• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2005년도 한국컴퓨터종합학술대회 논문집 Vol.32 No.1 (B)
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• pp.211-213
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• 2005

최근의 위치 측위 기술과 무선 통신 기술의 발전에 따라 위치 기반 서비스에 대한 관심이 크게 증가하고 있다. 기존의 단일 노드 기반 시스템으로는 처리하기 힘든 휴대폰 사용자와 같은 대용량의 객체를 처리하기 위해 제시된 클러스터 기반 분산 컴퓨팅 구조로 GALIS 아키텍처가 제안되었다. 본 논문에서는 제시한 프로토타입은 그동안 구현된 기존 GALIS 프로토타입보다 개선된 구조로 SLDS에서 Global $Cell\_ID$를 적용하여 노드의 분할 합병 시 발생할 수 있는 처리 비용을 감소시켰다. 또한 LLDS에서는 필터링을 통해 손실들 수 있는 위치 데이타 정보를 보다 신뢰할 수 있는 데이타로 만들기 위한 기능을 추가하여 질의 시 발생할 수 있는 여러 가지 상황을 대비할 수 있게 되었다.

• Journal of Species Research
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• 제13권1호
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• pp.61-66
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• 2024

During an investigation of unrecorded prokaryotic species in Korea, six unrecorded bacterial strains were isolated from soil samples collected from Uljin-gun. Based on a similarity search using the 16S rRNA gene sequence of the isolated strains and the construction of the neighbor-joining phylogenetic tree, five strains were identified to the genus Pseudomonas of the family Pseudomonadaceae, while one strain was identified as a species belonging to the genus Paenibacillus of the family Paenibacillaceae. The details of these unreported species, including gram staining reaction, colony and cell morphology, basic biochemical characteristics, strain ID, and isolation source, are described in the description of the strains.

• 한국통신학회논문지
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• 제36권6A호
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• pp.558-567
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• 2011

본 논문에서는 Type 1 relay를 이용하는 3GPP (3rd Generation Pattnership Project) LTE Long Term Evolution)-Advanced 시스템을 위한 부분 전이중 (partial full duplex) relay 기법을 제안한다. Type 1 relay는 백홀 링크 (backhaul link)와 액세스 링크 (access link)가 같은 대역을 이용하는 inband relay로 동시에 백홀 링크와 액세스 링크에서 송수신 하는 경우에 self-interference가 발생하여 수신 성능이 크게 열화되기 때문에 동시에 송수신할 수 없다. 이와 같은 특징 때문에 Type 1 relay는 eNB (evolved NodeB)가 동기 신호를 송신할 때, 자신에게 접속하고 있는 R-UE (Relay-User Equipment)에게 동기 신호를 송신해야 하는 특정에 의해서 eNB가 송신하는 동기 신호를 수신할 수 없어 셀 ID (Identity)를 검출할 수 없는 문제점을 갖는다. 따라서, 이러한 문제점을 해결하기 위하여 본 논문에서는 eNB와 Type 1 relay가 동기 신호를 송신하는 subframe에서만 Type 1 relay가 동시에 송수신하는 부분 전이중 relay 기법을 제안한다. 또한, 동시에 Type 1 relay가 백홀 링크와 액세스 링크에서 송수신하여 발생하는 self-interference를 제거하기 위하여 Type 1 relay의 송수신 안테나 사이의 공간적 분리 (geometric isolation)와 SIC (Self-Interference Cancellation) 방식을 적용하고, SIC의 성능을 높이기 위한 정확한 채널 추정 방안으로 부분 채널 추정 (partial channel estimation) 기법을 제안하며, 다양한 환경에서의 성능 평가를 통해 제안된 방식이 Type 1 relay를 이용하는 3GPP LTE-Advanced 시스템에서 매우 유용한 것을 입증하였다.

• 대한수의학회지
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• 제30권3호
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• pp.333-341
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• 1990

To investigate bovine leukosis virus (BLV) infection in the cattle rearing in a dairy farm where a case of bovine lymphosarcoma had been identified several years ago, the 196 Holstein cattle including newborn calves to 12 years of age were tested. The BLV antibody test and peripheral lymphocyte count for bovine leukosis were carried out by the immunodiffusion (ID) test and Bendixen's Kep. These tests were performed 2 to 4 times at the interval of 3 to 5 months. The observed results were as follows: 1. The positive rates of BLV-antibody in the 1st, the 2nd, the 3rd and the 4th tests were 23.3%, 28.1%, 49.0% and 55.7%, respectively. The conversion rates from negative to positive in the 2nd, the 3rd and the 4th tests were 8.9%, 41.4%, and 20.0%, respectively. Results showed that the highest conversion rate was observed at the 3rd test which was conducted after winter. The highest positive rate by ID test were observed in 4 year old cattle in the 1st and 2nd tests, and in 2 year old herd in the 3rd and 4th tests. 2. In hematological test by Bendixen's Key, the positive and suspicious rates in the 1st, the 2nd, the 3rd and the 4th tests were 5.8 and 7.8%, 8.3 and 6.6%, 8.7 and 10.1%, 10.8 and 19.6% respectively. Results showed that the positive and. suspicious rates increased in course of time. 3. 70 to 100% of the positive cattle in hematological test were positive for BLV-antibody test. All of 13 cattle with persistent lymphocytosis (PL) were also positive for BLV-antibody, indicating the high relationship between PL and BLV-antibody. 4. The number of total leukocytes and absolute lymphocytes in the BLV-antibody positive cattle appeared significantly higher than those of the negative cattle. The markedly increased cell counts were observed in the cattle over one year old. 5. The mean of total leukocytes and absolute lymphocytes in the negative cattle for BLV-antibody increased slightly after sero-conversion into positive. 6. In the clinical examinations during experimental periods, none of the 72 positive cattle for BLV-antibody showed any lesions for bovine leukosis.

• Journal of Oral Medicine and Pain
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• 제26권1호
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• pp.39-50
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• 2001

In order to investigate the effect of Transforming growth factor ${\beta}1$(below TGF-${\beta}1$) and osteogenic protein-1(below Op-1) onto the myogenic differentiation, C2C12 satellite myoblastic cell line was cultured and treated with both growth factors. At first morphological changes with microscopical examination were examined, and isolated total RNA to analyse mRNA expression of bone marker proteins, muscle regulatory proteins, TGF-${\beta}$ receptor and their ligands by Northern blot analysis. And cellular proliferative inducibility of both growth factors was also tested to C2C12 cells. Incubating the cell with $5ng/m{\ell}$ of TGF-${\beta}1$ until 4 days almost inhibited multinucleated myotube formation expressing muscular regulatory proteins, and induced decreasing Id proteins. However, no osteoblastic phenotypes was induced by TGF-${\beta}1$ in C2C12 cells. The mRNA expression of TGF-${\beta}$ receptors with TGF-${\beta}1$ was conversed after 48 hours cultured. Type I TGF-${\beta}$ receptor was seemed to play a role in negative signalling for inhibition of myogenic differentiation. OP-1 dose dependently induced ALP activity, osteopontine production and bone sialoprotein production at concentrations above $100ng/m{\ell}$ and osteocalcin production at concentrations above $300ng/m{\ell}$. The concentration of OP-1 required to induce these osteoblastic phenotypes was the same as that required to almost completely inhibit myotube formation. Incubation with above $100ng/m{\ell}$ OP-1 suppressed the expression of mRNA for muscular egulatory proteins from 2 days after incubation. Expression of Id-1, 2, 3 mRNA were stimulated by OP-1 at concentration above $300ng/m{\ell}$. When C2C12 cells were treated with both growth factors, TGF-${\beta}1$ potentiated the inhibitory effect of OP-1 on myotube formation and expression of mRNA for myogenin at 12 days. And TGF-${\beta}1$ reduced osteocalcin and bone sialoprotein production induced by OP-1 at 12 days in C2C12 cells. Both growth factor had no mitogenic effect. These results indicate that OP-1 converts the differentiation pathway of C2C12 myoblasts into that of osteoblastic lineage cells and it's not heritable, but TGF-${\beta}1$ does not and has reversible inhibitory activity on the myogenic differentiation. TGF-${\beta}1$ and OP-1 play a role in myogenic differentiation via different mechanism between them.

• 대한전자공학회논문지TC
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• 제43권12호
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• pp.53-60
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• 2006

WiBro의 핸드오버는 IEEE 802.16e 기반인 하드 핸드오버 방법이고 핸드오버시 주위 neighbor advertisement 메시지에서 주위 cell의 상태와 RAS(Radio Access Station) ID를 확인하여 핸드오버를 한다. 이때 주변 RAS로 HO-notification 메시지를 보낸다. 예상되는 RAS로 HO-notification 메시지를 보냄으로써 불필요한 signal이 많이 발생하게 되고 핸드오버 수행 시 packet 손실이 발생한다. 이로 인하여 서비스의 품질저하가 발생한다. 이러한 문제점을 해결하기 위하여 LPM(Last Packet Marker) 핸드오버 방법이 제안되었다. LPM 핸드오버는 핸드오버 동안 미리 data packet을 저장하기 때문에, seamless 핸드오버를 지원한다. 또한, GPS를 이용하여 PSS(Portable Subscriber Station)의 위치를 파악함으로써, 이동이 예상되는 RAS를 예측하는 방법과 선인증 과정을 이용하여 이동하고자 하는 RAS를 미리 예약하는 방법들이 제안되고 있다. LPM 핸드오버 방법과 선인증 과정을 이용한 방법은 PSS와 RAS에 부담을 주고, 많은 traffic이 발생한다. 본 논문에서는 이러한 문제점을 해결하기 위해 PSS 이동 예측 알고리즘을 제안한다. PSS가 history cache를 가지고 있고 history cache가 가지고 있는 과거의 핸드오버 data와 비교하여 target RAS를 정하고 HO-notification-RSP 메시지를 target RAS로부터 받을 때 crossover node에 target RAS를 알림으로써 serving RAS와 target RAS로 data 패킷을 bicast하고 target RAS는 buffer에 저장하였다가 핸드오버 완료시 전송함으로써 패킷 손실을 막고 불필요한 시그널링 트래픽을 막는 알고리즘을 제안하였다. 시그널링 트래픽은 history cache가 성공시 약 48%의 traffic이 감소되었고 history cache 실패시 약 기존 핸드오버 보다 약 6%의 traffic이 증가되었다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제49권1호
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• pp.1-7
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• 2000

The SNOSFET memory devices with ultrathin ONO(tunnel oxide-nitride-blocking oxide) gate dielectric were fabricated using n-well CMOS process and investigated its characteristics. The thicknesses of tunnel oxide, nitride and blocking oxide were $23{\AA},\; 53{\AA}\; and\; 33{\AA}$, respectively. Auger analysis shows that the ONO layer is made up of $SiO_2(upper layer of blocking oxide)/O-rich\; SiO_x\N\_y$. It clearly shows that the converting layer with $SiO_x\N\_y(lower layer of blocking oxide)/N-rich SiO_x\N\_y(nitride)/O-rich SiO_x\N\_y(tunnel oxide)$. It clearly shows that the converting layer with $SiO_x\N\_y$ phase exists near the interface between the blocking oxide and nitride. The programming condition of +8 V, 20 ms, -8 V, 50 ms is determined and data retention over 10 years is obtained. Under the condition of 8 V programming, it was confirmed that the modified Fowler-Nordheim tunneling id dominant charge transport mechanism. The programmed threshold voltage is distributed less than 0.1 V so that the reading error of memory stated can be minimized. An $8\times8$ NAND type flash EEPROM with SONOSFET memory cell was designed and simulated with the extracted SPICE parameters. The sufficient read cell current was obtained and the upper limit of $V_{TH}$ for write state was over 2V.

• 대한한의학방제학회지
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• 제28권1호
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• pp.15-27
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• 2020

Objectives : We selected three herb-combined remedies, Bigihwan (BGH), Daechilgitang (DCGT) and Mokwhyangbinranghwan (MHBRH), through Donguibogam text-mining analysis, and evaluated their anti-cancer effects on human hepatocellular carcinoma Hep3B cells. Methods : Cytotoxicity was assessed by an MTT assay. Apoptosis rate, autophagy and ROS level were detected by flow cytometry. The autophagy was also observed by Cyto-ID staining fluorescence microscopy. The expression of autophagy, mitophagy and pexophagy regulatory proteins was detected by Western blot analysis. Results : BGH showed the strongest effect among the three prescriptions in inhibiting Hep3B cell viability, which was associated with the induction of apoptosis and autophagy. Autophagy blockers improved cell viability and reduced apoptosis after BGH and DCGT treatments, indicating that autophagy by these prescriptions enhanced Hep3B cells against their cytotoxicity. However, MHBRH enhanced the reduction of cell viability and apoptosis by autophagy blockers. Induction of autophagy by BGH treatment was associated with mitophagy due to mitochondrial dysfunction than DCGT and MHBRH-treated cells. In addition, induction of apoptosis by BGH treatment was ROS-dependent and showed the possibility of pexophagy involvement. Conclusion : Although further studies need to be conducted to study the efficacy and mechanism of accurate anticancer activity, the present results will serve as important sources of understanding the mechanism of action of herbal remedies prescribed for liver disease as documented in Donguibogam.

• Journal of Chest Surgery
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• 제29권1호
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• pp.7-13
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• 1996

The conventional glutaraldehyde (GA) fixation method of tissue valves is considered to be responsible for accelerated valve degeneration. The release of toxic GA from the valve tissue is believed to limit endothelial cell (EC) ingrowth. Removal of toxic GA by reaction with L-glutamic acid and storage in a Paraben solution may offer good EC growth. To investigate the conditions for endothelialization of tissue valves, the growth properties of ECs on the conventionally and alternatively treated pericardial tissue were compared. Conventional preparation included zero-pressure fixation for 72 hours in phosphated-buffered saline (PBS) solution containing 0.5% GA at 4$^{\circ}C$ and storage into PBS containing 0.2% GA(group I). Alternatively treated pericardial tissues were divided into three postfixation treatment groups : (1) storage in PBS solution containing Paraben(group II), (2) treatment with PBS containing 8$^{\circ}C$ L-glutamic acid(PH 7.35) and storage in PBS solution containing Paraben (g oup III), (3) treatment with L-glutamic acid dissolved in distilled water (PH 3.5) (group IV). Pericardial tissue were transferred into the 24-well plate after storage for 4 weeks. ECs were harvested enzymatically from the bovine pulmonary artery and grown to confluence on culture flask surfaces. Detached ECs by trypsin were incubated into the each well of the 24-well plate including test pericardial tissues. Cells were detached by trypsin, 1, 2, 3, 5, 7 days after incubation and counted on the hemacytometer. Cell viability test was performed by frypan-blue exclusion method. Acute cell death in the group I were found even after prolonged washing. The group II showed prolonged cell survival compared with the group I. Both group III and group IV showed better cell growth than group II. There was no statistically significant difference between group III and group IV method in terms of EC growth. This results suggest that treatment by L-glutamic ac id and storage in a Paraben solution be a promising approach for improvement of durability of GA-treated tissue valves.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권2호
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• pp.169-178
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• 2008

목 적: 건강한 모유 수유아의 경우 생후 6개월까지는 철분 결핍이 일어나지 않으며 6개월 이전에는 철분을 보충할 필요가 없다고 알려져 있으나, 최근 건강한 모유 수유아에서도 생후 6개월 이전에 철 결핍과 철 결핍성 빈혈이 발생한다는 보고가 있다. 따라서 본 연구에서는 생후 6개월과 12개월 영아들의 철 영양상태를 알아보고, 생후 2개월부터 조기 저용량 철분보충요법을 시행하여 철 결핍과 철 결핍성 빈혈을 예방하는데 효과가 있는지 알아보고자 하였다. 방 법: 2004년 8월부터 2005년 7월까지 만 1년간 충북대학교병원 산부인과에서 만삭으로 출생한 건강한 신생아 87명을 대상으로 하였다. 이들을 생후 2개월에 분유 수유군(A군), 모유 대조군(B군), 모유 보충군(S군, 철분 5 mg/일 보충)으로 나누어 출생 시(제대혈), 생후 6개월, 12개월에 저장철(ferritin), 혈청 철(iron), 총철결합능(total iron binding capacity, TIBC), 트랜스 페린 포화도(transferrin saturation rate, TFSAT)와 헤모글로빈(hemoglobin), 헤마토크릿(hematocrit), 평균적 혈구용적(mean corpuscular volume, MCV), 평균적혈구혈색소량(mean corpuscular hemoglobin, MCH), 적혈구분포폭(red cell distribution width, RDW)을 측정하였다. 결 과: 1) 생후 6개월에 측정한 저장철, 혈청 철, TFSAT, 헤모글로빈은 세 군 중 모유 대조군에서 가장 낮았으며, 총철결합능과 적혈구분포폭은 가장 높았다. 저장철 고갈, 철 결핍, 철 결핍성 빈혈의 빈도는 모유대조군에서 각각 33, 33, 30%로 분유 수유군의 0, 5, 8%나 모유 보충군의 1, 7, 5%보다 높았다. 2) 생후 12 개월의 저장철, TFSAT, 헤모글로빈, MCV, MCH는 세군 중 모유 대조군에서 가장 낮았으며, 총철결합능과 적혈구분포폭은 가장 높았으나, 혈청 철과 헤마토크릿은 세 군 간에 유의한 차이가 없었다. 저장철 고갈, 철결핍, 철 결핍성 빈혈의 빈도는 모유 대조군에서 각각 73, 64, 50%로 분유 수유군의 4, 4, 3%나 모유 보충군의 9, 9, 7%보다 높았다. 결 론: 철 결핍 상태와 철 결핍성 빈혈은 모유 수유아에서 분유 수유아에 비해 높은 빈도를 보였다. 또한, 철분 보충 없이 모유 수유만 했던 영아의 경우 생후 6개월에도 철 결핍과 철 결핍성 빈혈이 발생하였으며, 조기 저용량 철분보충요법은 모유 수유아에서 철 결핍과철 결핍성 빈혈을 예방하는데 효과가 있었다.