• Journal of the Korean Mathematical Society
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• v.35 no.3
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• pp.675-690
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• 1998

A role of singletons in quantum central limit theorems is studied. A common feature of quantum central limit distributions, the singleton condition which guarantees the symmetry of the limit distributions, is revisited in the category of discrete groups and monoids. Introducing a general notion of quantum independence, the singleton independence which include the singleton condition as an extremal case, we clarify the role of singletons and investigate the mechanism of arising non-symmetric limit distributions.

• Journal of Industrial and Engineering Chemistry
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• v.67
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• pp.99-108
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• 2018

In this paper, novel thiadiazole-thione surfactants including 5-heptyl-1,3,4-thiadiazole-2-thione (HpSDT), 5-phenyl-1,3,4-thiadiazole-2-thione (PSDT) and 5-(2-hydroxyphenyl)-1,3,4-thiadiazole-2-thione (HPhSDT) were synthesized and originally introduced as collectors in froth flotation. Microflotation tests showed that HpSDT exhibited better flotation response to malachite than PSDT and HPhSDT, as well as excellent flotation selectivity against quartz. The contact angle results inferred that the hydrophobization intensity of these collectors toward malachite was in the order as HpSDT> PSDT> HPhSDT. ${\zeta}$-potential recommended a chemisorption of HpSDT on malachite surfaces. FTIR deduced that cupric or cuprous atoms might bond with the S and N atoms of HpSDT to form a conjugated ring. XPS further gave an additional evidence that HpSDT-Cu(I) complexes were produced on malachite surfaces via combining surface Cu atoms with HpSDT's N and S atoms, with reducing surface Cu(II) to Cu (I). The tighter orientation arrangement on malachite and stronger hydrophobicity rendered HpSDT to possess better flotation affinity toward malachite than PSDT and HPhSDT.

• Molecules and Cells
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• v.39 no.2
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• pp.96-102
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• 2016

miR-101 is considered to play an important role in hepatocellular carcinoma (HCC), but the underlying molecular mechanism remains to be elucidated. Here, we aimed to confirm whether Girdin is a target gene of miR-101 and determine the tumor suppressor of miR-101 through Girdin pathway. In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients. After specific small interfering RNA of Girdin was transfected into HepG2 and Huh7.5.1 cells, the proliferation and invasion ability of tumor cells were significantly inhibited. In this study, we further explored the detailed molecular mechanism of Girdin in HCC. Interestingly, we found that miR-101 significantly low-expressed in HCC tissues compared with that in matched normal tissues while Girdin had a relative higher expression, and miR-101 was inversely correlated with Girdin expression. In addition, after miR-101 transfection, the proliferation, migration and invasion abilities of HepG2 cells were weakened. Furthermore, we confirmed that Girdin is a direct target gene of miR-101. Finally we confirmed Talen-mediated Girdin knockout markedly suppressed cell proliferation, migration and invasion in HCC while downregulation of miR-101 significantly restored the inhibitory effect. Our findings suggested that miR-101/Girdin axis could be a potential application of HCC treatment.

• BMB Reports
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• v.39 no.2
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• pp.171-177
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• 2006

Nonsteroidal anti-inflammatory drugs such as indomethacin (IN) can exert anti-colorectal cancer (CRC) activity through cyclooxygenase independent mechanism, but the exactly biological mechanism is not completely known. Here we use proteomic tools to investigate the molecular mechanism of this action. First, nude mice bearing tumors derived from subcutaneous injection with human CRC cell line HCT116 were randomly allocated to groups treated with or without indomethacin. Later, tumor lumps were incised and then total proteins extracted. After separated with two-dimensional electrophoresis, thirty-one differently expressed spots were found between IN-treated and non-IN-treated groups, of which 25 spots decreased and 6 spots increased in abundance in IN-treated group. Through matrix-assisted laser desorption ionization time of flight mass spectrometry and then NCBInr and SWISS-PROT databases searching, 12 protein spots were finally identified including galectin-1, annexin A1, annexin IV, trancription factor BTF3A, calreticulin. Most of the identified proteins are correlated with tumor's biological prosperities of proliferation, invasion, apoptosis and immunity, or take part in cell's signal transduction. From above we thought that indomethacin can exert its effect on colorectal cancer through regulating several proteins' expression directly or indirectly. Further study of these proteins may be helpful in founding new targets of drugs for cancer chemotherapy.

• Tribology and Lubricants
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• v.19 no.2
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• pp.85-93
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• 2003

In this study, a multigrid multi-integration method has been used to solve the steady-state, elastohydrodynamic lubrication (EHL) point contact problem of a ball joint mechanism used in small reciprocating compressors. Pressure and film thickness profiles have been calculated at minimum and maximum Moes M parameter conditions during one revolution of crankshaft. The effects of various lubricant viscosities, loads, ball velocities, elastic modulli, and radii of curvature on the calculated pressure distribution and film thicknesses have been investigated. The results indicate that the viscosity of lubricant, the sliding velocity of ball, and the reduced radius of curvature have considerable effects on the minimum and central film thicknesses. Solutions obtained with the multigrid analysis are compared with results calculated according to the Hamrock ＆ Dowson relations for the minimum and central film thicknesses.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.920-924
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• 2002

This paper presents the reverse design of a cam mechanism using NURBS(Nonuniform Rational B-spline curve). Cam is very difficult to make the accurate shape on the design and the manufacture. Because the cam shape is commonly made in order to move in special functions. The reverse design can be used to check accuracy between the designed data and the manufactured data of the cam shape and also reproduce the cam without the design data. The reverse design procedures consist of motion analysis and curve fitting. The motion analysis is used the central difference method and the relative velocity method to find the displacement and velocity. The curve fitting is used NURBS to develope the whole curve. The central difference method is derived in the 3 dimensional space.

• Biomedical Science Letters
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• v.15 no.1
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• pp.73-80
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• 2009

Bloodstream infections (BSI) are caused by planktonic microorganisms, sometimes leading to serious infections such as bacteremia and sepsis. BSI occurs more frequently to the patients wearing the central venous catheter (CVC). The ciprofloxacin-incorporated CVC (CFX-CVC) has been reported previously to possess antimicrobial activity. In this study, the antibacterial activity of CFX-CVC and its mechanism against planktonic BSI cells were explored by using the shake flask test and by examining the release rate of 260 nm-absorbing substances from the bacterial cells indicative of the membrane damage of the bacterial cells. CFX-CVC reduced more than 99.9% of the viable planktonic BSI cells demonstrating its potent antibacterial activity. It provoked bacteriolysis causing leakage of a large amount of 260 nm-absorbing materials from the planktonic bacterial cells like S. aureus and E. coli. These results provide evidence that the antibacterial activity of CFX-CVC came from the inhibition of the stability of the planktonic bacterial cells.

• Steel and Composite Structures
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• v.11 no.1
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• pp.77-91
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• 2011

This study experimentally evaluated the seismic performance of steel knee braced frame structures with energy dissipation mechanism. A series of cyclic load tests were conducted on the steel moment resisting frames and the proposed knee braced frames. Test results validated that the demand in the beam-to-column connection designs was alleviated by the proposed design method. Test results also showed that the strength and stiffness of the proposed design were effectively enhanced. Comparisons in energy dissipation between the steel moment resisting frames and the steel knee braced frames further justified the applicability of the proposed method.

• Geomechanics and Engineering
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• v.13 no.2
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• pp.301-318
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• 2017

Based on the existing research results, a three-dimensional failure mechanism of tunnel face was constructed. The dynamic seismic effect was taken into account on the basis of quasi-static method, and the nonlinear Mohr-Coulomb failure criterion was introduced into the limit analysis by using the tangent technique. The collapse pressure along with the failure scope of tunnel face was obtained through nonlinear limit analysis. Results show that nonlinear coefficient and initial cohesion have a significant impact on the collapse pressure and failure zone. However, horizontal seismic coefficient and vertical seismic proportional coefficient merely affect the collapse pressure and the location of failure surface. And their influences on the volume and height of failure mechanism are not obvious. By virtue of reliability theory, the influences of horizontal and vertical seismic forces on supporting pressure were discussed. Meanwhile, safety factors and supporting pressures with respect to 3 different safety levels are also obtained, which may provide references to seismic design of tunnels.

• Journal of the Korea Society of Computer and Information
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• v.11 no.6 s.44
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• pp.35-47
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• 2006

In an Ubiquitous Environment, the growth of various services and equipment is forecasted to increase both the multicast users and diverse hacking attacks of the multicast key. Rapid increasing of multicast users and application security protocols reduce the performance of the Central key management system. Accordingly. We propose to elevate the functionality of the key management mechanism for greater efficiency and stability of the multicast services. in this paper The existing key management mechanism comparison and simulation will analyze these problems. We propose the advanced SMKD (Secure Multicast Key Distribution) mechanism application of the small group and key length control new security protocol by methods to solve these problems. The SMKD Model in this paper will help reduce loading the key distribution and encryption execution of a central key management system, and this model can also ensure stability to a central key management system by efficient key management.