• Molecules and Cells
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• 제42권9호
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• pp.617-627
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• 2019

Brain organoids are an exciting new technology with the potential to significantly change our understanding of the development and disorders of the human brain. With step-by-step differentiation protocols, three-dimensional neural tissues are self-organized from pluripotent stem cells, and recapitulate the major millstones of human brain development in vitro. Recent studies have shown that brain organoids can mimic the spatiotemporal dynamicity of neurogenesis, the formation of regional neural circuitry, and the integration of glial cells into a neural network. This suggests that brain organoids could serve as a representative model system to study the human brain. In this review, we will overview the development of brain organoid technology, its current progress and applications, and future prospects of this technology.

• 생물정신의학
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• 제20권4호
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• pp.136-143
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• 2013

Objectives We reviewed cellular and synaptic dysconnectivity, disturbances in micro- and macro- circuitries, and neurodevelopmentally-derived disruptions of neural connectivity in the pathogenesis of schizophrenia. Method We reviewed the selected articles about disturbances in neural circuits which had been proposed as a pathogenetic mechanism of schizophrenia. Results The literature review reveals that schizophrenia may be a disease related to disturbance in neurodevelopmental mechanism, shown as 'a misconnection syndrome of neural circuit or neural network'. In descriptive psychopathological view, definition of a disorder of brain connectivity has limitation to explain other aspects of schizophrenia including deterministic strictness in thought process. Conclusion Schizophrenia is considered as a disorder of brain connectivity as well as a neurodevelopmental disorder related with genetic and environmental factors. We could make a suggestion that "JoHyeonByung (attunement disorder)" denotes the disturbances of psychic fine-tuning which correspond to the neural correlates of brain dysconnectivity metaphorically.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2002년도 춘계학술대회 및 임시총회
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• pp.231-234
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• 2002

셀룰라 신경회로망의 연상 메모리를 이용하여 시각적인 입력 데이터의 연산을 통하여 영상 패턴의 분류와 인식을 수행한다. 셀룰라 신경회로망은 일반적인 신경회로망과 같이 비선형 데이터의 실시간 처리가 가능하고, 세 포자동자와 같이 격자구조의 셀로 이루어져 인접한 셀과 직접 정보를 주고받는다. 응용 분야로는 최적화, 선형/비선형화, 연상 메모리, 패턴인식, 컴퓨터 비젼 등에 적용할 수 있다. 영상의 이미지 픽셀을 셀룰라 신경회로망의 셀에 대응하여 전체 이미지 영상을 모든 셀룰라 신경회로망의 셀에서 동시에 병렬로 처리할 수 있어 2-D 이미지 처리에 적합하다 본 논문은 셀룰라 신경회로망에 의한 연상 메모리 구조를 설계하고, 학습된 하중값 메모리에서 가장 적당한 하중값을 선택하여 학습된 영상과 정확히 일치하는 출력을 얻는 방법을 제시한다. 학습을 통한 연상 메모리 구현에는 각각의 뉴런에서 일정하지 않은 다른 템플릿을 사용한다. 각각의 템플릿은 뉴런들 간의 연결 하중값을 나타내고 학습011 따라 갱신된다. 학습방법으로는 템플릿 하중값 학습에 뉴런들 간의 연결 하중값을 조정하는 가장 단순한 규칙인 Hebb의 학습방법이 사용되었고 분류값 학습에 LMS 알고리즘이 사용되었다

• 한국정보처리학회논문지
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• 제6권2호
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• pp.439-448
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• 1999

본 논문에서는 신경회로망과 유전자 알고리즘을 이용하여 셀룰러 무선채널 할당을 위한 최적화 알고리즘을 제안하였다. 채널할당 과정을 채널할당 문제에 내포된 제한사항들을 나타내는 에너지함수의 최소화 과정으로 규정하였다. 채널간, 인접채널, 사이트간의 세 가지 제한사항이 고려되었다. 최적의 채널할당을 위하여 신경회로망을 이용한 방식에서는 강제적인 채널 할당 및 셀 순서 변화 등의 기법이 개발되었고 유전자 알고리즘 방식에서는 자료구조와 적절한 유전연산자를 개발하였다. 실험결과로서, 두 최적화 방법의 채널할당률을 나타내었고 그 결과들을 비교하였다.

• Molecules and Cells
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• 제46권1호
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• pp.65-67
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• 2023

SMILES (simplified molecular-input line-entry system) information of small molecules parsed by one-hot array is passed to a convolutional neural network called black box. Outputs data representing a gene signature is then matched to the genetic signature of a disease to predict the appropriate small molecule. Efficacy of the predicted small molecules is examined by in vivo animal models. GSEA, gene set enrichment analysis.

• 한국정보과학회논문지:소프트웨어및응용
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• 제27권5호
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• pp.463-472
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• 2000

본 논문에서는 연상 메모리 기능을 수행하는 셀룰라 신경망(Cellular Neural Network)의 설계를 위한 새로운 방법론을 제안한다. 먼저, 셀룰라 신경망 모델의 기본적 특성들을 소개한 후, 최적 성능을 가지고 이진 원형 패턴들을 저장할 수 있는 셀룰라 신경망 모델의 설계 방법을 제약 조건이 가해진 최적화 문제로 공식화한다. 다음으로 이 문제의 제약 조건을 선형 행렬 부등식(Linear Matrix Inequalities)을 포함하는 부등식의 형태로 변환시킬 수 있음을 관찰한다. 마지막으로 셀룰라 신경망 최적 설계 문제를 내부점 방법(interior point method)에 의해 효율적으로 풀릴 수 있는 일반화된 고유값 문제(Genaralized EigenValue Problem)로 변환한다. 본 논문에서 제시하는 셀룰라 신경망 설계 방법론은 공간 변형 형판 셀룰라 신경망과 공간 불변 형판 셀룰라 신경망 설계에 모두 적용될 수 있다. 설계 예제를 통해 제안된 방법의 유효성을 검증한다.

• The Journal of Korean Physical Therapy
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• 제13권3호
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• pp.791-797
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• 2001

After brain injury, patients show a wide range in the degree of recovery. By a variety of mechanisms, the human brain is constantly undergoing plastic changes. Spontaneous recovery from brain injury in the chronic stage omes about because of plasticity. The brain regions are altered. resulting in functionally modified cortical network. This review cnsidered the neural plasticity from cellular and molecular mechanisms of synapse formation to behavioural recovery from brain injury in elderly humans. The stimuli required to elicit plasticity are thought to be activity-dependent elements. especially exercise and learning. Knowledge about the physiology of brain plasticity has led to the development of methods for rehabilitation.

• 반도체디스플레이기술학회지
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• 제2권1호
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• pp.7-9
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• 2003

In order to predict the moldability of an injection molded part, a simulation of filling is needed. Short shot is one of the most frequent troubles encountered during injection molding process. The adjustment of process conditions is the most economic way to troubleshoot the problematic short shot in cost and time since the mold doesn't need to be modified at all. But it is difficult to adjust the process conditions appropriately in no times since it requires an empirical knowledge of injection molding. In this paper, the intelligent CAE system synergistically combines fuzzy-neural network(FNN) for heuristic knowledge with CAE programs for analytical knowledge. To evaluate the intelligent algorithms, a cellular phone flip has been chosen as a finite element model and filling analyses have been performed with a commercial CAE software. As the results, the intelligent CAE system drastically reduces the troubleshooting time of short shot in comparison with the expert's conventional way which is similar to the golden section search algorithm.

• 한국반도체및디스플레이장비학회:학술대회논문집
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• 한국반도체및디스플레이장비학회 2002년도 추계학술대회 발표 논문집
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• pp.127-129
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• 2002

In order to predict the moldability of an injection molded part, a simulation of filling is needed. Short shot is one of the most frequent troubles encountered during injection molding process. The adjustment of process conditions is the most economic way to troubleshoot the problematic short shot in cost and time since the mold doesn't need to be modified at all. But it is difficult to adjust the process conditions appropriately in no times since it requires an empirical knowledge of injection molding. In this paper, the intelligent CAE system synergistically combines fuzzy-neural network(FNN) for heuristic knowledge with CAE programs for analytical knowledge. To evaluate the intelligent algorithms, a cellular phone flip has been chosen as a finite element model and filling analyses have been performed with a commercial CAE software. As the results, the intelligent CAE system drastically reduces the troubleshooting time of short shot in comparison with the expert's conventional way which is similar to the golden section search algorithm.

• 산업경영시스템학회지
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• 제39권3호
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• pp.83-89
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• 2016

The group formation problem of the machine and part is a critical issue in the planning stage of cellular manufacturing systems. The machine-part grouping with alternative process plans means to form machine-part groupings in which a part may be processed not only by a specific process but by many alternative processes. For this problem, this study presents an algorithm based on self organizing neural networks, so called SOM (Self Organizing feature Map). The SOM, a special type of neural networks is an intelligent tool for grouping machines and parts in group formation problem of the machine and part. SOM can learn from complex, multi-dimensional data and transform them into visually decipherable clusters. In the proposed algorithm, output layer in SOM network had been set as one-dimensional structure and the number of output node has been set sufficiently large in order to spread out the input vectors in the order of similarity. In the first stage of the proposed algorithm, SOM has been applied twice to form an initial machine-process group. In the second stage, grouping efficacy is considered to transform the initial machine-process group into a final machine-process group and a final machine-part group. The proposed algorithm was tested on well-known machine-part grouping problems with alternative process plans. The results of this computational study demonstrate the superiority of the proposed algorithm. The proposed algorithm can be easily applied to the group formation problem compared to other meta-heuristic based algorithms. In addition, it can be used to solve large-scale group formation problems.