• YAKHAK HOEJI
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• v.51 no.4
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• pp.285-290
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• 2007

The oxidative stress causes many diseases like cancer, aging, cardiovascular disease, degenerative neurological disorders (Parkinson’s disease, and Alzheimer's disease) by damage of cell membrane, protein deformation, and damage of DNA due to the oxidation of lipid of cell membrane, protein of tissue or enzyme, carbohydrate, and DNA. It is caused by the reactive oxygen species (ROS) that is produced in the metabolic process of oxygen in cell. The superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in cell systemize the antioxidative enzymes to control the oxidative stress. In this research, it is measured that the survival rate of cell by the typical isoflavonoid of daidzein or genistein, activity of antioxidative enzyme, and ROS level, in order to study the effect of isoflavonoid over the ROS production in cell and antioxidative system. As the similar action of the isoflavonoid with the estrogen is examined, women are encouraged to get bean. In view of this trend, it is very important to find out a combination medicine that lowers the oxidative stress caused by the daidzein in the ovarian cell. In the combined treatment of the typical antioxidant of vitamin C to oxidative stress which induced by daidzein recover the control level particularly lowering the ROS in cell by 30%. However, it made no effect in the combined treatment with genistein. Therefore, the research took the combination effect of daidzein with vitamin C in order to check it effect over the antioxidative system. In conclusion, it was disclosed that the oxidative stress caused by daidzein is related to the lowering activity of SOD, and the specific combination effect of daidzein with vitamin C is related to the recovery of SOD activity.

• IMMUNE NETWORK
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• v.23 no.3
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• pp.29.1-29.23
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• 2023

Cholesterol (CL) is required for various biomolecular production processes, including those of cell membrane components. Therefore, to meet these needs, CL is converted into various derivatives. Among these derivatives is cholesterol sulfate (CS), a naturally produced CL derivative by the sulfotransferase family 2B1 (SULT2B1), which is widely present in human plasma. CS is involved in cell membrane stabilization, blood clotting, keratinocyte differentiation, and TCR nanocluster deformation. This study shows that treatment of T cells with CS resulted in the decreased surface expression of some surface T-cell proteins and reduced IL-2 release. Furthermore, T cells treated with CS significantly reduced lipid raft contents and membrane CLs. Surprisingly, using the electron microscope, we also observed that CS led to the disruption of T-cell microvilli, releasing small microvilli particles containing TCRs and other microvillar proteins. However, in vivo, T cells with CS showed aberrant migration to high endothelial venules and limited infiltrating splenic T-cell zones compared with the untreated T cells. Additionally, we observed significant alleviation of atopic dermatitis in mice injected with CS in the animal model. Based on these results, we conclude that CS is an immunosuppressive natural lipid that impairs TCR signaling by disrupting microvillar function in T cells, suggesting its usefulness as a therapeutic agent for alleviating T-cell-mediated hypersensitivity and a potential target for treating autoimmune diseases.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.209-212
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• 2004

A navel fast-switching LCD with dual-domain bend (DDB) mode is described DDB alignment is achieved using antiparallel-rubbed cell filled with chiral-doped LC. Initial alignment is mono-domain 180-degree twist. Tilt direction is controlled by oblique electric field to be counter direction in each domain Twist-to-DDB deformation occurs continuously so that DDB mode does not require high-voltage initialization which is inevitable in Optically Compensated Bend (OCB) mode. DDB gives wide and symmetric viewing angle in contrast to mono-domain bend formed from 180-degree twist showing strong asymmetry.

• Journal of the Semiconductor & Display Technology
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• v.3 no.2
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• pp.23-26
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• 2004

Thin film is one of the most general structures used in micro-electro-mechanical systems (MEMS). To measure the mechanical properties of SU-8 film, tensile testing was adopted which offers not only elastic modulus but also yield strength and plastic deformation by load-displacement curve. Tensile testing system was constructed with linear guided servo motor for actuation, load cell for force measurement and dual microscope for strain measurement.

• Korean Journal of Food Science and Technology
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• v.29 no.2
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• pp.266-272
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• 1997

In order to investigate the compression and decompression properties of cucumber, radish, garlic, ginger and potato, edible parts of samples were prepared to size of ${\Phi}\;5\;mm{\times}H\;5\;mm$, and force deformation relationship during application and removal of force were observed. Compositions of sample and cell characteristics were measured, and correlations between them were investigated. Deformation rate was large in initial stage of compression and decreased afterward, but the reverse trends were observed in the decompression. The time and deformation to 9 N were large of 5.30 sec and 1.344 mm in potato, and small of 4.62 sec and 0.896 mm in garlic, respectively. Force(y)-deformation(x) curve between compression and decompression were clearly showed hysteresis loop and relationship of x and y were as follows: y=esp (a+b log(x)). The maximum work was $3.888{\sim}5.099{\times}10^{-3}\;J$ for potato in compression and $2.09{\times}10^{-3}\;J$ for garlic in decompression. Irrecoverable work were large as $77{\sim}96%$ in cucumber, radish and potato, and small as $36{\sim}42%$ in garlic. Compression deformation were large as $1.016{\sim}1.344\;mm$ in potato, and small as $0.656{\sim}0.896\;mm$ in garlic. Degree of elasticity were large as $0.756{\sim}0.777$ in garlic, and small as $0.301{\sim}0.465$ in radish and potato. Compression and decompression characteristic values were showed high correlation with moisture, viscosity of juice, ceil size, density and regularity.

• Journal of the Korean Mathematical Society
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• v.33 no.3
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• pp.625-639
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• 1996

A convex $RP^n$-structure on a smooth anifold M is a representation of M as a quotient of a convex domain $\Omega \subset RP^n$ by a discrete group $\Gamma$ of collineations of $RP^n$ acting properly on $\Omega$. When M is a closed surface of genus g > 1, then the equivalence classes of such structures form a moduli space $B(M)$ homeomorphic to an open cell of dimension 16(g-1) (Goldman [2]). This cell contains the Teichmuller space $T(M)$ of M and it is of interest to know what of the rich geometric structure extends to $B(M)$. In [3], a symplectic structure on $B(M)$ is defined, which extends the symplectic structure on $T(M)$ defined by the Weil-Petersson Kahler form.

• 한국정보디스플레이학회:학술대회논문집
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• 2003.07a
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• pp.524-527
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• 2003

Plastic LCDs have remarkable advantages as compared to glass LCDs, but there still exist reliability issue. Regarding the reliability issue of plastic LCDs, we investigated the phenomena of dark spots that often occurred in plastic LCDs. It was recognized that dark spots are mainly caused by air bubbles that are induced from outside of LCD panel due to cell volume change with external stress and incomplete encapsulation. We have found that cell gap uniformity, spacer density and size and film deformation are important factors influencing dark spot behavior. In this paper, we discuss the phenomena and origin of dark spots in plastic LCDs

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.585-590
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• 2003

The distributions of mass flow rate and pressure are major factors to deside the performance of a proton exchange membrane fuel cell (PEMFC). These factors are affected by channel configuration of air plate. In this paper. structural analysis is performed to investigate deformation of porous media. Two kind of models are suggest for flow analyses. Deformed porous media and undeformed porous media are considered for air plate model. The Numerical flow analysis results with deformed porous media and undeformed porous media had some discrepancy in pressure distribution. The pressure and velocity in a working condition are numerically calculated to predict the performance of the air plates. Distributions of the parameters in the PEMFC are analyzed numerically under steady-state conditions.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.2
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• pp.79-88
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• 2005

Evaluating the effective properties of materials containing various types of in-homogeneities is an important issue in the analysis of structures composed of those materials. A simple and effective method for the purpose is to impose the periodic displacement boundary conditions on the finite element model of a unit cell. Their theoretical background is explained based on the purely kinematical relations in the regularly spaced in-homogeneity problems, and the strategies to implement them into the analysis and to evaluate the homogenized material constants are introduced. The creep behavior of a thin sheet with square arrayed rectangular voids is characterized, where the orthotropy is induced by the presence of the voids. The homogenization method is validated through the comparison of the analysis of detailed model with that of the simplified one with the effective parameters.

• 한국정보디스플레이학회:학술대회논문집
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• 2005.07a
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• pp.167-170
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• 2005

The mechanism of striation in the coplanar- and matrix-type plasma display panel (PDP) cells has been studied using the particle-in-cell Monte-Carlo Collision (PIC-MCC) model. The striation formation is related to the ionization energy of neutral atoms and the well-like deformation of space potential by space charge distribution. Negative wall charge accumulation by electrons on the MgO surface of the anode region is also one of the key factors for the formation of striation. The clearness of the striation phenomenon in PIC-MCC code in comparison with fluid code can be explained by using nonlocal electron kinetic effect.