• 정보와 통신
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• 제28권12호
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• pp.50-60
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• 2011

Visible light communication(VLC) is one type of short-range, optical, and wireless communication system utilizing light emitting diode(LED) and laser diode(LD) as optical source. In a VLC system, visible light is used as a transmission medium and used to illuminate. Using VLC has a lot of advantages: it is harmless to human body; it transmits with high power, and it has excellent security, a high data rate, and a license free frequency band. With such a unique blend of communication and illumination in one system, the most common application would be an indoor environment. We aim at reviewing key issues in VLC network such as : FOV(field of view), priority MAC, cooperative MAC, link switching, LED-ID technique, cell site diversity, and link recovery.

• IMMUNE NETWORK
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• 제3권4호
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• pp.302-309
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• 2003

Background: CTLA4 (CD152), which is expressed on the surface of T cells following activation, has a much higher affinity for B7 molecules comparing to CD28, and is a negative regulator of T cell activation. In contrast to stimulating and agonistic capabilities of monoclonal antibodies specific to CTLA-4, CTLA4Ig fusion protein appears to act as CD28 antagonist and inhibits in vitro and in vivo T cell priming in variety of immunological conditions. We've set out to confirm whether inhibition of the CD28-B7 costimulatory response using a soluble form of human CTLA4Ig fusion protein would lead to persistent inhibition of alloreactive T cell activation. Methods: We have used CHO-$dhfr^-$ cell-line to produce CTLA4Ig fusion protein. After serum free culture of transfected cell line we purified this recombinant molecule by using protein A column. To confirm characterization of fusion protein, we carried out a series of Western blot, SDS-PAGE and silver staining analyses. We have also investigated the efficacy of CTLA4Ig in vitro such as mixed lymphocyte reaction (MLR) & cytotoxic T lymphocyte (CTL) response and in vivo such as experimental autoimmune encephalomyelitis (EAE), graft versus host disease (GVHD) and skin-graft whether this fusion protein could inhibit alloreactive T cell activation and lead to immunosuppression of activated T cell. Results: In vitro assay, CTLA4Ig fusion protein inhibited immune response in T cell-specific manner: 1) Human CTLA4Ig inhibited allogeneic stimulation in murine MLR; 2) CTLA4Ig prevented the specific killing activity of CTL. In vivo assay, human CTLA4Ig revealed the capacities to induce alloantigen-specific hyporesponsiveness in mouse model: 1) GVHD was efficiently blocked by dose-dependent manner; 2) Clinical score of EAE was significantly decreased compared to nomal control; 3) The time of skin-graft rejection was not different between CTLA4Ig treated and control group. Conclusion: Human CTLA4Ig suppress the T cell-mediated immune response and efficiently inhibit the EAE, GVHD in mouse model. The mechanism of T cell suppression by human CTLA4Ig fusion protein may be originated from the suppression of activity of cytotoxic T cell. Human CTLA4Ig could not suppress the rejection in mouse skin-graft, this finding suggests that other mechanism except the suppression of cytotoxic T cell may exist on the suppression of graft rejection.

• 한국멀티미디어학회논문지
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• 제5권4호
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• pp.441-449
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• 2002

무선 네트워크 환경에서 멀티미디어 통신을 성공적으로 지원하기 위해서는 핸드오프 시 발생 가능한 연결중단 확률을 최소화함으로써 이동 호스트(클라이언트)에게 연결성을 위한 QoS(Quality of Service)를 보장해야 한다. 그러나, 핸드오프를 필요로 하는 클라이언트의 이동성으로 인해 이동 호스트와 네트워크 간에 협상된 QoS가 보장되지 못할 수도 있다. 이는 각 셀에서 발생하는 트래픽에 할당되는 가용 채널의 제약에 기인한다. 본 논문에서는, 가용채널의 효과적인 확보를 위해 대역폭 예약 기법을 기반으로 한 부하 균형 알고리즘을 제안한다. 제안된 알고리즘은 셀 내의 클라이언트의 이동 방향을 예측한 후, 해당 셀의 부하 상태에 따라 예약될 채널의 크기를 균형있게 조절하여 가용채널을 확보한다. 핸드오프 채널로 예약된 대역폭은 우선적으로 핸드오프를 위해서 사용이 되어지며, 목적지 셀의 가용 채널이 주어진 임계치 이하일 경우, 해당 셀의 가용 채널을 추가로 확보하기 위해서 적응적 대역폭 예약을 이용한 부하균형 알고리즘을 설계함으로써 채널의 이용 효율을 최대화한다. 본 논문에서 제시한 알고리즘의 성능을 평가하기 위해, 신규 호 탈락율, 핸드오프호의 강제종료율을 측정하였다. 시뮬레이션 결과, 본 논문의 성능이 기존의 기법보다 우수함을 알 수 있었다.

• 한국통신학회논문지
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• 제33권4A호
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• pp.377-386
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• 2008

본 논문에서는 IPv6기반 와이브로(WiBro) 시스템에서 핸드오버 지연을 최소화하고, 핸드오버 시 패킷손실이 없는 빠른 이동성제공방안을 제안한다. 이동검출과정에서의 처리지연을 줄이기 위해 링크계층에서 감지한 트리거 정보를 기반으로 링크계층(L2)의 핸드오버와 네트워크 계층(L3)의 핸드오버 처리과정을 결합시켜 단말과 네트워크간의 핸드오버 메시지교환 절차를 단순화하는 방안을 제안한다. 새로운 임시주소 생성과정에서 처리지연을 줄이기 위해 주소생성, 분배 및 관리를 새로운 네트워크 쪽에서 제어하는 방안을 제안한다. 또한, 패킷 전달지연의 최소화 및 패킷손실을 없애기 위해 PACR와 NACR를 연결하는 차 상위계층의 크로스오버 라우터(CR) 개념을 도입하고, CR에 패킷버퍼기능을 제안한다. 시뮬레이션 결과는 본 논문에서 제안한 방안이 셀 중첩반경이 좁고 단말의 이동속도가 빠른 핸드오버 환경에서도 기존 방식에 비해 처리지연이 최소화되고 패킷 손실이 없음을 보여준다.

• 대한전자공학회논문지TC
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• 제45권1호
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• pp.27-32
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• 2008

전파가 도달하지 않는 지하 공간에서는 전파를 중계해주는 중계기가 필요하고, 전파를 방사하기 위한 안테나가 필요하다. 지하공간에서 방사 형태에 따라 안테나 방식과 LCX(Leakage Coxial Cable)방식 또는 RCX(Radiax Coaxcial cable)의 두 종류가 있으며, 설치환경 및 주파수 등 용도에 따라 선택이 틀려질 수 있다. 일반적으로 이동통신에서 주로 많이 사용 되고있는 주파수가 비교적 높은(500MHz대역이상)에서는 안테나 방식을 적용하고, FM, T-DMB, 소방무선, 지하철 자가통신망 등 주파수가 낮은 대역(500MHz이하)에서는 LCX방식을 적용하는 것이 효율적이라고 볼수 있다. 중계망의 설계는 자유공간손실, LCX의 결합/전송 손실의 이론 바탕에서 셀 설계를 할 수 있으며, 무엇보다 필드에서의 실측 실험치의 데이터에 의하여 셀 설계가 가장 현실에 적용하기 적합한 방법이라고 할 수 있다.

• 치과방사선
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• 제20권1호
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• pp.41-49
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• 1990

The author observed the changes of vasculature of pre-and post-irradiation on DMBA induced rat tongue cancer. The study was performed by using vascular corrosion resin casting, and scanning electron microscopy. The results were as follows. 1. The capillaries runned parallely and formed bundles and, sometimes, plexus. The endothelial cells were arranged regularly and small pores were observed. 2. In irradiated normal tongue the capillaries were curved slightly and formed plexus on initial day of post-irradiation. On third day the capillaries and capillary pores were dilated and the endothelial cell arrangement was irregular. The effects of irradiation were gradually increased from initial to the 3rd day, though it was decreased after 7th day. 3. The vasculature of DMBA induced tongue cancer group were very irregular, and large avascular lesions were formed according to the cancer necrosis or tumor cell nest and the vasculature was narrowed and paralleled around the avascular lesion by compression of cancer cell nest. The vascular wall was roughened and dilated, forming club shaped or varix. 4. The vessels were curved and formed reticular network in irradiated DMBA induced tongue carinoma group. The free end of newly formed capillaries had regular width, and also irregular club shaped or aneurysmal dilatation were observed. The vascular structures were destroyed and vessels were fused in tumor necrosis lesion. The radiation effects were marked on the first and third day of irradiation and the effects were decreased after seventh day and showed capillary regeneration.

• BMB Reports
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• 제48권11호
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• pp.597-598
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• 2015

Mitochondrial respiratory defect is a key bioenergetics feature of hepatocellular carcinoma (HCC) cells. However, their involvement and roles in HCC development and progression remain unclear. Recently, we identified 10 common mitochondrial defect (CMD) signature genes that may be induced by retrograde signaling-mediated transcriptional reprogramming in response to HCC mitochondrial defects. HCC patients with enriched expression of these genes had poor prognostic outcomes, such as shorter periods of overall survival and recurrence-free survival. Nuclear protein 1 (NUPR1), a key transcription regulator, was up-regulated by Ca⁺⁺-mediated retrograde signaling. NUPR1-centric network analysis and a biochemical promoter-binding assay demonstrated that granulin (GRN) is a key downstream effector of NUPR1 for the regulation of HCC cell invasiveness; association analysis of the NUPR1-GRN pathway supported this conclusion. Mitochondrial respiratory defects and retrograde signaling thus play pivotal roles in HCC progression, highlighting the potential of the NUPR1-GRN axis as a novel diagnostic marker and therapeutic target for HCC.

• IMMUNE NETWORK
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• 제10권6호
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• pp.188-197
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• 2010

Background: Lichen-derived glucans have been known to stimulate the functions of immune cells. However, immunostimulatory activity of glucan obtained from edible lichen, Umbilicaria esculenta, has not been reported. Thus we evaluated the phenotype and functional maturation of dendritic cells (DCs) following treatment of extracted glucan (PUE). Methods: The phenotypic and functional maturation of PUE-treated DCs was assessed by flow cytometric analysis and cytokine production, respectively. PUE-treated DCs was also used for mixed leukocyte reaction to evaluate T cell-priming capacity. Finally we detected the activation of MAPK and NF-${\kappa}B$ by immunoblot. Results: Phenotypic maturation of DCs was shown by the elevated expressions of CD40, CD80, CD86, and MHC class I/II molecules. Functional activation of DCs was proved by increased cytokine production of IL-12, IL-$1{\beta}$, TNF-${\alpha}$, and IFN-${\alpha}/{\beta}$, decreased endocytosis, and enhanced proliferation of allogenic T cells. Polymyxin B, specific inhibitor of lipopolysaccharide (LPS), did not affect PUE activity, which suggested that PUE was free of LPS contamination. As a mechanism of action, PUE increased phosphorylation of ERK, JNK, and p38 MAPKs, and enhanced nuclear translocation of NF-${\kappa}B$ p50/p65 in DCs. Conclusion: These results indicate that PUE induced DC maturation via MAPK and NF-${\kappa}B$ signaling pathways.

• IMMUNE NETWORK
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• 제20권3호
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• pp.27.1-27.11
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• 2020

Although various studies on predictive markers in the use of PD-1/PD-L1 inhibitors are in progress, only PD-L1 expression levels in tumor tissues are currently used. In the present study, we investigated whether baseline serum levels of IL-6 can predict the treatment response of patients with advanced non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors. In our cohort of 125 NSCLC patients, the objective response rate (ORR) and disease control rate (DCR) were significantly higher in those with low IL-6 (<13.1 pg/ml) than those with high IL-6 (ORR 33.9% vs. 11.1%, p=0.003; DCR 80.6% vs. 34.9%, p<0.001). The median progression-free survival was 6.3 months (95% confidence interval [CI], 3.9-8.7) in the low IL-6 group, significantly longer than in the high IL-6 group (1.9 months, 95% CI, 1.6-2.2, p<0.001). The median overall survival in the low IL-6 group was significantly longer than in the high IL-6 group (not reached vs. 7.4 months, 95% CI, 4.8-10.0). Thus, baseline serum IL-6 levels could be a potential biomarker for predicting the efficacy and survival benefit of PD-1/PD-L1 inhibitors in NSCLC.

• Korean Chemical Engineering Research
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• 제62권3호
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• pp.274-280
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• 2024

기계학습법의 신경망 기술을 이용한 자료분석은 질병 유전자 탐색 및 진단, 신약 개발, 약인성 간 손상 예측 등과 같은 다양한 분야에서 활용되고 있다. 질병 특징 발견을 위한 자료분석은 DNA 정보를 기반으로 이루어질 수 있다. 본 연구에서는 DNA의 분자 정보 중 DNA의 길이와 용액 내 DNA의 길이별 종 개수를 예측하는 신경망을 개발하였다. 겔 전기영동을 통한 기존 방법론의 시간 소요 한계점을 해결하고자, 미세유체역학적 농축 장치의 동역학 자료를 분석 대상으로 하여 실험 분석 과정 중의 시간 소요 문제점을 해결하였다. 동역학 자료를 공간시간 지도로 재구성하여 학습 및 예측에 필요한 계산용량을 낮추었으며, 공간시간 지도에 대한 분석 정확도를 높이기 위해 합성곱 신경망을 활용하였다. 그 결과, 단일 변수 회귀로써의 단일 DNA 길이 예측과 복합 변수 회귀로써의 다종 DNA 길이의 동시 예측 및 이진 분류로써의 DNA 혼합 종 개수 예측을 성공적으로 수행하였다. 추가적으로, 예측 과정 중 발생할 수 있는 예측 편향을 학습 자료 구성 방식을 통한 해결책을 제시하였다. 본 연구를 활용한다면, 광학 측정 자료를 이용하는 액체생검 기반의 세포유리 DNA 분석 및 암 진단 등의 의학 자료 분석을 효과적으로 수행할 수 있을 것이다.