• 대한기계학회논문집A
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• 제40권9호
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• pp.827-833
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• 2016

와이어 직조 Kagome는 와이어로 직조된 Periodic Cellular Metal의 일종으로서 Kagome 구조로 이루어져 있다. 와이어 직조 Kagome는 무게 대비 높은 강도와 강성을 가지면서 대량 생산에도 큰 가능성을 가지는 것으로 알려졌다. 본 연구에서는 ${\alpha}$-cristobalite 구조적 특성을 모사하여 음의 푸아송비를 갖는 새로운 직조 구조체를 개발하였다. 와이어 직조 Kagome를 제작한 후 사면체 단위셀 부분을 강구와Epoxy를 이용하여 채우고, 초기 변형을 주어 시편을 제작하였다. 또한 FEA 시뮬레이션을 통해 제작 가능성을 확인하고, 실제 제작한 구조체를 대상으로 기계적 특성을 연구하였다.

• 대한기계학회논문집A
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• 제22권4호
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• pp.826-833
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• 1998

The energy-absorbing characteristic of impact limiters affects the cask design so significantly that it should be evaluated as accurate as possible. The objective of this study is to find the influence of the impact limiter's steel case and gusset plates which enclose the shock absorbing cellular material on the impact energy absorption. The influence of impact limiter's steel case and gusset plate stiffeners on the impact energy absorption behavior under horizontal drop impact was evaluated for a radioactive isotope transport cask. Though the impact limiters mitigate the impact damage of the cask, the impact limiter's steel case and gusset plate stiffeners increase the impact force so significantly that should be designed as soft as possible. The impact analysis without considering impact limiter's steel case and gusset plates stiffener gives non-conservative results, so the stiffness of the steel case and gusset plates should be considered in impact analysis.

• 한국산업융합학회 논문집
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• 제20권2호
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• pp.133-140
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• 2017

This paper is a study of the central structural unit model of the sandwich core structure. The applied model is based on the honeycomb structure formed by the truss, the H-shaped honeycomb structure formed by adding the truss of H shape to the space of the center portion, and the honeycomb structure formed by the plate. Applied material property is AISI 304 stainless steel, which has cost effectiveness and easy to get near place. The truss diameter of the model is three different type: 1mm, 2mm and 3mm. ABAQUS software is obtained to do the analysis and applied test is quasi-static loading. Boundary conditions for the analysis are that vertical direction loading at top place without any rotation and bottom surface is fixed. The test results show that the H-truss model has the highest stiffness and yield strength. Therefore, it is hoped that more and more researching for the development of a unit model in sandwich core structure has been investigating and that the developed sandwich core model can be applied into various industrial fields such as mechanical or aerospace industries.

• BMB Reports
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• 제57권2호
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• pp.116-121
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• 2024

We investigated the therapeutic potential of bone marrow-derived mesenchymal stem cell-conditioned medium (BMSC-CM) on immortalized renal proximal tubule epithelial cells (RPTEC/TERT1) in a fibrotic environment. To replicate the increased stiffness characteristic of kidneys in chronic kidney disease, we utilized polyacrylamide gel platforms. A stiff matrix was shown to increase α-smooth muscle actin (α-SMA) levels, indicating fibrogenic activation in RPTEC/TERT1 cells. Interestingly, treatment with BMSC-CM resulted in significant reductions in the levels of fibrotic markers (α-SMA and vimentin) and increases in the levels of the epithelial marker E-cadherin and aquaporin 7, particularly under stiff conditions. Furthermore, BMSC-CM modified microRNA (miRNA) expression and reduced oxidative stress levels in these cells. Our findings suggest that BMSC-CM can modulate cellular morphology, miRNA expression, and oxidative stress in RPTEC/TERT1 cells, highlighting its therapeutic potential in fibrotic kidney disease.

• 한국항공우주학회지
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• 제32권8호
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• pp.82-90
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• 2004

등방성의 2차원 단위 셀 형상을 지닌 세 종류의 심재-삼각형 심재, 육각형 심재와 starcell 심재-에 대하여 샌드위치 구조물 내에서의 응용과 관련된 기계적 특성을 연구하였다. 세 종류의 심재에 대하여 축 방향 Young 계수, 전단 계수를 계산하여 비교하고, 심재의 셀 벽을 압축 하중과 전단 하중을 받고 있는 판재로 가정하여 축 방향 압축 좌굴 강도와 전단 좌굴 강도를 산출하였다. 심재의 유연성을 나타내는 평면탄성계수를 비교하고 쌍축 굴곡 실험 (biaxial flexural test)을 실시하여 유연성을 측정하였다. 세 가지 심재 모두 축 방향으로 같은 강성을 가지고 있었으나, 삼각형 심재는 다른 두 종류의 심재에 비하여 낮은 강도를 나타내었고, starcell 심재는 다른 심재들에 비해 월등히 높은 유연성 을 나타내었다. 이러한 유연성은 starcell 심재가 곡면에 적용되는 샌드위치 구조물의 심재로서 응용될 수 있음을 보여주었다.

• Steel and Composite Structures
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• 제23권2호
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• pp.195-204
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• 2017

The effects of plaster on the behavior of single-story single-bay masonry-infilled steel frames under in-plane base accelerations have been experimentally investigated by a shake-table. Tested structures were made in a 1/3 scale, with realistic material properties and construction methods. Steel frames with high and low flexural rigidity of beams and columns were considered. Each type of frame was tested with three variants of masonry: (i) non-plastered masonry; (ii) masonry infill with conventional plaster on both sides; and (iii) masonry infill with a polyvinyl chloride (PVC) net reinforced plaster on both sides. Masonry bricks were made of lightweight cellular concrete. Each frame was firstly successively exposed to horizontal base accelerations of an artificial accelerogram, and afterwards, to horizontal base accelerations of a real earthquake. Characteristic displacements, strains and cracks in the masonry were established for each applied excitation. It has been concluded that plaster strengthens the infill and prevents damages in it, which results in more favorable behavior and increased bearing capacity of plastered masonry-infilled frames compared to non-plastered masonry-infilled frames. The load-bearing contribution of the adopted PVC net in the plaster was not noticeable for the tested specimens, probably due to relative small cross section area of fibers in the net. Behavior of masonry-infilled steel frames significantly depends on frame stiffness. Strong frames have smaller displacements than weak frames, which reduces deformations and damages of an infill.

• Molecules and Cells
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• 제41권2호
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• pp.73-82
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• 2018

Cancer preventive activities of green tea and its main constituent, (-)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. Since 1983, we have studied the cancer chemopreventive effects of EGCG as well as green tea extract and underlying molecular mechanisms. The first part of this review summarizes groundbreaking topics with EGCG and green tea extract: 1) Delayed cancer onset as revealed by a 10-year prospective cohort study, 2) Prevention of colorectal adenoma recurrence by a double-blind randomized clinical phase II trial, 3) Inhibition of metastasis of B16 melanoma cells to the lungs of mice, 4) Increase in the average value of Young's moduli, i.e., cell stiffness, for human lung cancer cell lines and inhibition of cell motility and 5) Synergistic enhancement of anticancer activity against human cancer cell lines with the combination of EGCG and anticancer compounds. In the second part, we became interested in cancer stem cells (CSCs). 1) Cancer stem cells in mouse skin carcinogenesis by way of introduction, after which we discuss two subjects from our review on human CSCs reported by other investigators gathered from a search of PubMed, 2) Expression of stemness markers of human CSCs compared with their parental cells, and 3) EGCG decreases or increases the expression of mRNA and protein in human CSCs. On this point, EGCG inhibited self-renewal and expression of pluripotency-maintaining transcription factors in human CSCs. Human CSCs are thus a target for cancer prevention and treatment with EGCG and green tea catechins.

• Steel and Composite Structures
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• 제22권6호
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• pp.1417-1443
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• 2016

Cellular and castellated steel beams are used to obtain higher stiffness and bending capacity using the same weight of steel. In addition, the beam openings may be used as a pass for different mechanical fixtures such as ducts and pipes. The aim of this study is to investigate the effect of different parameters on both elastic and inelastic critical buckling stresses of steel web plates with openings. These parameters are plate aspect ratio; opening shape (circular or rectangular); end distance to the first opening; opening spacing; opening size; plate slenderness ratio; steel grade; and initial web imperfection. The web/flange interaction has been simplified by web edge restraints representing simply supported boundary conditions. A numerical parametric study has been performed through linear and nonlinear finite element (FE) models, where the FE results have been verified against both experimental and numerical results in the literature. The web plates are subject to in-plane linearly varying compression with different loading patterns, ranging from uniform compression to pure bending. A buckling stress modification factor (${\beta}$-factor) has been introduced as a ratio of buckling stress of web plate with openings to buckling stress of the corresponding solid web plate. The variation of ${\beta}$-factor against the aforementioned parameters has been reported. Furthermore, the critical plate slenderness ratio separating elastic buckling and yielding has been identified and discussed for two steel grades of DIN-17100, namely: ST-37/2 and ST-52/3. The FE results revealed that the minimum ${\beta}$-factor is 0.9 for web plates under uniform compression and 0.7 for those under both compression and tension.

• Advances in nano research
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• 제7권6호
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• pp.443-457
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• 2019

In this investigation, dynamic and bending behaviors of isolated protein microtubules are analyzed. Microtubules (MTs) can be considered as bio-composite structures that are elements of the cytoskeleton in eukaryotic cells and posses considerable roles in cellular activities. They have higher mechanical characteristics such as superior flexibility and stiffness. In the modeling purpose of microtubules according to a hollow beam element, a novel single variable sinusoidal beam model is proposed with the conjunction of modified strain gradient theory. The advantage of this model is found in its new displacement field involving only one unknown as the Euler-Bernoulli beam theory, which is even less than the Timoshenko beam theory. The equations of motion are constructed by considering Hamilton's principle. The obtained results are validated by comparing them with those given based on higher shear deformation beam theory containing a higher number of variables. A parametric investigation is established to examine the impacts of shear deformation, length scale coefficient, aspect ratio and shear modulus ratio on dynamic and bending behaviors of microtubules. It is remarked that when length scale coefficients are almost identical of the outer diameter of MTs, microstructure-dependent behavior becomes more important.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.673-697
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• 2018

BACKGROUND: Cartilage tissue engineering (CTE) aims to obtain a structure mimicking native cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and extraneous signals. Implantation of 'matured' constructs is thus expected to provide solution for treating large injury of articular cartilage. Type I collagen is widely used as scaffolds for CTE products undergoing clinical trial, owing to its ubiquitous biocompatibility and vast clinical approval. However, the long-term performance of pure type I collagen scaffolds would suffer from its limited chondrogenic capacity and inferior mechanical properties. This paper aims to provide insights necessary for advancing type I collagen scaffolds in the CTE applications. METHODS: Initially, the interactions of type I/II collagen with CTE-relevant cells [i.e., articular chondrocytes (ACs) and mesenchymal stem cells (MSCs)] are discussed. Next, the physical features and chemical composition of the scaffolds crucial to support chondrogenic activities of AC and MSC are highlighted. Attempts to optimize the collagen scaffolds by blending with natural/synthetic polymers are described. Hybrid strategy in which collagen and structural polymers are combined in non-blending manner is detailed. RESULTS: Type I collagen is sufficient to support cellular activities of ACs and MSCs; however it shows limited chondrogenic performance than type II collagen. Nonetheless, type I collagen is the clinically feasible option since type II collagen shows arthritogenic potency. Physical features of scaffolds such as internal structure, pore size, stiffness, etc. are shown to be crucial in influencing the differentiation fate and secreting extracellular matrixes from ACs and MSCs. Collagen can be blended with native or synthetic polymer to improve the mechanical and bioactivities of final composites. However, the versatility of blending strategy is limited due to denaturation of type I collagen at harsh processing condition. Hybrid strategy is successful in maximizing bioactivity of collagen scaffolds and mechanical robustness of structural polymer. CONCLUSION: Considering the previous improvements of physical and compositional properties of collagen scaffolds and recent manufacturing developments of structural polymer, it is concluded that hybrid strategy is a promising approach to advance further collagen-based scaffolds in CTE.