• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.14 no.6
• /
• pp.90-97
• /
• 2015

Optimization of multi-quality characteristics in injection molded parts is very important, but it is sometimes difficult for part/mold designers. The objective of this study is to develop a practical design methodology for optimizing two-quality characteristics of injection molded parts. To attain this end, we developed a new design-range reduction algorithm based on Taguchi's orthogonal arrays for two characteristics. Then, the algorithm was integrated with commercial injection-molding simulation tools. A feature of the proposed methodology is that it allows field-designers unfamiliar with general optimization methods to be able to apply the methodology to their design problems with ease. Finally, we have applied the proposed design methodology to optimization of weldlines and deflections in an actual bezel model. The results show the usefulness of this methodology.

• Journal of the Korean Society of Manufacturing Technology Engineers
• /
• v.18 no.3
• /
• pp.241-247
• /
• 2009

It is important to satisfy the requirements and standards for the protections of passengers in a car accident. There are lots of studies on the crushing energy absorption of a structure members in automobiles. We have studied to investigate collapse characteristics and moisture absorption movements of CFRP(Carbon Fiber Reinforced Plastics) hat shaped sectional members when CFRP laminates are under the hygrothermal environment. In particular, the absorbed energy, mean collapse load and deformation mode were analyzed for side members which absorbed most of the collision energy. Variation of CFRP interlaminar numbers is important to increase the energy absorption capability. Therefore we have made a static collapse experiment to research into the difference of absorbed energy and deformation mode between moisture absorbed specimen and non-moisture absorbed.

• Journal of the Korean Society for Precision Engineering
• /
• v.17 no.12
• /
• pp.129-136
• /
• 2000

In the frontal collision the spot welded hat-shaped section side member is the fundamental structure for automobiles and has a great amount of absorbing capacity. For this reason LS-DYNA3D has been used for analyzing impact collapse characteristics on hat shaped section member with respect to the valuables; thickness, width ratio and spot weld potch on impact load(7.19m/sec, 1034J). By comparing the results from simulation and the experimental results, the utilization of simulation has been certified.

• Proceedings of the Korean Nuclear Society Conference
• /
• 1997.05a
• /
• pp.219-226
• /
• 1997

This paper presents the development of an Integrated Test Facility (ITF) that consists of a full-scope Human Machine Simulator (HMS) and some experimental measurement systems. This facility is aimed to experiment with tile design of the control room environment and the human interaction as it relates to the control of advanced nuclear power plants.

• Journal of the Korean Operations Research and Management Science Society
• /
• v.31 no.3
• /
• pp.97-105
• /
• 2006

Brand Pricing is the most important issue for the brand manager in the dynamic market. in the typical dynamic pricing model, a linear function has been used based on the assumption that the non-Price Influences and the price influences were independent. However, to incorporate the characteristics of the dynamic market, it is natural to consider the multiplicative relationship. We are going to try the multiplicative linkage between the non-price Influences and the price influences and suggest a new dynamic pricing model with e multiplicative functional form. An empirical study of 19 brands in the Korean cigarette market shows the feasibility of the suggested model.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2005.05a
• /
• pp.658-663
• /
• 2005

This study presents the empirical results of comparing several demand forecasting methods for Supply Chain Management(SCM). Adaptive exponential smoothing using change detection statistics (Jun) is compared with Trigg and Leach's adaptive methods and SAS time series forecasting systems using weekly SCM demand data. The results show that Jun's method is superior to others in terms of one-step-ahead forecast error and eight-step-ahead forecast error. Based on the results, we conclude that the forecasting performance of SCM solution can be improved by the proposed adaptive forecasting method.

• Korean Journal of Pharmacognosy
• /
• v.27 no.4
• /
• pp.350-353
• /
• 1996

The effects of acid hydrolysis product of Panax ginseng and MeOH extract of Euphorbia humifusa on the growth of human brain tumor cells were evaluated using U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells as model cellular systems. These plant extracts induced cytotoxicity in both cells in a dose-dependent manner. These cytotoxic effects were significantly inhibited by GSH, an antioxidant, in both cells. BAPTA/AM, an intracellular $Ca^{2+}$ chelator, significantly blocked the cytotoxic effects of these extracts in U-373 cells, but enhanced these effects in SK-N-MC cells. These results suggest that the plant extracts may be a valuable choice for the studies on the treatment of human brain tumors.

• Korean Journal of Pharmacognosy
• /
• v.34 no.1 s.132
• /
• pp.86-90
• /
• 2003

For the determination of inhibiting cytochrome P450(CYP)3A4 activity, an improvement HPLC method was established by using a new internal standard and solvent system. Moreover, CYP3A4 amount for a optimum reaction of enzyme was determined by a comparative study with a variety concentration of enzyme. Using a established method, inhibitory effect of CYP3A4 that is drug metabolizing enzyme Investigated on EtOAc extracts of 5-class spices. As a result of experiment, EtOAc extract of white pepper (Piper nigrum L.) showed strong inhibitory activity. On a continuous experiment, the fraction 2, 4 and 5 of while pepper extract showed remarkable inhibitory activity. Pipeline, a main constituent of pepper was not included in these fraction. It is suggested that major compounds for the inhibitory activity of white pepper may be other ingredient that is not piperine.

• Korean Journal of Pharmacognosy
• /
• v.45 no.1
• /
• pp.35-40
• /
• 2014

In this study, in order to search for new functional materials from natural products, was carried out the study of antioxidant active ingredients in persimmon calyx(calyx of Diospyros kaki Thunberg). I have experimented with the effect of antioxidant activity of five different extract(MeOH, n-hexane, EtOAc, n-BuOH and $H_2O$ extract) obtained from persimmon calyx. As a result, the butanol extract, that is the main component fraction of antioxidant activity was found. Three compounds were isolated by silica gel column chromatography from the n-BuOH extract of persimmon calyx. Their structures of compound 1, 2 and 3 isolated from n-BuOH extract of persimmon calyx were identified as quercetin, (+)-catechin and gallic acid by using the TLC, $^1H$-NMR and $^{13}C$-NMR.

• Korean Journal of Pharmacognosy
• /
• v.48 no.1
• /
• pp.10-17
• /
• 2017

Ursi Fel's component ursodeoxycholic acid (UDCA), a traditional medicine, is used for the treatment of hepatic diseases. UDCA derivatives prepared by conjugation with antioxidant moiety such as maltol, sesamol, eugenol, mesitol and 3,4-(methylenedeoxy)aniline were expected to have various biological activity caused by synergistic effect of UDCA. Therefore, in this study, it was conducted the study of the manufacture of the UDCA derivatives and their biological activity. As a result, UDCA derivatives showed weak antioxidant activity in TBA method in vitro compared to original agents. SJ-505, SJ-502 and SJ-504 showed the effect of reducing ALT, AST, sorbitol dehydrogenase and ${\gamma}-glutamyltransferase$ in $CCl_4-induced$ liver injury experiment in vivo, even if the effects are weaker than UDCA and silymarin of the control group.