• IMMUNE NETWORK
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• v.6 no.4
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• pp.185-191
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• 2006

Background: Based on outstanding progresses in animal experiments, vaccines for some human tumors have been developed. However, clinical effects of these vaccines have been far below than expected. This discrepancy might come from differences between animal models and human patients with respect to immunocompetency. The immune status of mice after tumor inoculation has not been well studied, which make us cautious in interpreting and applying the results from mice to human. We evaluated cell-mediated immune responses in mice after tumor cell inoculation. Methods: Mice were inoculated with TA3Ha, CT26, or 4T1. Delayed-type hypersensitivity (DTH) responses were induced 2-4 weeks after inoculation using 2,4-dinitro-1-fluorobenzene as an antigen. The relationships between the severity of DTH responses and the duration of tumor inoculation or the size of tumor mass were analyzed. Results: In T A3Ha groups, DTH response was elevated 2 weeks after inoculation, but depressed after 4 weeks, compared to the control group. When analyzed based on the sizes of tumor masses elicited, DTH responses were inversely related to the mass size, especially in those greater than 10 mm in diameter. In CT26 groups, while the duration after inoculation did not affect the severity of DTH responses, those with large mass showed depressed responses regardless the duration of inoculation. 4T1 cells grew so slowly that the size of tumor mass was small even 4 weeks after inoculation, and this group showed much higher DTH responses compared to that of tumor-free group. Conclusion: At least in an experimental setting where tumor model was induced by inoculating tumor cell lines into immunologically competent mice, the host immune response was elevated in early stage, and then depressed in late stage when the mass grew over a critical size.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.47.2-47.2
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• 2015

At local, galaxy properties are well known to be clearly different in different environments. However, it is still an open question how this environment-dependent trend has been shaped. In this presentation, we will show the results of our investigation about the evolution of star-formation properties of galaxies over a wide redshift range, from z~2 to z~0.5, focusing its dependence on their stellar mass and environment. In the UKIDSS/UDS region, we estimated photometric redshifts and stellar population properties, such as stellar masses and star-formation rates, using the deep optical and near-infrared data available in this field. Then, we identified galaxy cluster candidates at z~0.5-2. Through the analysis and comparison of star-formation (SF) properties of galaxies in clusters and in field, we found interesting results regarding the evolution of SF properties of galaxies: (1) regardless of redshifts, stellar mass is a key parameter controlling quenching of star formation in galaxies; (2) At z<1, environmental effects become important at quenching star formation regardless of stellar mass of galaxies; and (3) However, the result of the environmental quenching is prominent only for low mass galaxies (M* < $10^{10}M_{\odot}$) since the star formation in most of high mass galaxies are already quenched at z > 1.

• Physical Therapy Korea
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• v.27 no.2
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• pp.155-161
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• 2020

Background: The consequences of falls are often debilitating, and prevention is important. In theory, the lower the center of mass (COM), the greater postural stability during standing, and a weight belt at the waist level may help to lower the COM and improve the standing balance. Objects: We examined how the limit of stability (LOS) was affected by the lowered center of mass with the weight belt. Methods: Twenty healthy individuals participated in the LOS test. After calculating each participant's COM, a weight belt was fastened ten centimeters below the COM. Trials were acquired with five weight belt conditions: 0%, 2%, 4%, 6%, and 8% of body weight. Outcome measures included reaction time, movement velocity, endpoint excursion, maximum excursion, and directional control in 4 cardinal moving directions. Results: None of our outcome variables were associated with a weight belt (p > 0.075), but all of them were associated with moving direction (p < 0.01). On average, movement velocity of the COM and maximum excursion were 31% and 18% greater, respectively, in mediolateral than anteroposterior direction (5.4°/s vs. 4.1°/s; 97.5% vs. 82.6%). Conclusion: Our results suggest that postural stability was not affected by the weight-induced lowered COM, informing the development and improvement of balance training strategies.

• Journal of Astronomy and Space Sciences
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• v.12 no.2
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• pp.179-195
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• 1995

RT Per has been known as a close binary of which the orbital period has unpredictably varied so far. Although there are no agreements with the working mechanism for the changes of the period, two interpretations have been suggested and waiting for to be tested: 1) light-time effects due to the unseen 3rd and 4rd bodies (Panchatsaram 1981), 2) Abrupt period-changes, due to internal variations of the system (e.g. mass transfer or mass loss) superimposing to the light-time effect by a 3rd body (Frieboes-Conde & Herczeg 1973). In the point of view that the former interprepation models could predict the behavior of the changes of the orbital period theoretically, we checked whether the recent observed times of minimum lights follow the perdictions by the first model or not. We confirmed that the observed times of minimum lights have followed the variations calculated by the light-times effects due to the 3rd and 4rd bodies suggested by Panchatsatam. In this paper a total of 626 times of minimum lights were reanalyzed in terms of the light-time effects by the 3rd and 4rd bodies. We concluded that the eclipsing pair in SVCam system moves in an elliptic orbit about center of mass of the triple system with a period of about $42.^y2$, while the mass center of the triplet is in light-time orbit about the center of mass of the quadruple system with a period of $120^y$. The mean masses deduced for the 3rd and 4rd bodies were $0.89m_\odot$ and $0.82m_\odot$, respectively.

• Mass Spectrometry Letters
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• v.13 no.4
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• pp.115-124
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• 2022

Emerging evidence has shown that RNA-binding proteins (RBPs) dynamically regulate all aspects of RNA in cells and involve in major biological processes of RNA, including splicing, modification, transport, transcription and degradation. RBPs, as powerful and versatile regulatory molecule, are essential to maintain cellular homeostasis. Perturbation of RNA-protein interactions and aberration of RBPs function is associated with diverse diseases, such as cancer, autoimmune disease, and neurological disorders. Therefore, it is crucial to systematically investigate the RNA-binding proteome for understanding interactions of RNA with proteins. Thanks to the development of the mass spectrometry, a variety of proteome-wide methods have been explored to define comprehensively RNA-protein interactions in recent years and thereby contributed to speeding up the study of RNA biology. In this review, we systematically described these methods and summarized the advantages and disadvantages of each method.

• Bulletin of the Korean Chemical Society
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• v.28 no.12
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• pp.2359-2362
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• 2007

MALDI-TOF-MS technique was applied to obtain structural and compositional information of synthetic polyamides, Nylon6 and Nylon66. Mass spectra of both the original and the hydrolyzed polyamide samples were analyzed using the self calibration method as well as the internal calibration method with the standard materials of known masses. The MALDI-TOF mass spectra of Nylon6 samples showed the presence of protonated, sodiated, and potassiated ions that were assigned to cyclic and NH2/COOH terminated linear oligomers. From the MALDI-TOF mass spectra of Nylon66 samples, the potassiated linear oligomers with three different end groups are identified as well as the cyclic oligomers, i.e., NH2/COOH terminated oligomers, NH2/NH2 terminated oligomers, and COOH/COOH terminated oligomers. Full characterization of the molecular species and end groups present in the polyamide samples has been achieved, and also the changes in mass spectral patterns after the hydrolysis of the samples are presented.

• Korean Journal of Head & Neck Oncology
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• v.29 no.2
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• pp.71-74
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• 2013

Neck mass is a common manifestation from head and neck malignancy, most of which come from mucosal squamous cell carcinomas in the upper aero-digestive tract. However, once aspiration cytology suggests atypical malignant cells in the neck mass rather than metastatic squamous cell carcinomas, it is confusing to decide the adequate diagnostic work-ups and treatment planning. Here, we report a 29-year-old woman presenting with a growing neck mass mimicking malignancy of unknown origin, which was finally diagnosed as primary lymphoepithelial carcinoma in the parotid gland with multiple metastases to the lymph nodes. The patient underwent comprehensive neck dissection and total parotidectomy and the adjuvant radiation treatment was given. Our report highlight that the primary salivary gland cancer should be considered as the potential tumor origin in case of malignancy of unknown origin in the head and neck region and neck mass suggestive of atypical carcinomas.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.48.3-49
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• 2015

Scaling relations of early-type galaxies (ETG) provide a deep insight into their formation and evolution. Interestingly enough, most relations extending into the dwarf regimes display non-linear or broken-linear features, unlike the linear relations for normal (i.e., intermediate-mass to giant) ETGs only. Here we investigate the mass-size scaling relation of ETGs using a massive database of galaxies from SDSS DR12. We divide ETGs into two groups by the indication of star formation such as colors, and examine their distinction along the mass-size relation. We find that the mass-size distribution of blue, young normal galaxies is in good agreement with that of dwarf ETGs. Our result suggests that blue, young normal ETGs may serve as links between (passive) normal ETGs and dwarfs. We discuss the possibility of blue, young ETGs being progenitors of dwarf ETGs.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2002.05a
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• pp.45-52
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• 2002

The tribological role of mass transfer layer was studied with silver coatings under various ranges of load and sliding speed. Silver coating was performed with a functionally gradient coating method. Tests were performed in dry sliding conditions, using a ball-on-disk contact configuration, at the load of 0.0196-17.64 N and the sliding speed of 20-1,000 mm/s in ambient air. Optical microscope and EPMA analyses showed that contact surfaces were covered with the mass transfer layers of agglomerated wear particles depending upon the contact conditions, and they greatly influenced the tribological characteristics of the surfaces. However, the formation of mass transfer layer was suppressed as the sliding speed increased, and above a critical sliding speed, no mass transfer layer was able to form. For building up a general framework of tribological behavior of the coated silver films, all test data were summarized on a map whose axes are contact pressure and sliding speed.

• Journal of Multimedia Information System
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• v.3 no.3
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• pp.97-102
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• 2016

Deep learning enables machines to have perception and can potentially outperform humans in the medical field. It can save a lot of time and reduce human error by detecting certain patterns from medical images without being trained. The main goal of this paper is to build the optimal model for breast mass classification by applying various methods that influence the performance of Convolutional Neural Network (CNN). Google's newly developed software library Tensorflow was used to build CNN and the mammogram dataset used in this study was obtained from 340 breast cancer cases. The best classification performance we achieved was an accuracy of 0.887, sensitivity of 0.903, and specificity of 0.869 for normal tissue versus malignant mass classification with augmented data, more convolutional filters, and ADAM optimizer. A limitation of this method, however, was that it only considered malignant masses which are relatively easier to classify than benign masses. Therefore, further studies are required in order to properly classify any given data for medical uses.