• The Korean Journal of Urological Oncology
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• 제15권3호
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• pp.103-110
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• 2017

Cancer is the tissue complex consisted with heterogeneous cellular compositions, and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell-cell interactions as well as cell-extracellular matrix play major roles. Conventional cancer models both 2-dimensional and 3-dimensional (3D) present numerous limitations, which restrict their use as biomimetic models for drug screening and fundamental cancer biology studies. Recently, bioprinting biofabrication platform enables the creation of high-resolution 3D structures. Moreover this platform has been extensively used to model multiple organs and diseases, and this versatile technique has further found its creation of accurate models that figure out the complexity of the cancer microenvironment. In this review we will focus on cancer biology and limitations with current cancer models and we discuss vascular structures bioprinting that are critical to the construction of complex 3D cancer organoids. We finally conclude with current literature on bioprinting cancer models and propose future perspectives.

• BMB Reports
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• v.56 no.11
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• pp.612-617
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• 2023

Pleiotropic regulator 1 (PLRG1), a highly conserved element in the spliceosome, can form a NineTeen Complex (NTC) with Prp19, SPF27, and CDC5L. This complex plays crucial roles in both pre-mRNA splicing and DNA repair processes. Here, we provide evidence that PLRG1 has a multifaceted impact on cancer cell proliferation. Comparing its expression levels in cancer and normal cells, we observed that PLRG1 was upregulated in various tumor tissues and cell lines. Knockdown of PLRG1 resulted in tumor-specific cell death. Depletion of PLRG1 had notable effects, including mitotic arrest, microtubule instability, endoplasmic reticulum (ER) stress, and accumulation of autophagy, ultimately culminating in apoptosis. Our results also demonstrated that PLRG1 downregulation contributed to DNA damage in cancer cells, which we confirmed through experimental validation as DNA repair impairment. Interestingly, when PLRG1 was decreased in normal cells, it induced G1 arrest as a self-protective mechanism, distinguishing it from effects observed in cancer cells. These results highlight multifaceted impacts of PLRG1 in cancer and underscore its potential as a novel anti-cancer strategy by selectively targeting cancer cells.

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.246.3-247
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• 2001

• Bulletin of the Korean Chemical Society
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• v.22 no.10
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• pp.1131-1135
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• 2001

• Proceedings of The Korean Society of Agricultural and Forest Meteorology Conference
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• 2016.09a
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• pp.135-138
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• 2016

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.143.3-144
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• 2001

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.143.1-143.1
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• 2001

• Proceedings of the PSK Conference
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• 2001.10a
• /
• pp.244.1-244.1
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• 2001

• Communications for Statistical Applications and Methods
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• v.9 no.3
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• pp.853-864
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• 2002

In the analysis of categorical data subject to misclassification errors, the observed cell proportions are adjusted by a misclassification probabilities and estimates of variances are adjusted accordingly. In this case, it is important to determine the extent to which misclassification probabilities are homogeneous within a population. This paper considers methods to evaluate the power of chi-squared tests for homogeneity with complex survey data subject to misclassification errors. Two cases are considered: adjustment with homogeneous misclassification probabilities; adjustment with heterogeneous misclassification probabilities. To estimate misclassification probabilities, logistic regression method is considered.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.127-128
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• 2006

Nafion/basic polymer composite membranes were prepared to reduce the methanol crossover for the application of direct methanol fuel cell. The thermal and mechanical properties increased with increasing basic polymer contents due to the formation of complex via acid/basic interaction. The water uptake, proton conductivity, methanol permeability decreased with increasing basic polymer concentration by reduction of acidity associated with the formation of acid/base complex. The molecular effect on those properties was not considerable.