• 대한토목학회논문집
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• 제30권4B호
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• pp.389-397
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• 2010

본 논문에서는 극치수문자료의 경향성 분석 개념을 소개하고 이를 빈도해석과 연계시켜 해석하는 방법론을 제시하고자 Gumbel 극치분포를 기반으로, 시간변화에 의한 수문빈도 특성 변화를 모의할 수 있는 Bayesian 모형을 구성하였다. 사후분포의 매개변수는 깁스표본법에 의한 Markov Chain Monte Carlo Simulation을 통해 추정하였으며, 이를 통해 경향성을 고려한 확률강우량과 불확실성 구간을 추정하였다. 또한 경향성을 고려한 확률강우량이 현재 알려진 확률강우량을 초과할 확률을 통해 동적 위험도 해석과정을 소개하였으며, 현재의 경향성에 대해서 시간에 따라 연속으로 추정된 확률밀도함수를 비교하여 수문학적 위험도가 증가할 수 있음을 모의결과를 통해 확인하였다. 이와 더불어 단순히 경향성의 존재여부를 확인하는데 그치지 않고 사후분포를 통해서 통계적 추론을 수행함으로써 경향성에 대한 통계학적인 유의성을 정량적으로 평가할 수 있었다.

• 한국수자원학회논문집
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• 제48권12호
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• pp.969-979
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• 2015

본 연구에서는 가뭄의 특성분석에 유리하며, 확률론적 접근이 가능한 은닉 마코프 모델(HMM) 기반의 가뭄 분석 기법을 적용하였다. HMM 기반의 가뭄의 심도뿐만 아니라 지속시간을 동시에 평가할 수 있도록 코플라 함수 기반의 이변량 가뭄빈도해석 기법을 도입하여 우리나라의 2015년 가뭄 빈도를 평가하였다. 가뭄빈도분석 결과 최근 40년 자료를 기준으로 영동지방에 비해 영서지방이 전체적으로 가뭄이 발생할 경우 가뭄의 심도가 큰 것으로 평가되었다. 심한가뭄의 발생 비율의 경우에 철원의 경우 10%를 상회하는 등 임진강 유역에서 상대적으로 심한가뭄의 발생비율이 크다는 것을 확인할 수 있었다. 한강유역 일부지점에서는 2014/2015년의 가뭄 지속기간 및 심도의 결합재현기간이 1,000년이 넘는 가뭄이 발생하고 있는 것으로 평가되었다. 특히 북한강 및 임진강 유역에 심한 가뭄이 발생하고 있으며 전반적으로 100년 이상의 기왕최대가뭄을 나타내고 있는 것으로 판단되었다.

• Molecules and Cells
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• 제38권11호
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• pp.950-958
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• 2015

BCS1L gene encodes mitochondrial protein and is a member of conserved AAA protein family. This gene is involved in the incorporation of Rieske FeS and Qcr10p into complex III of respiratory chain. In our previous study, AluYRa2-derived alternative transcript in rhesus monkey genome was identified. However, this transcript has not been reported in human genome. In present study, we conducted evolutionary analysis of AluYRa2-exonized transcript with various primate genomic DNAs and cDNAs from humans, rhesus monkeys, and crabeating monkeys. Remarkably, our results show that AluYRa2 element has only been integrated into genomes of Macaca species. This Macaca lineage-specific integration of AluYRa2 element led to exonization event in the first intron region of BCS1L gene by producing a conserved 3' splice site. Intriguingly, in rhesus and crabeating monkeys, more diverse transcript variants by alternative splicing (AS) events, including exon skipping and different 5' splice sites from humans, were identified. Alignment of amino acid sequences revealed that AluYRa2-exonized transcript has short N-terminal peptides. Therefore, AS events play a major role in the generation of various transcripts and proteins during primate evolution. In particular, lineage-specific integration of Alu elements and species-specific Alu-derived exonization events could be important sources of gene diversification in primates.

• 식물분류학회지
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• 제49권1호
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• pp.1-7
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• 2019

Early leaves within the Viola albida complex were investigated by scanning electron microscopy in order to determine the morphological segments during morphogenesis. The early leaf development of V. albida var. albida could be morphologically divided into the eight stages in the following order: I, the initiation of shoot germination; II, the conical growth directionally of the leaf; III, the adaxial and abaxial formation of the leaf; IV, the initiation of the stipule; V, the formation of a transitional zone between the leaf blade and petiole; VI, the expansion of the upper part of the leaf blade; VII, the formation of almost all parts of the early leaf; VIII, the early simple leaf. Viola albida var. takahashii differs from V. albida var. albida by additional stages, i.e., V-1, the initiation of the first lateral lobe at the both lateral parts of the leaf after the stage V and an early lobed leaf. Viola albida var. chaerophylloides is also distinguished from two taxa by two developmental features, V-2, the initiation of a second lateral lobe below of the first lateral lobe, and an early palmately compound leaf. These findings suggest that the Viola albida complex would be in the process of peramorphosis, showing developmental changes in a chain of events, leading to a different leaf shape. These data would also be useful for isolating genes that give rise to different leaf morphogenesis outcomes among the taxa in the Viola albida complex.

• 융합경영연구
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• 제10권3호
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• pp.9-19
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• 2022

Purpose: Previous studies have shown that consumers feel more happiness when they have experiential purchases than material purchases. This experiential advantage has aroused great concern of researchers in the field of social and consumer psychology. Focusing on this issue, the paper aims to tease out the relevant academic work and to further provide with some significant implications. Research design, data and methodology: The paper has divided the review into the following parts. Firstly, the connotation of experiential purchase and material purchase has been simply defined; Secondly, based on the logical framework of pre-factor variables, intermediary variables and regulating boundary conditions, this paper has collated the causal chain of the influence of purchases types on happiness; Finally, this paper has reviewed and summarized the shortcomings of existing studies, and have pointed out specific objectives of future research. Results: From the perspective of time utility and space form, this paper has expounded the substantive differences between the two types of purchase, which lays a foundation for the explanation of the follow-up mechanism. Moreover, the paper has mainly interpreted the intermediary mechanism from two aspects, namely, individual elements of consumers and social elements of consumption situations. Conclusions: This study expands the scope of previous happiness research and strengthens the negative events adaptation research.

• Natural Product Sciences
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• 제18권1호
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• pp.52-59
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• 2012

In our continuous efforts to procure the active materials from natural products in the protective effects of oxidative stress or UV damage to skin cells we found the Prunus persica flesh extract (PPFE) is considerable to meet the demand to protect the skin damage. PPFE attenuated cell damage induced by hypoxanthine-xanthine oxidase in cultured human keratinocytes, indicating that PPFE has the potential of the scavenging effect of reactive oxygen species (ROS) in human skin cell. Moreover, PPFE significantly suppressed UVA-induced ROS production determined by the oxidation of 2,7-dichlorodihydrofluorescein diacetate (DCFH) using FACS analysis. Additional study revealed that UVA irradiation of HaCaT human keratinocytes increased the gelatinolytic activities of matrix metalloproteinase-2, and -9 (MMP-2, -9) and mRNA expression of MMP-9 analyzing by a real-time reverse transcriptase-polymerase chain reaction (RT-PCR), and these events were significantly suppressed by the treatment with PPFE. These results suggest that PPFE might be applicable as natural ingredients for skin antiaging agents via UV-induced ROS scavenging activity and suppression of MMP expression in the skin cells.

• 융합경영연구
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• 제2권2호
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• pp.1-9
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• 2014

This study investigated solutions of not only weak organization but also poor communication with customers from point of view of SNS such as Naver blog, Naver band, Kakao Talk and Facebook to promote local business market. The study gave strategies: First, SNS marketing strategy shall be used to do public relations and communicate in accordance with features of each SNS. Naver Blog that is opened SNS shall be used to do public relations and to invite new customers, and Kakao Talk that is closed SNS shall be used to increase customers having high loyalty, and Facebook that has both properties of SNS, that is to say, openness and closure, shall be used to raise effects of word-of-mouth to make use of new sales window. The communication can find out customers' needs to provide customers with customized services. Second, Naver Band and/or cafe shall be opened to increase link and friendliness and to have community consciousness realizing common goal and to destroy merchants' helplessness and individualism and to make change of the market for the place of community. Changes among the merchants may get better ideas to do events continuously and to get more SNS marketing effects and synergy. Third, the merchants shall make change not momentarily but continuously by making efforts steadily. Good communication in and out of the market may create inherent brand value to differ from super chain and/or SSM and to increase sales as well as traditional market image and to attain customers' loyalty.

• Structural Engineering and Mechanics
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• 제25권3호
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• pp.347-363
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• 2007

A novel methodology, referred to as Auxiliary Domain Method (ADM), allowing for a very efficient solution of nonlinear reliability problems is presented. The target nonlinear failure domain is first populated by samples generated with the help of a Markov Chain. Based on these samples an auxiliary failure domain (AFD), corresponding to an auxiliary reliability problem, is introduced. The criteria for selecting the AFD are discussed. The emphasis in this paper is on the selection of the auxiliary linear failure domain in the case where the original nonlinear reliability problem involves multiple objectives rather than a single objective. Each reliability objective is assumed to correspond to a particular response quantity not exceeding a corresponding threshold. Once the AFD has been specified the method proceeds with a modified subset simulation procedure where the first step involves the direct simulation of samples in the AFD, rather than standard Monte Carlo simulation as required in standard subset simulation. While the method is applicable to general nonlinear reliability problems herein the focus is on the calculation of the probability of failure of nonlinear dynamical systems subjected to Gaussian random excitations. The method is demonstrated through such a numerical example involving two reliability objectives and a very large number of random variables. It is found that ADM is very efficient and offers drastic improvements over standard subset simulation, especially when one deals with low probability failure events.

• 한국생활과학회지
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• 제18권2호
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• pp.325-340
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• 2009

The study aims at verifying the parents' and children's changing process while using parents' play therapy in parent education program to improve the relationship between parents and their children. The experimental group consisted of 42 mothers who have preschoolers in the age range of 3-5, and was compared with the control group of 42 mothers. They joined together a series of 8 sessions (2 hours? or 16 hours?) once a week and took pre- and post-test. All of the sessions were recorded with a VCR camera. All the changing process the mothers showed was analyzed qualitatively to see what happened to the mothers and their children by the methods of coding, taxonomic analysis, critical events, componential analysis, and casual chain analysis suggested by Spradley(1980). The analyses showed that the mothers who participated in the program come to take more sympathetic, receptive attitudes to their children, while the children get better in the children's emotional behavioral problems in the qualitative analysis as well as the quantitative analysis.

• The Korean Journal of Physiology and Pharmacology
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• 제21권4호
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• pp.449-456
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• 2017

Beauvericin (BEA), a cyclic hexadepsipeptide produced by the fungus Beauveria bassiana, is known to have anti-cancer, anti-inflammatory, and anti-microbial actions. However, how BEA suppresses macrophage-induced inflammatory responses has not been fully elucidated. In this study, we explored the anti-inflammatory properties of BEA and the underlying molecular mechanisms using lipopolysaccharide (LPS)-treated macrophage-like RAW264.7 cells. Levels of nitric oxide (NO), mRNA levels of transcription factors and the inflammatory genes inducible NO synthase (iNOS) and interleukin (IL)-1, and protein levels of activated intracellular signaling molecules were determined by Griess assay, semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), luciferase reporter gene assay, and immunoblotting analysis. BEA dose-dependently blocked the production of NO in LPS-treated RAW264.7 cells without inducing cell cytotoxicity. BEA also prevented LPS-triggered morphological changes. This compound significantly inhibited nuclear translocation of the $NF-{\kappa}B$ subunits p65 and p50. Luciferase reporter gene assays demonstrated that BEA suppresses MyD88-dependent NF-${\kappa}B$ activation. By analyzing upstream signaling events for $NF-{\kappa}B$ activation and overexpressing Src and Syk, these two enzymes were revealed to be targets of BEA. Together, these results suggest that BEA suppresses $NF-{\kappa}B$-dependent inflammatory responses by suppressing both Src and Syk.