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http://dx.doi.org/10.7314/APJCP.2012.13.4.1575

Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases  

Zhang, Jian-Hua (Department of Radiology, East Hospital, Tongji University School of Medicine)
Wang, Ming-Sheng (Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University)
Pan, Hai-Hong (Department of Radiology, East Hospital, Tongji University School of Medicine)
Li, Shu-Feng (Department of Radiology, East Hospital, Tongji University School of Medicine)
Wang, Zhong-Qiu (Department of Radiology, East Hospital, Tongji University School of Medicine)
Chen, Wang-Sheng (Department of Radiology, Hainan Provincial Pepole's Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.4, 2012 , pp. 1575-1578 More about this Journal
Abstract
Objectives: To obtain permeability surface (PS) values using multi-slice helical CT perfusion imaging and to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor (VEGF) expression in solitary brain metastases. Methods: Imaging was performed on 21 patients, PS values being calculated from the central, border and peripheral parts of tumours. VEGF expression was determined by immunohistochemical staining. Results: Rim enhancement was found in 16 cases, the border of the tumour featuring PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, the border and the central part had high permeability and VEGF expression was high in all cases, the correlation being significant (P<0.01). Conclusion: VEGF expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases.
Keywords
Computed tomography; X-rays; PS value; vascular endothelial growth factor; metastases; brain;
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