• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.25-25
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• 2003

Atrial myocytes have two functionally separate $Ca^{2+}$ release sites: those in peripheral sarcoplasmic reticulum (SR) adjacent to the $Ca^{2+}$ channels of surface membrane and those in central SR not associated with $Ca^{2+}$ channels. Study on the spatio-temporal properties of focal $Ca^{2+}$ releases (“sparks”) occurring spontaneously in central and peripheral sites of voltage-clamped rat atrial myocytes, using rapid two-dimensional (2-D) confocal $Ca^{2+}$ imaging revealed that peripheral and central sparks were similar in size and release time (~300,000 $Ca^{2+}$ ions for=12 ms), but significantly larger and longer than ventricular sparks. Both sites were resistant to Cd$^{2+}$ and inhibited by ryanodine. Peripheral sparks were brighter and flattened against surface membrane, had ~5-fold higher frequency, ~2 times faster diffusion coefficient, and dissipated abruptly. Central sparks, in contrast, occurred less frequently, were elongated along the cellular longitudinal axis, and dissipated slowly. Compound sparks (composed of 2-5 unitary focal releases) aligned longitudinally, occurred more frequently at the center.at the center.

• Imaging Science in Dentistry
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• v.41 no.2
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• pp.85-88
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• 2011

Central odontogenic fibroma is a rare odontogenic neoplasm that originates from odontogenic ectomesenchyme. Here, a case of central odontogenic fibroma in a 17-year-old male is reported. Since the present case showed a multilocular radiolucency with partially ill-defined border between the right mandibular condyle and the distal root of the right mandibular third molar, differential diagnosis involved a wide range of pathosis from benign lesions like ameoloblastic fibroma and odontogenic myxoma to more aggressive lesions such as desmoplastic fibroma, juvenile aggressive fibromatosis, or fibrosarcoma.

• Imaging Science in Dentistry
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• v.32 no.4
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• pp.227-230
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• 2002

The central odontogenic fibroma is a rare benign neoplasm, and considered to be derived from the mesenchymal tissue of dental origin. It is a poorly defined tumor of the jawbones which has only been infrequently reported in the literature. We report a histologically proven case of simple-type central odontogenic fibroma, which affected the left canine-premolar region of the maxilla in a 52-year-old woman.

• Imaging Science in Dentistry
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• v.47 no.2
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• pp.99-107
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• 2017

Purpose: Erosions and osteophytes are radiographic characteristics that are found in different stages of temporomandibular joint (TMJ) osteoarthritis. This study assessed the effectiveness of digital subtraction radiography (DSR) in diagnosing simulated osteophytes and erosions in the TMJ. Materials and Methods: Five intact, dry human skulls were used to assess the effectiveness of DSR in detecting osteophytes. Four cortical bone chips of varying thicknesses (0.5 mm, 1.0 mm, 1.5 mm, and 2.0 mm) were placed at the medial, central, and lateral aspects of the condyle anterior surface. Two defects of varying depth (1.0 mm and 1.5 mm) were created on the lateral, central, and medial poles of the condyles of 2 skulls to simulate erosions. Panoramic images of the condyles were acquired before and after artificially creating the changes. Digital subtraction was performed with Emago dental image archiving software. Five observers familiar with the interpretation of TMJ radiographs evaluated the images. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic accuracy of the imaging methods. Results: The area under the ROC curve (Az) value for the overall diagnostic accuracy of DSR in detecting osteophytic changes was 0.931. The Az value for the overall diagnostic accuracy of panoramic imaging was 0.695. The accuracy of DSR in detecting erosive changes was 0.854 and 0.696 for panoramic imaging. DSR was remarkably more accurate than panoramic imaging in detecting simulated osteophytic and erosive changes. Conclusion: The accuracy of panoramic imaging in detecting degenerative changes was significantly lower than the accuracy of DSR (P<.05). DSR improved the accuracy of detection using panoramic images.

• Journal of Korean Neurosurgical Society
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• v.50 no.4
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• pp.304-310
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• 2011

Objective : Intrathecal methotrexate (MTX) therapy combined with whole brain radiotherapy (WBRT) is one of the major treatment modalities for leukemia and lymphoma involving the central nervous system (CNS). The purpose of this study was to retrospectively determine the incidences of leukoencephalopathy and disseminated necrotizing leukoencephalopathy (DNL) following intrathecal MTX therapy for CNS lymphoma or leukemia and to assess the potential risk factors. Methods : Between January 2000 and August 2009, 143 patients with CNS lymphoma or leukemia received intrathecal MTX therapy alone or in combination with WBRT at a single institution. Patients were followed up clinically and radiologically at regular two- or three-month intervals. Medical records were reviewed to obtain information regarding the patients' demographics, medical histories, radiologic characteristics, treatments, and clinical courses. Results : On follow-up MR images, leukoencephalopathy was found in 95 of 143 patients (66.4%). The median time to develop leukoencephalopathy was 6.6 months. Among those with leukoencephalopathy, four patients showed seven extensive white-matter changes with strongly enhancing lesions demonstrating DNL. Histological confirmation was done in six lesions of three patients and radiological diagnosis alone in one patient. Four lesions spontaneously disappeared on MR images without any treatment, with a mean duration of 14 months before disappearance of DNL. Conclusion : Leukoencephalopathy is a common phenomenon that occurs following intrathecal MTX therapy; however, DNL occurs at a very low incidence. For newly developed enhancing lesions, consideration for the occurrence of DNL should be taken to avoid unnecessary invasive procedures or therapies.

• Journal of the Korean Society of Radiology
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• v.12 no.5
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• pp.631-636
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• 2018

The problem that the existing the magnetic resonance image (MRI) was prone to have not only long readout duration and low bandwidth in the phase-encode direction, but also geometric distortion was pointed out. The purpose of this study is to identify the usefulness of FOCUS-DWI through comparing FOCUS-DWI with the Conventional-DWI on a degree of uniformity and artifacts caused by the distance change in the central axis within the magnetic field. In terms of artifacts, there happened irregular striped artifacts in the Conventional-DWI technique, which in particular, more often arose in the central axis. Also, the overlap of imaging drastically increased. By contrast, there were no irregular striped artifacts in the FOCUS-DWI technique. In conclusion, it was found that the FOCUS-DWI technique was superior to the Conventional-DWI technique in terms of artifacts, the overlap of imaging, and a degree of uniformity. In addition, there was no difference of the change in distance from the central axis between the FOCUS-DWI technique and the Conventional-DWI technique. Thus, it is considered the FOCUS-DWI technique having less imaging distortion and high image quality will be highly clinically used.

• Imaging Science in Dentistry
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• v.44 no.2
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• pp.161-164
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• 2014

Mucoepidermoid carcinomas (MECs) arising within the jaws as primary central bony lesions are termed central MECs. Central MECs are extremely rare, comprising 2-3% of all mucoepidermoid carcinomas. We herein report a rare case of central MEC of the maxilla in a 52-year-old male whose plain radiographs showed a "ground glass" pattern and computed tomographic images, a hypodense mass with numerous calcifications. To the best of our knowledge, this is the first report of central MEC showing a "ground glass" appearance.

• Investigative Magnetic Resonance Imaging
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• v.22 no.3
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• pp.187-193
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• 2018

Sweet's syndrome also known as acute neutrophilic dermatosis is a multisystem inflammatory disorder characterized by fever, malaise, leukocytosis, and skin lesions. Sweet's syndrome affects multiple organs though only rarely does it affect the central nervous system (CNS) when it does it is called Neuro-Sweet disease (NSD). We report on a case study of a biopsy-proven NSD in a 50 year old man. Serial magnetic resonance imaging (MRI) showed repeated CNS involvement of Sweet's syndrome after a respiratory tract infection preceded it. On the MRI, T2 hyperintense lesions occurred at multiple sites and disappeared after steroid therapy.

• Journal of information and communication convergence engineering
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• v.13 no.4
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• pp.270-274
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• 2015

In this paper, we propose an improved framework to analyze an N-ocular imaging system under fixed constrained resources such as the number of image sensors, the pixel size of image sensors, the distance between adjacent image sensors, the focal length of image sensors, and field of view of image sensors. This proposed framework takes into consideration, for the first time, the defocusing effect of the imaging lenses according to the object distance. Based on the proposed framework, the N-ocular imaging system such as integral imaging is analyzed in terms of depth resolution using two-point-source resolution analysis. By taking into consideration the defocusing effect of the imaging lenses using ray projection model, it is shown that an improved depth resolution can be obtained near the central depth plane as the number of cameras increases. To validate the proposed framework, Monte Carlo simulations are carried out and the results are analyzed.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1575-1578
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• 2012

Objectives: To obtain permeability surface (PS) values using multi-slice helical CT perfusion imaging and to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor (VEGF) expression in solitary brain metastases. Methods: Imaging was performed on 21 patients, PS values being calculated from the central, border and peripheral parts of tumours. VEGF expression was determined by immunohistochemical staining. Results: Rim enhancement was found in 16 cases, the border of the tumour featuring PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, the border and the central part had high permeability and VEGF expression was high in all cases, the correlation being significant (P<0.01). Conclusion: VEGF expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases.