• Tuberculosis and Respiratory Diseases
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• v.76 no.1
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• pp.38-41
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• 2014

Immunoglobulin G4 (IgG4)-related disease is a newly recognized condition characterized by fibroinflammatory lesions with dense lymphoplasmacytic infiltration, storiform-type fibrosis and obliterative phlebitis. The pathogenesis is not fully understood but multiple immune-mediated mechanisms are believed to contribute. This rare disease can involve various organs and pleural involvement is even rarer. We report a case of IgG4-related disease involving pleura. A 66-year-old man presented with cough and sputum production for a week. Chest radiography revealed consolidation and a pleural mass at right hemithorax. Treatment with antibiotics resolved the consolidation and respiratory symptoms disappeared, but the pleural mass was unchanged. Video-assisted thoracoscopic surgery was performed. Histopathology revealed dense lymphoplasmacytic infiltration and storiform fibrosis with numerous IgG4-bearing plasma cells. The serum IgG4 level was also elevated. Further examination ruled out the involvement of any other organ. The patient was discharged without further treatment and there is no evidence of recurrence to date.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.36.2-36.2
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• 2014

We present results of the analysis of FLS 1718+59, a galaxy-galaxy gravitational lens system in the Spitzer First Look Survey (FLS) Field. A background galaxy (z = 0.245) is severely distorted by an elliptical galaxy (z = 0.08), by gravitational lensing. We analyze this system by several methods, including Ellipse and Galfit fitting, gravitational lens modeling (gravlens), and SED fitting. Properties of the lens galaxy can be obtained: from Galfit we measure the effective radius and the average surface brightness inside it, and from gravlens we estimate the total mass inside the Einstein radius (lensing mass). We use these parameters to check that the lens galaxy is located on the Fundamental Plane. Also, we conduct SED fitting for the lens galaxy and estimate the stellar mass, and compare this with the lensing mass of the lens galaxy to check the M-L relation.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.9
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• pp.22-29
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• 1995

An experimental method to identify the rigid properties (mass, moment of inertia, center of mass) of mounted structures is presented. A direct system identification method is developed and applied to identify the mass, damping and stiffness martix directly from the translational response of vibration testing. Conventional method is sensitive to noise since it needs artificial rotational response of temporary center of mass which is made by the linear transformation of translational response. A presented method needs only the translational response, and it is robuster to noise than conventional method. Several experimental and numerical implementations show the presented method is effective.

• Journal of Chest Surgery
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• v.44 no.5
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• pp.373-376
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• 2011

Lymphangiohemangiomas of the mediastinum are exceedingly rare and few cases have been published in the English literature. This report may be the only reported case in which lymphangiohemangiomas were found bilaterally. We report a case of a 7-year-old boy with an incidental finding of an abnormal mediastinal shadow on a chest X-ray. The chest CT showed a large mass in the left superior mediastinum and another in the right posterior mediastinum. The left mass had anomalous venous channels connected to the left innominate vein, and the right mass to the left atrium. We performed an excision of the mass in the left side first and then the right side one month later. Anomalous venous channels were dissected carefully and ligated. There were no complications and no signs of recurrence 30 months after the operation.

• Mass Spectrometry Letters
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• v.9 no.3
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• pp.67-72
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• 2018

Alkaline phosphatase (AP) is a membrane-bound glycoprotein that is widely distributed in the plasma membrane of cells of various organs and also found in many organisms from bacteria to humans. The complete amino acid sequence and three-dimensional structure of human placental alkaline phosphatase have been reported. Based on the literature data, AP consists of two presumptive glycosylation sites, at Asn-144 and Asn-271. However, it only contains a single occupied N-linked glycosylation site and no occupied O-linked glycosylation sites. Hydrophilic interaction chromatography (HILIC) has been primarily employed for the characterization of the glycan structures derived from glycoproteins. N-glycan structures from human placental alkaline phosphatase (PLAP) were investigated using HILIC-Orbitrap MS, and subsequent data processing and glycan assignment software. 16 structures including 10 sialylated N-glycans were identified from PLAP.

• Journal of Chest Surgery
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• v.21 no.4
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• pp.787-792
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• 1988

Esophageal duplication constitute about 10% of all the mediastinal tumor and relatively rare condition. We have experienced one case of esophageal duplication which was found 2 years previously by radiologic study of chest, as mediastinal mass, in 37 years old male. He had neither clinical manifestations nor physical findings leading to the surgical discovery of the duplication. During the last 2 years, the size k location of the mass were stationary in character. Operative therapy of complete excision performed without surgical complication. On microscopic study, the lining cell of inner wall of cyst. Noted pseudostratified ciliated columnar epithelium with smooth muscle.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.7
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• pp.937-944
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• 2002

An experimental study has been conducted to investigate the heat/mass transfer characteristics within a square film cooling hole with asymmetric inlet now condition. The asymmetric inlet now condition is achieved by making distances between side walls of the secondary now duct and the film cooling hole different; one side wall is $2D_h$ apart from the center of the film cooling hole, while the other side wall is $1.5D_h$ apart from the center of the film cooling hole. The heat/mass transfer experiments for this study have been performed using a naphthalene sublimation method and the now field has been analyzed by numerical calculation using a commercial code. Swirl now is generated at the inlet region and the heat/mass transfer pattem with the asymmetric inlet now condition is changed significantly from that with the symmetric condition. In the exit region, the effect of mainstream on the inside hole now is reduced with the asymmetric condition. The average heat/mass transfer coefficient is higher than that with the symmetric condition due to the swirl now generated by the asymmetric inlet condition.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.60.1-60.1
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• 2013

We study tidal disruption and subsequent mass fallback process for stars approaching supermassive black holes on bound orbits, by performing three dimensional Smoothed Particle Hydrodynamics simulations with a pseudo-Newtonian potential. We find that the mass fallback rate decays with the expected -5/3 power of time for parabolic orbits, albeit with a slight deviation due to the self-gravity of the stellar debris. For eccentric orbits, however, there is a critical value of the orbital eccentricity, significantly below which all of the stellar debris is bound to the supermassive black hole. All the mass therefore falls back to the supermassive black hole in a much shorter time than in the standard, parabolic case. The resultant mass fallback rate considerably exceeds the Eddington accretion rate and substantially differs from the -5/3 power of time. We also show that general relativistic precession is crucial for accretion disk formation via circularization of stellar debris from stars on moderately eccentric orbits.

• Journal of Radiation Industry
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• v.17 no.2
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• pp.127-134
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• 2023

Pharmacokinetic (PK) data provide pivotal information in drug development, and they are usually first studied in the preclinical stage using various animals. However, quite often, animal PK data may not match with human PK, especially in metabolites. Thus, most regulatory agencies in the world make it mandatory to obtain metabolite information using ¹⁴C radiolabeled drug in human for small molecule drug candidates. However, such studies are expensive and time consuming and they are usually done at the end of Phase II trials using ~3.7 MBq of ¹⁴C labeled drug in a limited number of human subjects. Introduction of accelerator mass spectrometry (AMS) in this kind of study has revolutionized it. Since AMS can measure ¹⁴C level as close as natural abundance, it can quantify the amounts of ¹⁴C labeled drugs and their metabolites produced in human body that consumes less than the amount of 0.0037 MBq of ¹⁴C labeled drug, a very safe level of radioactive dose in human. Therefore, it is now possible to conduct human ¹⁴C studies safely in early clinical trials without spending hefty amount of money and time. Korea Radioisotope Center for Pharmaceuticals(KRICP) at Korea Institute of Biological and Medical Sciences(KIRAMS) has established an AMS facility in 2018, housing a 0.5MV AMS manufactured at the US National Electrostatics Corps (NEC). The AMS instrument has been validated using various standard samples that have been prepared at Lawrence Livermore National Laboratory in the US, a worldly reputable provider of AMS standards. In this paper, we present a mass balance study for acetaminophen in rats using AMS and prove that the study results are equivalent with those of literature, which shows the AMS facilities at KRICP has successfully installed and be ready to be used in the various PK studies using ¹⁴C labelled compounds for new drug development.

• Membrane and Water Treatment
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• v.4 no.3
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• pp.191-202
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• 2013

The application of ultrafiltration operation to the dialysis in countercurrently parallel-flow rectangular membrane modules was investigated. The assumption of uniform ultrafiltration flux was made for operation with slight concentration polarization and declination of transmembrane pressure. Considerable improvement in mass transfer is achievable if the operation of ultrafiltration is applied, especially for the system with low mass transfer coefficient. The enhancement in separation efficiency is significantly increased with increasing ultrafiltration flux, as well as with increasing the volumetric flow rates. Furthermore, increasing the volumetric flow rate in retentate phase is more beneficial to mass transfer than increasing in dialysate phase.