulation of JNK, Fas, FasL and Bax.

• Journal of Sasang Constitutional Medicine
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• v.8 no.2
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• pp.41-68
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• 1996

This thesis is a try for examining the historical characteristics of Constiutional medicine. For this purpose, I have examined their theory, and made a comparison carefully. Through this study, I have obtained several results as following. Both Chang and Lee lived in the time of change, which was unstable and uncertain. Under the condition, they both rejected following the existing trends of learned circles, and developed new thoughts and clinical techniques. They rejected superstitious beliefs and fatalism, and conducted the pursuit of experimental knowledge and rationale idea. Clinical experience was the very base of their study. They both criticized the bad habits of abuse of tonifing medication and health seeking. Especially Lee regarded control of emotion and regulation of a way of life as the best way for preservation of one's health. Chang regarded pathogenic factors as the ultimate factor of diseases, and strived for eliminating pathogenic factors, but L brought to a conclusion that the final factor of diseases was what is called "heart" itself, and emotional changes were the most essential causes of disease. It can be said that the pathogenesis insisted by Chang can be called The insistence that pathologic factors are the very etiology of all the disease (邪氣致病論), or all the diseases result from pathologic factors. And his whole remedy can be summarized as following, A study on the method of eliminating pathogenic factors. But the purpose of Constitutional medicine is to correct imbalance intrinsic to one's internal organs. In this aspect, Constitutional medicine is a "regulatory medicine". Depending on the classification of six vital substances, Chang classified all disease into six categories. These were based on symptoms and sings represented. While classification of diseases made by Lee was likely to rely upon constitutional characteristics. Chang thought that the three remedies made up of perspiration, purgation, vomiting were the most efficient way of eliminating pathogenic factors. Lee, however, thought those weren't methods of eliminating pathogenic factors but the best ways restoring one's self-regulation power. Chang thought that all the febrile disease essentially has a tendency in properties to belong to "heat", but Lee pointed out that pathologic processes are variable in accordance with constitutional features. They both regarded pathogenesis of diabetes as fire. That is to say, fire is the most essential factor of diabetes. And there are many risk factors such as inappropriate foods, drugs, climate, etc., but Lee thought what is most important is heart. Putting all accounts together, medical characteristics of Chang are similar to those of T aiyinjen and Shaoyangjen, and have no relation to those of those of Shaoyinjen. Therefore we can conclude that Chang understood pathologic processes of disease of T aiyinjen and Shaoyangjen, whether he knew about constitutional features or not.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2000.06a
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• pp.205-218
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• 2000

Hull forms of Jiao Yi Ship for shipping and foreign trade in Silla and Tang Dynasty were transformed and developed in accordance to their voyage and rational routes. The trade ship was a sea ship, used by Chang Po Go's, the Silla great sea merchant ship, in the marine trade with China during the 8th and 9th century. It is not easy to presume the hull type and trade formal of Chang Po Go's Jiao Yi Ship of the 8th and 9th Century. Studying on the ship type of the trade ship is the urgent problem to be solved, in the sphere of leaning about the history of communication between China and Korea. The authors take the initial prove into this subjects, by researching Chang Po Go's marine activities, and point out that the trade ship's original type should be the Sha Ship which was the sea ship sailing th sea in northern China, in the Tang Dynasty. This study aims to present materials concerning hull forms of Chang Po Go's Jian Yi Ship by analysing ancient voyage history, foreign trade history, and ship history of Silla, Tang and Japan during the 8th and 9th century.

• Journal of the Earthquake Engineering Society of Korea
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• v.22 no.1
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• pp.33-43
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• 2018

'Seismic Performance Evaluation Method for Existing Buildings (2013)' developed in accordance with the overseas guidelines ASCE 41 - 06 is the most widely used procedure among domestic seismic performance evaluation guidelines in Korea. However, unlike ASCE 41 - 06, it stipulates that the final performance should be derived as the gravity load distribution ratio of the lateral force resistance system in the guideline. Therefore, in the case of a dual steel structure system with slender braces, where the internal moment frame is mostly responsible for the gravity load, the evaluation of slender braces based on gravity load distribution ratio is difficult to be achieved. In this research, we propose an objective evaluation process for such system by evaluating seismic performance for large-scale factory facilities as an example.

• Journal of the Optical Society of Korea
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• v.20 no.5
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• pp.541-546
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• 2016

In this paper, by using the Rayleigh-Sommer field theory and the cross-spectral density function, the analytical expression for the intensity distribution of a double half-Gaussian hollow beam in a turbulent atmosphere is obtained. The influence of the initial spot size of this beam on its propagation properties in a turbulent atmosphere is simulated, and the intensity distributions for such beams with different spot sizes are obtained. The results show that the initial spot size has an important influence on the propagation properties in the near field, while this influence in the far field is very weak.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.229-234
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• 2006

There are still some key problems having to be solved in theory and technique applications when GPS is used to monitor the vertical deformation of ground with high precision. Utilizing the GPS technology to monitor the deformation of the land subsidence and ground fissure in Xi'an, this paper puts forward advice that the datum frame of GPS network has significant influence on the precision and accuracy of the vertical deformation results by some research. The co-authors make some theoretical study of the datum error and practice by establishing the datum error models, especially the influence of scale and azimuth datum errors on GPS monitoring network. Then the datum frame design methods and arithmetic of GPS monitoring network are presented and have taken a good effect.

• Journal of Korea Foundry Society
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• v.17 no.5
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• pp.450-457
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• 1997

Effects of Ti addition and homogenizing heat treatment on the mechanical properties in Cu-Zn-Al alloy (high strength yellow brass) were investigated. Grain refinement was successfully achieved by Ti addition. The microstructure, which was composed of island or fine feather-like branched Ti compounds was changed to feather-like eutectic microstructure as the content of Ti increased. The highest hardness value was obtained for 0.5 wt.% Ti specimen and the second was Ti non-added specimen in as-cast condition. The highest tensile strength was obtained for 0.5 wt.% Ti specimen. Because of the presence of cast defects and worse castability, tensile strength decreased as the content of Ti increased. Elongation increased with increasing homogenizing time and temperature; remarkable increase was obtained for $400^{\circ}C$ homogenizing temperature in the 0.5 wt.% Ti specimen. For $500^{\circ}C$ and $600^{\circ}C$ homhgenizing, temperature, high elongation was obtained in 2 and 4 wt.% Ti specimen.

• Journal of Korea Foundry Society
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• v.17 no.5
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• pp.443-449
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• 1997

The purpose of this study is to investigate the effect of P addition and homogenizing heat treatment on the mechanical properties of Cu-Sn-Ni alloy. The addition of P was 0.025wt.%P to 0.085wt.%P and homogenizing heat-treated at 400, 500, $600^{\circ}C$ under $N_2$ gas atmosphere. Mechanical properties was investigated in this study were Rockwell hardness, tensile strength, and elongation. Tensile strength and elongation increased with P and homogenizing time. Temperature was significantly influence on mechanical properties. Hardness decreased with increasing homogenizing time and temperature, but 0.085wt.%P specimen was showed higher hardness and lower tensile strength and elongation than 0.073wt.%P specimen due to the presence of more $Cu_3P$ in matrix.

• Steel and Composite Structures
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• v.32 no.2
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• pp.265-279
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• 2019

The self-centering capacity and energy dissipation performance have been recognized critically for increasing the seismic performance of structures. This paper presents an innovative steel moment frame with self-centering steel reinforced concrete (SRC) wall panel incorporating replaceable energy dissipation devices (SF-SCWD). The self-centering mechanism and energy dissipation mechanism of the structure were validated by cyclic tests. The earthquake resilience of wall panel has the ability to limit structural damage and residual drift, while the energy dissipation devices located at wall toes are used to dissipate energy and reduce the seismic response. The oriented post-tensioned strands provide additional overturning force resistance and help to reduce residual drift. The main parameters were studied by numerical analysis to understand the complex structural behavior of this new system, such as initial stress of post-tensioning strands, yield strength of damper plates and height-width ratio of the wall panel. The static push-over analysis was conducted to investigate the failure process of the SF-SCWD. Moreover, nonlinear time history analysis of the 6-story frame was carried out, which confirmed the availability of the proposed structures in permanent drift mitigation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.16 no.2
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• pp.121-127
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• 2006

Recently, Chang et at.$^[9]$ proposed a new password-based key agreement protocol and a password change protocol to improve the efficiency in the password-based authenticated key agreement protocol proposed by Yeh et at.$^[8]$. However, Wang et al.$^[10]$ showed that their protected password change protocol is not secure under the denial of service attack and the dictionary attack This paper proposes an improved password change protocol to solve this problems in the Chang et al's protocol. In the proposed protocol, the format of communication messages is modified not to have any clue for the guessing of the password and verifying of the guessed password. The proposed protocol supports the advantages in the previous password-based protocols and solves the problems in them effectively.