• The Journal of Korean Institute of Communications and Information Sciences
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• 제41권8호
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• pp.903-910
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• 2016

This paper investigates an advanced receiver for interference mitigation of downlink control channel in the 3GPP Rel-13 standard. There are several features for downlink throughput performance improvement with inter-cell interference management such as network coordination and advanced receivers during Rel-10~Rel-12. These features can be operated always under the assumption that UE perfectly decodes control channels (PCFICH and PDCCH) of serving cell. However, the performance of control channels could be deteriorated in the cell edge region due to inter-cell interference. In this paper, we introduce the advanced receivers and analyze performance for control channel interference mitigation (CCIM) based on 3GPP Rel-13 standard. Additionally, we propose UE behavior depending on network condition.

• Journal of the Institute of Electronics Engineers of Korea TC
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• 제41권11호
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• pp.57-66
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• 2004

It is widely accepted that the coverage with high user densities in mobile multimedia environments can only be achieved with small cell such as micro- and pico-cell. The smaller cell size causes frequent handovers between cells and a decrease in the permissible handover processing delay. This may result in the handover failure, in addition to the loss of some packets during the handover. In these cases, re-transmission is needed in order to compensate errors, which triggers a rapid degradation of throughput. In this paper, we propose a new handover scheme in the next generation mobile communication systems, in which the handover setup process is done in advance before a handover request by predicting the handover cell based on mobile terminal's current position and moving direction. Simulation is focused on the handover failure rate and packet loss rate. The simulation results show that our proposed method provides a better performance than the conventional method.

• Journal of Pharmacopuncture
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• 제15권3호
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• pp.19-30
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• 2012

Objectives: Many efforts have shown multi-oncologic roles of galectin-3 for cell proliferation, angiogenesis, and apoptosis. However, the mechanisms by which galectin-3 is involved in cell proliferation are not yet fully understood, especially in human colon cancer cells. Methods: To cluster genes showing positively or negatively correlated expression with galectin-3, we employed human colon cancer cell lines, SNU-61, SNU-81, SNU-769B, SNU-C4 and SNU-C5 in high-throughput gene expression profiling. Gene and protein expression levels were determined by using real-time quantitative polymerase chain reaction (PCR) and western blot analysis, respectively. The proliferation rate of human colon cancer cells was measured by using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results: Expression of ${\gamma}$-aminobutyric acid B receptor 1 (GABABR1) showed a positive correlation with galectin-3 at both the transcriptional and the translational levels. Down-regulation of galectin-3 decreased not only GABABR1 expression but also the proliferation rate of human colon cancer cells. However, Korean herbal extract, HangAmDan-B (HAD-B), decreased expression of GABABR1 without any expressional change of galectin-3, and offset ${\gamma}$-aminobutyric acid (GABA)-enhanced human colon cancer cell proliferation. Conclusions: Our present study confirmed that GABABR1 expression was regulated by galectin-3. HAD-B induced galectin-3-independent down-regulation of GABABR1, which resulted in a decreased proliferation of human colon cancer cells. The therapeutic effect of HAD-B for the treatment of human colon cancer needs to be further validated.

• Biomolecules & Therapeutics
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• 제22권5호
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• pp.371-383
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• 2014

The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and functional analysis of drugs (or small-molecules) in vivo. In this review, we describe conserved oncogenic signaling pathways (Wnt, Notch, and Ras) and their potential roles in the development of cancer stem cells. During C. elegans germline development, these signaling pathways regulate multiple cellular processes such as germline stem cell niche specification, germline stem cell maintenance, and germ cell fate specification. Therefore, the aberrant regulations of these signaling pathways can cause either loss of germline stem cells or overproliferation of a specific cell type, resulting in sterility. This sterility phenotype allows us to identify drugs that can modulate the oncogenic signaling pathways directly or indirectly through a high-throughput screening. Current in vivo or in vitro screening methods are largely focused on the specific core signaling components. However, this phenotype-based screening will identify drugs that possibly target upstream or downstream of core signaling pathways as well as exclude toxic effects. Although phenotype-based drug screening is ideal, the identification of drug targets is a major challenge. We here introduce a new technique, called Drug Affinity Responsive Target Stability (DARTS). This innovative method is able to identify the target of the identified drug. Importantly, signaling pathways and their regulators in C. elegans are highly conserved in most vertebrates, including humans. Therefore, C. elegans will provide a great opportunity to identify therapeutic drugs and their targets, as well as to understand mechanisms underlying the formation of cancer.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제36권3A호
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• pp.259-266
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• 2011

Femtocells are expected as the surest way to increase the system capacity with higher-quality links and more spatial reuse in future networks. In spite of their great potential, the system capacity is highly susceptible to network density because a large portion of users are exposed to inter-cell interference (ICI). In this work, we proposed a dynamic interference avoidance scheme in densely deployed cell environments. Our proposed DDIA (Distributed Dynamic ICI Avoidance) scheme not only works in a fully distributed manner, but also controls interference link connectivity of users with high agility so that it is suited for self-organizing networks (SONs). We introduced the concept of ICI-link and two-tier scheduling in designing the DDIA scheme. To avoid ICI without any central entity, our scheme tries to harmonize all base stations (BSs) with users adaptively. Through extensive simulations, it was shown that our proposed scheme improves the throughput of users by more than twice on average compared to the frequency reuse factor 1 scheme, who are exposed to ICI while maintaining or even improving overall network performance. Our scheme operates well regardless of network density and topology.

• KIPS Transactions on Computer and Communication Systems
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• 제7권8호
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• pp.203-210
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• 2018

Mobile traffic is increasing consistently, and mobile carriers are becoming more and more hard to meet this ever-increasing mobile traffic demand by means of additional installation of base stations. To overcome this problem, heterogeneous networks, which can reuse space and frequency by installing small cells such as femto cells in existing macro cells, were introduced. However, existing macro cell users are difficult to increase the spectral efficiency without the cooperation of femto owners. Femto owners are also reluctant to accommodate other mobile stations in their femto stations without proper incentive. In this paper, a method of obtaining the optimal incentive is proposed, which adopts a utility function based on the logarithm of throughput of mobile stations, and the incentive is calculated to maximize the utility of the entire network.

• Journal of the Korea Society of Computer and Information
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• 제11권3호
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• pp.1-10
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• 2006

It is widely accepted that the coverage with high user densities can only be achieved with small cell such as micro- and pico-cell. The smaller cell size causes frequent handovers between cells and a decrease in the permissible handover Processing delay. This may result in the handover failure. in addition to the loss of some Packets during the handover. In these cases. re-transmission is needed in order to compensate errors, which triggers a rapid degradation of throughput. In this paper, we propose a new handover scheme in the next generation mobile communication systems, in which the handover setup process is done in advance before a handover request by predicting the handover cell based on mobile terminal's current position and moving direction. Simulation is focused on the handover failure rate and Packet loss rate. The simulation results show that our proposed method provides a better performance than the conventional method.

• BMB Reports
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• 제55권12호
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• pp.645-650
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• 2022

Epithelial-to-mesenchymal transition (EMT)-subtype gastric cancers have the worst prognosis due to their higher recurrence rate, higher probability of developing metastases and higher chemo-resistance compared to those of other molecular subtypes. Pharmacologically actionable somatic mutations are rarely found in EMT-subtype gastric cancers, limiting the utility of targeted therapies. Here, we conducted a high-throughput chemical screen using 37 gastric cancer cell lines and 48,467 synthetic small-molecule compounds. We identified YK-135, a small-molecule compound that showed higher cytotoxicity toward EMT-subtype gastric cancer cell lines than toward non-EMT-subtype gastric cancer cell lines. YK-135 exerts its cytotoxic effects by inhibiting mitochondrial complex I activity and inducing AMP-activated protein kinase (AMPK)-mediated apoptosis. We found that the lower glycolytic capacity of the EMT-subtype gastric cancer cells confers synthetic lethality to the inhibition of mitochondrial complex I, possibly by failing to maintain energy homeostasis. Other well-known mitochondrial complex I inhibitors (e.g., rotenone and phenformin) mimic the efficacy of YK-135, supporting our results. These findings highlight mitochondrial complex I inhibitors as promising therapeutic agents for EMT-subtype gastric cancers and YK-135 as a novel chemical scaffold for further drug development.

• Journal of the Korean Institute of Telematics and Electronics S
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• 제35S권11호
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• pp.44-52
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• 1998

In this paper, we proposed a node architecture and cell routing strategies for ATM applications in WDM multihop networks. The proposed node architecture employs the optical delay loop for storing the cell which is failed in out-link contention. This optical delay loop allows the delay of one cell without the electro-optic conversion. Therefore, we can get the advantages of S&F(Store-and-Forward) routing in Deflection-based all-optical networks. To support the ATM applications efficiently. we considered the transmission priority of ATM cell so that high priority cell can be transmitted with lower loss and shorter delay than low priority one. Two kinds of routing strategies are designed for this architecture: Scheme-Ⅰand Scheme-Ⅱ. Scheme-Ⅰapplies S&F routing to high cell and Deflection routing to low cell, i.e., high cells are routed along the shortest path based on S&F routing, but low cells are deflected or lost. Schem-Ⅱ is similar to Scheme-Ⅰexcept that low cells can occupy the optical loop if it is available. This Scheme-Ⅱ increases the utilization of network resources without decreasing the throughput of high cell by reducing the low cell loss rate when traffic load is low. Simulation results show that our routing strategies have better performance than conventional ones under non-uniform traffic as well as uniform traffic.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제37A권12호
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• pp.1076-1084
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• 2012

In the CS/CB(Coordinated Scheduling/Beamforming) scheme, the cell edge user throughput is increased by selecting MIMO (Multiple Input Multiple Output) precoders which can minimize the interferences from adjacent base stations (BSs). However, in current LTE(Long Term Evolution) systems, the serving cell is selected in the initialization stage by using the synchronization signals and cell specific reference signals transmitted by adjacent BSs with a single antenna. The selected BS in the initialization stage may not be the best one since the MIMO precoding gain has not been considered in the cell selection stage. In this paper, a new cell selection technique is proposed for LTE systems with MIMO precoder by taking into account the effect of the precoder in the initialization stage. The proposed technique enables a user equipment (UE) in the cell boundary to select the serving BS by using the information (channel rank, effective channel capacity, and effective SINR(Signal to Interference plus Noise Ratio)) acquired from cell specific reference signals of candidate BSs. It is verified by computer simulation that the proposed technique can increase the channel capacity significantly in the multi-cell environments, compared with the conventional CS/CB scheme.